{"id":"https://openalex.org/W3161641908","doi":"https://doi.org/10.1007/s10238-021-00719-7","title":"Single nucleotide polymorphisms of TRAF2 and TRAF5 gene in ankylosing spondylitis: a case\u2013control study","display_name":"Single nucleotide polymorphisms of TRAF2 and TRAF5 gene in ankylosing spondylitis: a case\u2013control study","publication_year":2021,"publication_date":"2021-05-17","ids":{"openalex":"https://openalex.org/W3161641908","doi":"https://doi.org/10.1007/s10238-021-00719-7","mag":"3161641908","pmid":"https://pubmed.ncbi.nlm.nih.gov/33997937"},"language":"en","primary_location":{"id":"doi:10.1007/s10238-021-00719-7","doi":"https://doi.org/10.1007/s10238-021-00719-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10238-021-00719-7","pdf_url":null,"source":{"id":"https://openalex.org/S1255940","display_name":"Clinical and Experimental Medicine","issn_l":"1591-8890","issn":["1591-8890","1591-9528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-280696/v1.pdf?c=1631893191000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101515785","display_name":"Shanshan Xu","orcid":"https://orcid.org/0000-0002-8236-7687","observed_orcids":["https://orcid.org/0000-0002-8236-7687"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Xu","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China","Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China","institution_ids":["https://openalex.org/I4210136596"]},{"raw_affiliation_string":"Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008952011","display_name":"Jiangping Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangping Kong","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100744864","display_name":"Huang Li","orcid":"https://orcid.org/0000-0003-4154-818X","observed_orcids":["https://orcid.org/0000-0003-4154-818X"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Huang","raw_affiliation_strings":["Anhui Medical College, 387 Wuhu Road, Hefei, 230032, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anhui Medical College, 387 Wuhu Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huimin Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Xie","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060390994","display_name":"Feier Wang","orcid":"https://orcid.org/0000-0003-0411-3494","observed_orcids":["https://orcid.org/0000-0003-0411-3494"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feier Wang","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031470939","display_name":"Tingting Zhou","orcid":"https://orcid.org/0000-0001-8084-178X","observed_orcids":["https://orcid.org/0000-0001-8084-178X"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Zhou","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357468","display_name":"Xiaoyi Zhang","orcid":"https://orcid.org/0000-0002-4988-819X","observed_orcids":["https://orcid.org/0000-0002-4988-819X"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyi Zhang","raw_affiliation_strings":["Department of Toxicology, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107934720","display_name":"Lingxiang Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingxiang Yu","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002437368","display_name":"Shengqian Xu","orcid":"https://orcid.org/0000-0002-9559-1143","observed_orcids":["https://orcid.org/0000-0002-9559-1143","https://orcid.org/0009-0008-5338-6409","https://orcid.org/0000-0001-8274-4502"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengqian Xu","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China","Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China","institution_ids":["https://openalex.org/I4210136596"]},{"raw_affiliation_string":"Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080689817","display_name":"Faming Pan","orcid":"https://orcid.org/0000-0003-4242-1025","observed_orcids":["https://orcid.org/0000-0003-4242-1025"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Faming Pan","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China. famingpan@ahmu.edu.cn","Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China. famingpan@ahmu.edu.cn","Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China"],"raw_orcid":"https://orcid.org/0000-0003-4242-1025","affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China. famingpan@ahmu.edu.cn","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China. famingpan@ahmu.edu.cn","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China","institution_ids":["https://openalex.org/I197869895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080689817"],"corresponding_institution_ids":["https://openalex.org/I197869895"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":0.7523,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68271694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"21","issue":"4","first_page":"645","last_page":"653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/traf2","display_name":"TRAF2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/traf5","display_name":"TRAF5","score":1.0},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9539999961853027},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9729999899864197},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.8809999823570251},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.6179999709129333},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.9039999842643738},{"id":"https://openalex.org/keywords/han-chinese","display_name":"Han Chinese","score":0.953000009059906}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8386726379394531},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5810331106185913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4544218182563782},{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.4300578236579895},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.42824459075927734},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4118293523788452},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3593195676803589},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3541472554206848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25101804733276367},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24566635489463806},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21148374676704407},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000089943","descriptor_name":"Sleep Quality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047992","descriptor_name":"TNF Receptor-Associated Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048015","descriptor_name":"TNF Receptor-Associated Factor 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10238-021-00719-7","doi":"https://doi.org/10.1007/s10238-021-00719-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10238-021-00719-7","pdf_url":null,"source":{"id":"https://openalex.org/S1255940","display_name":"Clinical and Experimental Medicine","issn_l":"1591-8890","issn":["1591-8890","1591-9528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Medicine","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-280696/v1","doi":"https://doi.org/10.21203/rs.3.rs-280696/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-280696/v1","pdf_url":"https://www.researchsquare.com/article/rs-280696/v1.pdf?c=1631893191000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:33997937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33997937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-280696/v1","doi":"https://doi.org/10.21203/rs.3.rs-280696/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-280696/v1","pdf_url":"https://www.researchsquare.com/article/rs-280696/v1.pdf?c=1631893191000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/15","display_name":"Life on land"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4285689056","display_name":null,"funder_award_id":"81,773,514","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4715700226","display_name":null,"funder_award_id":"82073655","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321603","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3161641908.pdf","grobid_xml":"https://content.openalex.org/works/W3161641908.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W202992177","https://openalex.org/W305361774","https://openalex.org/W1970219051","https://openalex.org/W1972296048","https://openalex.org/W1974768393","https://openalex.org/W1979595147","https://openalex.org/W1979652500","https://openalex.org/W2000458455","https://openalex.org/W2013012256","https://openalex.org/W2021794089","https://openalex.org/W2035544628","https://openalex.org/W2062092608","https://openalex.org/W2066224786","https://openalex.org/W2073357083","https://openalex.org/W2074286654","https://openalex.org/W2076232042","https://openalex.org/W2077088403","https://openalex.org/W2077200279","https://openalex.org/W2084061096","https://openalex.org/W2085759466","https://openalex.org/W2094863064","https://openalex.org/W2106132948","https://openalex.org/W2108695164","https://openalex.org/W2118706017","https://openalex.org/W2129668511","https://openalex.org/W2135199713","https://openalex.org/W2150795294","https://openalex.org/W2154572047","https://openalex.org/W2166560806","https://openalex.org/W2167259834","https://openalex.org/W2167418901","https://openalex.org/W2178194641","https://openalex.org/W2341966417","https://openalex.org/W2411700781","https://openalex.org/W2411807202","https://openalex.org/W2734764199","https://openalex.org/W2803639636","https://openalex.org/W2896648763","https://openalex.org/W2899780053","https://openalex.org/W2916776038","https://openalex.org/W2950148918","https://openalex.org/W2980788157","https://openalex.org/W3087326479"],"related_works":["https://openalex.org/W4407306716","https://openalex.org/W3160370487","https://openalex.org/W2014457867","https://openalex.org/W117601389","https://openalex.org/W2889737720","https://openalex.org/W1502744223","https://openalex.org/W3029994548","https://openalex.org/W2150842929","https://openalex.org/W2131847930","https://openalex.org/W2563967283"],"abstract_inverted_index":{"Abstract":[0],"ObjectiveTo":[1],"investigate":[2],"the":[3,25,72,136,167,174],"role":[4],"of":[5,9,47,62,74,82,95,100,106,124,138,171,176],"eight":[6],"locus":[7],"polymorphisms":[8,37],"tumor":[10],"necrosis":[11],"factor":[12,15],"receptor":[13],"associated":[14,165,183],"2":[16],"(TRAF2)":[17],"and":[18,21,49,58,64,90,97,116,126,158,169,178],"TRAF5":[19,50,65,117,179],"gene":[20,51],"their":[22],"interaction":[23,175],"in":[24,31,54,76,86],"susceptibility":[26,73,168],"to":[27,147],"ankylosing":[28],"spondylitis":[29],"(AS)":[30],"Chinese":[32,77],"Han":[33,78],"population.MethodsEight":[34],"single":[35],"nucleotide":[36],"(SNPs)":[38],"(rs3750511,":[39],"rs10781522,":[40],"rs17250673,":[41],"rs59471504,":[42],"rs6540679,":[43],"rs12569232,":[44],"rs4951523,":[45],"rs7514863)":[46],"TRAF2":[48,63,113,177],"were":[52],"genotyped":[53],"673":[55],"AS":[56,75,159,185],"patients":[57,89],"687":[59],"controls.ResultsThe":[60],"SNPs":[61],"does":[66],"not":[67],"indicate":[68],"a":[69,120,127],"correlation":[70],"with":[71,166,184],"population.":[79],"Genotype":[80],"frequencies":[81,94,99],"rs3750511were":[83,101],"statistically":[84,102],"significant":[85,103,134],"females":[87],"between":[88,104,155],"controls.":[91],"The":[92],"genotype":[93],"rs12569232":[96],"allele":[98],"groups":[105],"different":[107],"diseases":[108],"activity.":[109],"One":[110],"three-locus":[111],"model,":[112],"(rs10781522,":[114],"rs17250673)":[115],"(rs12569232),":[118],"had":[119],"maximum":[121,128],"testing":[122],"accuracy":[123],"52.67%":[125],"cross-validation":[129],"consistency":[130],"(10/10)":[131],"that":[132],"was":[133,153],"at":[135],"level":[137],"P=0.0001,":[139],"after":[140],"determined":[141],"empirically":[142],"by":[143],"permutation":[144],"testing.":[145],"As":[146],"environmental":[148],"variables,":[149],"only":[150],"marginal":[151],"association":[152],"found":[154],"sleep":[156],"quality":[157],"susceptibility.ConclusionTRAF2":[160],"rs3750511":[161],"polymorphism":[162],"may":[163,181],"be":[164,182],"severity":[170],"AS.":[172],"Besides,":[173],"genes":[180],"susceptibility,":[186],"but":[187],"many":[188],"open":[189],"questions":[190],"remain.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-05-24T00:00:00"}
