{"id":"https://openalex.org/W3165326565","doi":"https://doi.org/10.1002/alz.12351","title":"The \u201ccognitive clock\u201d: A novel indicator of brain health","display_name":"The \u201ccognitive clock\u201d: A novel indicator of brain health","publication_year":2021,"publication_date":"2021-06-01","ids":{"openalex":"https://openalex.org/W3165326565","doi":"https://doi.org/10.1002/alz.12351","mag":"3165326565","pmid":"https://pubmed.ncbi.nlm.nih.gov/34060702","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9014826"},"language":"en","primary_location":{"id":"doi:10.1002/alz.12351","doi":"https://doi.org/10.1002/alz.12351","is_oa":false,"landing_page_url":"https://doi.org/10.1002/alz.12351","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9014826","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043507147","display_name":"Patricia A. Boyle","orcid":"https://orcid.org/0000-0002-3245-3456","observed_orcids":["https://orcid.org/0000-0002-3245-3456"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patricia A. Boyle","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0002-3245-3456","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610987","display_name":"Tianhao Wang","orcid":"https://orcid.org/0000-0003-4269-2060","observed_orcids":["https://orcid.org/0000-0003-4269-2060"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianhao Wang","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101937767","display_name":"Lei Yu","orcid":"https://orcid.org/0000-0002-0237-8758","observed_orcids":["https://orcid.org/0000-0002-0237-8758","https://orcid.org/0000-0002-7176-1152","https://orcid.org/0000-0002-4044-0778"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Yu","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101486622","display_name":"Robert Smith Wilson","orcid":"https://orcid.org/0000-0001-9592-0333","observed_orcids":["https://orcid.org/0000-0001-9592-0333"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Wilson","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA","Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020715082","display_name":"Robert J. Dawe","orcid":"https://orcid.org/0000-0002-8266-9829","observed_orcids":["https://orcid.org/0000-0002-8266-9829"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Dawe","raw_affiliation_strings":["Department of Diagnostic Radiology and Nuclear Medicine, Chicago, Illinois, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Radiology and Nuclear Medicine, Chicago, Illinois, USA","institution_ids":[]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053836176","display_name":"Konstantinos Arfanakis","orcid":"https://orcid.org/0000-0001-9705-597X","observed_orcids":["https://orcid.org/0000-0001-9705-597X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I180949307","display_name":"Illinois Institute of Technology","ror":"https://ror.org/037t3ry66","country_code":"US","type":"education","lineage":["https://openalex.org/I180949307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konstantinos Arfanakis","raw_affiliation_strings":["Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA","Department of Diagnostic Radiology and Nuclear Medicine, Chicago, Illinois, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I180949307"]},{"raw_affiliation_string":"Department of Diagnostic Radiology and Nuclear Medicine, Chicago, Illinois, USA","institution_ids":[]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022605809","display_name":"Julie A. Schneider","orcid":"https://orcid.org/0000-0002-9482-1752","observed_orcids":["https://orcid.org/0000-0002-9482-1752"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Schneider","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA","Department of Pathology, Rush University Medical Center, Chicago, Illinois, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Pathology, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050784244","display_name":"Todd L. Beck","orcid":"https://orcid.org/0000-0001-8781-2105","observed_orcids":["https://orcid.org/0000-0001-8781-2105"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Beck","raw_affiliation_strings":["Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042824125","display_name":"Kumar Bharat Rajan","orcid":"https://orcid.org/0000-0001-7685-2101","observed_orcids":["https://orcid.org/0000-0001-7685-2101","https://orcid.org/0000-0003-1268-4617"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kumar B. Rajan","raw_affiliation_strings":["Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110403458","display_name":"Denis A. Evans","orcid":"https://orcid.org/0000-0003-4755-5401","observed_orcids":["https://orcid.org/0000-0003-4755-5401"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denis Evans","raw_affiliation_strings":["Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014075642","display_name":"David Alan Bennett","orcid":"https://orcid.org/0000-0003-3689-554X","observed_orcids":["https://orcid.org/0000-0003-3689-554X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Bennett","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043507147"],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":2.6265,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.8970143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"17","issue":"12","first_page":"1923","last_page":"1937"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11265","display_name":"Aging and Gerontology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3206","display_name":"Neuropsychology and Physiological Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cognitive-age","display_name":"cognitive age","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.7331398129463196},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.7122575640678406},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6847982406616211},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.5552463531494141},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.505120575428009},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.46534478664398193},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44118672609329224},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.4273565709590912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39990755915641785},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3871249556541443},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28266993165016174},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.215658038854599},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12702569365501404},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07122167944908142}],"mesh":[{"descriptor_ui":"D000066492","descriptor_name":"Cognitive Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000069338","descriptor_name":"Neuropathology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002641","descriptor_name":"Chicago","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/alz.12351","doi":"https://doi.org/10.1002/alz.12351","is_oa":false,"landing_page_url":"https://doi.org/10.1002/alz.12351","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},{"id":"pmid:34060702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34060702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia : the journal of the Alzheimer's Association","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9014826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9014826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Alzheimers Dement","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9014826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9014826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Alzheimers Dement","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1118445387","display_name":"Quantifying Lower Extremity Joint Motion in Community-Dwelling Older Adults to Elucidate its Contributions to Mobility Limitations, Incident Mobility Disability, and Falls","funder_award_id":"K25AG061254","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1129744104","display_name":"Epidemiologic Study of Neural Reserve and Neurobiology of Aging","funder_award_id":"R01AG017917","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2927332337","display_name":"Preserving Cognitive Resilience:  A Biracial Parent-Offspring Study","funder_award_id":"R01AG058679","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4335057330","display_name":"Nonlinear Models of Cognition Preceding AD in a Biracial Population Sample","funder_award_id":"R01AG051635","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5029820101","display_name":"Rush Alzheimer's Disease Core Center","funder_award_id":"P30AG010161","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000862480","display_name":"Epidemiologic Study of Decision Making in Preclinical Alzheimer's Disease","funder_award_id":"R01AG033678","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000868891","display_name":"Characterizing the Behavior Profile of Healthy Cognitive Aging","funder_award_id":"R01AG034374","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320308102","display_name":"Illinois Department of Public Health","ror":"https://ror.org/027bk5v43"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W38490725","https://openalex.org/W1581476053","https://openalex.org/W1690563009","https://openalex.org/W1847168837","https://openalex.org/W1974047233","https://openalex.org/W1993571512","https://openalex.org/W2008854521","https://openalex.org/W2028050242","https://openalex.org/W2033848869","https://openalex.org/W2063404606","https://openalex.org/W2093636642","https://openalex.org/W2099337407","https://openalex.org/W2102554143","https://openalex.org/W2108344016","https://openalex.org/W2114277576","https://openalex.org/W2121091193","https://openalex.org/W2122925474","https://openalex.org/W2148080316","https://openalex.org/W2156220037","https://openalex.org/W2159536887","https://openalex.org/W2166148093","https://openalex.org/W2167311298","https://openalex.org/W2173925865","https://openalex.org/W2547929024","https://openalex.org/W2602552939","https://openalex.org/W2809330972","https://openalex.org/W2920864695","https://openalex.org/W2937270320","https://openalex.org/W2990660366","https://openalex.org/W2990971304","https://openalex.org/W3010510502","https://openalex.org/W3111314674","https://openalex.org/W7074166569"],"related_works":["https://openalex.org/W4321749714","https://openalex.org/W4312088002","https://openalex.org/W4376611936","https://openalex.org/W4390195237","https://openalex.org/W4294692203","https://openalex.org/W2993770134","https://openalex.org/W4288802227","https://openalex.org/W4407295656","https://openalex.org/W3175501203","https://openalex.org/W4292061492"],"abstract_inverted_index":{"INTRODUCTION:":[0],"We":[1],"identified":[2],"a":[3,6,27,150,172,193,236,247,259],"\"cognitive":[4,88,164],"clock,\"":[5,89],"novel":[7],"indicator":[8,239,250],"of":[9,16,30,81,94,119,140,159,175,196,217,232,240,251],"brain":[10,31,127,214],"health":[11,32,253],"that":[12,23,167],"provides":[13],"person-specific":[14,92],"estimates":[15,93],"cognitive":[17,24,67,82,95,100,110,120,133,160,173,190,199,219,233],"age,":[18,205],"and":[19,53,56,65,90,112,114,126,147,201,206,213,255],"tested":[20],"the":[21,50,57,78,87,132,144,156,187,218,222,230],"hypothesis":[22],"age":[25,35,103,123,174,191,234,245],"is":[26,246],"better":[28,194],"predictor":[29,195],"than":[33,203],"chronological":[34,102,122,204],"in":[36,262],"two":[37],"independent":[38,137,223],"datasets.":[39],"METHODS:":[40],"The":[41,163],"initial":[42,188],"analyses":[43,98,116],"were":[44],"based":[45],"on":[46],"1057":[47],"participants":[48,142],"from":[49,143],"Rush":[51],"Memory":[52],"Aging":[54,148],"Project":[55],"Religious":[58],"Orders":[59],"Study":[60],"who":[61],"began":[62],"without":[63],"impairment":[64,111,200],"underwent":[66],"assessments":[68],"up":[69],"to":[70,135,154,221],"24":[71],"years.":[72],"A":[73],"shape":[74],"invariant":[75],"model":[76],"characterized":[77],"latent":[79],"pattern":[80],"decline,":[83],"conceptualized":[84],"here":[85],"as":[86,235,258],"yielded":[91],"age.":[96,161],"Survival":[97],"examined":[99,117],"versus":[101,121],"for":[104,229],"predicting":[105],"Alzheimer's":[106],"disease":[107],"dementia,":[108,197],"mild":[109,198],"mortality,":[113],"regression":[115],"associations":[118],"with":[124,211],"neuropathology":[125,212],"atrophy.":[128,215],"Finally,":[129],"we":[130],"applied":[131],"clock":[134,220],"an":[136],"validation":[138,224],"sample":[139,225],"2592":[141],"Chicago":[145],"Health":[146],"Project,":[149],"biracial":[151],"population-based":[152],"study,":[153],"confirm":[155],"predictive":[157],"utility":[158,231],"RESULTS:":[162],"clock\"":[165],"showed":[166],"cognition":[168],"remained":[169],"stable":[170],"until":[171,181],"about":[176],"80,":[177],"then":[178,183],"declined":[179,184],"moderately":[180],"90,":[182],"precipitously.":[185],"In":[186],"dataset,":[189],"was":[192,207],"mortality":[202],"more":[208],"strongly":[209],"associated":[210],"Application":[216],"provided":[226],"further":[227],"support":[228],"strong":[237],"prognostic":[238,249],"adverse":[241,252],"outcomes.":[242],"DISCUSSION:":[243],"Cognitive":[244],"robust":[248],"outcomes":[254],"may":[256],"serve":[257],"useful":[260],"biomarker":[261],"aging":[263],"research.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-06-07T00:00:00"}
