{"id":"https://openalex.org/W3164254751","doi":"https://doi.org/10.1369/00221554211022703","title":"Autocrine Hyaluronan Influences Sprouting and Lumen Formation During HUVEC Tubulogenesis In Vitro","display_name":"Autocrine Hyaluronan Influences Sprouting and Lumen Formation During HUVEC Tubulogenesis In Vitro","publication_year":2021,"publication_date":"2021-06-01","ids":{"openalex":"https://openalex.org/W3164254751","doi":"https://doi.org/10.1369/00221554211022703","mag":"3164254751","pmid":"https://pubmed.ncbi.nlm.nih.gov/34080894","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8182639"},"language":"en","primary_location":{"id":"doi:10.1369/00221554211022703","doi":"https://doi.org/10.1369/00221554211022703","is_oa":false,"landing_page_url":"https://doi.org/10.1369/00221554211022703","pdf_url":null,"source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry & Cytochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8182639","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090359807","display_name":"Robert B. Vernon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert B. Vernon","raw_affiliation_strings":["Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078557071","display_name":"Michel D. Gooden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michel D. Gooden","raw_affiliation_strings":["Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029741064","display_name":"Christina K. Chan","orcid":"https://orcid.org/0000-0003-0028-3808","observed_orcids":["https://orcid.org/0000-0003-0028-3808"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina K. Chan","raw_affiliation_strings":["Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078685804","display_name":"Gail A. Workman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gail Workman","raw_affiliation_strings":["Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043585387","display_name":"Masanari Obika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanari Obika","raw_affiliation_strings":["Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035268339","display_name":"Thomas N. Wight","orcid":"https://orcid.org/0000-0002-2794-4197","observed_orcids":["https://orcid.org/0000-0002-2794-4197"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas N. Wight","raw_affiliation_strings":["Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington","institution_ids":["https://openalex.org/I4391012615"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090359807"],"corresponding_institution_ids":["https://openalex.org/I4391012615"],"apc_list":{"value":1200,"currency":"USD","value_usd":1200},"apc_paid":null,"fwci":0.3831,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.45844165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"69","issue":"6","first_page":"415","last_page":"428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tubulogenesis","display_name":"tubulogenesis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/lumen-formation","display_name":"lumen formation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hyaluronan-synthase-2","display_name":"HAS2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hyaluronan-synthesis","display_name":"hyaluronan synthesis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hyaluronidase","display_name":"hyaluronidase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mannose","display_name":"mannose","score":0.6830000281333923},{"id":"https://openalex.org/keywords/4-methylumbelliferone","display_name":"4-methylumbelliferone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/vasculogenesis","display_name":"vasculogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/collagen-gel-culture","display_name":"collagen gel culture","score":0.6679999828338623},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6402225494384766},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5832680463790894},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5702876448631287},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47998592257499695},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.44299203157424927},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.43073445558547974},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4193047285079956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3834117650985718},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3676019012928009},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.32511240243911743},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24203485250473022},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09449401497840881}],"mesh":[{"descriptor_ui":"D000076002","descriptor_name":"Hyaluronan Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000076002","descriptor_name":"Hyaluronan Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1369/00221554211022703","doi":"https://doi.org/10.1369/00221554211022703","is_oa":false,"landing_page_url":"https://doi.org/10.1369/00221554211022703","pdf_url":null,"source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry & Cytochemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8182639","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8182639","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Histochem Cytochem","raw_type":"Text"},{"id":"pmid:34080894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34080894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8182639","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8182639","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Histochem Cytochem","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2877532123","display_name":"Engineering vascular replacements for strength and elasticity","funder_award_id":"R01EB012558","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W173386824","https://openalex.org/W213450906","https://openalex.org/W344266619","https://openalex.org/W1498442127","https://openalex.org/W1698380454","https://openalex.org/W1794039655","https://openalex.org/W1917825152","https://openalex.org/W1949898671","https://openalex.org/W1975173778","https://openalex.org/W1979312850","https://openalex.org/W1984914037","https://openalex.org/W2003117646","https://openalex.org/W2003978264","https://openalex.org/W2005703350","https://openalex.org/W2009275174","https://openalex.org/W2012228004","https://openalex.org/W2026093892","https://openalex.org/W2033306446","https://openalex.org/W2036954068","https://openalex.org/W2038372277","https://openalex.org/W2038838654","https://openalex.org/W2046682881","https://openalex.org/W2050902848","https://openalex.org/W2057694188","https://openalex.org/W2058015990","https://openalex.org/W2058081151","https://openalex.org/W2058692868","https://openalex.org/W2061095488","https://openalex.org/W2066212925","https://openalex.org/W2071561174","https://openalex.org/W2079070267","https://openalex.org/W2082452847","https://openalex.org/W2089753996","https://openalex.org/W2097847761","https://openalex.org/W2103504619","https://openalex.org/W2103836570","https://openalex.org/W2122420953","https://openalex.org/W2127466034","https://openalex.org/W2131207346","https://openalex.org/W2133328496","https://openalex.org/W2134213816","https://openalex.org/W2136785863","https://openalex.org/W2146505397","https://openalex.org/W2151761229","https://openalex.org/W2153315863","https://openalex.org/W2157506600","https://openalex.org/W2167003210","https://openalex.org/W2285630455","https://openalex.org/W2305920863","https://openalex.org/W2396187739","https://openalex.org/W2416624154","https://openalex.org/W2551906031","https://openalex.org/W2599130141","https://openalex.org/W2612727390","https://openalex.org/W2885470166","https://openalex.org/W2890624098","https://openalex.org/W2913224919","https://openalex.org/W2918155223","https://openalex.org/W2947916580","https://openalex.org/W3081661743","https://openalex.org/W3094444664"],"related_works":["https://openalex.org/W3007032661","https://openalex.org/W2807896387","https://openalex.org/W1965866002","https://openalex.org/W3090450232","https://openalex.org/W2142944353","https://openalex.org/W1435595155","https://openalex.org/W2065864290","https://openalex.org/W7097081196","https://openalex.org/W2320826168","https://openalex.org/W344266619"],"abstract_inverted_index":{"Although":[0],"many":[1],"studies":[2],"have":[3],"focused":[4],"on":[5,39,80,131],"a":[6,190],"role":[7,191],"for":[8,108,192],"hyaluronan":[9],"(HA)":[10],"of":[11,30,69,135,157],"interstitial":[12],"extracellular":[13],"matrix":[14],"(presumably":[15],"produced":[16,33],"by":[17,34,120,154],"non-vascular":[18],"\u201cstromal\u201d":[19],"cells)":[20],"in":[21,48,91,139,146,168,173,196],"regulating":[22],"vascular":[23,35],"growth,":[24],"we":[25],"herein":[26],"examine":[27],"the":[28,67,132,136,140],"influence":[29],"\u201cautocrine":[31],"HA\u201d":[32],"endothelial":[36,45],"cells":[37,46],"themselves":[38],"tubulogenesis,":[40],"using":[41,110],"human":[42],"umbilical":[43],"vein":[44],"(HUVECs)":[47],"angiogenic":[49,147,169],"and":[50,65,94,118,148,161,199],"vasculogenic":[51,149,174],"three-dimensional":[52],"collagen":[53,142],"gel":[54],"cultures.":[55],"Relative":[56],"to":[57,104,182,189],"unstimulated":[58],"controls,":[59],"tubulogenic":[60],"HUVECs":[61],"upregulated":[62],"HAS2":[63,90],"mRNA":[64],"increased":[66],"synthesis":[68,159],"cell-associated":[70],"HA":[71,74,109,124,130,158,195],"(but":[72],"not":[73,172,180],"secreted":[75],"into":[76],"media).":[77],"Confocal":[78],"microscopy/immunofluorescence":[79],"cultures":[81,150,175],"fixed":[82,97],"with":[83,98,116],"neutral-buffered":[84],"10%":[85],"formalin":[86],"(NBF)":[87],"revealed":[88],"cytoplasmic":[89],"HUVEC":[92],"cords":[93],"tubes.":[95],"Cultures":[96],"NBF":[99],"(with":[100],"cetylpyridinium":[101],"chloride":[102],"added":[103],"retain":[105],"HA),":[106],"stained":[107],"\u201caffinity":[111],"fluorescence\u201d":[112],"(biotinylated":[113],"HA-binding":[114],"protein":[115],"streptavidin-fluor),":[117],"viewed":[119],"confocal":[121],"microscopy":[122],"showed":[123],"throughout":[125],"tube":[126],"lumens,":[127],"but":[128,171],"little/no":[129],"abluminal":[133],"sides":[134],"tubes":[137],"or":[138],"surrounding":[141],"gel.":[143],"Lumen":[144],"formation":[145,167],"was":[151],"strongly":[152,164],"suppressed":[153],"metabolic":[155],"inhibitors":[156],"(mannose":[160],"4-methylumbelliferone).":[162],"Hyaluronidase":[163],"inhibited":[165],"lumen":[166,200],"cultures,":[170],"(where":[176],"developing":[177],"lumens":[178],"are":[179],"open":[181],"culture":[183],"medium).":[184],"Collectively,":[185],"our":[186],"results":[187],"point":[188],"autocrine,":[193],"luminal":[194],"microvascular":[197],"sprouting":[198],"development.":[201],"(J":[202],"Histochem":[203],"Cytochem":[204],"69:":[205],"415\u2013428,":[206],"2021)":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-07T00:00:00"}