{"id":"https://openalex.org/W3163357366","doi":"https://doi.org/10.1101/2020.09.03.281733","title":"Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts","display_name":"Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts","publication_year":2020,"publication_date":"2020-09-06","ids":{"openalex":"https://openalex.org/W3163357366","doi":"https://doi.org/10.1101/2020.09.03.281733","mag":"3163357366"},"language":"en","primary_location":{"id":"doi:10.1101/2020.09.03.281733","doi":"https://doi.org/10.1101/2020.09.03.281733","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.09.03.281733","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/19/2020.09.03.281733.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/19/2020.09.03.281733.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047973280","display_name":"Hemant Suryawanshi","orcid":"https://orcid.org/0000-0002-8102-9678","observed_orcids":["https://orcid.org/0000-0002-8102-9678"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hemant Suryawanshi","raw_affiliation_strings":["Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065","Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 0065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 0065","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078869065","display_name":"Hua Yang","orcid":"https://orcid.org/0000-0003-4993-7796","observed_orcids":["https://orcid.org/0000-0003-4993-7796"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Yang","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068172076","display_name":"Michelle Lubetzky","orcid":"https://orcid.org/0000-0003-1076-7953","observed_orcids":["https://orcid.org/0000-0003-1076-7953"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Lubetzky","raw_affiliation_strings":["Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10065","Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070082045","display_name":"Pavel S Morozov","orcid":"https://orcid.org/0000-0001-7085-9134","observed_orcids":["https://orcid.org/0000-0001-7085-9134"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavel Morozov","raw_affiliation_strings":["Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065","Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 0065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 0065","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109471584","display_name":"Mila Lagman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mila Lagman","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052245011","display_name":"Gaurav Thareja","orcid":"https://orcid.org/0000-0003-2277-6400","observed_orcids":["https://orcid.org/0000-0003-2277-6400"]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Gaurav Thareja","raw_affiliation_strings":["Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Doha, Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Doha, Qatar","institution_ids":["https://openalex.org/I4210152471"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alicia Alonso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia Alonso","raw_affiliation_strings":["Epigenomics Core Facility, Weill Cornell Medical College, New York, NY 10065","Epigenomics Core Facility, Weill Cornell Medical College, New York, NY 1006"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenomics Core Facility, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Epigenomics Core Facility, Weill Cornell Medical College, New York, NY 1006","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037032270","display_name":"Carol Y. Li","orcid":"https://orcid.org/0000-0002-0576-2181","observed_orcids":["https://orcid.org/0000-0002-0576-2181"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Li","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020508500","display_name":"Catherine Snopkowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Snopkowski","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035945935","display_name":"Aziz Belkadi","orcid":"https://orcid.org/0000-0003-1564-0468","observed_orcids":["https://orcid.org/0000-0003-1564-0468"]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Aziz Belkadi","raw_affiliation_strings":["Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Doha, Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Doha, Qatar","institution_ids":["https://openalex.org/I4210152471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012686761","display_name":"Franco B. Mueller","orcid":"https://orcid.org/0000-0002-0304-1268","observed_orcids":["https://orcid.org/0000-0002-0304-1268"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franco B. Mueller","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101480458","display_name":"John R. Lee","orcid":"https://orcid.org/0000-0002-9612-5742","observed_orcids":["https://orcid.org/0000-0002-9612-5742"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Lee","raw_affiliation_strings":["Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10065","Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068404213","display_name":"Darshana M. Dadhania","orcid":"https://orcid.org/0000-0002-7973-1521","observed_orcids":["https://orcid.org/0000-0002-7973-1521"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darshana M. Dadhania","raw_affiliation_strings":["Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10065","Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073289319","display_name":"Steven Salvatore","orcid":"https://orcid.org/0000-0001-7237-2696","observed_orcids":["https://orcid.org/0000-0001-7237-2696"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven P. Salvatore","raw_affiliation_strings":["Division of Renal Pathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065","Division of Renal Pathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 1005"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Pathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Division of Renal Pathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 1005","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071939353","display_name":"Surya V. Seshan","orcid":"https://orcid.org/0000-0003-4384-0694","observed_orcids":["https://orcid.org/0000-0003-4384-0694"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surya V. Seshan","raw_affiliation_strings":["Division of Renal Pathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065","Division of Renal Pathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 1005"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Pathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Division of Renal Pathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 1005","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031431276","display_name":"Vijay Kumar Sharma","orcid":"https://orcid.org/0000-0002-8976-5696","observed_orcids":["https://orcid.org/0000-0002-8976-5696"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay K. Sharma","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034424670","display_name":"Karsten Suhre","orcid":"https://orcid.org/0000-0001-9638-3912","observed_orcids":["https://orcid.org/0000-0001-9638-3912"]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Karsten Suhre","raw_affiliation_strings":["Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Doha, Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Doha, Qatar","institution_ids":["https://openalex.org/I4210152471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073533672","display_name":"Manikkam Suthanthiran","orcid":"https://orcid.org/0000-0001-6894-0486","observed_orcids":["https://orcid.org/0000-0001-6894-0486"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manikkam Suthanthiran","raw_affiliation_strings":["Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10065","Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042084987","display_name":"Thomas Tuschl","orcid":"https://orcid.org/0000-0002-6483-5678","observed_orcids":["https://orcid.org/0000-0002-6483-5678"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas Tuschl","raw_affiliation_strings":["Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065","Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 0065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 0065","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009885369","display_name":"Thangamani Muthukumar","orcid":"https://orcid.org/0000-0002-0294-6209","observed_orcids":["https://orcid.org/0000-0002-0294-6209"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thangamani Muthukumar","raw_affiliation_strings":["Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10065","Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065"],"raw_orcid":"https://orcid.org/0000-0002-0294-6209","affiliations":[{"raw_affiliation_string":"Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, NY 10065","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5009885369","https://openalex.org/A5042084987","https://openalex.org/A5047973280"],"corresponding_institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4387153466","https://openalex.org/I4405272987","https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-allograft","display_name":"kidney allograft","score":0.871999979019165},{"id":"https://openalex.org/keywords/transplant-glomerulopathy","display_name":"transplant glomerulopathy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/alloimmune-injury","display_name":"alloimmune injury","score":0.8289999961853027},{"id":"https://openalex.org/keywords/antibody-mediated-rejection","display_name":"antibody-mediated rejection","score":0.7839999794960022},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8040000200271606},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.6629999876022339},{"id":"https://openalex.org/keywords/sex-mismatch","display_name":"sex mismatch","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6308330297470093},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5960788726806641},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5713487863540649},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5644806623458862},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5614317655563354},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.5459368228912354},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5234474539756775},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.45963340997695923},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.451491117477417},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3925769627094269},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38906654715538025},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3844841420650482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.275720477104187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2615044116973877},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.23764833807945251},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23206329345703125},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1940934658050537},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1763416826725006},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10776233673095703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09884685277938843}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1101/2020.09.03.281733","doi":"https://doi.org/10.1101/2020.09.03.281733","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.09.03.281733","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/19/2020.09.03.281733.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:doaj.org/article:83187766d5604e109b43277b65fa3517","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/83187766d5604e109b43277b65fa3517","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 17, Iss 6 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1101/2020.09.03.281733","doi":"https://doi.org/10.1101/2020.09.03.281733","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.09.03.281733","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/19/2020.09.03.281733.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G560750094","display_name":"Biomolecular Markers of Renal Allograft Status","funder_award_id":"K08DK087824","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7057546020","display_name":"Biomolecular Markers for Safe Minimization of Immunosuppression","funder_award_id":"R37AI051652","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7225957187","display_name":"Clinical and Translational Science Center","funder_award_id":"UL1TR000457","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000909024","display_name":"Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success","funder_award_id":"UL1TR001866","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320314083","display_name":"Mendez National Institute of Transplantation Foundation","ror":"https://ror.org/02ega5r05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332513","display_name":"Weill Cornell Medical College","ror":"https://ror.org/02r109517"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3163357366.pdf","grobid_xml":"https://content.openalex.org/works/W3163357366.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W109896574","https://openalex.org/W1723715242","https://openalex.org/W1955674559","https://openalex.org/W2032942532","https://openalex.org/W2051533103","https://openalex.org/W2059225878","https://openalex.org/W2085204161","https://openalex.org/W2104324467","https://openalex.org/W2106256269","https://openalex.org/W2109672057","https://openalex.org/W2116493322","https://openalex.org/W2119792393","https://openalex.org/W2120400691","https://openalex.org/W2124572189","https://openalex.org/W2133265721","https://openalex.org/W2140501857","https://openalex.org/W2141700579","https://openalex.org/W2150393481","https://openalex.org/W2161222128","https://openalex.org/W2257742640","https://openalex.org/W2329432593","https://openalex.org/W2411149830","https://openalex.org/W2470157805","https://openalex.org/W2552263672","https://openalex.org/W2572293469","https://openalex.org/W2586476886","https://openalex.org/W2589113597","https://openalex.org/W2613409207","https://openalex.org/W2756096397","https://openalex.org/W2759615793","https://openalex.org/W2763015765","https://openalex.org/W2774126255","https://openalex.org/W2778248285","https://openalex.org/W2783252067","https://openalex.org/W2784035183","https://openalex.org/W2791851267","https://openalex.org/W2792464793","https://openalex.org/W2814758512","https://openalex.org/W2898759023","https://openalex.org/W2920064913","https://openalex.org/W2924322433","https://openalex.org/W2930440495","https://openalex.org/W2942537534","https://openalex.org/W2944872709","https://openalex.org/W2947560654","https://openalex.org/W2949177718","https://openalex.org/W2949631571","https://openalex.org/W2950705185","https://openalex.org/W2951506174","https://openalex.org/W2953151710","https://openalex.org/W2958767428","https://openalex.org/W2967460951","https://openalex.org/W2975589949","https://openalex.org/W2979684492","https://openalex.org/W2982597870","https://openalex.org/W3005233576","https://openalex.org/W3023290106","https://openalex.org/W3032384683","https://openalex.org/W3042998165","https://openalex.org/W3091968197","https://openalex.org/W3092854319","https://openalex.org/W3104014715","https://openalex.org/W3111428798","https://openalex.org/W3126195938","https://openalex.org/W3164692211","https://openalex.org/W4211224216","https://openalex.org/W4251268122","https://openalex.org/W4384816663"],"related_works":["https://openalex.org/W3083059049","https://openalex.org/W3111428798","https://openalex.org/W4384929481","https://openalex.org/W7161127319","https://openalex.org/W4296385758","https://openalex.org/W4322625969","https://openalex.org/W2814758512","https://openalex.org/W2883444799","https://openalex.org/W4412850402","https://openalex.org/W7160504787"],"abstract_inverted_index":{"Abstract":[0],"We":[1,33,92,98],"tested":[2],"the":[3,27,54,108,136,206,218,222],"hypothesis":[4],"that":[5,123,186],"single-cell":[6,209],"RNA-sequencing":[7],"(scRNA-seq)":[8],"analysis":[9,198],"of":[10,30,37,88,107,135,181,224],"human":[11],"kidney":[12,38,61,70,84,137],"allograft":[13,69,83,138],"biopsies":[14,36],"will":[15],"reveal":[16],"distinct":[17],"cell":[18,103,201],"types":[19,202],"and":[20,22,45,76,80,115,142,146,203],"states":[21,204],"yield":[23],"insights":[24],"to":[25,193],"decipher":[26],"complex":[28],"heterogeneity":[29],"alloimmune":[31],"injury.":[32],"selected":[34],"3":[35,41],"cortex":[39],"from":[40,63],"individuals":[42],"for":[43,166,220],"scRNA-seq":[44],"processed":[46],"them":[47],"fresh":[48],"using":[49],"an":[50],"identical":[51],"protocol":[52],"on":[53],"10x":[55],"Chromium":[56],"platform;":[57],"(i)":[58],"HK:":[59],"native":[60],"biopsy":[62],"a":[64],"living":[65],"donor,":[66],"(ii)":[67],"AK1:":[68],"with":[71,126],"transplant":[72,225],"glomerulopathy,":[73],"tubulointerstitial":[74],"fibrosis,":[75,127,153],"worsening":[77],"graft":[78,147],"function,":[79],"(iii)":[81],"AK2:":[82],"after":[85,130,156,178],"successful":[86,179],"treatment":[87,180],"active":[89],"antibody-mediated":[90],"rejection.":[91],"did":[93],"not":[94],"study":[95],"T-cell-mediated":[96],"rejections.":[97],"generated":[99],"7217":[100],"high-quality":[101],"single":[102],"transcriptomes.":[104],"Taking":[105],"advantage":[106],"recipient-donor":[109],"sex":[110],"mismatches":[111],"revealed":[112,199],"by":[113],"X":[114],"Y":[116],"chromosome":[117],"autosomal":[118],"gene":[119],"expression,":[120],"we":[121],"determined":[122],"in":[124,150,205],"AK1":[125,163],"42":[128],"months":[129,155,177],"transplantation,":[131,157],"more":[132],"than":[133],"half":[134],"fibroblasts":[139,159],"were":[140,160],"recipient-derived":[141],"therefore":[143],"likely":[144],"migratory":[145],"infiltrative,":[148],"whereas":[149],"AK2":[151],"without":[152],"84":[154],"most":[158],"donor-organ-derived.":[161],"Furthermore,":[162],"was":[164],"enriched":[165],"tubular":[167],"progenitor":[168],"cells":[169,185],"overexpressing":[170],"profibrotic":[171],"extracellular":[172],"matrix":[173],"genes.":[174],"AK2,":[175],"eight":[176],"rejection,":[182],"contained":[183],"endothelial":[184],"expressed":[187],"T-cell":[188],"chemoattractant":[189],"cytokines.":[190],"In":[191],"addition":[192],"these":[194],"key":[195],"findings,":[196],"our":[197],"unique":[200],"kidney.":[207],"Altogether,":[208],"transcriptomics":[210],"yielded":[211],"novel":[212],"mechanistic":[213],"insights,":[214],"which":[215],"could":[216],"pave":[217],"way":[219],"individualizing":[221],"care":[223],"recipients.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-05-24T00:00:00"}
