{"id":"https://openalex.org/W3161693752","doi":"https://doi.org/10.21203/rs.3.rs-62365/v1","title":"MYCN Fish combined with immunohistochemistry is a more prognostic factor for neuroblastoma","display_name":"MYCN Fish combined with immunohistochemistry is a more prognostic factor for neuroblastoma","publication_year":2020,"publication_date":"2020-08-28","ids":{"openalex":"https://openalex.org/W3161693752","doi":"https://doi.org/10.21203/rs.3.rs-62365/v1","mag":"3161693752"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-62365/v1","doi":"https://doi.org/10.21203/rs.3.rs-62365/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-62365/v1","pdf_url":"https://www.researchsquare.com/article/rs-62365/v1.pdf?c=1598663554000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-62365/v1.pdf?c=1598663554000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100393482","display_name":"Yi Yang","orcid":"https://orcid.org/0000-0001-9044-0277","observed_orcids":["https://orcid.org/0000-0001-9044-0277"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Yang","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066253463","display_name":"Jie Zhao","orcid":"https://orcid.org/0000-0002-3209-3534","observed_orcids":["https://orcid.org/0000-0002-3209-3534"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhao","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101927805","display_name":"Yingwen Zhang","orcid":"https://orcid.org/0000-0001-5668-2723","observed_orcids":["https://orcid.org/0000-0001-5668-2723"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingwen Zhang","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053452379","display_name":"Bo Yv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Yv","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378656","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0003-1580-1356","observed_orcids":["https://orcid.org/0000-0003-1580-1356","https://orcid.org/0009-0009-7012-5216","https://orcid.org/0000-0002-1980-539X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039882986","display_name":"Haizhong Feng","orcid":"https://orcid.org/0000-0003-3552-6865","observed_orcids":["https://orcid.org/0000-0003-3552-6865"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haizhong Feng","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046542691","display_name":"Yijin Gao","orcid":"https://orcid.org/0000-0002-7592-4115","observed_orcids":["https://orcid.org/0000-0002-7592-4115"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yijin Gao","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102245637","display_name":"Minzhi Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minzhi Yin","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110918787","display_name":"Jingyan Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyan Tang","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100611945","display_name":"Yanxin Li","orcid":"https://orcid.org/0000-0003-1055-5029","observed_orcids":["https://orcid.org/0000-0003-1055-5029","https://orcid.org/0009-0005-9327-782X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanxin Li","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mycn-amplification","display_name":"MYCN amplification","score":0.6639999747276306},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"fluorescence in situ hybridization","score":0.8769999742507935},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.8920000195503235},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/antibody-validation","display_name":"antibody validation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5260000228881836},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.9414036273956299},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.760124683380127},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.7324806451797485},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.5359588265419006},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5317847728729248},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5212690830230713},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4921504855155945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4826546311378479},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4680953323841095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42461445927619934},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4192752242088318},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39366135001182556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1517985463142395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1262229084968567},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.10713464021682739},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.09444049000740051},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-62365/v1","doi":"https://doi.org/10.21203/rs.3.rs-62365/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-62365/v1","pdf_url":"https://www.researchsquare.com/article/rs-62365/v1.pdf?c=1598663554000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-62365/v1","doi":"https://doi.org/10.21203/rs.3.rs-62365/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-62365/v1","pdf_url":"https://www.researchsquare.com/article/rs-62365/v1.pdf?c=1598663554000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2017004945","display_name":null,"funder_award_id":"No. 81972341","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4159824788","display_name":null,"funder_award_id":"81,972,341","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4581275746","display_name":null,"funder_award_id":"PKJ2018-Y47","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G549295334","display_name":null,"funder_award_id":"YG2017MS32","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"},{"id":"https://openalex.org/G7595718255","display_name":null,"funder_award_id":"2018YFC1313000","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G795987962","display_name":null,"funder_award_id":"81772663","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8104817941","display_name":null,"funder_award_id":"2018YFC1313005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3161693752.pdf","grobid_xml":"https://content.openalex.org/works/W3161693752.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1753717414","https://openalex.org/W1979914953","https://openalex.org/W1987909964","https://openalex.org/W2000448141","https://openalex.org/W2012044781","https://openalex.org/W2029126296","https://openalex.org/W2044033792","https://openalex.org/W2056645079","https://openalex.org/W2067606868","https://openalex.org/W2095296988","https://openalex.org/W2096998441","https://openalex.org/W2097120541","https://openalex.org/W2103932306","https://openalex.org/W2126560854","https://openalex.org/W2136078203","https://openalex.org/W2147575945","https://openalex.org/W2371341694","https://openalex.org/W2415715325","https://openalex.org/W2462285332","https://openalex.org/W2778951961","https://openalex.org/W2900463817","https://openalex.org/W2920124895","https://openalex.org/W2966119387","https://openalex.org/W2968733595","https://openalex.org/W2975852890","https://openalex.org/W2989558326","https://openalex.org/W2998168034","https://openalex.org/W3010068847","https://openalex.org/W4211031423"],"related_works":["https://openalex.org/W4285095117","https://openalex.org/W2966119387","https://openalex.org/W4320495076","https://openalex.org/W2305550469","https://openalex.org/W2126560854","https://openalex.org/W6901908296","https://openalex.org/W7221444314","https://openalex.org/W1981757527","https://openalex.org/W2989558326","https://openalex.org/W1753717414"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"MYCN":[2,26,33,56,86,150,157,174],"is":[3,58,189],"an":[4],"identified":[5],"driver":[6],"and":[7,12,29,69,139,193,203],"important":[8],"prognosticator":[9],"of":[10,48,63,161,168],"neuroblastoma":[11,49,96],"performs":[13,198],"biological":[14],"function":[15],"at":[16,71],"protein":[17,34,158,177],"level.":[18],"At":[19],"present,":[20],"most":[21],"detection":[22],"methodologies":[23],"focus":[24],"on":[25,90],"DNA":[27,87],"level":[28,73,88],"fail":[30],"to":[31,84,143,148],"detect":[32],"expression":[35,51,57,178],"for":[36],"poor":[37,145,164],"antibody,":[38],"especially":[39,65],"in":[40,66,74,191,200],"China.Results\uff1aIn":[41],"the":[42,46,169],"present":[43],"study,":[44],"through":[45],"analysis":[47,99],"gene":[50,175],"profile":[52],"data,":[53],"we":[54,121],"found":[55,122],"closely":[59],"related":[60],"with":[61,112,118,124,137,172,196],"prognosis":[62,202],"neuroblastoma,":[64],"stage":[67],"I-III":[68],"IVs":[70],"RNA":[72],"current":[75],"medical":[76],"conditions.":[77],"FISH":[78,197],"was":[79],"almost":[80],"accurate":[81],"as":[82],"WES":[83],"test":[85],"based":[89],"our":[91],"hospital":[92],"data.":[93],"In":[94],"56":[95],"cases,":[97],"IHC":[98,127,140,194],"by":[100],"a":[101,109],"newfound":[102,187],"antibody":[103,188],"(#84406s,":[104],"Cell":[105],"Signaling":[106],"Technology)":[107],"demonstrated":[108],"75%-85%":[110],"concordance":[111],"FISH.":[113],"Further":[114],"analyzing":[115],"those":[116,149],"cases":[117],"inconsistent":[119],"results,":[120],"patients":[123,136,171],"FISH+":[125,138],"but":[126],"score<9":[128],"all":[129,160],"had":[130,179],"no":[131],"adverse":[132],"events,":[133],"while":[134,166],"63.6%":[135],"score\u22659":[141],"tended":[142],"have":[144],"outcome.":[146],"As":[147],"FISH-":[151],"patients,":[152],"once":[153],"their":[154],"tumor":[155],"showed":[156],"expression,":[159],"them":[162],"were":[163],"prognosis,":[165],"81%":[167],"rest":[170],"neither":[173],"nor":[176],"ideal":[180],"prognosis.Conclusions:":[181],"The":[182],"results":[183],"suggest":[184],"that":[185],"this":[186],"reliable":[190],"IHC,":[192],"combined":[195],"better":[199],"evaluating":[201],"guiding":[204],"treatment.":[205]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-05-24T00:00:00"}