{"id":"https://openalex.org/W3166409686","doi":"https://doi.org/10.1155/2021/5572899","title":"Inhibition of \u03b1\u2010Synuclein Accumulation Improves Neuronal Apoptosis and Delayed Postoperative Cognitive Recovery in Aged Mice","display_name":"Inhibition of \u03b1\u2010Synuclein Accumulation Improves Neuronal Apoptosis and Delayed Postoperative Cognitive Recovery in Aged Mice","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3166409686","doi":"https://doi.org/10.1155/2021/5572899","mag":"3166409686","pmid":"https://pubmed.ncbi.nlm.nih.gov/34194605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8181110"},"language":"en","primary_location":{"id":"doi:10.1155/2021/5572899","doi":"https://doi.org/10.1155/2021/5572899","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5572899","pdf_url":"https://downloads.hindawi.com/journals/omcl/2021/5572899.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/omcl/2021/5572899.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100387835","display_name":"Yue Li","orcid":"https://orcid.org/0000-0002-9894-5904","observed_orcids":["https://orcid.org/0000-0002-9894-5904"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Li","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0002-9894-5904","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035580968","display_name":"Yi Yuan","orcid":"https://orcid.org/0000-0003-3914-2447","observed_orcids":["https://orcid.org/0000-0003-3914-2447"]},"institutions":[{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Yuan","raw_affiliation_strings":["Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, China","institution_ids":["https://openalex.org/I2802957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413879","display_name":"Yitong Li","orcid":"https://orcid.org/0000-0003-1992-7861","observed_orcids":["https://orcid.org/0000-0003-1992-7861"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yitong Li","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0003-1992-7861","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000882707","display_name":"Dengyang Han","orcid":"https://orcid.org/0000-0001-8155-1709","observed_orcids":["https://orcid.org/0000-0001-8155-1709"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dengyang Han","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0001-8155-1709","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725999","display_name":"Taotao Liu","orcid":"https://orcid.org/0000-0002-4623-9012","observed_orcids":["https://orcid.org/0000-0002-4623-9012"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Taotao Liu","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100747376","display_name":"Ning Yang","orcid":"https://orcid.org/0000-0002-1496-0411","observed_orcids":["https://orcid.org/0000-0002-1496-0411"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Yang","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0002-1496-0411","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020865905","display_name":"Xinning Mi","orcid":"https://orcid.org/0000-0002-8965-6852","observed_orcids":["https://orcid.org/0000-0002-8965-6852"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinning Mi","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0002-8965-6852","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015292794","display_name":"Jingshu Hong","orcid":"https://orcid.org/0000-0003-2875-4042","observed_orcids":["https://orcid.org/0000-0003-2875-4042"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingshu Hong","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046318570","display_name":"Kaixi Liu","orcid":"https://orcid.org/0000-0002-6746-3929","observed_orcids":["https://orcid.org/0000-0002-6746-3929"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaixi Liu","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040644900","display_name":"Yanan Song","orcid":"https://orcid.org/0000-0003-0721-1145","observed_orcids":["https://orcid.org/0000-0003-0721-1145"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Song","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608615","display_name":"Jindan He","orcid":"https://orcid.org/0000-0001-5296-2277","observed_orcids":["https://orcid.org/0000-0001-5296-2277"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jindan He","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023673240","display_name":"Yang Zhou","orcid":"https://orcid.org/0000-0002-1548-973X","observed_orcids":["https://orcid.org/0000-0002-1548-973X"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhou","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0002-1548-973X","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025470937","display_name":"Yongzheng Han","orcid":"https://orcid.org/0000-0002-7523-8801","observed_orcids":["https://orcid.org/0000-0002-7523-8801"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongzheng Han","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0002-7523-8801","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079859567","display_name":"Chengmei Shi","orcid":"https://orcid.org/0000-0003-4498-7241","observed_orcids":["https://orcid.org/0000-0003-4498-7241"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengmei Shi","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0003-4498-7241","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077239703","display_name":"Shun Yu","orcid":"https://orcid.org/0000-0002-2591-9764","observed_orcids":["https://orcid.org/0000-0002-2591-9764"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]},{"id":"https://openalex.org/I4405270397","display_name":"Beijing Institute for Brain Disorders","ror":"https://ror.org/00m0cqn82","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shun Yu","raw_affiliation_strings":["Beijing Key Laboratory for Parkinson's Disease, Beijing 100053, China","Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China","Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Parkinson's Disease, Beijing 100053, China","institution_ids":[]},{"raw_affiliation_string":"Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China","institution_ids":["https://openalex.org/I4405270397"]},{"raw_affiliation_string":"Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210116048","display_name":"Beijing National Laboratory for Molecular Sciences","ror":"https://ror.org/02601yx74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210116048"]},{"id":"https://openalex.org/I4405271629","display_name":"Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education","ror":"https://ror.org/02rmypw07","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271629"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zou","raw_affiliation_strings":["College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking University, Beijing 100871, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking University, Beijing 100871, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210116048","https://openalex.org/I4405271629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002025387","display_name":"Xiangyang Guo","orcid":"https://orcid.org/0000-0002-5694-2174","observed_orcids":["https://orcid.org/0000-0002-5694-2174"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangyang Guo","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0002-5694-2174","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047499666","display_name":"Zhengqian Li","orcid":"https://orcid.org/0000-0001-6758-0685","observed_orcids":["https://orcid.org/0000-0001-6758-0685","https://orcid.org/0000-0003-3434-009X"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhengqian Li","raw_affiliation_strings":["Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0001-6758-0685","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5002025387","https://openalex.org/A5047499666"],"corresponding_institution_ids":["https://openalex.org/I4210141942"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":1.7072,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.83315038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2021","issue":"1","first_page":"5572899","last_page":"5572899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.6010000109672546},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.6420000195503235},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/clenbuterol","display_name":"clenbuterol","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6919999718666077},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5270000100135803},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7509999871253967},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7739999890327454},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.7089999914169312},{"id":"https://openalex.org/keywords/aged-mice","display_name":"aged mice","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7335905432701111},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39736026525497437},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38031744956970215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35702332854270935},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3464430570602417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3359954357147217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32927587628364563},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1804932951927185}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015928","descriptor_name":"Cognitive Behavioral Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1155/2021/5572899","doi":"https://doi.org/10.1155/2021/5572899","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5572899","pdf_url":"https://downloads.hindawi.com/journals/omcl/2021/5572899.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},{"id":"pmid:34194605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34194605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative medicine and cellular longevity","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8181110","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8181110/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxid Med Cell Longev","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f5246806516a454b984e48a82b5916f9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f5246806516a454b984e48a82b5916f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2021/5572899","doi":"https://doi.org/10.1155/2021/5572899","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5572899","pdf_url":"https://downloads.hindawi.com/journals/omcl/2021/5572899.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1086402206","display_name":null,"funder_award_id":"BMU2017MC006","funder_id":"https://openalex.org/F4320324787","funder_display_name":"Peking University"},{"id":"https://openalex.org/G2104388317","display_name":null,"funder_award_id":"81971012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2456349188","display_name":null,"funder_award_id":"PKU2020LCXQ016","funder_id":"https://openalex.org/F4320324787","funder_display_name":"Peking University"},{"id":"https://openalex.org/G2678916878","display_name":null,"funder_award_id":"PKU2020LCXQ016","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5073534811","display_name":null,"funder_award_id":"81901095","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G716271093","display_name":null,"funder_award_id":"BMU2017MC006","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G721091474","display_name":null,"funder_award_id":"BYSYZD2019027","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8117064784","display_name":null,"funder_award_id":"BYSYZD2019029","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8398181630","display_name":null,"funder_award_id":"81873726","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8507722339","display_name":null,"funder_award_id":"BYSYZD2019029","funder_id":"https://openalex.org/F4320325739","funder_display_name":"Peking University Third Hospital"},{"id":"https://openalex.org/G8718840370","display_name":null,"funder_award_id":"BMU2017MC006","funder_id":"https://openalex.org/F4320335889","funder_display_name":"Interdisciplinary Medicine Seed Fund of Peking University"},{"id":"https://openalex.org/G8724685479","display_name":null,"funder_award_id":"BYSYZD2019027","funder_id":"https://openalex.org/F4320325739","funder_display_name":"Peking University Third Hospital"},{"id":"https://openalex.org/G8875022867","display_name":null,"funder_award_id":"81801070","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"},{"id":"https://openalex.org/F4320325739","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12"},{"id":"https://openalex.org/F4320335889","display_name":"Interdisciplinary Medicine Seed Fund of Peking University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3166409686.pdf","grobid_xml":"https://content.openalex.org/works/W3166409686.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W23957462","https://openalex.org/W62603772","https://openalex.org/W207007096","https://openalex.org/W1496790952","https://openalex.org/W1506435342","https://openalex.org/W1511705190","https://openalex.org/W1527671059","https://openalex.org/W1573440420","https://openalex.org/W1925325724","https://openalex.org/W1966976790","https://openalex.org/W1990473626","https://openalex.org/W1995191747","https://openalex.org/W2001708468","https://openalex.org/W2013313629","https://openalex.org/W2035787181","https://openalex.org/W2036203077","https://openalex.org/W2036386225","https://openalex.org/W2047206971","https://openalex.org/W2048256242","https://openalex.org/W2061995199","https://openalex.org/W2069367001","https://openalex.org/W2075793841","https://openalex.org/W2075997185","https://openalex.org/W2083990390","https://openalex.org/W2087482196","https://openalex.org/W2094221501","https://openalex.org/W2160572200","https://openalex.org/W2229506676","https://openalex.org/W2342533302","https://openalex.org/W2553675679","https://openalex.org/W2560733355","https://openalex.org/W2613766619","https://openalex.org/W2745164635","https://openalex.org/W2753292637","https://openalex.org/W2768157591","https://openalex.org/W2771082365","https://openalex.org/W2797341671","https://openalex.org/W2883221432","https://openalex.org/W2884041324","https://openalex.org/W2885733789","https://openalex.org/W2890520974","https://openalex.org/W2897448689","https://openalex.org/W2936320435","https://openalex.org/W2937118846","https://openalex.org/W2944578833","https://openalex.org/W2944764789","https://openalex.org/W2951348834","https://openalex.org/W2965940241","https://openalex.org/W2980622391","https://openalex.org/W2989885451","https://openalex.org/W3005749712","https://openalex.org/W3012290874","https://openalex.org/W3019481105","https://openalex.org/W3044114834","https://openalex.org/W3088489717","https://openalex.org/W3089139034","https://openalex.org/W3118744915"],"related_works":["https://openalex.org/W7114922658","https://openalex.org/W4396618272","https://openalex.org/W4362581274","https://openalex.org/W2789848543","https://openalex.org/W4408922354","https://openalex.org/W7164756933","https://openalex.org/W2558500810","https://openalex.org/W2620632682","https://openalex.org/W2977593986","https://openalex.org/W2763286333"],"abstract_inverted_index":{"Delayed":[0],"neurocognitive":[1],"recovery":[2],"(dNCR)":[3],"is":[4,96],"a":[5,69,97,167],"major":[6],"complication":[7],"after":[8,92],"anesthesia":[9],"and":[10,49,64,82,89,122,137,149,202,226],"surgery":[11],"in":[12,31,68,86,114,125,141,188,230],"older":[13],"adults.":[14],"Alpha\u2010synuclein":[15],"(\u03b1\u2010syn;":[16],"encoded":[17],"by":[18,183],"the":[19,115,159,184,197,231,236],"gene,":[20],"SNCA)":[21],"has":[22],"recently":[23],"been":[24],"shown":[25],"to":[26,154,171,191,199],"play":[27],"an":[28],"important":[29],"role":[30],"hippocampus\u2010dependent":[32],"working":[33],"memory.":[34],"Aggregated":[35],"forms":[36,75,113],"of":[37,72,76,101,109,162,209,223,228,239],"\u03b1\u2010syn":[38,59,77,112,135,163,194,217,241],"are":[39],"associated":[40],"with":[41],"multiple":[42],"neurotoxic":[43],"mechanisms,":[44],"such":[45],"as":[46,117,119,204,206],"mitochondrial":[47,62,120,134,185,200,224],"dysfunction":[48],"cell":[50],"death.":[51],"In":[52],"this":[53],"study,":[54],"we":[55,165],"found":[56],"that":[57,214],"blocking":[58],"improved":[60,196],"both":[61],"function":[63],"mitochondria\u2010dependent":[65],"neuronal":[66,180],"apoptosis":[67,140,181,186,229],"mouse":[70],"model":[71],"dNCR.":[73,243],"Various":[74],"(including":[78],"total":[79],"\u03b1\u2010syn,":[80],"phosphorylated\u2010Ser129\u2010\u03b1\u2010syn,":[81],"oligomers)":[83],"were":[84],"upregulated":[85],"hippocampal":[87,151],"tissue":[88],"extracted":[90],"mitochondria":[91],"surgical":[93],"challenge.":[94],"Clenbuterol":[95,103],"novel":[98],"transcription":[99],"modulator":[100],"Scna.":[102],"significantly":[104,178],"attenuated":[105],"surgery\u2010induced":[106],"progressive":[107],"accumulation":[108,136],"various":[110],"toxic":[111],"hippocampus,":[116,233],"well":[118,205],"damage":[121],"memory":[123],"deficits":[124],"aged":[126,232],"mice":[127],"following":[128],"surgery.":[129],"We":[130],"also":[131],"observed":[132],"excessive":[133],"increased":[138],"mitochondria\u2010mediated":[139],"vitro":[142],"using":[143],"nerve":[144],"growth":[145],"factor\u2010differentiated":[146],"PC12":[147],"cells":[148],"primary":[150],"neurons":[152,189],"exposed":[153,190],"lipopolysaccharide.":[155,192],"To":[156],"further":[157,234],"validate":[158],"neuroprotective":[160],"effect":[161],"inhibition,":[164],"used":[166],"lentiviral":[168],"Snca\u2010shRNA":[169],"(Lv\u2010shSnca)":[170],"knockdown":[172],"Snca.":[173],"Of":[174],"note,":[175],"Lv\u2010shSnca":[176],"transfection":[177],"inhibited":[179],"mediated":[182],"pathway":[187],"This":[193],"inhibition":[195],"disruption":[198],"morphology":[201],"function,":[203],"decreased":[207],"levels":[208],"apoptosis.":[210],"Our":[211],"results":[212],"suggest":[213],"targeting":[215,240],"pathological":[216],"may":[218],"achieve":[219],"neuroprotection":[220],"through":[221],"regulation":[222],"homeostasis":[225],"suppression":[227],"strengthening":[235],"therapeutic":[237],"potential":[238],"for":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-06-22T00:00:00"}
