{"id":"https://openalex.org/W3165581230","doi":"https://doi.org/10.1186/s12864-021-07670-7","title":"Secretome characterization of clinical isolates from the Mycobacterium abscessus complex provides insight into antigenic differences","display_name":"Secretome characterization of clinical isolates from the Mycobacterium abscessus complex provides insight into antigenic differences","publication_year":2021,"publication_date":"2021-05-25","ids":{"openalex":"https://openalex.org/W3165581230","doi":"https://doi.org/10.1186/s12864-021-07670-7","mag":"3165581230","pmid":"https://pubmed.ncbi.nlm.nih.gov/34034663","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8152154"},"language":"en","primary_location":{"id":"doi:10.1186/s12864-021-07670-7","doi":"https://doi.org/10.1186/s12864-021-07670-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-021-07670-7","pdf_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-021-07670-7","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-021-07670-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058051345","display_name":"Fernanda Cornejo\u2010Granados","orcid":"https://orcid.org/0000-0002-8860-0996","observed_orcids":["https://orcid.org/0000-0002-8860-0996"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Fernanda Cornejo-Granados","raw_affiliation_strings":["Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico","Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico, Cuernavaca, Morelos, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico, Cuernavaca, Morelos, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040272200","display_name":"Thomas Andreas Kohl","orcid":"https://orcid.org/0000-0002-1126-6803","observed_orcids":["https://orcid.org/0000-0002-1126-6803"]},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas A. Kohl","raw_affiliation_strings":["German Center for Infection Research (DZIF)","Molecular and Experimental Mycobacteriology, Research Center Borstel","Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research (DZIF)","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017649537","display_name":"Flor V\u00e1squez Sotomayor","orcid":"https://orcid.org/0000-0003-1695-0409","observed_orcids":["https://orcid.org/0000-0003-1695-0409"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Flor V\u00e1squez Sotomayor","raw_affiliation_strings":["National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center","National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065671234","display_name":"S\u00f6nke Andres","orcid":"https://orcid.org/0009-0009-6063-3487","observed_orcids":["https://orcid.org/0009-0009-6063-3487"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S\u00f6nke Andres","raw_affiliation_strings":["National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center","National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016385354","display_name":"Rog\u00e9lio Hern\u00e1ndez\u2010Pando","orcid":"https://orcid.org/0000-0003-1292-3833","observed_orcids":["https://orcid.org/0000-0003-1292-3833"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Rogelio Hern\u00e1ndez-Pando","raw_affiliation_strings":["Experimental Pathology Section, National Institute of Medical Sciences and Nutrition Salvador Zubir\u00e1n","Experimental Pathology Section, National Institute of Medical Sciences and Nutrition Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology Section, National Institute of Medical Sciences and Nutrition Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Experimental Pathology Section, National Institute of Medical Sciences and Nutrition Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000918689","display_name":"Juan Manuel Hurtado-Ram\u00edrez","orcid":"https://orcid.org/0000-0003-1710-7886","observed_orcids":["https://orcid.org/0000-0003-1710-7886"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Juan Manuel Hurtado-Ram\u00edrez","raw_affiliation_strings":["Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico","Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico, Cuernavaca, Morelos, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico, Cuernavaca, Morelos, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041222465","display_name":"Christian Utpatel","orcid":"https://orcid.org/0000-0001-5416-8253","observed_orcids":["https://orcid.org/0000-0001-5416-8253"]},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Utpatel","raw_affiliation_strings":["German Center for Infection Research (DZIF)","Molecular and Experimental Mycobacteriology, Research Center Borstel","Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research (DZIF)","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063438724","display_name":"Stefan Niemann","orcid":"https://orcid.org/0000-0002-6604-0684","observed_orcids":["https://orcid.org/0000-0002-6604-0684"]},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Niemann","raw_affiliation_strings":["German Center for Infection Research (DZIF)","Molecular and Experimental Mycobacteriology, Research Center Borstel","German Center for Infection Research (DZIF), Partner site Hamburg-L\u00fcbeck-Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research (DZIF)","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Partner site Hamburg-L\u00fcbeck-Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210115305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019449593","display_name":"Florian P. Maurer","orcid":"https://orcid.org/0000-0001-8353-5964","observed_orcids":["https://orcid.org/0000-0001-8353-5964"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Florian P. Maurer","raw_affiliation_strings":["Institute of Medical Microbiology, Virology and Hospital Hygiene, University Medical Center Hamburg-Eppendorf","National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center","German Center for Infection Research (DZIF), Partner site Hamburg-L\u00fcbeck-Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, Virology and Hospital Hygiene, University Medical Center Hamburg-Eppendorf","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Partner site Hamburg-L\u00fcbeck-Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210115305"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054937250","display_name":"Adri\u00e1n Ochoa\u2010Leyva","orcid":"https://orcid.org/0000-0002-4701-2303","observed_orcids":["https://orcid.org/0000-0002-4701-2303"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Adrian Ochoa-Leyva","raw_affiliation_strings":["Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico","Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico, Cuernavaca, Morelos, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-4701-2303","affiliations":[{"raw_affiliation_string":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Autonoma de M\u00e9xico, Cuernavaca, Morelos, Mexico","institution_ids":["https://openalex.org/I8961855"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5019449593","https://openalex.org/A5054937250"],"corresponding_institution_ids":["https://openalex.org/I4210108711","https://openalex.org/I4210115305","https://openalex.org/I4210128097","https://openalex.org/I8961855"],"apc_list":{"value":2380,"currency":"USD","value_usd":2380},"apc_paid":{"value":2380,"currency":"USD","value_usd":2380},"fwci":0.3792,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.55247293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"1","first_page":"385","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-abscessus-complex","display_name":"Mycobacterium abscessus complex","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nontuberculous-mycobacteria","display_name":"nontuberculous mycobacteria","score":0.972000002861023},{"id":"https://openalex.org/keywords/mycobacterium-abscessus-subsp-abscessus","display_name":"Mycobacterium abscessus subsp. abscessus","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mycobacterium-abscessus-subsp-bolletii","display_name":"Mycobacterium abscessus subsp. bolletii","score":0.996999979019165},{"id":"https://openalex.org/keywords/mycobacterium-abscessus-subsp-massiliense","display_name":"Mycobacterium abscessus subsp. massiliense","score":1.0},{"id":"https://openalex.org/keywords/colony-morphotypes","display_name":"colony morphotypes","score":0.6589999794960022},{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.8889999985694885},{"id":"https://openalex.org/keywords/essential-genes","display_name":"essential genes","score":0.7039999961853027},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5929999947547913},{"id":"https://openalex.org/keywords/vaccine-candidate","display_name":"vaccine candidate","score":0.6110000014305115},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.625}],"concepts":[{"id":"https://openalex.org/C2776111603","wikidata":"https://www.wikidata.org/wiki/Q6946978","display_name":"Mycobacterium abscessus","level":4,"score":0.8580609560012817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7900958061218262},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7372137308120728},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6946256160736084},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.5506625771522522},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.49454304575920105},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.45342373847961426},{"id":"https://openalex.org/C2778293455","wikidata":"https://www.wikidata.org/wiki/Q414506","display_name":"Mycolic acid","level":4,"score":0.4514429569244385},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43071526288986206},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42912235856056213},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3114677667617798},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2611220180988312},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1869589388370514}],"mesh":[{"descriptor_ui":"D000073358","descriptor_name":"Mycobacterium abscessus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009165","descriptor_name":"Mycobacterium Infections, Nontuberculous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12864-021-07670-7","doi":"https://doi.org/10.1186/s12864-021-07670-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-021-07670-7","pdf_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-021-07670-7","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"doi:10.1101/2020.10.22.349720","doi":"https://doi.org/10.1101/2020.10.22.349720","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.22.349720","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/22/2020.10.22.349720.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8152154","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8152154","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmid:34034663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34034663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3c746e9824c14e4fa23611512b8ec7f0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3c746e9824c14e4fa23611512b8ec7f0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12864-021-07670-7","doi":"https://doi.org/10.1186/s12864-021-07670-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-021-07670-7","pdf_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-021-07670-7","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3222935605","display_name":null,"funder_award_id":"IN215520","funder_id":"https://openalex.org/F4320335100","funder_display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico"}],"funders":[{"id":"https://openalex.org/F4320310697","display_name":"Joachim Herz Stiftung","ror":"https://ror.org/01j8qgg43"},{"id":"https://openalex.org/F4320311052","display_name":"Deutsches Zentrum f\u00fcr Infektionsforschung","ror":"https://ror.org/028s4q594"},{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320335100","display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3165581230.pdf","grobid_xml":"https://content.openalex.org/works/W3165581230.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W206421451","https://openalex.org/W1537641994","https://openalex.org/W1935158889","https://openalex.org/W1981835811","https://openalex.org/W2001338440","https://openalex.org/W2004548026","https://openalex.org/W2012416775","https://openalex.org/W2022366078","https://openalex.org/W2037921546","https://openalex.org/W2039399915","https://openalex.org/W2051650567","https://openalex.org/W2052547168","https://openalex.org/W2072708417","https://openalex.org/W2073612072","https://openalex.org/W2074401088","https://openalex.org/W2076729878","https://openalex.org/W2078178166","https://openalex.org/W2082020230","https://openalex.org/W2094201044","https://openalex.org/W2096830865","https://openalex.org/W2098455244","https://openalex.org/W2104325455","https://openalex.org/W2108459792","https://openalex.org/W2110215664","https://openalex.org/W2114083522","https://openalex.org/W2116279310","https://openalex.org/W2116788456","https://openalex.org/W2120902911","https://openalex.org/W2124088653","https://openalex.org/W2131271579","https://openalex.org/W2131778683","https://openalex.org/W2133274440","https://openalex.org/W2133330626","https://openalex.org/W2133579817","https://openalex.org/W2136307168","https://openalex.org/W2158450933","https://openalex.org/W2170726218","https://openalex.org/W2189462271","https://openalex.org/W2201075490","https://openalex.org/W2223993952","https://openalex.org/W2270176699","https://openalex.org/W2340254326","https://openalex.org/W2479610484","https://openalex.org/W2506753654","https://openalex.org/W2558222949","https://openalex.org/W2586329336","https://openalex.org/W2751144760","https://openalex.org/W2762985876","https://openalex.org/W2781862115","https://openalex.org/W2783698286","https://openalex.org/W2803716777","https://openalex.org/W2897559173","https://openalex.org/W2899469009","https://openalex.org/W2909180420","https://openalex.org/W2931314706","https://openalex.org/W2952404779","https://openalex.org/W2969057284","https://openalex.org/W3001272310"],"related_works":["https://openalex.org/W6902243808","https://openalex.org/W6958289436","https://openalex.org/W2051650567","https://openalex.org/W2586329336","https://openalex.org/W7214852273","https://openalex.org/W6920753487","https://openalex.org/W6976952997","https://openalex.org/W4391752979","https://openalex.org/W6977134848","https://openalex.org/W4284974578"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mycobacterium":[1],"abscessus":[2,50,66,70,75,242],"(MAB)":[3],"is":[4],"a":[5,39,112,124,159,209],"widely":[6],"disseminated":[7],"pathogenic":[8],"non-tuberculous":[9],"mycobacterium":[10],"(NTM).":[11],"Like":[12],"with":[13,111,123,173,195,245],"the":[14,34,45,48,85,89,98,106,132,150,201,225,237,246,269,278,336],"M.":[15,49,65,69,74,178,241],"tuberculosis":[16,179],"complex":[17,303],"(MTBC),":[18],"excreted":[19],"/":[20],"secreted":[21,95,254],"(ES)":[22],"proteins":[23,86,129,157,172,192,213,255,259,317],"play":[24],"an":[25],"essential":[26,249,258],"role":[27],"for":[28,230,261,318],"its":[29],"virulence":[30],"and":[31,55,73,96,190,217,233,273,299,304,321,328],"survival":[32],"inside":[33],"host.":[35],"Here,":[36],"we":[37],"used":[38],"robust":[40],"bioinformatics":[41,285],"pipeline":[42],"to":[43,60,131,145,215,222,257,289,300,324],"predict":[44],"secretome":[46,239],"of":[47,84,105,134,149,188,212,227,236,240,248,277,296],"ATCC":[51,243],"19977":[52,244],"reference":[53],"strain":[54],"15":[56],"clinical":[57,297],"isolates":[58,110,122,298],"belonging":[59],"all":[61,153],"three":[62,99],"MAB":[63,90,100,109,135,170,206,231,279],"subspecies,":[64],"subsp.":[67,71,76],"abscessus,":[68],"bolletii,":[72],"massiliense.":[77],"RESULTS:":[78],"We":[79,167],"found":[80],"that":[81,97,252,284],"~":[82],"18%":[83],"encoded":[87],"in":[88,175,200,262,274,335],"genomes":[91],"were":[92,333],"predicted":[93,107,119,205,238,331],"as":[94,220],"subspecies":[101],"shared":[102],">":[103],"85%":[104],"secretomes.":[108,180],"rough":[113],"(R)":[114],"colony":[115],"morphotype":[116],"showed":[117,193,208],"larger":[118],"secretomes":[120,133,207,293,332],"than":[121,142,164],"smooth":[125],"(S)":[126],"morphotype.":[127],"Additionally,":[128],"exclusive":[130,144],"R":[136],"variants":[137],"had":[138,158],"higher":[139,161,210],"antigenic":[140,162],"densities":[141],"those":[143,295],"S":[146],"variants,":[147],"independent":[148],"subspecies.":[151],"For":[152],"investigated":[154,177],"isolates,":[155],"ES":[156,171],"significantly":[160],"density":[163],"non-ES":[165],"proteins.":[166],"identified":[168],"337":[169],"homologues":[174],"previously":[176],"Among":[181],"these,":[182],"222":[183],"have":[184],"previous":[185],"experimental":[186,306],"support":[187,312],"secretion,":[189],"some":[191],"homology":[194],"protein":[196],"drug":[197],"targets":[198],"reported":[199],"DrugBank":[202],"database.":[203],"The":[204],"abundance":[211],"related":[214],"quorum-sensing":[216],"Mce":[218],"domains":[219],"compared":[221],"MTBC":[223],"indicating":[224],"importance":[226],"these":[228],"pathways":[229],"pathogenicity":[232],"virulence.":[234],"Comparison":[235],"list":[247],"genes":[250],"revealed":[251],"99":[253],"corresponded":[256],"required":[260],"vitro":[263],"growth.":[264],"CONCLUSIONS:":[265],"This":[266,309],"study":[267,282],"represents":[268],"first":[270],"systematic":[271,313],"prediction":[272],"silico":[275],"characterization":[276],"secretome.":[280],"Our":[281],"demonstrates":[283],"strategies":[286],"can":[287,311],"help":[288],"broadly":[290],"explore":[291],"mycobacterial":[292],"including":[294],"tailor":[301],"subsequent,":[302],"time-consuming":[305],"approaches":[307],"accordingly.":[308],"approach":[310],"investigation":[314],"exploring":[315],"candidate":[316],"new":[319],"vaccines":[320],"diagnostic":[322],"markers":[323],"distinguish":[325],"between":[326],"colonization":[327],"infection.":[329],"All":[330],"deposited":[334],"Secret-AAR":[337],"web-server":[338],"(":[339],"http://microbiomics.ibt.unam.mx/tools/aar/index.php":[340],").":[341]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-06-07T00:00:00"}
