{"id":"https://openalex.org/W3166344253","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.553.21","title":"Cross\u2010Presentation of peptides Chaperoned by Heat Shock Protein gp96","display_name":"Cross\u2010Presentation of peptides Chaperoned by Heat Shock Protein gp96","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W3166344253","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.553.21","mag":"3166344253"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.553.21","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.553.21","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.553.21","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030740727","display_name":"Shantell Sherie Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48205209","display_name":"Texas Southern University","ror":"https://ror.org/05ch0aw77","country_code":"US","type":"education","lineage":["https://openalex.org/I48205209"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shantell Sherie Phillips","raw_affiliation_strings":["Biology, Texas Southern University, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology, Texas Southern University, Houston, TX","institution_ids":["https://openalex.org/I48205209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034098296","display_name":"Robert Julian Binder","orcid":"https://orcid.org/0000-0003-0857-3949","observed_orcids":["https://orcid.org/0000-0003-0857-3949"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J Binder","raw_affiliation_strings":["Immunology, University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28213504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cross-presentation","display_name":"cross-presentation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/heat-shock-protein-gp96","display_name":"heat shock protein gp96","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/lrp1","display_name":"LRP1","score":0.7400000095367432},{"id":"https://openalex.org/keywords/mhc-class-i-antigen-presentation","display_name":"MHC class I antigen presentation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.6539999842643738},{"id":"https://openalex.org/keywords/antigen-uptake","display_name":"antigen uptake","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.7520497441291809},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7431066036224365},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.7262623906135559},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.6715509295463562},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6451679468154907},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6251471638679504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5944346785545349},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.5565191507339478},{"id":"https://openalex.org/C2778973524","wikidata":"https://www.wikidata.org/wiki/Q3910755","display_name":"Cross-presentation","level":5,"score":0.5167688131332397},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5082375407218933},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.47139838337898254},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4667024612426758},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.44605591893196106},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.43482476472854614},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.4292924404144287},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.42189812660217285},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.365342378616333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3096235394477844},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.255415678024292},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.06847938895225525},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.553.21","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.553.21","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.553.21","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992482869","https://openalex.org/W2097373411","https://openalex.org/W2103221390","https://openalex.org/W178904085","https://openalex.org/W2160605889","https://openalex.org/W2290904250","https://openalex.org/W2099161199","https://openalex.org/W2122991510","https://openalex.org/W2280739860","https://openalex.org/W2001015172"],"abstract_inverted_index":{"Cross\u2010presentation":[0],"is":[1,74,116,119],"the":[2,56,63,66,77,82,85,96,104,120,126,131,146,159,166,186,201,205,213],"ability":[3],"of":[4,79,112,122,133,142,148,165,215],"Dendritic":[5],"Cells":[6],"(DCs)":[7],"to":[8,58,84,95,144,156,184],"uptake":[9],"and":[10,14,54,118,162,168,189,191,203],"process":[11],"extracellular":[12],"antigens":[13],"present":[15],"them":[16],"on":[17],"their":[18],"major":[19],"histocompatibility":[20],"class":[21],"I":[22],"molecules":[23],"(MHC).":[24],"Heat":[25],"shock":[26,48],"protein":[27,49],"(HSP)\u2010chaperoned":[28],"peptides":[29,80,91],"are":[30,92,101],"cross\u2010presented":[31],"by":[32,62],"DCs.":[33],"It":[34],"has":[35],"been":[36],"demonstrated":[37],"that":[38,72,170,193],"CD91":[39],"acts":[40],"as":[41],"a":[42],"cell":[43,64,107,140],"surface":[44,108],"receptor":[45],"for":[46,76,87,106],"heat":[47],"gp96,":[50],"binding":[51],"gp96":[52,113,134,171,196,217],"directly":[53],"allowing":[55],"HSP\u2010peptide":[57],"be":[59],"up":[60],"taken":[61],"into":[65],"endosome.":[67],"Previous":[68],"studies":[69],"have":[70],"shown":[71],"HSP90":[73],"critical":[75],"translocation":[78],"from":[81],"endosome":[83],"cytosol":[86,202],"proteasomal":[88],"degradation.":[89],"These":[90,209],"then":[93],"translocated":[94],"endoplasmic":[97],"reticulum":[98],"where":[99],"they":[100],"loaded":[102],"onto":[103],"MHCs":[105],"display.":[109],"The":[110],"fate":[111,132],"after":[114,135],"endocytosis":[115],"unknown":[117],"focus":[121],"this":[123,151],"study.":[124],"In":[125],"current":[127],"study,":[128],"we":[129,153,181],"investigate":[130],"internalization.":[136],"We":[137],"used":[138],"selective":[139],"fractionation":[141],"DCs":[143,167],"identify":[145],"location":[147],"gp96.":[149],"Through":[150],"procedure,":[152],"were":[154,182],"able":[155,183],"initially":[157],"separate":[158],"intracellular":[160,176],"membranes":[161,164],"plasma":[163],"showed":[169,192],"was":[172,197],"primarily":[173,198],"associated":[174,218],"with":[175,219],"membranes.":[177],"With":[178],"further":[179],"fractionations,":[180],"isolate":[185],"cytosol,":[187],"mitochondria,":[188],"nucleus":[190,206],"at":[194],"30mins":[195],"located":[199],"in":[200],"not":[204],"or":[207],"mitochondria.":[208],"study":[210],"results":[211],"show":[212],"route":[214],"trafficking":[216],"cross\u2010presentation.":[220]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-06-22T00:00:00"}