{"id":"https://openalex.org/W3163366071","doi":"https://doi.org/10.1016/j.biopha.2021.111386","title":"Small molecules against the origin and activation of myofibroblast for renal interstitial fibrosis therapy","display_name":"Small molecules against the origin and activation of myofibroblast for renal interstitial fibrosis therapy","publication_year":2021,"publication_date":"2021-05-11","ids":{"openalex":"https://openalex.org/W3163366071","doi":"https://doi.org/10.1016/j.biopha.2021.111386","mag":"3163366071","pmid":"https://pubmed.ncbi.nlm.nih.gov/34243594"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2021.111386","doi":"https://doi.org/10.1016/j.biopha.2021.111386","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2021.111386","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332221001712/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S0753332221001712/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075079353","display_name":"Ya\u2010Long Feng","orcid":"https://orcid.org/0000-0001-5207-5010","observed_orcids":["https://orcid.org/0000-0001-5207-5010"]},"institutions":[{"id":"https://openalex.org/I4210118093","display_name":"Xianyang Normal University","ror":"https://ror.org/01r45yt97","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210118093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-long Feng","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Xianyang Normal University, No.43 Wenlin Road, Xianyang 712000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Xianyang Normal University, No.43 Wenlin Road, Xianyang 712000, Shaanxi, China","institution_ids":["https://openalex.org/I4210118093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350659","display_name":"Wenbo Wang","orcid":"https://orcid.org/0000-0001-5501-1039","observed_orcids":["https://orcid.org/0000-0001-5501-1039"]},"institutions":[{"id":"https://openalex.org/I4210118093","display_name":"Xianyang Normal University","ror":"https://ror.org/01r45yt97","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210118093"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wen-bo Wang","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Xianyang Normal University, No.43 Wenlin Road, Xianyang 712000, Shaanxi, China. Electronic address: wenbowang@163.com","School of Chemistry and Chemical Engineering, Xianyang Normal University, No.43 Wenlin Road, Xianyang 712000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Xianyang Normal University, No.43 Wenlin Road, Xianyang 712000, Shaanxi, China. Electronic address: wenbowang@163.com","institution_ids":["https://openalex.org/I4210118093"]},{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Xianyang Normal University, No.43 Wenlin Road, Xianyang 712000, Shaanxi, China","institution_ids":["https://openalex.org/I4210118093"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yue Ning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118093","display_name":"Xianyang Normal University","ror":"https://ror.org/01r45yt97","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210118093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Ning","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Xianyang Normal University, No.43 Wenlin Road, Xianyang 712000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Xianyang Normal University, No.43 Wenlin Road, Xianyang 712000, Shaanxi, China","institution_ids":["https://openalex.org/I4210118093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380200","display_name":"Hua Chen","orcid":"https://orcid.org/0009-0001-1241-4978","observed_orcids":["https://orcid.org/0009-0001-1241-4978","https://orcid.org/0000-0001-5564-4610"]},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hua Chen","raw_affiliation_strings":["College of Pharmacy, Ningxia Medical University, No. 692 Shengli Road, Yinchuan, Ningxia 750003, China. Electronic address: chenhnwu@163.com","College of Pharmacy, Ningxia Medical University, No. 692 Shengli Road, Yinchuan, Ningxia 750003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ningxia Medical University, No. 692 Shengli Road, Yinchuan, Ningxia 750003, China. Electronic address: chenhnwu@163.com","institution_ids":["https://openalex.org/I4210127460"]},{"raw_affiliation_string":"College of Pharmacy, Ningxia Medical University, No. 692 Shengli Road, Yinchuan, Ningxia 750003, China","institution_ids":["https://openalex.org/I4210127460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100383844","display_name":"Pei Liu","orcid":"https://orcid.org/0009-0006-0772-8434","observed_orcids":["https://orcid.org/0009-0006-0772-8434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pei Liu","raw_affiliation_strings":["Shaanxi Institute for Food and Drug Control, Xian, Shaanxi, 710065, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shaanxi Institute for Food and Drug Control, Xian, Shaanxi, 710065, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100350659","https://openalex.org/A5100380200"],"corresponding_institution_ids":["https://openalex.org/I4210118093","https://openalex.org/I4210127460"],"apc_list":{"value":2660,"currency":"USD","value_usd":2660},"apc_paid":{"value":2660,"currency":"USD","value_usd":2660},"fwci":0.6354,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.52665495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"139","issue":null,"first_page":"111386","last_page":"111386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":1.0},{"id":"https://openalex.org/keywords/myofibroblast-origin","display_name":"myofibroblast origin","score":0.8059999942779541},{"id":"https://openalex.org/keywords/myofibroblast-activation","display_name":"myofibroblast activation","score":1.0},{"id":"https://openalex.org/keywords/small-molecule-drugs","display_name":"small molecule drugs","score":0.7789999842643738},{"id":"https://openalex.org/keywords/renal-fibrogenesis","display_name":"renal fibrogenesis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tgf-beta1-signaling","display_name":"TGF-\u03b21 signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9729999899864197},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.640999972820282},{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.8978267312049866},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5971753001213074},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5566526055335999},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5122599005699158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4887959659099579},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.48787784576416016},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4550716280937195},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.41441506147384644},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34381169080734253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3232570290565491},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28704553842544556},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26637405157089233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15556266903877258},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D058628","descriptor_name":"Myofibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biopha.2021.111386","doi":"https://doi.org/10.1016/j.biopha.2021.111386","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2021.111386","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332221001712/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:34243594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34243594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:34fb2263c2eb40f798c7e3677e93983d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/34fb2263c2eb40f798c7e3677e93983d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicine & Pharmacotherapy, Vol 139, Iss , Pp 111386- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2021.111386","doi":"https://doi.org/10.1016/j.biopha.2021.111386","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2021.111386","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332221001712/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1328974476","display_name":null,"funder_award_id":"31872175","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322425","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848"},{"id":"https://openalex.org/F4320336350","display_name":"Key Research and Development Projects of Shaanxi Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3163366071.pdf","grobid_xml":"https://content.openalex.org/works/W3163366071.grobid-xml"},"referenced_works_count":136,"referenced_works":["https://openalex.org/W1527057389","https://openalex.org/W1579634595","https://openalex.org/W1918138029","https://openalex.org/W1928724315","https://openalex.org/W1966151380","https://openalex.org/W1975015638","https://openalex.org/W1977437151","https://openalex.org/W1980325398","https://openalex.org/W1987081656","https://openalex.org/W2008163822","https://openalex.org/W2009188044","https://openalex.org/W2013452502","https://openalex.org/W2014887084","https://openalex.org/W2018079417","https://openalex.org/W2020759737","https://openalex.org/W2021017423","https://openalex.org/W2022263966","https://openalex.org/W2033457930","https://openalex.org/W2044982400","https://openalex.org/W2052092179","https://openalex.org/W2054282870","https://openalex.org/W2066867055","https://openalex.org/W2079070598","https://openalex.org/W2080921752","https://openalex.org/W2086182209","https://openalex.org/W2106256269","https://openalex.org/W2113079550","https://openalex.org/W2138043907","https://openalex.org/W2155261039","https://openalex.org/W2165440636","https://openalex.org/W2171990628","https://openalex.org/W2174804983","https://openalex.org/W2197344230","https://openalex.org/W2229353670","https://openalex.org/W2256742438","https://openalex.org/W2290278411","https://openalex.org/W2313885686","https://openalex.org/W2315128454","https://openalex.org/W2315231005","https://openalex.org/W2323645949","https://openalex.org/W2342679639","https://openalex.org/W2344687745","https://openalex.org/W2409779133","https://openalex.org/W2470157805","https://openalex.org/W2479269302","https://openalex.org/W2480216278","https://openalex.org/W2549141852","https://openalex.org/W2552360097","https://openalex.org/W2558929801","https://openalex.org/W2559257586","https://openalex.org/W2566412311","https://openalex.org/W2587945689","https://openalex.org/W2589113597","https://openalex.org/W2591251590","https://openalex.org/W2603641223","https://openalex.org/W2604690869","https://openalex.org/W2606686342","https://openalex.org/W2607179358","https://openalex.org/W2731771427","https://openalex.org/W2745823686","https://openalex.org/W2749881696","https://openalex.org/W2753188950","https://openalex.org/W2760186430","https://openalex.org/W2764034683","https://openalex.org/W2766423705","https://openalex.org/W2769011958","https://openalex.org/W2769078956","https://openalex.org/W2769234034","https://openalex.org/W2769288944","https://openalex.org/W2770489992","https://openalex.org/W2781934183","https://openalex.org/W2794972124","https://openalex.org/W2797776510","https://openalex.org/W2804443706","https://openalex.org/W2809667088","https://openalex.org/W2810136386","https://openalex.org/W2883016826","https://openalex.org/W2884090760","https://openalex.org/W2886444621","https://openalex.org/W2889050155","https://openalex.org/W2889074463","https://openalex.org/W2890188297","https://openalex.org/W2890544808","https://openalex.org/W2891619543","https://openalex.org/W2894384638","https://openalex.org/W2895911020","https://openalex.org/W2896885270","https://openalex.org/W2898136018","https://openalex.org/W2899211152","https://openalex.org/W2901435720","https://openalex.org/W2903596927","https://openalex.org/W2908817863","https://openalex.org/W2909018284","https://openalex.org/W2909424354","https://openalex.org/W2921692877","https://openalex.org/W2922478652","https://openalex.org/W2928176820","https://openalex.org/W2940884725","https://openalex.org/W2944596914","https://openalex.org/W2946469229","https://openalex.org/W2946959514","https://openalex.org/W2947379553","https://openalex.org/W2950591949","https://openalex.org/W2953132927","https://openalex.org/W2954917865","https://openalex.org/W2955913628","https://openalex.org/W2964630023","https://openalex.org/W2968785777","https://openalex.org/W2970691550","https://openalex.org/W2974274976","https://openalex.org/W2975701363","https://openalex.org/W2981284985","https://openalex.org/W2981812006","https://openalex.org/W2982219695","https://openalex.org/W2982495996","https://openalex.org/W2992524785","https://openalex.org/W2993765917","https://openalex.org/W2998221009","https://openalex.org/W2999284120","https://openalex.org/W3000030544","https://openalex.org/W3005608016","https://openalex.org/W3007378416","https://openalex.org/W3008074101","https://openalex.org/W3013704768","https://openalex.org/W3014344943","https://openalex.org/W3014596954","https://openalex.org/W3015776250","https://openalex.org/W3024098528","https://openalex.org/W3029187477","https://openalex.org/W3047457746","https://openalex.org/W3095983237","https://openalex.org/W6666877579","https://openalex.org/W6752884469","https://openalex.org/W6754264519","https://openalex.org/W6774090109","https://openalex.org/W6776946210"],"related_works":["https://openalex.org/W2411149830","https://openalex.org/W2968510883","https://openalex.org/W2967869023","https://openalex.org/W4410594671","https://openalex.org/W2370660897","https://openalex.org/W2202217605","https://openalex.org/W2081925030","https://openalex.org/W2323645949","https://openalex.org/W2018079417","https://openalex.org/W7142957543"],"abstract_inverted_index":{"Renal":[0],"interstitial":[1],"fibrosis":[2],"(RIF)":[3],"is":[4],"a":[5,10,29,167],"common":[6],"pathological":[7],"response":[8],"in":[9,99,154],"broad":[11],"range":[12],"of":[13,49,53,71,81,135,146,151],"prevalent":[14],"chronic":[15],"kidney":[16],"diseases":[17],"and":[18,24,62,69,83,87,93,133,149,156],"ultimately":[19],"leads":[20],"to":[21,65],"renal":[22,66,100,104,136,152],"failure":[23],"death.":[25],"Although":[26],"RIF":[27,128,155,171],"causes":[28],"high":[30],"morbi-mortality":[31],"worldwide,":[32],"effective":[33],"therapeutic":[34,125],"drugs":[35],"are":[36,40,97],"urgently":[37],"needed.":[38],"Myofibroblasts":[39],"identified":[41],"as":[42],"the":[43,47,112,131,140,144,147,157],"main":[44],"effector":[45],"during":[46,103],"process":[48],"RIF.":[50,117],"Multiple":[51],"types":[52],"cells,":[54,58,60],"including":[55,73],"fibroblasts,":[56],"epithelial":[57],"endothelial":[59],"macrophages":[61],"pericytes,":[63],"contribute":[64],"myofibroblasts":[67,101,153],"origin,":[68],"lots":[70],"mediators,":[72],"signaling":[74],"pathways":[75],"(Transforming":[76],"growth":[77],"factor-\u03b21,":[78],"mammalian":[79],"target":[80],"rapamycin":[82],"reactive":[84],"oxygen":[85],"species)":[86],"epigenetic":[88],"modifications":[89],"(Histone":[90],"acetylation,":[91],"microRNA":[92],"long":[94],"non-coding":[95],"RNA)":[96],"participated":[98],"activation":[102,134,150],"fibrogenesis,":[105],"suggesting":[106],"that":[107],"these":[108],"mediators":[109],"may":[110],"be":[111],"promising":[113],"targets":[114],"for":[115,170],"treating":[116],"In":[118],"addition,":[119],"many":[120],"small":[121,158],"molecules":[122,159],"show":[123],"profound":[124],"effects":[126],"on":[127,143],"by":[129],"suppressing":[130],"origin":[132,148],"myofibroblasts.":[137],"Taken":[138],"together,":[139],"review":[141],"focuses":[142],"mechanisms":[145],"against":[160],"them":[161],"improving":[162],"RIF,":[163],"which":[164],"will":[165],"provide":[166],"new":[168],"insight":[169],"therapy.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-05-24T00:00:00"}
