{"id":"https://openalex.org/W316350110","doi":null,"title":"Neural plasticity of the hippocampal (CA1) pyramidal cell--quantitative changes in spine density following handling and injection for drug testing.","display_name":"Neural plasticity of the hippocampal (CA1) pyramidal cell--quantitative changes in spine density following handling and injection for drug testing.","publication_year":1991,"publication_date":"1991-02-01","ids":{"openalex":"https://openalex.org/W316350110","mag":"316350110","pmid":"https://pubmed.ncbi.nlm.nih.gov/2032937","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1256057"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:343572","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1256057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1256057","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050358550","display_name":"Catherine H. Horner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"C H Horner","raw_affiliation_strings":["Department of Anatomy, Trinity College, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Trinity College, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109129064","display_name":"M.E. O'Regan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M O'Regan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010915699","display_name":"Elinor R. Arbuthnott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Arbuthnott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5919,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.57261267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"174","issue":null,"first_page":"229","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dendritic-spine-density","display_name":"dendritic spine density","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/sensory-stimulation","display_name":"sensory stimulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/handling","display_name":"handling","score":0.6179999709129333},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dendritic-morphology","display_name":"dendritic morphology","score":0.6790000200271606},{"id":"https://openalex.org/keywords/apical-dendrites","display_name":"apical dendrites","score":0.6909999847412109},{"id":"https://openalex.org/keywords/basal-dendrites","display_name":"basal dendrites","score":0.9700000286102295},{"id":"https://openalex.org/keywords/drug-testing","display_name":"drug testing","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7512639760971069},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.7499135136604309},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5830839276313782},{"id":"https://openalex.org/C205383261","wikidata":"https://www.wikidata.org/wiki/Q7392570","display_name":"SPINE (molecular biology)","level":2,"score":0.5821572542190552},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5749227404594421},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.5347124338150024},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.43134766817092896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36347147822380066},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.355889230966568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32906800508499146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3005765378475189},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.12995854020118713},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002997","descriptor_name":"Clomipramine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011712","descriptor_name":"Pyramidal Tracts","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D011712","descriptor_name":"Pyramidal Tracts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:343572","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1256057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:2032937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2032937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of anatomy","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:1256057","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1256057/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anat","raw_type":"Text"},{"id":"mag:316350110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2032937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:343572","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1256057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W252298518","https://openalex.org/W1965510709","https://openalex.org/W1969484228","https://openalex.org/W1969906951","https://openalex.org/W1973183299","https://openalex.org/W1980274515","https://openalex.org/W1982931040","https://openalex.org/W1998173762","https://openalex.org/W2016505524","https://openalex.org/W2017613746","https://openalex.org/W2023687632","https://openalex.org/W2026179327","https://openalex.org/W2032774015","https://openalex.org/W2037387800","https://openalex.org/W2042649681","https://openalex.org/W2049198136","https://openalex.org/W2049255471","https://openalex.org/W2054575433","https://openalex.org/W2058584260","https://openalex.org/W2062815987","https://openalex.org/W2074556733","https://openalex.org/W2074888281","https://openalex.org/W2075164262","https://openalex.org/W2077733542","https://openalex.org/W2081003681","https://openalex.org/W2081113831","https://openalex.org/W2081481357","https://openalex.org/W2122427440","https://openalex.org/W2134357598","https://openalex.org/W2149375724","https://openalex.org/W2395343821","https://openalex.org/W2414452718","https://openalex.org/W4407044924"],"related_works":["https://openalex.org/W2038066779","https://openalex.org/W2042741332","https://openalex.org/W2136249808","https://openalex.org/W2469420885","https://openalex.org/W2087570284","https://openalex.org/W2017199587","https://openalex.org/W1979246511","https://openalex.org/W2141167930","https://openalex.org/W2007583330","https://openalex.org/W2035352997"],"abstract_inverted_index":{"A":[0,50,109],"quantitative":[1],"assessment":[2],"of":[3,7,16,19,30,53,75,117],"the":[4,20,76,87,99,126],"spine":[5,102],"density":[6,103],"apical,":[8],"basal":[9],"and":[10,45,64,67,70,80,94,106,125],"oblique":[11,81],"dendrites":[12],"on":[13],"pyramidal":[14],"neurons":[15],"area":[17],"CA1":[18],"hippocampus":[21],"was":[22],"made":[23],"in":[24,73,101,104,115],"three":[25],"experimental":[26],"groups.":[27],"The":[28],"results":[29],"a":[31,35,42],"group":[32,44,112],"injected":[33],"with":[34,41],"tricyclic":[36],"antidepressant":[37],"were":[38],"compared":[39],"statistically":[40],"saline-injected":[43,107],"an":[46],"unhandled":[47],"control":[48,65,71,111],"group.":[49],"statistical":[51],"analysis":[52],"variance":[54],"indicated":[55],"significant":[56],"(P":[57],"less":[58],"than":[59],"0.01)":[60],"differences":[61],"between":[62,68],"drug":[63],"groups":[66,72],"saline":[69],"two":[74],"loci":[77],"assessed":[78],"(basal":[79],"dendrites).":[82],"These":[83],"findings":[84],"suggest":[85],"that":[86],"sensory":[88],"stimulation":[89],"provided":[90],"by":[91,131],"daily":[92],"injection":[93],"handling":[95],"is":[96,113,122],"responsible":[97],"for":[98],"increases":[100],"drug-":[105],"animals.":[108],"single":[110],"insufficient":[114],"experiments":[116],"this":[118],"type.":[119],"Experimental":[120],"protocol":[121],"extremely":[123],"important":[124],"dramatic":[127],"morphological":[128],"changes":[129],"produced":[130],"simple":[132],"routine":[133],"processes":[134],"should":[135],"not":[136],"be":[137],"under-estimated.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
