{"id":"https://openalex.org/W3162998211","doi":"https://doi.org/10.1038/s41375-021-01287-1","title":"CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity","display_name":"CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity","publication_year":2021,"publication_date":"2021-05-21","ids":{"openalex":"https://openalex.org/W3162998211","doi":"https://doi.org/10.1038/s41375-021-01287-1","mag":"3162998211","pmid":"https://pubmed.ncbi.nlm.nih.gov/34021248","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8632678"},"language":"en","primary_location":{"id":"doi:10.1038/s41375-021-01287-1","doi":"https://doi.org/10.1038/s41375-021-01287-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-021-01287-1","pdf_url":"https://www.nature.com/articles/s41375-021-01287-1.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41375-021-01287-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088500363","display_name":"Andrej Stoll","orcid":"https://orcid.org/0000-0003-2179-878X","observed_orcids":["https://orcid.org/0000-0003-2179-878X"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Stoll","raw_affiliation_strings":["Department of Medicine 5 for Hematology and Oncology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2179-878X","affiliations":[{"raw_affiliation_string":"Department of Medicine 5 for Hematology and Oncology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059771243","display_name":"Heiko Bruns","orcid":"https://orcid.org/0000-0002-8463-6924","observed_orcids":["https://orcid.org/0000-0002-8463-6924"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Bruns","raw_affiliation_strings":["Department of Medicine 5 for Hematology and Oncology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine 5 for Hematology and Oncology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089679111","display_name":"Maximilian Fuchs","orcid":"https://orcid.org/0000-0002-8099-9541","observed_orcids":["https://orcid.org/0000-0002-8099-9541"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Fuchs","raw_affiliation_strings":["Chair of Medical Informatics, Friedrich-Alexander University (FAU) of Erlangen-N\u00fcrnberg, Erlangen, Germany","Functional Genomics and Systems Biology Group, Department of Bioinformatics, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Medical Informatics, Friedrich-Alexander University (FAU) of Erlangen-N\u00fcrnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Functional Genomics and Systems Biology Group, Department of Bioinformatics, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075333464","display_name":"Simon V\u00f6lkl","orcid":"https://orcid.org/0000-0003-2193-3048","observed_orcids":["https://orcid.org/0000-0003-2193-3048"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. V\u00f6lkl","raw_affiliation_strings":["Department of Medicine 5 for Hematology and Oncology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine 5 for Hematology and Oncology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086501578","display_name":"Falk Nimmerjahn","orcid":"https://orcid.org/0000-0002-5418-316X","observed_orcids":["https://orcid.org/0000-0002-5418-316X"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Nimmerjahn","raw_affiliation_strings":["Division of Genetics, Department of Biology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5418-316X","affiliations":[{"raw_affiliation_string":"Division of Genetics, Department of Biology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086909191","display_name":"Meik Kunz","orcid":"https://orcid.org/0000-0003-0385-2084","observed_orcids":["https://orcid.org/0000-0003-0385-2084"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Kunz","raw_affiliation_strings":["Chair of Medical Informatics, Friedrich-Alexander University (FAU) of Erlangen-N\u00fcrnberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Medical Informatics, Friedrich-Alexander University (FAU) of Erlangen-N\u00fcrnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012207265","display_name":"Matthias Peipp","orcid":"https://orcid.org/0000-0002-5088-3804","observed_orcids":["https://orcid.org/0000-0002-5088-3804"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Peipp","raw_affiliation_strings":["Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian-Albrechts-University Kiel, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian-Albrechts-University Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081818015","display_name":"Andr\u00e9as Mackensen","orcid":"https://orcid.org/0000-0002-0685-4483","observed_orcids":["https://orcid.org/0000-0002-0685-4483","https://orcid.org/0000-0003-2193-3048"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Mackensen","raw_affiliation_strings":["Department of Medicine 5 for Hematology and Oncology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany","Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Erlangen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0685-4483","affiliations":[{"raw_affiliation_string":"Department of Medicine 5 for Hematology and Oncology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Erlangen, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011903306","display_name":"Dimitrios Mougiakakos","orcid":"https://orcid.org/0000-0002-2817-6660","observed_orcids":["https://orcid.org/0000-0002-2817-6660","https://orcid.org/0000-0003-3412-1102"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"D. Mougiakakos","raw_affiliation_strings":["Department of Medicine 5 for Hematology and Oncology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany. dimitrios.mougiakakos@uk-erlangen.de","Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Erlangen, Germany. dimitrios.mougiakakos@uk-erlangen.de","Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Erlangen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2817-6660","affiliations":[{"raw_affiliation_string":"Department of Medicine 5 for Hematology and Oncology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany. dimitrios.mougiakakos@uk-erlangen.de","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Erlangen, Germany. dimitrios.mougiakakos@uk-erlangen.de","institution_ids":[]},{"raw_affiliation_string":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Erlangen, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011903306"],"corresponding_institution_ids":["https://openalex.org/I181369854"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":{"value":4480,"currency":"USD","value_usd":4480},"fwci":3.5506,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.94641953,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"35","issue":"12","first_page":"3482","last_page":"3496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.9940000176429749},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9229999780654907},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9959999918937683},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.7039999961853027},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/antibody-dependent-phagocytosis","display_name":"antibody-dependent phagocytosis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/phagocytic-capacity","display_name":"phagocytic capacity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/m1-macrophage-polarization","display_name":"M1 macrophage polarization","score":0.7300000190734863},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8740000128746033},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tumor-targeting-antibodies","display_name":"tumor-targeting antibodies","score":0.597000002861023},{"id":"https://openalex.org/keywords/agonistic-antibodies","display_name":"agonistic antibodies","score":0.5680000185966492},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2780249625","wikidata":"https://www.wikidata.org/wiki/Q14913226","display_name":"CD137","level":4,"score":0.9458063244819641},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5453627705574036},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5178495049476624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48409879207611084},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4570621848106384},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4486831724643707},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4460488259792328},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.440178781747818}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053261","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 9","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053261","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41375-021-01287-1","doi":"https://doi.org/10.1038/s41375-021-01287-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-021-01287-1","pdf_url":"https://www.nature.com/articles/s41375-021-01287-1.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8632678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8632678","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Text"},{"id":"pmid:34021248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34021248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},{"id":"pmh:oai:ub.uni-erlangen.de-opus:22371","doi":null,"is_oa":true,"landing_page_url":"https://opus4.kobv.de/opus4-fau/files/22371/s41375-021-01287-1.pdf","pdf_url":"https://opus4.kobv.de/opus4-fau/files/22371/s41375-021-01287-1.pdf","source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:frl.publisso.de:frl:6443822","doi":null,"is_oa":true,"landing_page_url":"https://repository.publisso.de/resource/frl:6443822","pdf_url":null,"source":{"id":"https://openalex.org/S4306402606","display_name":"Informationszentrum Lebenswissenschaften (ZB MED)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Leukemia, 35(12):3482-3496","raw_type":"Zeitschriftenartikel"}],"best_oa_location":{"id":"doi:10.1038/s41375-021-01287-1","doi":"https://doi.org/10.1038/s41375-021-01287-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-021-01287-1","pdf_url":"https://www.nature.com/articles/s41375-021-01287-1.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G101308371","display_name":null,"funder_award_id":"TRR221","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3162998211.pdf","grobid_xml":"https://content.openalex.org/works/W3162998211.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1548584275","https://openalex.org/W1557119871","https://openalex.org/W1560312836","https://openalex.org/W1902692042","https://openalex.org/W1922412259","https://openalex.org/W1967517831","https://openalex.org/W1970230889","https://openalex.org/W1975517407","https://openalex.org/W1985278235","https://openalex.org/W1998006783","https://openalex.org/W2003338662","https://openalex.org/W2043991982","https://openalex.org/W2058015212","https://openalex.org/W2076272449","https://openalex.org/W2092246736","https://openalex.org/W2092972513","https://openalex.org/W2097733789","https://openalex.org/W2113170011","https://openalex.org/W2134268411","https://openalex.org/W2138155731","https://openalex.org/W2139249889","https://openalex.org/W2140380746","https://openalex.org/W2153586956","https://openalex.org/W2155444336","https://openalex.org/W2155959680","https://openalex.org/W2159560463","https://openalex.org/W2190766406","https://openalex.org/W2201229208","https://openalex.org/W2206643120","https://openalex.org/W2271663961","https://openalex.org/W2301767920","https://openalex.org/W2417516531","https://openalex.org/W2468096222","https://openalex.org/W2481892372","https://openalex.org/W2519269392","https://openalex.org/W2522038806","https://openalex.org/W2537734913","https://openalex.org/W2562449006","https://openalex.org/W2567281524","https://openalex.org/W2587048937","https://openalex.org/W2594615455","https://openalex.org/W2615301036","https://openalex.org/W2711497375","https://openalex.org/W2792883957","https://openalex.org/W2887577080","https://openalex.org/W2911922390","https://openalex.org/W2912993773","https://openalex.org/W2938195179","https://openalex.org/W2939235761","https://openalex.org/W2968650703","https://openalex.org/W2986782963","https://openalex.org/W3012125081","https://openalex.org/W3014817487","https://openalex.org/W3080704705","https://openalex.org/W4253435468","https://openalex.org/W6688037776"],"related_works":["https://openalex.org/W7167907618","https://openalex.org/W2329133884","https://openalex.org/W2123280175","https://openalex.org/W2074031345","https://openalex.org/W7100494635","https://openalex.org/W2257044970","https://openalex.org/W2238959222","https://openalex.org/W3014731395","https://openalex.org/W2259284303","https://openalex.org/W7099530759"],"abstract_inverted_index":{"Abstract":[0],"Immunotherapies":[1],"have":[2,47,182],"heralded":[3],"a":[4,107,158,165,173],"new":[5],"era":[6],"in":[7,78,96,147,186],"the":[8,23,61,74],"cancer":[9],"treatment.":[10],"In":[11,154],"addition":[12],"to":[13,25,39,63],"checkpoint":[14,176],"inhibitors,":[15],"agonistic":[16],"antibodies":[17],"against":[18],"co-stimulatory":[19],"immune":[20,175],"receptors":[21],"hold":[22],"potential":[24],"invoke":[26],"efficient":[27],"antitumor":[28],"immunity.":[29],"Targeting":[30],"CD137":[31,77,83,103,140,171,193],"has":[32],"gained":[33],"momentum":[34],"based":[35],"on":[36,86,177],"its":[37],"ability":[38],"drive":[40],"NK-":[41],"and":[42,91,111,128,144,161],"T-cell-based":[43],"responses.":[44],"CD137-engaging":[45],"mAbs":[46],"already":[48],"entered":[49],"clinical":[50,68],"trials":[51],"for":[52],"different":[53],"types":[54],"of":[55,76,88,125,188],"tumors":[56],"showing":[57],"promising":[58],"results.":[59],"Despite":[60],"efforts":[62],"translate":[64],"CD137-mediated":[65],"immunotherapy":[66],"into":[67],"practice,":[69],"little":[70],"remains":[71],"known":[72],"regarding":[73],"role":[75],"human":[79,178],"monocytes/macrophages.":[80],"We":[81],"found":[82],"being":[84],"expressed":[85],"monocytes":[87,105],"healthy":[89],"controls":[90],"at":[92],"even":[93],"higher":[94],"levels":[95],"patients":[97],"with":[98,134,195],"multiple":[99,126],"myeloma":[100,127],"or":[101,136],"CLL.":[102],"HI(GH)":[104],"displayed":[106],"distinct":[108],"phenotypic,":[109,159],"transcriptomic,":[110,160],"metabolic":[112,143],"profile.":[113],"They":[114],"possessed":[115],"an":[116,148],"increased":[117],"phagocytic":[118],"capacity":[119],"enabling":[120],"superior":[121],"antibody-dependent":[122],"phagocytosis":[123],"(ADPC)":[124],"lymphoma":[129],"cells":[130],"that":[131],"were":[132],"treated":[133],"anti-CD38":[135],"anti-CD20":[137],"mAbs.":[138],"Triggering":[139],"promoted":[141],"both":[142],"tumoricidal":[145],"activity":[146],"extracellular":[149],"signal-regulated":[150],"kinase":[151],"(ERK)-dependent":[152],"fashion.":[153],"addition,":[155],"we":[156,169],"observed":[157],"functional":[162],"skewing":[163],"towards":[164],"M1-like":[166],"phenotype.":[167],"Overall,":[168],"introduce":[170],"as":[172],"positive":[174],"monocytes/macrophages,":[179],"which":[180],"can":[181],"therapeutic":[183],"implications":[184],"especially":[185],"view":[187],"synergistic":[189],"effects":[190],"when":[191],"combining":[192],"agonists":[194],"tumor-targeting":[196],"antibodies.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-05-24T00:00:00"}
