{"id":"https://openalex.org/W3161523909","doi":"https://doi.org/10.1158/1078-0432.ccr-21-1238","title":"Putting the Microenvironment into the Immunotherapy Companion Diagnostic","display_name":"Putting the Microenvironment into the Immunotherapy Companion Diagnostic","publication_year":2021,"publication_date":"2021-05-13","ids":{"openalex":"https://openalex.org/W3161523909","doi":"https://doi.org/10.1158/1078-0432.ccr-21-1238","mag":"3161523909","pmid":"https://pubmed.ncbi.nlm.nih.gov/33986024"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-21-1238","doi":"https://doi.org/10.1158/1078-0432.ccr-21-1238","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-21-1238","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085694950","display_name":"Myrto K. Moutafi","orcid":"https://orcid.org/0000-0002-9314-3187","observed_orcids":["https://orcid.org/0000-0002-9314-3187"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myrto Moutafi","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":"https://orcid.org/0000-0002-9314-3187","affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027326018","display_name":"David L. Rimm","orcid":"https://orcid.org/0000-0001-5820-4397","observed_orcids":["https://orcid.org/0000-0001-5820-4397"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David L. Rimm","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":"https://orcid.org/0000-0001-5820-4397","affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027326018"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.364,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.58905473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"27","issue":"14","first_page":"3812","last_page":"3814"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7599999904632568},{"id":"https://openalex.org/keywords/advanced-gastric-cancer","display_name":"advanced gastric cancer","score":0.8640000224113464},{"id":"https://openalex.org/keywords/combined-positive-score","display_name":"combined positive score","score":0.9800000190734863},{"id":"https://openalex.org/keywords/immune-cells","display_name":"immune cells","score":0.6190000176429749},{"id":"https://openalex.org/keywords/immunotherapy-response-prediction","display_name":"immunotherapy response prediction","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7760955095291138},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7695560455322266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5820837020874023},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5715968012809753},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5637776255607605},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5458720922470093},{"id":"https://openalex.org/C2992886853","wikidata":"https://www.wikidata.org/wiki/Q18381816","display_name":"Post hoc","level":2,"score":0.4130803346633911},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37787356972694397},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.357366681098938},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3471706509590149},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29540514945983887}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-21-1238","doi":"https://doi.org/10.1158/1078-0432.ccr-21-1238","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-21-1238","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:33986024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33986024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2594102731","https://openalex.org/W2655262992","https://openalex.org/W2804957255","https://openalex.org/W2900738779","https://openalex.org/W2961686530","https://openalex.org/W2970228237","https://openalex.org/W3017266548","https://openalex.org/W3149557634"],"related_works":["https://openalex.org/W4401729464","https://openalex.org/W4385251492","https://openalex.org/W3166071018","https://openalex.org/W2085125246","https://openalex.org/W4382628875","https://openalex.org/W4413951985","https://openalex.org/W2970228237","https://openalex.org/W2972336153","https://openalex.org/W2736774863","https://openalex.org/W3021168337"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"post":[2],"hoc":[3],"analysis":[4],"in":[5,36,39],"advanced":[6],"gastric":[7],"cancer":[8],"showed":[9],"stronger":[10],"association":[11],"of":[12,46],"programmed":[13],"cell":[14],"death-ligand":[15],"1":[16],"(PD-L1)":[17],"with":[18,28],"immunotherapy":[19],"efficacy":[20],"measured":[21],"by":[22,54],"combined":[23],"positive":[24],"score":[25],"(CPS)":[26],"compared":[27],"tumor":[29,41],"cells":[30,38],"(TC%).":[31],"This":[32],"finding":[33],"suggests":[34],"expression":[35],"immune":[37],"the":[40,44,47],"microenvironment":[42],"increases":[43],"value":[45],"companion":[48],"diagnostic":[49],"test.":[50],"See":[51],"related":[52],"article":[53],"Lei":[55],"et":[56],"al.,":[57],"p.":[58],"3926":[59]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-05-24T00:00:00"}
