{"id":"https://openalex.org/W3163368898","doi":"https://doi.org/10.1080/19490976.2021.1921925","title":"Gut microbiota as prognosis markers for patients with HBV-related acute-on-chronic liver failure","display_name":"Gut microbiota as prognosis markers for patients with HBV-related acute-on-chronic liver failure","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3163368898","doi":"https://doi.org/10.1080/19490976.2021.1921925","mag":"3163368898","pmid":"https://pubmed.ncbi.nlm.nih.gov/34006193"},"language":"en","primary_location":{"id":"doi:10.1080/19490976.2021.1921925","doi":"https://doi.org/10.1080/19490976.2021.1921925","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2021.1921925","pdf_url":null,"source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1080/19490976.2021.1921925","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100360112","display_name":"Ke Wang","orcid":"https://orcid.org/0000-0002-2824-1047","observed_orcids":["https://orcid.org/0000-0002-2824-1047","https://orcid.org/0009-0002-8612-548X","https://orcid.org/0000-0002-2698-0284"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Wang","raw_affiliation_strings":["Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423022","display_name":"Zhao Zhang","orcid":"https://orcid.org/0000-0002-3996-9893","observed_orcids":["https://orcid.org/0000-0002-3996-9893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhao Zhang","raw_affiliation_strings":["Guangdong Longsee Biomedical Corporation","Research and Development Department, Guangdong Longsee Biomedical Corporation, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Longsee Biomedical Corporation","institution_ids":[]},{"raw_affiliation_string":"Research and Development Department, Guangdong Longsee Biomedical Corporation, Guangzhou, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102826587","display_name":"Zhishuo Mo","orcid":"https://orcid.org/0000-0002-8520-2845","observed_orcids":["https://orcid.org/0000-0002-8520-2845"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Shuo Mo","raw_affiliation_strings":["Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003625073","display_name":"Xiaohua Yang","orcid":"https://orcid.org/0009-0001-4416-9962","observed_orcids":["https://orcid.org/0009-0001-4416-9962"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Hua Yang","raw_affiliation_strings":["Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005326970","display_name":"Bingliang Lin","orcid":"https://orcid.org/0000-0003-4069-6287","observed_orcids":["https://orcid.org/0000-0003-4069-6287"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing-Liang Lin","raw_affiliation_strings":["Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016684571","display_name":"Liang Peng","orcid":"https://orcid.org/0000-0003-1682-7064","observed_orcids":["https://orcid.org/0000-0003-1682-7064"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Peng","raw_affiliation_strings":["Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103135228","display_name":"Xu Yang","orcid":"https://orcid.org/0000-0003-2242-670X","observed_orcids":["https://orcid.org/0000-0003-2242-670X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Xu","raw_affiliation_strings":["Guangdong Longsee Biomedical Corporation","Research and Development Department, Guangdong Longsee Biomedical Corporation, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Longsee Biomedical Corporation","institution_ids":[]},{"raw_affiliation_string":"Research and Development Department, Guangdong Longsee Biomedical Corporation, Guangzhou, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chun-Yan Lei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun-Yan Lei","raw_affiliation_strings":["Guangdong Longsee Biomedical Corporation","Research and Development Department, Guangdong Longsee Biomedical Corporation, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Longsee Biomedical Corporation","institution_ids":[]},{"raw_affiliation_string":"Research and Development Department, Guangdong Longsee Biomedical Corporation, Guangzhou, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054796837","display_name":"Xiaodong  Alan Zhuang","orcid":"https://orcid.org/0000-0002-6870-9003","observed_orcids":["https://orcid.org/0000-0002-6870-9003"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Xiao-Dong Zhuang","raw_affiliation_strings":["University of Oxford","Nuffield Department of Medicine, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Nuffield Department of Medicine, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069748654","display_name":"Ling L\u00fc","orcid":"https://orcid.org/0000-0002-4983-5557","observed_orcids":["https://orcid.org/0000-0002-4983-5557"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Lu","raw_affiliation_strings":["Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University","Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100693489","display_name":"Ruifu Yang","orcid":"https://orcid.org/0000-0003-3219-7269","observed_orcids":["https://orcid.org/0000-0003-3219-7269"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rui-Fu Yang","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357770","display_name":"Tao Chen","orcid":"https://orcid.org/0009-0004-4951-6283","observed_orcids":["https://orcid.org/0009-0004-4951-6283"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tao Chen","raw_affiliation_strings":["Guangdong Longsee Biomedical Corporation","Research and Development Department, Guangdong Longsee Biomedical Corporation, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Longsee Biomedical Corporation","institution_ids":[]},{"raw_affiliation_string":"Research and Development Department, Guangdong Longsee Biomedical Corporation, Guangzhou, Guangdong, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009147506","display_name":"Zhiliang Gao","orcid":"https://orcid.org/0000-0001-7611-4416","observed_orcids":["https://orcid.org/0000-0001-7611-4416"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhi-Liang Gao","raw_affiliation_strings":["Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5009147506","https://openalex.org/A5100357770","https://openalex.org/A5100693489"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956","https://openalex.org/I4405260518"],"apc_list":{"value":2495,"currency":"GBP","value_usd":3060},"apc_paid":{"value":2495,"currency":"GBP","value_usd":3060},"fwci":1.9416,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.87646585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9850000143051147},{"id":"https://openalex.org/keywords/acute-on-chronic-liver-failure","display_name":"acute-on-chronic liver failure","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9570000171661377},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/microbiota-diversity","display_name":"microbiome diversity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/enterococcus-faecium","display_name":"Enterococcus faecium","score":0.859000027179718},{"id":"https://openalex.org/keywords/faecalibacterium-prausnitzii","display_name":"Faecalibacterium prausnitzii","score":0.9610000252723694},{"id":"https://openalex.org/keywords/parabacteroides-merdae","display_name":"Parabacteroides merdae","score":0.9869999885559082},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.906000018119812},{"id":"https://openalex.org/keywords/fecal-microbiota","display_name":"fecal microbiota","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780675110","wikidata":"https://www.wikidata.org/wiki/Q3738294","display_name":"Faecalibacterium prausnitzii","level":3,"score":0.8488718271255493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7207640409469604},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.605401337146759},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.558181643486023},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5096969604492188},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.4956170320510864},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4781143069267273},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.45522013306617737},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.41563987731933594},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.34777891635894775},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.2800493836402893},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.21348091959953308},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07594424486160278},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.07444503903388977},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0646941065788269}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065290","descriptor_name":"Acute-On-Chronic Liver Failure","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D065290","descriptor_name":"Acute-On-Chronic Liver Failure","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D065290","descriptor_name":"Acute-On-Chronic Liver Failure","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D065290","descriptor_name":"Acute-On-Chronic Liver Failure","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D065290","descriptor_name":"Acute-On-Chronic Liver Failure","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D065290","descriptor_name":"Acute-On-Chronic Liver Failure","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1080/19490976.2021.1921925","doi":"https://doi.org/10.1080/19490976.2021.1921925","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2021.1921925","pdf_url":null,"source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-32725/v1","doi":"https://doi.org/10.21203/rs.3.rs-32725/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-32725/v1","pdf_url":"https://www.researchsquare.com/article/rs-32725/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:34006193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34006193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut microbes","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8143260","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8143260","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gut Microbes","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e081a8a0b261467295a5ce9ce384c9f6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e081a8a0b261467295a5ce9ce384c9f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gut Microbes, Vol 13, Iss 1 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/19490976.2021.1921925","doi":"https://doi.org/10.1080/19490976.2021.1921925","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2021.1921925","pdf_url":null,"source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1850257411","display_name":null,"funder_award_id":"2018ZX10302204","funder_id":"https://openalex.org/F4320335960","funder_display_name":"National Major Science and Technology Projects of China"},{"id":"https://openalex.org/G3577911001","display_name":null,"funder_award_id":"2018ZX10302-204","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"},{"id":"https://openalex.org/G4099776927","display_name":null,"funder_award_id":"2018ZX10302204","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4830645299","display_name":null,"funder_award_id":"2019A1515110338","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G5165502421","display_name":null,"funder_award_id":"81672701","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"},{"id":"https://openalex.org/G7810190188","display_name":null,"funder_award_id":"81672701","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8629034295","display_name":null,"funder_award_id":"81700528","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null},{"id":"https://openalex.org/F4320335960","display_name":"National Major Science and Technology Projects of China","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1492544397","https://openalex.org/W1534898911","https://openalex.org/W1822961287","https://openalex.org/W1861168940","https://openalex.org/W1965554634","https://openalex.org/W1978906150","https://openalex.org/W1980914602","https://openalex.org/W1985499572","https://openalex.org/W2033829415","https://openalex.org/W2034687043","https://openalex.org/W2037833069","https://openalex.org/W2039675240","https://openalex.org/W2068894782","https://openalex.org/W2069243984","https://openalex.org/W2092648379","https://openalex.org/W2093829386","https://openalex.org/W2098268087","https://openalex.org/W2107414352","https://openalex.org/W2110235509","https://openalex.org/W2118645556","https://openalex.org/W2123008311","https://openalex.org/W2126524876","https://openalex.org/W2128385759","https://openalex.org/W2141125135","https://openalex.org/W2142536690","https://openalex.org/W2153896859","https://openalex.org/W2156656155","https://openalex.org/W2374395990","https://openalex.org/W2396875676","https://openalex.org/W2401857311","https://openalex.org/W2411730197","https://openalex.org/W2561736761","https://openalex.org/W2562582244","https://openalex.org/W2616825195","https://openalex.org/W2747802864","https://openalex.org/W2771115527","https://openalex.org/W2783317489","https://openalex.org/W2888833353","https://openalex.org/W2890556797","https://openalex.org/W2913147065","https://openalex.org/W2918180541","https://openalex.org/W2922448965","https://openalex.org/W2945997272","https://openalex.org/W3004165397","https://openalex.org/W6600195515","https://openalex.org/W6600291067"],"related_works":["https://openalex.org/W2217550124","https://openalex.org/W4245127321","https://openalex.org/W3134886809","https://openalex.org/W2166691283","https://openalex.org/W3032296780","https://openalex.org/W3067900727","https://openalex.org/W2913569503","https://openalex.org/W3135269674","https://openalex.org/W3171833977","https://openalex.org/W2783006976"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,116,212],"gut":[3,26,40,213],"microbiota":[4,27,214,243],"in":[5,28,31,42,101,125,152,160,178],"the":[6,22,25,39,86,102,106,126,136,146,153,161,190,207,242],"hepatitis":[7,71],"B":[8,72],"virus":[9],"related":[10],"acute-on-chronic":[11],"liver":[12],"failure":[13],"(HBV-ACLF)":[14],"is":[15,227,235],"poorly":[16],"defined.":[17],"We":[18,37,97],"aim":[19],"to":[20,120],"uncover":[21],"characteristics":[23],"of":[24,61,118,174,203,209,221,225,233,239],"HBV-ACLF":[29,45,127,137],"and":[30,51,58,79,89,109,169,186],"other":[32,47],"HBV":[33,48],"associated":[34,49,228,236],"pathologies.":[35],"Methods":[36],"analyzed":[38],"microbiome":[41,103],"patients":[43,65,91],"with":[44,66,69,75,130,229,237],"or":[46],"pathologies":[50],"healthy":[52,81,110,131],"individuals":[53,82],"by":[54],"16S":[55,113],"rRNA":[56,114],"sequencing":[57,60,165],"metagenomic":[59],"fecal":[62],"samples.":[63],"212":[64],"HBV-ACLF,":[67,107],"252":[68],"chronic":[70],"(CHB),":[73],"162":[74],"HBV-associated":[76],"cirrhosis":[77],"(HBV-LC)":[78],"877":[80],"were":[83],"recruited":[84],"for":[85,251],"study.":[87],"CHB":[88],"HBV-LC":[90],"are":[92],"grouped":[93],"as":[94,248],"HBV-Other.":[95],"Results":[96],"discovered":[98],"striking":[99],"differences":[100],"diversity":[104],"between":[105],"HBV-Other":[108],"groups":[111],"using":[112],"sequencing.":[115],"ratio":[117],"cocci":[119],"bacilli":[121],"was":[122,150,158,199],"significantly":[123],"elevated":[124],"group":[128,138,147,155],"compared":[129],"group.":[132,163,192],"Further":[133],"analysis":[134,195],"within":[135,145],"identified":[139],"52":[140],"genera":[141],"showing":[142],"distinct":[143,216],"richness":[144],"where":[148],"Enterococcus":[149,204,226],"enriched":[151,159],"progression":[154,179,208,230],"whilst":[156],"Faecalibacterium":[157,184,234],"regression":[162,191,238],"Metagenomic":[164],"validated":[166],"these":[167],"findings":[168],"further":[170],"uncovered":[171],"an":[172],"enrichment":[173],"Lactobacillus":[175],"casei":[176],"paracasei":[177],"group,":[180],"while":[181,231],"Alistipes":[182],"senegalensis,":[183],"prausnitzii":[185],"Parabacteroides":[187],"merdae":[188],"dominated":[189],"Importantly,":[193],"our":[194],"revealed":[196],"that":[197,232],"there":[198],"a":[200],"rapid":[201],"increase":[202],"faecium":[205],"during":[206],"HBV-ACLF.":[210,222,240,252],"Conclusions":[211],"displayed":[215],"composition":[217],"at":[218],"different":[219],"phases":[220],"High":[223],"abundance":[224],"Therefore":[241],"features":[244],"hold":[245],"promising":[246],"potential":[247],"prognostic":[249],"markers":[250]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}
