{"id":"https://openalex.org/W3165073729","doi":"https://doi.org/10.1186/s43094-021-00199-2","title":"Development, optimization and characterization of flurbiprofen matrix transdermal drug delivery system using Box\u2013Behnken statistical design","display_name":"Development, optimization and characterization of flurbiprofen matrix transdermal drug delivery system using Box\u2013Behnken statistical design","publication_year":2021,"publication_date":"2021-03-03","ids":{"openalex":"https://openalex.org/W3165073729","doi":"https://doi.org/10.1186/s43094-021-00199-2","mag":"3165073729"},"language":"en","primary_location":{"id":"doi:10.1186/s43094-021-00199-2","doi":"https://doi.org/10.1186/s43094-021-00199-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43094-021-00199-2","pdf_url":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-021-00199-2","source":{"id":"https://openalex.org/S2898388368","display_name":"Future Journal of Pharmaceutical Sciences","issn_l":"2314-7245","issn":["2314-7245","2314-7253"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-021-00199-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064737829","display_name":"Ramakant Joshi","orcid":"https://orcid.org/0000-0003-4103-4939","observed_orcids":["https://orcid.org/0000-0003-4103-4939"]},"institutions":[{"id":"https://openalex.org/I102471911","display_name":"Jiwaji University","ror":"https://ror.org/00w9a2z18","country_code":"IN","type":"education","lineage":["https://openalex.org/I102471911"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ramakant Joshi","raw_affiliation_strings":["School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, (M.P)-474011, India"],"raw_orcid":"https://orcid.org/0000-0003-4103-4939","affiliations":[{"raw_affiliation_string":"School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, (M.P)-474011, India","institution_ids":["https://openalex.org/I102471911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063340883","display_name":"Navneet Garud","orcid":"https://orcid.org/0000-0002-6661-8941","observed_orcids":["https://orcid.org/0000-0002-6661-8941"]},"institutions":[{"id":"https://openalex.org/I102471911","display_name":"Jiwaji University","ror":"https://ror.org/00w9a2z18","country_code":"IN","type":"education","lineage":["https://openalex.org/I102471911"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Navneet Garud","raw_affiliation_strings":["School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, (M.P)-474011, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, (M.P)-474011, India","institution_ids":["https://openalex.org/I102471911"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064737829"],"corresponding_institution_ids":["https://openalex.org/I102471911"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":1.521,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.77962603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flurbiprofen","display_name":"flurbiprofen","score":1.0},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.9380000233650208},{"id":"https://openalex.org/keywords/matrix-type-patch","display_name":"matrix-type patch","score":0.6880000233650208},{"id":"https://openalex.org/keywords/hpmc-k15m","display_name":"HPMC K15M","score":0.8450000286102295},{"id":"https://openalex.org/keywords/plasticizers","display_name":"plasticizers","score":0.8180000185966492},{"id":"https://openalex.org/keywords/d-limonene","display_name":"D-limonene","score":0.9100000262260437},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ex-vivo-skin-permeation","display_name":"ex vivo skin permeation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/franz-diffusion-cell","display_name":"Franz diffusion cell","score":0.7950000166893005},{"id":"https://openalex.org/keywords/porcine-skin","display_name":"porcine skin","score":0.7799999713897705},{"id":"https://openalex.org/keywords/tensile-strength","display_name":"tensile strength","score":0.7950000166893005},{"id":"https://openalex.org/keywords/skin-irritation","display_name":"skin irritation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C170295934","wikidata":"https://www.wikidata.org/wiki/Q4952019","display_name":"Box\u2013Behnken design","level":3,"score":0.8472263813018799},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.8440344929695129},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.8002902269363403},{"id":"https://openalex.org/C58968531","wikidata":"https://www.wikidata.org/wiki/Q910212","display_name":"Plasticizer","level":2,"score":0.7992081642150879},{"id":"https://openalex.org/C2781000538","wikidata":"https://www.wikidata.org/wiki/Q419890","display_name":"Flurbiprofen","level":2,"score":0.6174387335777283},{"id":"https://openalex.org/C2777937549","wikidata":"https://www.wikidata.org/wiki/Q5464303","display_name":"Folding endurance","level":4,"score":0.6152668595314026},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.5958203077316284},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5032326579093933},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.49411705136299133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4479696452617645},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4479038715362549},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4204469323158264},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.38289403915405273},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2785031795501709},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.2681376338005066},{"id":"https://openalex.org/C150077022","wikidata":"https://www.wikidata.org/wiki/Q3136137","display_name":"Response surface methodology","level":2,"score":0.18075865507125854},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12808451056480408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0924433171749115},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0},{"id":"https://openalex.org/C2776035855","wikidata":"https://www.wikidata.org/wiki/Q420113","display_name":"Ethyl cellulose","level":3,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s43094-021-00199-2","doi":"https://doi.org/10.1186/s43094-021-00199-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43094-021-00199-2","pdf_url":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-021-00199-2","source":{"id":"https://openalex.org/S2898388368","display_name":"Future Journal of Pharmaceutical Sciences","issn_l":"2314-7245","issn":["2314-7245","2314-7253"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d35f224eee9f440a9577499b2987b223","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d35f224eee9f440a9577499b2987b223","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-18 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s43094-021-00199-2","doi":"https://doi.org/10.1186/s43094-021-00199-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43094-021-00199-2","pdf_url":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-021-00199-2","source":{"id":"https://openalex.org/S2898388368","display_name":"Future Journal of Pharmaceutical Sciences","issn_l":"2314-7245","issn":["2314-7245","2314-7253"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316809","display_name":"Jiwaji University, Gwalior","ror":"https://ror.org/00w9a2z18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3165073729.pdf","grobid_xml":"https://content.openalex.org/works/W3165073729.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W154942222","https://openalex.org/W1550353272","https://openalex.org/W1566346393","https://openalex.org/W1631172523","https://openalex.org/W1941359867","https://openalex.org/W1965258535","https://openalex.org/W1980520425","https://openalex.org/W1995871572","https://openalex.org/W1997488570","https://openalex.org/W2012455674","https://openalex.org/W2026873054","https://openalex.org/W2033172982","https://openalex.org/W2044386300","https://openalex.org/W2051901426","https://openalex.org/W2060874516","https://openalex.org/W2061440920","https://openalex.org/W2064144933","https://openalex.org/W2069862291","https://openalex.org/W2084452063","https://openalex.org/W2084658721","https://openalex.org/W2089297936","https://openalex.org/W2096856702","https://openalex.org/W2128952811","https://openalex.org/W2152830831","https://openalex.org/W2162154476","https://openalex.org/W2172800700","https://openalex.org/W2311902495","https://openalex.org/W2413868188","https://openalex.org/W2471861825","https://openalex.org/W2884617501","https://openalex.org/W2900600920","https://openalex.org/W2916852204","https://openalex.org/W2996766851","https://openalex.org/W3029333607","https://openalex.org/W3036999724","https://openalex.org/W3041796688","https://openalex.org/W3084352722","https://openalex.org/W3092472781"],"related_works":["https://openalex.org/W1604632445","https://openalex.org/W2372151794","https://openalex.org/W6930904486","https://openalex.org/W2353331465","https://openalex.org/W2085621459","https://openalex.org/W2088847214","https://openalex.org/W2792526526","https://openalex.org/W1989606484","https://openalex.org/W2981957201","https://openalex.org/W2554439138"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Present":[2],"investigation":[3],"for":[4,48,251],"research":[5],"was":[6,103,139,239],"to":[7,39,121],"develop":[8],"matrix-type":[9],"transdermal":[10],"drug":[11,89,93,100,136,155,238],"delivery":[12],"system":[13],"of":[14,21,29,44,51,56,60,113,128,188,192,207,220,236,248],"flurbiprofen":[15],"(FBP)":[16],"with":[17],"the":[18,27,41,110,126,186,193,199,218,237,242,246],"various":[19],"ratio":[20,119,162],"matrix":[22,117,160],"polymers":[23],"(hydrophilic":[24],"and":[25,31,63,96,120,130,167,183,213,231],"hydrophobic),":[26],"concentration":[28,174],"plasticizer":[30,62,129],"natural":[32,131,168],"penetration":[33,64,132,169,235],"enhancer":[34,65,170],"by":[35,116,241],"Box\u2013Behnken":[36],"statistical":[37],"design":[38],"investigate":[40],"combined":[42],"outcome":[43],"selected":[45],"independent":[46],"variables":[47],"effective":[49,233],"management":[50],"rheumatoid":[52],"arthritis.":[53],"The":[54,106,190],"influence":[55],"a":[57,122,146,228],"binary":[58],"mixture":[59],"polymers,":[61],"on":[66,217],"physicochemical":[67],"considerations":[68],"including":[69],"thickness,":[70],"tensile":[71,111],"strength,":[72],"percent":[73,77,80],"elongation,":[74],"weight":[75],"variation,":[76],"moisture":[78,81],"content,":[79,90],"uptake,":[82],"water":[83],"vapour":[84],"transmission":[85],"rate,":[86],"folding":[87],"endurance,":[88],"in":[91,125,149,245],"vitro":[92],"dissolution":[94],"study":[95,102,107,138,157],"then":[97],"ex":[98],"vivo":[99,135,154],"permeation":[101,137,147,156,187,249],"evaluated.":[104],"Results":[105],"demonstrated":[108],"that":[109,159,198,227],"strength":[112],"films":[114],"improved":[115,185],"polymer":[118,161],"slighter":[123],"gradation":[124],"rise":[127],"enhancer.":[133],"Ex":[134,153],"accompanied":[140],"via":[141],"excised":[142],"porcine":[143],"skin":[144,194,208,234],"as":[145],"barrier":[148],"Franz":[150],"diffusion":[151],"cell.":[152],"indicated":[158],"(HPMC":[163],"K15M:ERL100)":[164],"at":[165,172],"3:1":[166],"(d-limonene)":[171],"highest":[173],"7.5%":[175],"w/w":[176],"containing":[177],"formulation":[178,201],"FBPT7":[179,244],"delivered":[180],"maximum":[181],"flux":[182],"supplementary":[184],"drug.":[189],"result":[191],"irritation":[195,209],"test":[196],"revealed":[197],"developed":[200],"is":[202],"free":[203],"from":[204],"any":[205],"type":[206],"effects":[210],"like":[211],"erythema":[212],"oedema.":[214],"Conclusion":[215],"Based":[216],"findings":[219],"this":[221],"research,":[222],"it":[223],"can":[224],"be":[225],"established":[226],"well-controlled":[229],"release":[230],"very":[232],"accomplished":[240],"film":[243],"existence":[247],"enhancers":[250],"prolonged":[252],"periods.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-07T00:00:00"}
