{"id":"https://openalex.org/W3162887900","doi":"https://doi.org/10.3390/vaccines9050484","title":"Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model","display_name":"Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model","publication_year":2021,"publication_date":"2021-05-10","ids":{"openalex":"https://openalex.org/W3162887900","doi":"https://doi.org/10.3390/vaccines9050484","mag":"3162887900","pmid":"https://pubmed.ncbi.nlm.nih.gov/34068677","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8151995"},"language":"en","primary_location":{"id":"doi:10.3390/vaccines9050484","doi":"https://doi.org/10.3390/vaccines9050484","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines9050484","pdf_url":"https://www.mdpi.com/2076-393X/9/5/484/pdf?version=1620716436","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-393X/9/5/484/pdf?version=1620716436","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079316878","display_name":"R\u00e9mi Vernet","orcid":"https://orcid.org/0000-0003-0213-3539","observed_orcids":["https://orcid.org/0000-0003-0213-3539"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"R\u00e9mi Vernet","raw_affiliation_strings":["Center for Translational Research in Onco-Hematology, Division of Oncology, Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland","Department of Oncology, Geneva University Hospitals and Medical School, 1211 Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0213-3539","affiliations":[{"raw_affiliation_string":"Center for Translational Research in Onco-Hematology, Division of Oncology, Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]},{"raw_affiliation_string":"Department of Oncology, Geneva University Hospitals and Medical School, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022577936","display_name":"Emily Charrier","orcid":"https://orcid.org/0000-0001-6143-509X","observed_orcids":["https://orcid.org/0000-0001-6143-509X"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Emily Charrier","raw_affiliation_strings":["Center for Translational Research in Onco-Hematology, Division of Oncology, Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland","Department of Oncology, Geneva University Hospitals and Medical School, 1211 Geneva, Switzerland","MaxiVAX SA, 1202 Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6143-509X","affiliations":[{"raw_affiliation_string":"Center for Translational Research in Onco-Hematology, Division of Oncology, Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]},{"raw_affiliation_string":"Department of Oncology, Geneva University Hospitals and Medical School, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]},{"raw_affiliation_string":"MaxiVAX SA, 1202 Geneva, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023172789","display_name":"Erika C. Cosset","orcid":"https://orcid.org/0000-0001-5481-6556","observed_orcids":["https://orcid.org/0000-0001-5481-6556"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Erika Cosset","raw_affiliation_strings":["Center for Translational Research in Onco-Hematology, Division of Oncology, Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research in Onco-Hematology, Division of Oncology, Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080340437","display_name":"Sabine Fi\u00e8vre","orcid":"https://orcid.org/0000-0001-6690-2283","observed_orcids":["https://orcid.org/0000-0001-6690-2283","https://orcid.org/0000-0002-9669-8671"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sabine Fi\u00e8vre","raw_affiliation_strings":["Department of Basic Neurosciences, University of Geneva, 1211 Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Neurosciences, University of Geneva, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082705018","display_name":"Ugo Tomasello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ugo Tomasello","raw_affiliation_strings":["Department of Basic Neurosciences, University of Geneva, 1211 Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Neurosciences, University of Geneva, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050485398","display_name":"Julien Grogg","orcid":"https://orcid.org/0000-0002-9479-0933","observed_orcids":["https://orcid.org/0000-0002-9479-0933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julien Grogg","raw_affiliation_strings":["MaxiVAX SA, 1202 Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MaxiVAX SA, 1202 Geneva, Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020235177","display_name":"Nicolas Mach","orcid":"https://orcid.org/0000-0001-8944-1088","observed_orcids":["https://orcid.org/0000-0001-8944-1088"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nicolas Mach","raw_affiliation_strings":["Center for Translational Research in Onco-Hematology, Division of Oncology, Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland","Department of Oncology, Geneva University Hospitals and Medical School, 1211 Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research in Onco-Hematology, Division of Oncology, Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]},{"raw_affiliation_string":"Department of Oncology, Geneva University Hospitals and Medical School, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079316878"],"corresponding_institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":0.4242,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.63344977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"9","issue":"5","first_page":"484","last_page":"484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9739999771118164},{"id":"https://openalex.org/keywords/spike-protein","display_name":"spike protein","score":0.9179999828338623},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.6700000166893005},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.921999990940094},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.843999981880188},{"id":"https://openalex.org/keywords/encapsulated-cells","display_name":"encapsulated cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.6470000147819519},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.996999979019165},{"id":"https://openalex.org/keywords/electroporation","display_name":"electroporation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7378873825073242},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6443948745727539},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.5895603895187378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5753836631774902},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5481569766998291},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5404772162437439},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.44661328196525574},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.43906891345977783},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.3791830539703369},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3390/vaccines9050484","doi":"https://doi.org/10.3390/vaccines9050484","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines9050484","pdf_url":"https://www.mdpi.com/2076-393X/9/5/484/pdf?version=1620716436","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},{"id":"pmid:34068677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34068677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8151995","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8151995/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines (Basel)","raw_type":"Text"},{"id":"pmh:oai:unige.ch:aou:unige:154119","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:154119","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines, vol. 9, no. 5 (2021) 484","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-04132241v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.sorbonne-universite.fr/hal-04132241","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines, 2021, 9 (5), pp.484. ⟨10.3390/vaccines9050484⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:058d3357e2aa4037858a44b741b9a240","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/058d3357e2aa4037858a44b741b9a240","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines, Vol 9, Iss 5, p 484 (2021)","raw_type":"article"},{"id":"pmh:oai:unige.ch:unige:154119","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:154119","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2076-393X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/vaccines9050484","doi":"https://doi.org/10.3390/vaccines9050484","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines9050484","pdf_url":"https://www.mdpi.com/2076-393X/9/5/484/pdf?version=1620716436","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3162887900.pdf","grobid_xml":"https://content.openalex.org/works/W3162887900.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W261295809","https://openalex.org/W1537962162","https://openalex.org/W1601707568","https://openalex.org/W1696096472","https://openalex.org/W1972591948","https://openalex.org/W1973149934","https://openalex.org/W1983894061","https://openalex.org/W2016101110","https://openalex.org/W2016685455","https://openalex.org/W2048685286","https://openalex.org/W2056644015","https://openalex.org/W2061829061","https://openalex.org/W2065818546","https://openalex.org/W2077133851","https://openalex.org/W2086265013","https://openalex.org/W2095135796","https://openalex.org/W2132042285","https://openalex.org/W2134898067","https://openalex.org/W2141792732","https://openalex.org/W2150847030","https://openalex.org/W2151666328","https://openalex.org/W2187841312","https://openalex.org/W2265325600","https://openalex.org/W2322706669","https://openalex.org/W2588129534","https://openalex.org/W2729744835","https://openalex.org/W2792649187","https://openalex.org/W2798026095","https://openalex.org/W2883067302","https://openalex.org/W2926474772","https://openalex.org/W2952109056","https://openalex.org/W3004280078","https://openalex.org/W3013525829","https://openalex.org/W3013855790","https://openalex.org/W3021880084","https://openalex.org/W3025577451","https://openalex.org/W3038307487","https://openalex.org/W3081073771","https://openalex.org/W3110188921","https://openalex.org/W6753164909"],"related_works":["https://openalex.org/W4392554771","https://openalex.org/W4319433807","https://openalex.org/W2320142843","https://openalex.org/W2172877814","https://openalex.org/W4412741157","https://openalex.org/W2048184935","https://openalex.org/W4404821906","https://openalex.org/W4380078060","https://openalex.org/W7128008618","https://openalex.org/W2392820072"],"abstract_inverted_index":{"Severe":[0],"acute":[1],"respiratory":[2],"syndrome":[3],"coronavirus":[4],"2":[5],"(SARS-CoV-2)":[6],"has":[7,32,77],"caused":[8],"a":[9,16,22,79,91,107,125,170],"worldwide":[10],"pandemic":[11],"with":[12,150,174],"recurrences.":[13],"Therefore,":[14],"finding":[15],"vaccine":[17,173],"for":[18,24,38,111,128,135],"this":[19,52,97,116],"virus":[20],"became":[21],"priority":[23],"the":[25,36,60,65,157,193,199],"scientific":[26],"community.":[27],"The":[28],"SARS-CoV-2":[29,48,129],"spike":[30,61,154,171],"protein":[31,62],"been":[33],"described":[34],"as":[35],"keystone":[37],"viral":[39],"entry":[40],"into":[41],"cells":[42],"and":[43,63,93,131,183,203],"effective":[44],"immune":[45,185],"protection":[46],"against":[47,85,187],"is":[49],"elicited":[50],"by":[51],"protein.":[53],"Consequently,":[54],"many":[55,86],"commercialized":[56],"vaccines":[57],"focus":[58],"on":[59],"require":[64],"use":[66],"of":[67,82,106,113,146,161,180,195,201],"an":[68,101],"optimal":[69],"adjuvant":[70,127],"during":[71],"vaccination.":[72],"Granulocyte-macrophage":[73],"colony-stimulating":[74],"factor":[75],"(GM-CSF)":[76],"demonstrated":[78,167],"powerful":[80],"enhancement":[81,179],"acquired":[83],"immunity":[84],"pathogens":[87],"when":[88],"delivered":[89],"in":[90,156,178],"sustained":[92],"local":[94],"manner.":[95],"In":[96,115],"context,":[98],"we":[99,118],"developed":[100],"encapsulated":[102],"cell-based":[103],"technology":[104],"consisting":[105],"biocompatible,":[108],"semipermeable":[109],"capsule":[110],"secretion":[112],"GM-CSF.":[114],"study,":[117],"investigated":[119],"whether":[120],"murine":[121],"GM-CSF":[122],"(muGM-CSF)":[123],"represents":[124],"suitable":[126],"immunization,":[130],"which":[132],"delivery":[133,196],"strategy":[134],"muGM-CSF":[136,176],"could":[137],"be":[138],"most":[139],"beneficial.":[140],"To":[141],"test":[142],"this,":[143],"different":[144],"groups":[145],"mice":[147],"were":[148],"immunized":[149],"intra-dermal":[151],"(i.d.)":[152],"electroporated":[153],"DNA":[155,172],"absence":[158],"or":[159,163],"presence":[160],"recombinant":[162],"secreted":[164,175],"muGM-CSF.":[165],"Results":[166],"that":[168],"adjuvanting":[169],"resulted":[177],"specific":[181],"cellular":[182,202],"humoral":[184],"responses":[186],"SARS-CoV-2.":[188],"Our":[189],"data":[190],"also":[191],"highlighted":[192],"importance":[194],"strategies":[197],"to":[198],"induction":[200],"humoral-mediated":[204],"responses.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-05-24T00:00:00"}