{"id":"https://openalex.org/W3164609772","doi":"https://doi.org/10.1038/s41598-021-98913-w","title":"Cell aging related genes can be used to characterize clinical prognoses and further stratify diffuse gliomas","display_name":"Cell aging related genes can be used to characterize clinical prognoses and further stratify diffuse gliomas","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W3164609772","doi":"https://doi.org/10.1038/s41598-021-98913-w","mag":"3164609772","pmid":"https://pubmed.ncbi.nlm.nih.gov/34593910"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-98913-w","doi":"https://doi.org/10.1038/s41598-021-98913-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-98913-w","pdf_url":"https://www.nature.com/articles/s41598-021-98913-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-98913-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100397400","display_name":"Yang Yang","orcid":"https://orcid.org/0000-0001-6417-3654","observed_orcids":["https://orcid.org/0000-0001-6417-3654","https://orcid.org/0009-0007-2484-7838"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["Department of Neurosurgery, Peking University Third Hospital","Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051899084","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-4120-1138","observed_orcids":["https://orcid.org/0000-0002-4120-1138"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Department of Neurosurgery, Peking University Third Hospital","Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157847244","display_name":"Hongbin Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongbin Han","raw_affiliation_strings":["Department of Radiology, Peking University Third Hospital","Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Peking University Third Hospital","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100537086","display_name":"Jianjun Sun","orcid":"https://orcid.org/0009-0007-7703-0493","observed_orcids":["https://orcid.org/0009-0007-7703-0493"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianjun Sun","raw_affiliation_strings":["Department of Neurosurgery, Peking University Third Hospital","Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012682209","display_name":"Suhua Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suhua Chen","raw_affiliation_strings":["Department of Neurosurgery, Peking University Third Hospital","Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111578300","display_name":"Chenlong Yang","orcid":"https://orcid.org/0000-0001-8720-5575","observed_orcids":["https://orcid.org/0000-0001-8720-5575"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenlong Yang","raw_affiliation_strings":["Department of Neurosurgery, Peking University Third Hospital","Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059757088","display_name":"Qianquan Ma","orcid":"https://orcid.org/0000-0002-5576-277X","observed_orcids":["https://orcid.org/0000-0002-5576-277X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianquan Ma","raw_affiliation_strings":["Department of Neurosurgery, Peking University Third Hospital","Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, 100191, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital, No.49 Huayuanbeilu, Haidian District, Beijing, 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055468768","display_name":"Jun Yang","orcid":"https://orcid.org/0000-0002-7460-2800","observed_orcids":["https://orcid.org/0000-0002-7460-2800"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Yang","raw_affiliation_strings":["Department of Neurosurgery, Peking University Third Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Peking University Third Hospital","institution_ids":["https://openalex.org/I4210141942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":0.8838,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71701585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"11","issue":"1","first_page":"19493","last_page":"19493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-glioma","display_name":"diffuse glioma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prognostic-risk-signature","display_name":"prognostic risk signature","score":0.871999979019165},{"id":"https://openalex.org/keywords/risk-score","display_name":"risk score","score":0.7929999828338623},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.7429999709129333},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.734000027179718},{"id":"https://openalex.org/keywords/glioma-prognosis","display_name":"glioma prognosis","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7109386324882507},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6079220771789551},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.5880255699157715},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.558252215385437},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.5188339948654175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5079420208930969},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.503055989742279},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48017898201942444},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3889808654785156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3142498731613159},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2606452405452728},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1711101531982422},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1657242476940155},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13230156898498535}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-021-98913-w","doi":"https://doi.org/10.1038/s41598-021-98913-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-98913-w","pdf_url":"https://www.nature.com/articles/s41598-021-98913-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-506358/v1","doi":"https://doi.org/10.21203/rs.3.rs-506358/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-506358/v1","pdf_url":"https://www.researchsquare.com/article/rs-506358/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:34593910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34593910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:7378708","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8484278","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8484278","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8484278","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4981edee5ea64d19a972e1dd02089352","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4981edee5ea64d19a972e1dd02089352","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-98913-w","doi":"https://doi.org/10.1038/s41598-021-98913-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-98913-w","pdf_url":"https://www.nature.com/articles/s41598-021-98913-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.44999998807907104,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3848272312","display_name":null,"funder_award_id":"81872051","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5194960237","display_name":null,"funder_award_id":"82072774","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6352338485","display_name":null,"funder_award_id":"2020M670064","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G7686912438","display_name":null,"funder_award_id":"BMU2019LCKXJ007","funder_id":"https://openalex.org/F4320324787","funder_display_name":"Peking University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"},{"id":"https://openalex.org/F4320325739","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3164609772.pdf","grobid_xml":"https://content.openalex.org/works/W3164609772.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1489456875","https://openalex.org/W1533042914","https://openalex.org/W1560814177","https://openalex.org/W1977820874","https://openalex.org/W1982395176","https://openalex.org/W2005837931","https://openalex.org/W2013090484","https://openalex.org/W2016821076","https://openalex.org/W2036044314","https://openalex.org/W2060632243","https://openalex.org/W2097617161","https://openalex.org/W2098723369","https://openalex.org/W2103251300","https://openalex.org/W2148977460","https://openalex.org/W2150740687","https://openalex.org/W2154345686","https://openalex.org/W2158681922","https://openalex.org/W2165871546","https://openalex.org/W2215801456","https://openalex.org/W2279568831","https://openalex.org/W2366536035","https://openalex.org/W2396132784","https://openalex.org/W2561396377","https://openalex.org/W2587945748","https://openalex.org/W2620914886","https://openalex.org/W2735468413","https://openalex.org/W2749511637","https://openalex.org/W2782274120","https://openalex.org/W2791853559","https://openalex.org/W2885494745","https://openalex.org/W2888853456","https://openalex.org/W2889646458","https://openalex.org/W2898476557","https://openalex.org/W2900254393","https://openalex.org/W2922723063","https://openalex.org/W2959402124","https://openalex.org/W2972692767","https://openalex.org/W3000460980","https://openalex.org/W3005807693","https://openalex.org/W3039510521","https://openalex.org/W3116069652","https://openalex.org/W3127848530","https://openalex.org/W3135035839","https://openalex.org/W3144429865","https://openalex.org/W3174246647","https://openalex.org/W4211132876","https://openalex.org/W4245392732"],"related_works":["https://openalex.org/W3208778134","https://openalex.org/W3005931108","https://openalex.org/W4386951147","https://openalex.org/W2887359201","https://openalex.org/W4308767530","https://openalex.org/W2362999506","https://openalex.org/W4205170363","https://openalex.org/W4223451915","https://openalex.org/W4220833452","https://openalex.org/W3161919037"],"abstract_inverted_index":{"Increasing":[0],"evidence":[1],"has":[2],"indicated":[3],"that":[4],"senescent":[5],"cells":[6],"are":[7,70],"associated":[8],"with":[9,166,184,186],"the":[10,18,21,27,47,54,64,74,80,84,106,120,127,144,148,155,167,180,193],"glioma":[11],"development.":[12],"Thus,":[13],"we":[14],"aimed":[15],"to":[16,72,78],"explore":[17],"relationship":[19],"between":[20],"cellular":[22],"senescence":[23],"gene":[24],"profile":[25],"and":[26,50,77,93,122,160],"clinical":[28,195],"prognosis":[29],"of":[30,83,137,151,182,197],"diffuse":[31],"glioma.":[32],"In":[33],"total,":[34],"699":[35],"gliomas":[36,52,133,185],"from":[37,53],"The":[38,109],"Cancer":[39],"Genome":[40,57],"Atlas":[41,58],"(TCGA)":[42],"dataset":[43,60],"were":[44,61,163],"used":[45,62,71],"as":[46,63],"training":[48],"cohort":[49],"693":[51],"Chinese":[55],"Glioma":[56],"(CGGA)":[59],"validation":[65,107],"cohort.":[66],"Bioinformatics":[67],"statistical":[68],"methods":[69],"develop":[73],"risk":[75,85,91,95,110,128,168,175],"signature":[76,92,111,129,176],"study":[79,171],"prognostic":[81,100,114],"value":[82,115],"signature.":[86],"We":[87],"identified":[88],"a":[89,173],"14-gene":[90,174],"its":[94],"score":[96],"was":[97],"an":[98],"independent":[99],"factor":[101],"(P":[102],"<":[103],"0.001)":[104],"in":[105,134,154,201],"dataset.":[108],"had":[112],"better":[113],"than":[116],"traditional":[117],"factors":[118],"for":[119,177],"3-":[121],"5-year":[123],"survival":[124,145],"rate.":[125,146],"Importantly,":[126],"could":[130],"further":[131,178],"stratify":[132],"specific":[135],"subgroups":[136],"World":[138],"Health":[139],"Organization":[140],"(WHO)":[141],"classification":[142],"by":[143],"Furthermore,":[147],"mRNA":[149],"levels":[150],"genes":[152,200],"involved":[153],"cell":[156,158,198],"cycle,":[157],"division":[159],"other":[161],"processes":[162],"significantly":[164],"correlated":[165],"score.":[169],"Our":[170],"highlighted":[172],"stratifying":[179],"outcomes":[181],"patients":[183],"definite":[187],"WHO":[188],"subgroups.":[189],"These":[190],"results":[191],"indicate":[192],"potential":[194],"implications":[196],"aging-related":[199],"gliomas.":[202]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}