{"id":"https://openalex.org/W31668367","doi":null,"title":"Management of prehospital thrombolytic therapy in ST-segment elevation acute coronary syndrome (<12 hours).","display_name":"Management of prehospital thrombolytic therapy in ST-segment elevation acute coronary syndrome (<12 hours).","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W31668367","mag":"31668367","pmid":"https://pubmed.ncbi.nlm.nih.gov/15886591"},"language":"en","primary_location":{"id":"pmid:15886591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15886591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva anestesiologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"P Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Goldstein","raw_affiliation_strings":["Emergency Department, Lille Univesity Hospital, CHRU Lille Cedex, France. Pgoldstein@chru-lille.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, Lille Univesity Hospital, CHRU Lille Cedex, France. Pgoldstein@chru-lille.fr","institution_ids":["https://openalex.org/I3018718406"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022414450","display_name":"\u00c9. Wiel","orcid":"https://orcid.org/0000-0003-1133-3129","observed_orcids":["https://orcid.org/0000-0003-1133-3129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Wiel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0813,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.7937065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"71","issue":"6","first_page":"297","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infarction","display_name":"infarction","score":0.7929999828338623},{"id":"https://openalex.org/keywords/prehospital-thrombolysis","display_name":"prehospital thrombolysis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/st-segment-elevation-acute-coronary-syndrome","display_name":"ST-elevation acute coronary syndrome","score":0.9430000185966492},{"id":"https://openalex.org/keywords/time-to-reperfusion","display_name":"reperfusion time","score":0.8939999938011169},{"id":"https://openalex.org/keywords/samu","display_name":"SAMU","score":0.6110000014305115},{"id":"https://openalex.org/keywords/mobile-intensive-care-unit","display_name":"mobile intensive care unit","score":0.9200000166893005},{"id":"https://openalex.org/keywords/primary-percutaneous-coronary-intervention","display_name":"primary percutaneous coronary intervention","score":0.9129999876022339},{"id":"https://openalex.org/keywords/antithrombotic-agents","display_name":"antithrombotic agents","score":0.6970000267028809},{"id":"https://openalex.org/keywords/chest-pain-management","display_name":"chest pain management","score":0.4359999895095825},{"id":"https://openalex.org/keywords/mortality-reduction","display_name":"mortality reduction","score":0.6100000143051147},{"id":"https://openalex.org/keywords/sudden-cardiac-death-prevention","display_name":"sudden cardiac death prevention","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9543474316596985},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.8689757585525513},{"id":"https://openalex.org/C2778704086","wikidata":"https://www.wikidata.org/wiki/Q693058","display_name":"Chest pain","level":2,"score":0.6489399075508118},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6415171027183533},{"id":"https://openalex.org/C545288138","wikidata":"https://www.wikidata.org/wiki/Q860447","display_name":"Emergency medical services","level":2,"score":0.5613526701927185},{"id":"https://openalex.org/C2780387585","wikidata":"https://www.wikidata.org/wiki/Q4816772","display_name":"Reperfusion therapy","level":3,"score":0.5042580366134644},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.48249387741088867},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4654923677444458},{"id":"https://openalex.org/C2780215737","wikidata":"https://www.wikidata.org/wiki/Q2708761","display_name":"Golden hour (medicine)","level":2,"score":0.4610196352005005},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.4506256878376007},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.43611961603164673},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.4165419042110443},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3316727578639984},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.19352561235427856},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004632","descriptor_name":"Emergency Medical Services","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015425","descriptor_name":"Myocardial Reperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15886591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15886591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva anestesiologica","raw_type":"Journal Article"},{"id":"mag:31668367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15886591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W571966314","https://openalex.org/W1125885849","https://openalex.org/W1964697646","https://openalex.org/W1990263689","https://openalex.org/W2039584472","https://openalex.org/W2051527449","https://openalex.org/W2058279246","https://openalex.org/W2066243100","https://openalex.org/W2085273941","https://openalex.org/W2094524658","https://openalex.org/W2101831741","https://openalex.org/W2110005071","https://openalex.org/W2114205889","https://openalex.org/W2117033836","https://openalex.org/W2121369371","https://openalex.org/W2121586076","https://openalex.org/W2121911476","https://openalex.org/W2132323196","https://openalex.org/W2148076902","https://openalex.org/W2152692480","https://openalex.org/W2157583453","https://openalex.org/W2159301256","https://openalex.org/W2160040448","https://openalex.org/W2161944342","https://openalex.org/W2168613507","https://openalex.org/W2180378587","https://openalex.org/W2267558281","https://openalex.org/W2299345761","https://openalex.org/W2528314448","https://openalex.org/W2559766601","https://openalex.org/W2575905642","https://openalex.org/W2619684722","https://openalex.org/W2626327057","https://openalex.org/W2747809796","https://openalex.org/W2772974601","https://openalex.org/W2791453261","https://openalex.org/W2808668519","https://openalex.org/W2895277465","https://openalex.org/W2899848198","https://openalex.org/W2903503946","https://openalex.org/W2903840912","https://openalex.org/W2904560398","https://openalex.org/W2905427937","https://openalex.org/W2905969970","https://openalex.org/W2950573547"],"related_works":["https://openalex.org/W2410116989","https://openalex.org/W1983213499","https://openalex.org/W188646075","https://openalex.org/W2061876960","https://openalex.org/W2359066495","https://openalex.org/W2466347960","https://openalex.org/W2183023103","https://openalex.org/W2181505445","https://openalex.org/W2121439923","https://openalex.org/W2127122325"],"abstract_inverted_index":{"UNLABELLED:":[0],"Acute":[1],"myocardial":[2,282,427,772],"infarction":[3,283,773],"(AMI)":[4],"is":[5,42,72,91,113,165,176,182,240,247,263,301,315,350,387,406,467,480,493,529,600,616,630,635,677,702,763,792,801],"the":[6,29,36,49,75,97,104,109,116,123,132,143,170,194,198,202,206,210,220,251,269,276,289,311,326,344,377,390,394,410,422,436,441,457,462,472,499,520,524,536,557,574,584,593,603,611,619,633,638,645,664,683,711,713,724,731,736,759,793],"prototype":[7],"of":[8,24,31,40,78,84,106,111,126,129,139,152,169,196,212,223,238,278,291,295,305,346,362,380,389,393,415,440,538,543,559,598,606,622,627,663,682,730,735,758],"a":[9,136,177,229,236,285,302,351,444,450,552,566,580,694,781],"real":[10,286,423,782],"emergency,":[11],"and":[12,15,63,188,205,266,293,371,563,582,632,648,666,685,742,744,752,756,778,787,806],"both":[13,264],"efficacy":[14,370,755],"speed":[16],"are":[17,364,455,705,719],"necessary":[18],"for":[19,330,425,690,770],"effective":[20,321],"management.":[21],"The":[22,69,174,255,453,548,596,625,698,718,754,767],"advent":[23],"thrombolysis":[25,112,119,246,262,292,401,447,465,479,506,546,562],"therapy":[26,56,154],"has":[27,57,258],"transformed":[28],"care":[30,172,233],"these":[32,319,686],"patients.":[33],"In":[34,131,160,209,341,565],"fact,":[35],"most":[37,327],"frequent":[38],"complication":[39],"AMI":[41,239,608],"sudden":[43],"death":[44],"which":[45,355],"still":[46],"occurs":[47],"within":[48],"first":[50,98],"hour":[51],"after":[52,103],"symptom":[53],"onset.":[54],"Thrombolytic":[55],"been":[58,148],"shown":[59,87,655],"to":[60,100,118,141,145,156,158,183,227,273,317,324,335,338,367,372,375,383,402,431,476,490,507,527,591,613,660,722,726,785,795,802],"reduce":[61,142],"early":[62,79],"long":[64],"term":[65,414],"mortality":[66,70,460,487,587],"about":[67],"20%.":[68],"gain":[71],"dependent":[73],"on":[74,504],"delay":[76,200,473,525],"time":[77,117,144,612,725],"reperfusion.":[80,340],"A":[81,359],"large":[82,137,360],"number":[83,138,304,361],"studies":[85,363],"have":[86,147,430,654,692],"that":[88,260,310,703,800],"this":[89,342,434,484,588,676],"relationship":[90],"best":[92,252,312,594,768],"described":[93],"as":[94,250,637,641],"exponential:":[95],"in":[96,413,433,461,519,541,551,577,644,679,780],"1":[99],"2":[101,482,532],"hours":[102,483,533],"onset":[105],"chest":[107,218],"pain,":[108,219],"benefit":[110],"greater.":[114],"Reducing":[115],"must":[120],"therefore":[121],"be":[122,384,421,556,592],"main":[124,391],"objective":[125],"prehospital":[127,162,245,261,400,607,623],"treatment":[128,253,528,727],"AMI.":[130],"last":[133,270],"10":[134],"years,":[135],"strategies":[140,412],"reperfusion":[146,279,659,691],"evaluated,":[149],"including":[150,572],"initiation":[151],"thrombolytic":[153],"prior":[155],"arrival":[157,597],"hospital.":[159],"France,":[161],"emergency":[163,185,214,714,776],"medicine":[164],"an":[166,190,213],"integral":[167],"part":[168],"medical":[171,186,215,221],"system.":[173],"SAMU":[175,224,256],"hospital":[178,446,464,478,545,561,750,761],"department":[179],"whose":[180],"function":[181],"centralize":[184],"calls":[187],"organise":[189],"appropriate":[191,207,328],"response":[192],"with":[193],"intention":[195],"ensuring":[197],"shortest":[199],"between":[201,288,409,474],"initial":[203],"call":[204,216,712],"treatment.":[208,614,624,753],"event":[211],"concerning":[217],"dispatcher":[222],"may":[225],"decide":[226],"send":[228],"MICU":[230],"(mobile":[231],"intensive":[232],"unit).":[234],"If":[235],"diagnosis":[237],"confirmed,":[241],"clinical":[242],"ECG":[243],"criteria,":[244],"currently":[248],"seen":[249],"strategy.":[254],"experience":[257],"proven":[259],"safe":[265],"effective.":[267],"During":[268],"ten":[271],"years":[272,275],"fifteen":[274],"field":[277],"during":[280,579],"acute":[281,426,771],"was":[284],"battlefield":[287],"proponents":[290],"those":[294],"primary":[296,403,416,508],"percutaneous":[297,348],"interventions.":[298],"Nowadays":[299],"there":[300],"growing":[303],"physicians":[306,777],"who":[307],"will":[308],"consider":[309,432],"way":[313,794],"forward":[314],"not":[316,673],"oppose":[318],"two":[320,411],"methods":[322],"but":[323],"find":[325],"niche":[329],"each":[331],"or":[332],"even":[333,667],"better":[334,494,740],"combine":[336],"them":[337],"achieve":[339],"respect,":[343],"concept":[345],"facilitated":[347],"intervention":[349],"very":[352,695],"attractive":[353],"one":[354,388,585],"shows":[356],"promising":[357],"results.":[358],"now":[365,601,618,764],"ongoing":[366],"demonstrate":[368],"its":[369],"help":[373],"us":[374],"choosing":[376],"ideal":[378],"combination":[379],"anti-thrombotic":[381],"agents":[382],"used.":[385],"That":[386,419,791],"interests":[392],"CAPTIM":[395,521],"study.":[396],"French":[397,568],"trial":[398],"comparing":[399,503],"angioplasty.":[404,452,564],"There":[405],"no":[407],"difference":[408],"end":[417],"points.":[418],"could":[420,555],"life":[424],"infarction.":[428],"We":[429],"study":[435,522],"fact":[437],"than":[438,531,656],"33%":[439],"patients":[442,575,665,687,704,732],"had":[443],"pre":[445,463,477,544,560,749,760],"followed":[448],"by":[449,609,739],"fast":[451],"results":[454,518],"impressing:":[456],"30":[458,485],"day":[459,486],"arm":[466],"only":[468,661],"3.8%.":[469],"But":[470],"if":[471],"pain":[475,526],"under":[481],"fall":[488],"down":[489],"2.2%.":[491],"This":[492,615],"RESULTS:":[495],"Than":[496],"il":[497],"all":[498,573,693],"recent":[500,567,652],"trials":[501],"published":[502],"site":[505],"angioplasty":[509],"(DANAM":[510],"II,":[511],"C":[512],"Port,":[513],"PRAGUE":[514],"II).":[515],"These":[516],"good":[517,549],"when":[523,670],"less":[530],"include":[534],"also":[535],"occurrence":[537],"cardiogenic":[539],"shock":[540],"favour":[542],"(1.3%).":[547],"strategy":[550,589,762,769],"next":[553,639],"future":[554],"association":[558],"register":[569],"(USIC":[570],"2000)":[571],"arriving":[576],"CICU":[578],"month":[581,586],"regarding":[583],"seems":[590],"(3.6%).":[595],"TNK-tPA":[599],"changing":[602],"general":[604],"management":[605],"reducing":[610],"clearly":[617],"new":[620],"standard":[621],"reduction":[626],"UHF":[628],"dose":[629],"recommended":[631],"LWMH":[634],"considered":[636],"step":[640],"recently":[642],"demonstrated":[643],"ASSENT":[646],"3":[647],"3+":[649],"trials.":[650],"Several":[651],"registries":[653],"we":[657,671],"offer":[658,674],"half":[662,681],"more":[668,746,797,807],"important,":[669],"do":[672],"it,":[675],"unjustified":[678],"nearly":[680],"cases":[684],",":[688,733,748],"forgotten":[689],"poor":[696],"prognosis.":[697],"other":[699],"major":[700],"problem":[701],"treated":[706],"too":[707,716],"late":[708],"mainly":[709],"because":[710],"system":[715],"late.":[717],"several":[720],"ways":[721],"improve":[723],":":[728],"information":[729],"shortening":[734],"intra-hospital":[737],"delays":[738],"organisation":[741],"finally":[743],"perhaps":[745],"importantly":[747],"triage":[751],"safety":[757],"recognised":[765],"worldwide.":[766],"should":[774],"involve":[775],"cardiologist":[779],"local":[783],"task-force":[784],"join":[786],"coordinate":[788],"their":[789],"efforts.":[790],"open":[796],"arteries":[798],"earlier,":[799],"say":[803],"save":[804],"myocardium":[805],"lives.":[808]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}