{"id":"https://openalex.org/W3165100722","doi":"https://doi.org/10.1097/ju.0000000000001841","title":"Apalutamide plus Androgen Deprivation Therapy for Metastatic Castration-Sensitive Prostate Cancer: Analysis of Pain and Fatigue in the Phase 3 TITAN Study","display_name":"Apalutamide plus Androgen Deprivation Therapy for Metastatic Castration-Sensitive Prostate Cancer: Analysis of Pain and Fatigue in the Phase 3 TITAN Study","publication_year":2021,"publication_date":"2021-05-27","ids":{"openalex":"https://openalex.org/W3165100722","doi":"https://doi.org/10.1097/ju.0000000000001841","mag":"3165100722","pmid":"https://pubmed.ncbi.nlm.nih.gov/34039013"},"language":"en","primary_location":{"id":"doi:10.1097/ju.0000000000001841","doi":"https://doi.org/10.1097/ju.0000000000001841","is_oa":true,"landing_page_url":"https://doi.org/10.1097/ju.0000000000001841","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/ju.0000000000001841","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100763587","display_name":"Neeraj Agarwal","orcid":"https://orcid.org/0000-0003-1076-0428","observed_orcids":["https://orcid.org/0000-0003-1076-0428","https://orcid.org/0000-0001-6574-8499"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neeraj Agarwal","raw_affiliation_strings":["Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075033014","display_name":"Kelly McQuarrie","orcid":"https://orcid.org/0000-0002-2362-1163","observed_orcids":["https://orcid.org/0000-0002-2362-1163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly McQuarrie","raw_affiliation_strings":["Janssen Research &amp; Development, Horsham, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research &amp; Development, Horsham, Pennsylvania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015634061","display_name":"Anders S Bjartell","orcid":"https://orcid.org/0000-0002-5761-3786","observed_orcids":["https://orcid.org/0000-0002-5761-3786"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Bjartell","raw_affiliation_strings":["Sk\u00e5ne University Hospital, Lund University, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sk\u00e5ne University Hospital, Lund University, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110735930","display_name":"Simon Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I172427033","display_name":"Sarah Cannon Research Institute","ror":"https://ror.org/03cp5cj42","country_code":"GB","type":"education","lineage":["https://openalex.org/I172427033"]},{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Chowdhury","raw_affiliation_strings":["Guy\u2019s, King\u2019s, and St Thomas\u2019 Hospitals, and Sarah Cannon Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy\u2019s, King\u2019s, and St Thomas\u2019 Hospitals, and Sarah Cannon Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I172427033","https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033798884","display_name":"Andrea Juliana Gomes","orcid":"https://orcid.org/0000-0001-7388-663X","observed_orcids":["https://orcid.org/0000-0001-7388-663X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea J. Pereira de Santana Gomes","raw_affiliation_strings":["Liga Norte Riograndense Contra O C\u00e2ncer, Natal, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liga Norte Riograndense Contra O C\u00e2ncer, Natal, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019918659","display_name":"Byung Ha Chung","orcid":"https://orcid.org/0000-0001-9817-3660","observed_orcids":["https://orcid.org/0000-0001-9817-3660"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung Ha Chung","raw_affiliation_strings":["Yonsei University College of Medicine and Gangnam Severance Hospital, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yonsei University College of Medicine and Gangnam Severance Hospital, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023874099","display_name":"Mustafa \u00d6zg\u00fcro\u011flu","orcid":"https://orcid.org/0000-0002-8417-8628","observed_orcids":["https://orcid.org/0000-0002-8417-8628"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa \u00d6zg\u00fcro\u011flu","raw_affiliation_strings":["Istanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa School of Medicine, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa School of Medicine, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034977009","display_name":"\u00c1lvaro Ju\u00e1rez Soto","orcid":"https://orcid.org/0000-0003-4026-082X","observed_orcids":["https://orcid.org/0000-0003-4026-082X"]},"institutions":[{"id":"https://openalex.org/I4405252667","display_name":"Hospital Universitario de Jerez","ror":"https://ror.org/01fyp5w42","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210152975","https://openalex.org/I4405252667","https://openalex.org/I918821925"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1lvaro Ju\u00e1rez Soto","raw_affiliation_strings":["Hospital Universitario de Jerez de la Frontera, Cadiz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Jerez de la Frontera, Cadiz, Spain","institution_ids":["https://openalex.org/I4405252667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016971686","display_name":"Axel S. Merseburger","orcid":"https://orcid.org/0000-0001-6467-3931","observed_orcids":["https://orcid.org/0000-0001-6467-3931"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel S. Merseburger","raw_affiliation_strings":["University Hospital Schleswig-Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112727083","display_name":"Hirotsugu Uemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotsugu Uemura","raw_affiliation_strings":["Kindai University Faculty of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kindai University Faculty of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101763457","display_name":"Dingwei Ye","orcid":"https://orcid.org/0000-0003-4974-3780","observed_orcids":["https://orcid.org/0000-0003-4974-3780","https://orcid.org/0000-0002-6761-5195","https://orcid.org/0000-0003-0704-7453","https://orcid.org/0000-0003-2993-2525"]},"institutions":[{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dingwei Ye","raw_affiliation_strings":["Fudan University Shanghai Cancer Center, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108936377","display_name":"Robert W Given","orcid":"https://orcid.org/0009-0004-1084-3869","observed_orcids":["https://orcid.org/0009-0004-1084-3869"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I4210088597","display_name":"Urology of Virginia","ror":"https://ror.org/009w2dq98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210088597"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Given","raw_affiliation_strings":["Urology of Virginia, Eastern Virginia Medical School, Norfolk, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology of Virginia, Eastern Virginia Medical School, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259","https://openalex.org/I4210088597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091400921","display_name":"Ethan Basch","orcid":"https://orcid.org/0000-0003-3813-9318","observed_orcids":["https://orcid.org/0000-0003-3813-9318"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Basch","raw_affiliation_strings":["University of North Carolina, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010579236","display_name":"Branko Miladinovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Branko Miladinovic","raw_affiliation_strings":["Janssen Research &amp; Development, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research &amp; Development, San Diego, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020669411","display_name":"Angela Mennicke Lopez- Gitlitz","orcid":"https://orcid.org/0000-0003-3323-7605","observed_orcids":["https://orcid.org/0000-0003-3323-7605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela Lopez-Gitlitz","raw_affiliation_strings":["Janssen Research &amp; Development, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research &amp; Development, Los Angeles, California","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005231494","display_name":"Kim N. Chi","orcid":"https://orcid.org/0000-0002-3782-7226","observed_orcids":["https://orcid.org/0000-0002-3782-7226"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kim N. Chi","raw_affiliation_strings":["BC Cancer, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BC Cancer, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I1289530486"]}]}],"institutions":[],"countries_distinct_count":10,"institutions_distinct_count":19,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.9162,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.86389952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"206","issue":"4","first_page":"914","last_page":"923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apalutamide","display_name":"apalutamide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/metastatic-hormone-sensitive-prostate-cancer","display_name":"metastatic hormone-sensitive prostate cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.8859999775886536},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.968999981880188},{"id":"https://openalex.org/keywords/time-to-deterioration","display_name":"time to deterioration","score":0.7889999747276306},{"id":"https://openalex.org/keywords/brief-pain-inventory","display_name":"Brief Pain Inventory","score":0.6790000200271606},{"id":"https://openalex.org/keywords/brief-fatigue-inventory","display_name":"Brief Fatigue Inventory","score":0.9890000224113464},{"id":"https://openalex.org/keywords/titan-trial","display_name":"TITAN trial","score":0.7609999775886536},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8941999673843384},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8389941453933716},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.707784116268158},{"id":"https://openalex.org/C2780052408","wikidata":"https://www.wikidata.org/wiki/Q4967024","display_name":"Brief Pain Inventory","level":3,"score":0.7006122469902039},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6458965539932251},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.6010880470275879},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4628746807575226},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.45620959997177124},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3766661286354065},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3719547986984253},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30998754501342773},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.25957703590393066},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.23473626375198364},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071066","descriptor_name":"Patient Reported Outcome Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D000075902","descriptor_name":"Clinical Deterioration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013867","descriptor_name":"Thiohydantoins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1097/ju.0000000000001841","doi":"https://doi.org/10.1097/ju.0000000000001841","is_oa":true,"landing_page_url":"https://doi.org/10.1097/ju.0000000000001841","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:34039013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34039013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:cdr.lib.unc.edu:cc08hr44f","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/e379-z049","pdf_url":"https://doi.org/10.17615/e379-z049","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of urology, 206(4)","raw_type":"Article"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/190578","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/190578","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:lup.lub.lu.se:d9b45cb0-ee40-4ad0-a9a7-d7ec23e9fa17","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/d9b45cb0-ee40-4ad0-a9a7-d7ec23e9fa17","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1527-3792","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.17615/e379-z049","doi":"https://doi.org/10.17615/e379-z049","is_oa":true,"landing_page_url":"https://doi.org/10.17615/e379-z049","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1097/ju.0000000000001841","doi":"https://doi.org/10.1097/ju.0000000000001841","is_oa":true,"landing_page_url":"https://doi.org/10.1097/ju.0000000000001841","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320310468","display_name":"Handok","ror":"https://ror.org/00exehz38"},{"id":"https://openalex.org/F4320315087","display_name":"Clovis Oncology","ror":"https://ror.org/04ps4d441"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320328455","display_name":"Ipsen","ror":"https://ror.org/00d801g55"},{"id":"https://openalex.org/F4320332932","display_name":"Merck Sharp and Dohme","ror":"https://ror.org/004nn4n27"},{"id":"https://openalex.org/F4320338413","display_name":"Cilag","ror":"https://ror.org/02fe4h741"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3165100722.pdf","grobid_xml":"https://content.openalex.org/works/W3165100722.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2991088225","https://openalex.org/W4205230104","https://openalex.org/W2975006240","https://openalex.org/W2977742381","https://openalex.org/W3158318954","https://openalex.org/W3112530361","https://openalex.org/W4220959221","https://openalex.org/W3168564732","https://openalex.org/W4322505162","https://openalex.org/W4389506762"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1],"performed":[2],"an":[3],"exploratory":[4],"analysis":[5],"of":[6,15,102,234],"prostate":[7,22,220],"cancer-related":[8],"pain":[9,53,104,141],"and":[10,54,64,79,116,195,208],"fatigue":[11,55,207,210,241],"on":[12],"health-related":[13],"quality":[14],"life":[16],"in":[17,36,99,125,154,240],"patients":[18],"with":[19,30,145,167,177,187,198,217,244],"metastatic":[20,218],"castration-sensitive":[21,219],"cancer":[23,221],"receiving":[24,222],"apalutamide":[25,146,223,245],"(240":[26],"mg/day)":[27],"or":[28,105],"placebo,":[29],"continuous":[31],"androgen":[32],"deprivation":[33],"therapy":[34],"(ADT),":[35],"the":[37,59,100,111,126,155],"phase":[38],"3,":[39],"randomized,":[40],"double-blind,":[41],"placebo":[42,148,227],"controlled":[43],"TITAN":[44],"trial":[45],"(NCT02489318).":[46],"MATERIALS":[47],"AND":[48],"METHODS:":[49],"Patient-reported":[50],"outcomes":[51],"for":[52,93,109,149,206,238],"were":[56,83,132,211],"evaluated":[57],"using":[58,85],"Brief":[60,65,112,117],"Pain":[61,113],"Inventory-Short":[62,114],"Form":[63,115],"Fatigue":[66,118],"Inventory.":[67],"Time":[68],"to":[69,123,137],"deterioration":[70],"(TTD)":[71],"was":[72,120,143,242],"estimated":[73,96],"by":[74],"Kaplan-Meier":[75],"method;":[76],"hazard":[77],"ratios":[78],"95%":[80],"confidence":[81],"intervals":[82],"calculated":[84],"Cox":[86],"proportional":[87],"hazards":[88],"model.":[89],"General":[90],"estimating":[91],"equations":[92],"logistic":[94],"regression":[95],"treatment-related":[97],"differences":[98],"likelihood":[101],"worsening":[103,209],"fatigue.":[106],"RESULTS:":[107],"Compliance":[108],"completing":[110],"Inventory":[119],"high":[121],"(96%":[122],"97%)":[124],"first":[127],"year.":[128],"Median":[129,140],"followup":[130],"times":[131],"similar":[133,212],"between":[134,213],"treatments":[135],"(19":[136],"22":[138],"months).":[139],"TTD":[142,233],"longer":[144],"than":[147],"\"pain":[150,165,175,185,196],"at":[151],"its":[152],"least":[153],"last":[156],"24":[157],"hours\"":[158],"(28.7":[159,180,200],"vs":[160,171,181,191,201,226,246],"21.8":[161],"months,":[162],"respectively;":[163],"p=0.0146),":[164],"interfered":[166,176,186,197],"mood\"":[168],"(not":[169,189],"estimable":[170,190],"22.4":[172],"months;":[173,183,193,203],"p=0.0017),":[174],"walking":[178],"ability\"":[179],"20.2":[182],"p=0.0027),":[184],"relations\"":[188],"23.0":[192],"p=0.0139)":[194],"sleep\"":[199],"20.9":[202],"p=0.0167).":[204],"Likelihood":[205],"groups.":[214],"CONCLUSIONS:":[215],"Patients":[216],"plus":[224,228],"ADT":[225,229],"reported":[230],"consistently":[231],"favorable":[232],"pain.":[235],"No":[236],"difference":[237],"change":[239],"observed":[243],"placebo.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-07T00:00:00"}
