{"id":"https://openalex.org/W3164592467","doi":"https://doi.org/10.1111/bjh.17567","title":"Clinical and histopathological features of myeloid neoplasms with concurrent Janus kinase 2 ( JAK2 ) V617F and KIT proto\u2010oncogene, receptor tyrosine kinase ( KIT ) D816V mutations","display_name":"Clinical and histopathological features of myeloid neoplasms with concurrent Janus kinase 2 ( JAK2 ) V617F and KIT proto\u2010oncogene, receptor tyrosine kinase ( KIT ) D816V mutations","publication_year":2021,"publication_date":"2021-06-01","ids":{"openalex":"https://openalex.org/W3164592467","doi":"https://doi.org/10.1111/bjh.17567","mag":"3164592467","pmid":"https://pubmed.ncbi.nlm.nih.gov/34060083"},"language":"en","primary_location":{"id":"doi:10.1111/bjh.17567","doi":"https://doi.org/10.1111/bjh.17567","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.17567","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.17567","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.17567","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009736563","display_name":"Nicole Naumann","orcid":"https://orcid.org/0000-0001-9177-9133","observed_orcids":["https://orcid.org/0000-0001-9177-9133"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicole Naumann","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9177-9133","affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057473205","display_name":"Johannes L\u00fcbke","orcid":"https://orcid.org/0000-0003-0767-1504","observed_orcids":["https://orcid.org/0000-0003-0767-1504"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes L\u00fcbke","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081557024","display_name":"William E. Shomali","orcid":"https://orcid.org/0000-0001-6500-350X","observed_orcids":["https://orcid.org/0000-0001-6500-350X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Shomali","raw_affiliation_strings":["Division of Hematology, Stanford Cancer Institute/Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-6500-350X","affiliations":[{"raw_affiliation_string":"Division of Hematology, Stanford Cancer Institute/Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lukas Reiter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lukas Reiter","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109146821","display_name":"Hans\u2010Peter Horny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259543","display_name":"Pathologisches Institut","ror":"https://ror.org/02cqe8q68","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans\u2010Peter Horny","raw_affiliation_strings":["Institute of Pathology, Ludwig-Maximilian-University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Ludwig-Maximilian-University, Munich, Germany","institution_ids":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011354162","display_name":"Mohamad Jawhar","orcid":"https://orcid.org/0000-0001-9148-9398","observed_orcids":["https://orcid.org/0000-0001-9148-9398","https://orcid.org/0000-0001-6312-237X"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mohamad Jawhar","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034774721","display_name":"Vito Dangelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vito Dangelo","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007614326","display_name":"Alice Charlotte Fabarius","orcid":"https://orcid.org/0000-0001-5976-2876","observed_orcids":["https://orcid.org/0000-0001-5976-2876"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alice Fabarius","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038769308","display_name":"Georgia Metzgeroth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georgia Metzgeroth","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070912129","display_name":"Sebastian Kreil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Kreil","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047616627","display_name":"Karl Sotlar","orcid":"https://orcid.org/0000-0002-0116-3675","observed_orcids":["https://orcid.org/0000-0002-0116-3675"]},"institutions":[{"id":"https://openalex.org/I27945538","display_name":"Paracelsus Medical University","ror":"https://ror.org/03z3mg085","country_code":"AT","type":"education","lineage":["https://openalex.org/I27945538"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Karl Sotlar","raw_affiliation_strings":["Institute of Pathology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria","institution_ids":["https://openalex.org/I27945538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015764036","display_name":"Claire Oni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire Oni","raw_affiliation_strings":["Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046827092","display_name":"Claire N. Harrison","orcid":"https://orcid.org/0000-0002-3212-920X","observed_orcids":["https://orcid.org/0000-0002-3212-920X"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire Harrison","raw_affiliation_strings":["Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110195351","display_name":"Wolf\u2010Karsten Hofmann","orcid":"https://orcid.org/0000-0002-9856-8563","observed_orcids":["https://orcid.org/0000-0002-9856-8563"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolf\u2010Karsten Hofmann","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036839901","display_name":"Nicholas C.P. Cross","orcid":"https://orcid.org/0000-0001-5481-2555","observed_orcids":["https://orcid.org/0000-0001-5481-2555"]},"institutions":[{"id":"https://openalex.org/I4210129558","display_name":"Wessex Regional Genetics Laboratory","ror":"https://ror.org/02t83f864","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210129558","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas C. P. Cross","raw_affiliation_strings":["School of Medicine, University of Southampton, Southampton, UK","Wessex Regional Genetics Laboratory, Salisbury, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Wessex Regional Genetics Laboratory, Salisbury, UK","institution_ids":["https://openalex.org/I4210129558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006306448","display_name":"Peter Valent","orcid":"https://orcid.org/0000-0003-0456-5095","observed_orcids":["https://orcid.org/0000-0003-0456-5095"]},"institutions":[{"id":"https://openalex.org/I4405261830","display_name":"Ludwig Boltzmann Institute for Hematology and Oncology","ror":"https://ror.org/05xfe3w07","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4405261830"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Peter Valent","raw_affiliation_strings":["Department of Internal Medicine I, Division of Haematology and Ludwig Boltzmann Institute for Haematology and Oncology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Division of Haematology and Ludwig Boltzmann Institute for Haematology and Oncology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I4405261830","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028061272","display_name":"Deepti H. Radia","orcid":"https://orcid.org/0000-0002-3578-0102","observed_orcids":["https://orcid.org/0000-0002-3578-0102"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Deepti Radia","raw_affiliation_strings":["Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-3578-0102","affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065621786","display_name":"Jason R. Gotlib","orcid":"https://orcid.org/0000-0001-8253-6156","observed_orcids":["https://orcid.org/0000-0001-8253-6156"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Gotlib","raw_affiliation_strings":["Division of Hematology, Stanford Cancer Institute/Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Stanford Cancer Institute/Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021124944","display_name":"Andreas Reiter","orcid":"https://orcid.org/0000-0002-7718-6507","observed_orcids":["https://orcid.org/0000-0002-7718-6507"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Reiter","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035879639","display_name":"Juliana Schwaab","orcid":"https://orcid.org/0000-0001-9208-5264","observed_orcids":["https://orcid.org/0000-0001-9208-5264"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Juliana Schwaab","raw_affiliation_strings":["Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9208-5264","affiliations":[{"raw_affiliation_string":"Haematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5035879639"],"corresponding_institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":{"value":4600,"currency":"USD","value_usd":4600},"fwci":1.8067,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.84633862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"194","issue":"2","first_page":"344","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/kit-d816v-mutation","display_name":"KIT D816V mutation","score":1.0},{"id":"https://openalex.org/keywords/myeloid-neoplasms","display_name":"myeloid neoplasms","score":0.968999981880188},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9890000224113464},{"id":"https://openalex.org/keywords/systemic-mastocytosis","display_name":"systemic mastocytosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.6140000224113464},{"id":"https://openalex.org/keywords/variant-allele-frequency","display_name":"variant allele frequency","score":0.8080000281333923},{"id":"https://openalex.org/keywords/srsf2","display_name":"SRSF2","score":0.8529999852180481},{"id":"https://openalex.org/keywords/asxl1","display_name":"ASXL1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.703000009059906},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5540000200271606},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.8040000200271606},{"id":"https://openalex.org/keywords/bone-marrow-fibrosis","display_name":"bone marrow fibrosis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cytopenia","display_name":"cytopenia","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2780581156","wikidata":"https://www.wikidata.org/wiki/Q112670","display_name":"Systemic mastocytosis","level":3,"score":0.7884543538093567},{"id":"https://openalex.org/C2781107747","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative neoplasm","level":4,"score":0.6193087100982666},{"id":"https://openalex.org/C2779788118","wikidata":"https://www.wikidata.org/wiki/Q1542410","display_name":"Thrombocytosis","level":3,"score":0.6146160960197449},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5942714214324951},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5105499029159546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4778170883655548},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.46304967999458313},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.45991814136505127},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4026602506637573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3456294536590576},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.34002748131752014},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3297162353992462},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.32114264369010925},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2956668734550476},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.23671865463256836},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18844035267829895},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D034721","descriptor_name":"Mastocytosis, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034721","descriptor_name":"Mastocytosis, Systemic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/bjh.17567","doi":"https://doi.org/10.1111/bjh.17567","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.17567","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.17567","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:34060083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34060083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:449147","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1111/bjh.17567>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1111/bjh.17567","doi":"https://doi.org/10.1111/bjh.17567","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.17567","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.17567","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G545914830","display_name":null,"funder_award_id":"DJCLS 08 R/2020","funder_id":"https://openalex.org/F4320323359","funder_display_name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung"},{"id":"https://openalex.org/G7479197888","display_name":null,"funder_award_id":"08 R/2020","funder_id":"https://openalex.org/F4320323359","funder_display_name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung"}],"funders":[{"id":"https://openalex.org/F4320323359","display_name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","ror":"https://ror.org/00826gz80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3164592467.pdf","grobid_xml":"https://content.openalex.org/works/W3164592467.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W118655145","https://openalex.org/W1987628847","https://openalex.org/W1987946408","https://openalex.org/W1995840402","https://openalex.org/W1997494441","https://openalex.org/W2006786878","https://openalex.org/W2014268597","https://openalex.org/W2019097688","https://openalex.org/W2030493432","https://openalex.org/W2030868349","https://openalex.org/W2037798465","https://openalex.org/W2066465348","https://openalex.org/W2075345073","https://openalex.org/W2084824002","https://openalex.org/W2107058988","https://openalex.org/W2119478585","https://openalex.org/W2126532431","https://openalex.org/W2126665281","https://openalex.org/W2139464974","https://openalex.org/W2157066112","https://openalex.org/W2168082317","https://openalex.org/W2283625240","https://openalex.org/W2472403803","https://openalex.org/W2473366697","https://openalex.org/W2532173015","https://openalex.org/W2559562829","https://openalex.org/W2565342730","https://openalex.org/W2606840432","https://openalex.org/W2736420338","https://openalex.org/W2775539199","https://openalex.org/W2791464448","https://openalex.org/W2904893969","https://openalex.org/W2912217799","https://openalex.org/W2913605210","https://openalex.org/W2924794247","https://openalex.org/W2951419909","https://openalex.org/W2973165746","https://openalex.org/W2982563310","https://openalex.org/W3025062642","https://openalex.org/W3110618077"],"related_works":["https://openalex.org/W118655145","https://openalex.org/W2188826520","https://openalex.org/W1999608888","https://openalex.org/W2086127552","https://openalex.org/W2997782168","https://openalex.org/W2025914116","https://openalex.org/W2065003815","https://openalex.org/W2135475379","https://openalex.org/W2550481020","https://openalex.org/W2589535207"],"abstract_inverted_index":{"Summary":[0],"We":[1],"report":[2],"on":[3,230],"45":[4,87],"patients":[5,45,54,88,124,169,181],"with":[6,46,55,72,83,90],"myeloid":[7],"neoplasms":[8,49],"and":[9,18,51,104,113,131,147,191,227],"concurrent":[10,63],"Janus":[11],"kinase":[12,23],"2":[13,195],"(":[14,24,28,196,203,211],"JAK2":[15,29,174,225],")":[16,26,36,205],"V617F":[17,226],"KIT":[19,25,33,178,228],"proto\u2010oncogene,":[20],"receptor":[21],"tyrosine":[22],"D816V":[27,229],"pos":[30,34,175,179],".":[31,35,176,180],"/":[32,177],"mutations,":[37],"which":[38],"are":[39],"individually":[40],"identified":[41,120],"in":[42,121,158,166,189,242],">60%":[43,167],"of":[44,53,65,94,98,123,140,149,168,173,224,239],"classical":[47],"myeloproliferative":[48],"(MPN)":[50],">90%":[52],"systemic":[56],"mastocytosis":[57],"(SM)":[58],"respectively.":[59],"In":[60],"SM,":[61],"the":[62,99,221,236,243],"presence":[64],"a":[66,79,91],"clonal":[67],"non\u2010mast":[68],"cell":[69],"neoplasm":[70,75],"[SM":[71],"associated":[73,82],"haematological":[74],"(SM\u2010AHN)]":[76],"usually":[77],"constitutes":[78],"distinct":[80],"subtype":[81],"poor":[84],"survival.":[85],"All":[86],"presented":[89],"heterogeneous":[92],"combination":[93],"clinical/morphological":[95],"features":[96,119],"typical":[97],"individual":[100,244],"disorders":[101],"(e.g.":[102],"leuco\u2010/erythro\u2010/thrombocytosis":[103],"elevated":[105,110],"lactate":[106],"dehydrogenase":[107],"for":[108,116,144],"MPN;":[109],"serum":[111],"tryptase":[112],"alkaline":[114],"phosphatase":[115],"SM).":[117],"Overlapping":[118],"70%":[122],"included":[125],"splenomegaly,":[126],"cytopenia(s),":[127],"bone":[128],"marrow":[129],"fibrosis":[130],"additional":[132,183,199,240],"somatic":[133,184],"mutations.":[134],"Molecular":[135],"dissection":[136],"revealed":[137],"discordant":[138],"development":[139],"variant":[141],"allele":[142],"frequency":[143],"both":[145],"mutations":[146,186],"absence":[148],"concurrently":[150],"positive":[151],"single\u2010cell":[152],"derived":[153],"colonies,":[154],"indicating":[155,219],"disease":[156,165],"evolution":[157],"two":[159],"independent":[160],"clones":[161],"rather":[162],"than":[163],"monoclonal":[164],"examined.":[170],"Overall":[171],"survival":[172],"without":[182],"high\u2010risk":[185],"[HRM,":[187],"e.g.":[188],"serine":[190],"arginine\u2010rich":[192],"splicing":[193],"factor":[194,209],"SRSF2":[197],"),":[198],"sex":[200],"combs":[201],"like\u20101":[202],"ASXL1":[204],"or":[206],"Runt\u2010related":[207],"transcription":[208],"1":[210],"RUNX1":[212],")]":[213],"at":[214],"5":[215],"years":[216],"was":[217],"77%,":[218],"that":[220],"mutual":[222],"impact":[223,238],"prognosis":[231],"is":[232],"fundamentally":[233],"different":[234],"from":[235],"adverse":[237],"HRM":[241],"disorders.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-07T00:00:00"}