{"id":"https://openalex.org/W3161473741","doi":null,"title":"Quantification of a panel for dry-eye protein biomarkers in tears: A comparative pilot study using standard ELISA and customized microarrays.","display_name":"Quantification of a panel for dry-eye protein biomarkers in tears: A comparative pilot study using standard ELISA and customized microarrays.","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3161473741","mag":"3161473741","pmid":"https://pubmed.ncbi.nlm.nih.gov/34012227","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8116255"},"language":"en","primary_location":{"id":"pmid:34012227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34012227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8116255/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108134498","display_name":"Jose Benitez-del-Castillo","orcid":"https://orcid.org/0000-0002-2010-1701","observed_orcids":["https://orcid.org/0000-0002-2010-1701"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Manuel Benitez-Del-Castillo","raw_affiliation_strings":["Instituto de Investigaciones Oftalmol\u00f3gicas Ram\u00f3n Castroviejo, Facultad de Medicina. Universidad Complutense de Madrid, Madrid, Spain","Ophthalmology Department, Hospital Cl\u00ednico San Carlos, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Oftalmol\u00f3gicas Ram\u00f3n Castroviejo, Facultad de Medicina. Universidad Complutense de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Ophthalmology Department, Hospital Cl\u00ednico San Carlos, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017706342","display_name":"Javier Mill\u00e1n Soria","orcid":"https://orcid.org/0000-0002-2758-7783","observed_orcids":["https://orcid.org/0000-0002-2758-7783"]},"institutions":[{"id":"https://openalex.org/I4210091170","display_name":"Euskadiko Parke Teknologikoa","ror":"https://ror.org/00caq9197","country_code":"ES","type":"archive","lineage":["https://openalex.org/I4210091170"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Soria","raw_affiliation_strings":["Bioftalmik Applied Research. Bizkaia Science and Technology Park, Bizkaia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioftalmik Applied Research. Bizkaia Science and Technology Park, Bizkaia, Spain","institution_ids":["https://openalex.org/I4210091170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016541873","display_name":"Arantxa Acera","orcid":"https://orcid.org/0000-0002-6942-6144","observed_orcids":["https://orcid.org/0000-0002-6942-6144"]},"institutions":[{"id":"https://openalex.org/I4210091170","display_name":"Euskadiko Parke Teknologikoa","ror":"https://ror.org/00caq9197","country_code":"ES","type":"archive","lineage":["https://openalex.org/I4210091170"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Arantxa Acera","raw_affiliation_strings":["Bioftalmik Applied Research. Bizkaia Science and Technology Park, Bizkaia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioftalmik Applied Research. Bizkaia Science and Technology Park, Bizkaia, Spain","institution_ids":["https://openalex.org/I4210091170"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ana Mar\u00eda Mu\u00f1oz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Mar\u00eda Mu\u00f1oz","raw_affiliation_strings":["Ophthalmology Department, Hospital Cl\u00ednico San Carlos, Madrid, Spain","Ophthalmology Department, Hospital Clinico San Carlos, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Hospital Cl\u00ednico San Carlos, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182"]},{"raw_affiliation_string":"Ophthalmology Department, Hospital Clinico San Carlos, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sandra Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091170","display_name":"Euskadiko Parke Teknologikoa","ror":"https://ror.org/00caq9197","country_code":"ES","type":"archive","lineage":["https://openalex.org/I4210091170"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sandra Rodr\u00edguez","raw_affiliation_strings":["Bioftalmik Applied Research. Bizkaia Science and Technology Park, Bizkaia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioftalmik Applied Research. Bizkaia Science and Technology Park, Bizkaia, Spain","institution_ids":["https://openalex.org/I4210091170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109053829","display_name":"Tatiana Su\u00e1rez","orcid":"https://orcid.org/0009-0007-7954-2847","observed_orcids":["https://orcid.org/0009-0007-7954-2847"]},"institutions":[{"id":"https://openalex.org/I4210091170","display_name":"Euskadiko Parke Teknologikoa","ror":"https://ror.org/00caq9197","country_code":"ES","type":"archive","lineage":["https://openalex.org/I4210091170"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Tatiana Su\u00e1rez","raw_affiliation_strings":["Bioftalmik Applied Research. Bizkaia Science and Technology Park, Bizkaia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioftalmik Applied Research. Bizkaia Science and Technology Park, Bizkaia, Spain","institution_ids":["https://openalex.org/I4210091170"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6161,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.93660993,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"27","issue":null,"first_page":"243","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cystatin-s","display_name":"cystatin S","score":0.906000018119812},{"id":"https://openalex.org/keywords/s100a6","display_name":"S100A6","score":0.9309999942779541},{"id":"https://openalex.org/keywords/s100a8","display_name":"S100A8","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antibody-microarrays","display_name":"antibody microarrays","score":0.8619999885559082},{"id":"https://openalex.org/keywords/elisa-comparison","display_name":"ELISA comparison","score":0.8090000152587891},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/meibomian-gland-dysfunction","display_name":"meibomian gland dysfunction","score":0.7360000014305115},{"id":"https://openalex.org/keywords/ocular-surface-disease","display_name":"ocular surface disease","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tear-osmolarity","display_name":"tear osmolarity","score":0.781000018119812},{"id":"https://openalex.org/keywords/tear-film-break-up-time","display_name":"tear film break-up time","score":0.6510000228881836},{"id":"https://openalex.org/keywords/corneal-staining","display_name":"corneal staining","score":0.8169999718666077},{"id":"https://openalex.org/keywords/multiplexed-protein-quantification","display_name":"multiplexed protein quantification","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2778275304","wikidata":"https://www.wikidata.org/wiki/Q76469","display_name":"Tears","level":2,"score":0.7569963335990906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6776567697525024},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6104791164398193},{"id":"https://openalex.org/C2778557267","wikidata":"https://www.wikidata.org/wiki/Q20969990","display_name":"S100A8","level":3,"score":0.5397971272468567},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.47554728388786316},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.4525146782398224},{"id":"https://openalex.org/C171196145","wikidata":"https://www.wikidata.org/wiki/Q4774577","display_name":"Antibody microarray","level":3,"score":0.425383061170578},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40948712825775146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40693265199661255},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3530665338039398},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29943859577178955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21144574880599976},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.13094624876976013},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1275433897972107},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075383","descriptor_name":"S100 Calcium Binding Protein A6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013666","descriptor_name":"Tears","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040501","descriptor_name":"Calgranulin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055333","descriptor_name":"Salivary Cystatins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:34012227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34012227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:8116255","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8116255/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"mag:3161473741","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116255","pdf_url":null,"source":{"id":"https://openalex.org/S182284546","display_name":"Molecular vision","issn_l":"1090-0535","issn":["1090-0535"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315722","host_organization_name":"Emory University","host_organization_lineage":["https://openalex.org/P4310315722"],"host_organization_lineage_names":["Emory University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Molecular vision","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8116255","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8116255/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W156594437","https://openalex.org/W1484632349","https://openalex.org/W1542814291","https://openalex.org/W1921578580","https://openalex.org/W1955838455","https://openalex.org/W1973513527","https://openalex.org/W1974782875","https://openalex.org/W1980174408","https://openalex.org/W1981351886","https://openalex.org/W1993900282","https://openalex.org/W1994521493","https://openalex.org/W1995945296","https://openalex.org/W2020999562","https://openalex.org/W2023351487","https://openalex.org/W2042794878","https://openalex.org/W2043766216","https://openalex.org/W2045557044","https://openalex.org/W2048380539","https://openalex.org/W2054567926","https://openalex.org/W2055370551","https://openalex.org/W2071658063","https://openalex.org/W2088594156","https://openalex.org/W2090916970","https://openalex.org/W2091427621","https://openalex.org/W2102568715","https://openalex.org/W2113761013","https://openalex.org/W2138321161","https://openalex.org/W2148450076","https://openalex.org/W2152209587","https://openalex.org/W2154484733","https://openalex.org/W2155951997","https://openalex.org/W2161153914","https://openalex.org/W2163071831","https://openalex.org/W2168425651","https://openalex.org/W2172258164","https://openalex.org/W2215862606","https://openalex.org/W2282542002","https://openalex.org/W2331355337","https://openalex.org/W2391288867","https://openalex.org/W2482331033","https://openalex.org/W2523275226","https://openalex.org/W2551139658","https://openalex.org/W2590408703","https://openalex.org/W2591759817","https://openalex.org/W2596391620","https://openalex.org/W2600976021","https://openalex.org/W2602181527","https://openalex.org/W2610374659","https://openalex.org/W2735954633","https://openalex.org/W2738160893","https://openalex.org/W2773829297","https://openalex.org/W2911961397","https://openalex.org/W2912269178"],"related_works":["https://openalex.org/W2773829297","https://openalex.org/W2091427621","https://openalex.org/W2086525415","https://openalex.org/W1994521493","https://openalex.org/W1997765086","https://openalex.org/W2274805013","https://openalex.org/W4366749178","https://openalex.org/W2993600795","https://openalex.org/W2095558497","https://openalex.org/W2331355337"],"abstract_inverted_index":{"Purpose:":[0],"This":[1,57],"paper":[2],"examines":[3],"the":[4,22,42,84,159,189,249,289],"tear":[5,80,88,152,327],"concentration":[6,160],"of":[7,41,107,122,151,161,169,191,240],"cystatin":[8],"S":[9],"(CST4),":[10],"calcyclin":[11],"(S100A6),":[12],"calgranulin":[13],"A":[14,39],"(S100A8),":[15],"and":[16,21,29,49,66,94,100,111,125,140,182,195,200,227,243,270,291,299,310],"matrix":[17],"metalloproteinase":[18],"9":[19],"(MMP9),":[20],"correlation":[23],"between":[24,136],"biomarker":[25,283],"expression,":[26],"clinical":[27,307],"parameters,":[28],"disease":[30,236],"severity":[31],"in":[32,167,172,188,203,213,225],"patients":[33,171,193,215],"suffering":[34],"from":[35],"dry":[36,234],"eye":[37,235],"(DE).":[38],"comparison":[40,173,204],"results":[43],"is":[44],"obtained":[45],"via":[46],"ELISA":[47,118,156,250,335],"tests":[48],"customized":[50,131],"antibody":[51,133,246,321],"microarrays":[52],"for":[53,258,265,273,315,326],"protein":[54,153],"quantification.":[55],"Methods:":[56],"single-center,":[58],"observational":[59],"study":[60],"recruited":[61],"59":[62],"participants":[63],"(45":[64],"DE":[65,170,192,214,317],"14":[67],"controls).":[68],"Clinical":[69],"evaluation":[70,103],"included":[71],"an":[72],"Ocular":[73],"Surface":[74],"Disease":[75],"Index":[76],"(OSDI)":[77],"questionnaire,":[78],"a":[79,141],"osmolarity":[81],"(OSM)":[82],"test,":[83],"Schirmer":[85],"test":[86],"(SCH),":[87],"breakup":[89],"time":[90],"(TBUT),":[91],"fluorescein":[92],"(FLUO)":[93],"lissamine":[95],"green":[96],"(LG)":[97],"corneal":[98],"staining,":[99],"meibomian":[101],"gland":[102],"(MGE).":[104],"Tear":[105],"concentrations":[106,184,229,284],"CST4,":[108,123,241],"S100A6,":[109,124,242,297],"S100A8,":[110,298],"MMP9":[112,126,208,274],"were":[113,127,138,185,230,254,285],"measured":[114,129],"using":[115,130,245],"standard":[116,334],"individual":[117],"assays.":[119],"The":[120,149,207,223,282,319],"levels":[121],"also":[128,211,313],"multiplexed":[132,320],"microarrays.":[134],"Correlations":[135],"variables":[137],"evaluated,":[139],"significance":[142],"level":[143,209],"was":[144,163,210],"p":[145,197],"value":[146,261,268,276],"<0.05.":[147],"Results:":[148],"quantification":[150],"biomarkers":[154,302],"with":[155,174,205,233,279,288,294,305],"showed":[157],"that":[158],"CST4":[162,226,259,300,311],"significantly":[164,186,219,231,286],"(2.14-fold)":[165],"reduced":[166],"tears":[168,190],"control":[175],"(CT)":[176],"subjects":[177],"(p":[178,220,260,267,275],"<":[179,198],"0.001).":[180],"S100A6":[181,228,266,309],"S100A8":[183],"higher":[187,212,280],"(1.36-":[194],"2.29-fold;":[196],"0.001":[199],"0.025,":[201],"respectively)":[202],"CT.":[206],"(5.83-fold),":[216],"but":[217,278],"not":[218],"=":[221],"0.22).":[222],"changes":[224],"correlated":[232],"(DED)":[237],"severity.":[238,318],"Quantification":[239],"MMP9,":[244],"microarrays,":[247],"confirmed":[248],"results.":[251],"Similar":[252],"trends":[253],"observed:":[255],"1.83-fold":[256],"reduction":[257],"0.01),":[262],"8.63-fold":[263],"increase":[264,272],"<0.001)":[269],"9.67-fold":[271],"0.94),":[277],"sensitivity.":[281],"associated":[287],"signs":[290],"symptoms":[292],"related":[293],"DED.":[295],"Conclusions:":[296],"diagnostic":[301],"strongly":[303],"correlate":[304],"DED":[306],"parameters.":[308],"are":[312],"useful":[314],"grading":[316],"microarray":[322],"technique,":[323],"used":[324],"here":[325],"multi-marker":[328],"quantification,":[329],"appears":[330],"more":[331],"sensitive":[332],"than":[333],"tests.":[336]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-05-24T00:00:00"}