{"id":"https://openalex.org/W3166137802","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.04515","title":"Chronic Circadian Disruption Induces Cardiovascular Disease in Male Mice","display_name":"Chronic Circadian Disruption Induces Cardiovascular Disease in Male Mice","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3166137802","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.04515","mag":"3166137802"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2021.35.s1.04515","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.04515","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2021.35.s1.04515","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007148734","display_name":"Paramita Pati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paramita Pati","raw_affiliation_strings":["Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091863700","display_name":"Megan Kathleen Rhoads","orcid":"https://orcid.org/0000-0001-7494-9815","observed_orcids":["https://orcid.org/0000-0001-7494-9815"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Rhoads","raw_affiliation_strings":["Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028067969","display_name":"Rachel Meek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Meek","raw_affiliation_strings":["Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011116579","display_name":"Jackson C. Colson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jackson Colson","raw_affiliation_strings":["Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066047278","display_name":"David M. Pollock","orcid":"https://orcid.org/0000-0002-0233-2362","observed_orcids":["https://orcid.org/0000-0002-0233-2362","https://orcid.org/0000-0002-7546-6003"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Pollock","raw_affiliation_strings":["Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003642259","display_name":"Jennifer S. Pollock","orcid":"https://orcid.org/0000-0003-1956-0449","observed_orcids":["https://orcid.org/0000-0003-1956-0449"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Pollock","raw_affiliation_strings":["Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardio\u2010Renal Physiology &amp; Medicine, Division of Nephrology, Department of Medicine University of Alabama at Birmingham Birmingham AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06538372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm-disruption","display_name":"circadian rhythm disruption","score":0.8090000152587891},{"id":"https://openalex.org/keywords/shift-work","display_name":"shift work","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/vascular-stiffness","display_name":"vascular stiffness","score":0.6980000138282776},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5350000262260437},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.6579999923706055},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.7559999823570251},{"id":"https://openalex.org/keywords/diurnal-cycle","display_name":"diurnal cycle","score":0.6899999976158142},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.6129999756813049},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.38499999046325684},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.7070000171661377},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.699999988079071},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9760000109672546},{"id":"https://openalex.org/keywords/locomotor-activity-rhythm","display_name":"locomotor activity rhythm","score":0.7789999842643738},{"id":"https://openalex.org/keywords/heart-rate-rhythm","display_name":"heart rate rhythm","score":0.6439999938011169},{"id":"https://openalex.org/keywords/time-of-day","display_name":"time of day","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8574458360671997},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.753167986869812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7499378323554993},{"id":"https://openalex.org/C2910755853","wikidata":"https://www.wikidata.org/wiki/Q17130203","display_name":"Light Cycle","level":3,"score":0.6188650131225586},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6136467456817627},{"id":"https://openalex.org/C2776176791","wikidata":"https://www.wikidata.org/wiki/Q1068683","display_name":"Shift work","level":2,"score":0.5807999968528748},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.48443225026130676},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.45123133063316345},{"id":"https://openalex.org/C2778319312","wikidata":"https://www.wikidata.org/wiki/Q2118022","display_name":"Pulse wave velocity","level":3,"score":0.413700133562088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3921651840209961},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3857772946357727},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2021.35.s1.04515","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.04515","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2021.35.s1.04515","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387543026","https://openalex.org/W3196422446","https://openalex.org/W4378648997","https://openalex.org/W2966463948","https://openalex.org/W6922089024","https://openalex.org/W7165122442","https://openalex.org/W2888156343","https://openalex.org/W2259214365","https://openalex.org/W3120868419","https://openalex.org/W4225426845"],"abstract_inverted_index":{"Circadian":[0],"rhythm":[1,328],"disruption":[2,80,114,316],"similar":[3,137],"to":[4,82,110,129,144,172,185,318],"shift":[5,19],"work":[6,41],"experience":[7],"increases":[8],"the":[9,58,63,240,287],"risk":[10,24],"of":[11,25,37,49,156,225,284,291,331],"cardiometabolic":[12],"disease.":[13],"Numerous":[14],"studies":[15],"have":[16,21],"demonstrated":[17],"that":[18,76,313],"workers":[20],"an":[22,34,154],"increased":[23,86,192,321],"developing":[26],"hypertension,":[27],"show":[28],"decreased":[29],"endothelial":[30],"function,":[31],"and":[32,62,72,85,131,141,213,242,286,293,300,305,324,334],"demonstrate":[33,312],"impaired":[35,325],"pattern":[36],"sodium":[38],"excretion.":[39],"Shift":[40],"has":[42,67],"also":[43,189],"been":[44],"associated":[45],"with":[46,125],"higher":[47,161],"incidence":[48],"metabolic":[50],"syndrome.":[51],"Desynchrony":[52],"between":[53,138,239,289,298],"environmental":[54,78],"conditions,":[55],"such":[56],"as":[57],"light\u2010dark":[59],"(LD)":[60],"cycle,":[61,124],"endogenous":[64],"circadian":[65,79,113,315],"clock":[66],"detrimental":[68],"effects":[69],"in":[70,162,220,235,250,280,336],"humans":[71],"animals.":[73],"We":[74],"hypothesized":[75],"chronic":[77,112,314],"leads":[81,317],"vascular":[83,157,319],"disease":[84,333],"blood":[87,209,326],"pressure.":[88],"Male":[89],"8\u2010week":[90],"old":[91],"mice":[92,140,142,163,174,221,230,252,302],"(C57BL/6J)":[93],"were":[94,218,296],"maintained":[95],"under":[96,164,222],"a":[97,111,122,145,165,186,226,232],"standard":[98],"light/dark":[99],"cycle":[100,167,188,295],"(12":[101],"hr":[102,105,117,120],"light,":[103,118],"12":[104],"dark,":[106],"controls)":[107],"or":[108],"subjected":[109,143,184],"protocol":[115],"(10":[116],"10":[119,223],"dark),":[121],"T20":[123,166,187,227,251,266,301],"ad":[126],"libitum":[127],"access":[128],"food":[130,134],"water.":[132],"Weekly":[133],"intake":[135],"was":[136,159,248],"control":[139,173,299],"shortened":[146],"light":[147,294],"cycle.":[148,228],"Aortic":[149],"pulse":[150],"wave":[151],"velocity":[152],"(PWV),":[153],"index":[155],"stiffness,":[158,320],"significantly":[160,191],"for":[168],"6":[169,197],"weeks":[170,198,224],"compared":[171],"(Control:":[175,199],"1.60\u00b10.1":[176],"m/s;":[177,180],"T20:":[178,202],"2.25\u00b10.1":[179],"n=6,":[181,205],"p=0.0037).":[182],"Mice":[183],"showed":[190,231],"body":[193],"weight":[194,322],"gain":[195],"after":[196],"1.7\u00b10.3":[200],"g;":[201,204],"2.9\u00b10.4":[203],"p=0.03).":[206],"Radiotelemetry":[207],"revealed":[208],"pressure,":[210],"heart":[211],"rate,":[212],"locomotor":[214],"activity":[215],"diurnal":[216],"rhythms":[217],"disrupted":[219],"Control":[229],"significant":[233,297],"difference":[234],"mean":[236],"arterial":[237],"pressure":[238,327],"inactive":[241],"active":[243,261,274],"periods,":[244],"while":[245],"this":[246],"variation":[247],"absent":[249],"(Control":[253],"119\u00b13":[254],"mm":[255,259,268,272],"Hg":[256,269],"vs.":[257,262,270,275],"101\u00b12":[258],"Hg,":[260,273],"inactive,":[263,276],"respectively,":[264,277],"p=0.01;":[265],"115\u00b115":[267],"114\u00b111":[271],"p=0.92;":[278],"n=3\u20104":[279],"all":[281],"groups).":[282],"Time":[283],"day":[285,292],"interaction":[288],"time":[290],"(n=3\u20104,":[303],"p=0.02":[304],"p=0.04,":[306],"respectively).":[307],"In":[308],"conclusion,":[309],"these":[310],"findings":[311],"gain,":[323],"suggesting":[329],"development":[330],"cardiovascular":[332],"alterations":[335],"metabolism.":[337]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-06-22T00:00:00"}
