{"id":"https://openalex.org/W3160806387","doi":"https://doi.org/10.3389/fragi.2021.667193","title":"Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness","display_name":"Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness","publication_year":2021,"publication_date":"2021-05-11","ids":{"openalex":"https://openalex.org/W3160806387","doi":"https://doi.org/10.3389/fragi.2021.667193","mag":"3160806387","pmid":"https://pubmed.ncbi.nlm.nih.gov/35474946"},"language":"en","primary_location":{"id":"doi:10.3389/fragi.2021.667193","doi":"https://doi.org/10.3389/fragi.2021.667193","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2021.667193","pdf_url":"https://www.frontiersin.org/articles/10.3389/fragi.2021.667193/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fragi.2021.667193/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024579050","display_name":"Daan K. J. Pieren","orcid":"https://orcid.org/0000-0003-0461-5064","observed_orcids":["https://orcid.org/0000-0003-0461-5064"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Daan K. J. Pieren","raw_affiliation_strings":["Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088948166","display_name":"Noortje A. M. Smits","orcid":"https://orcid.org/0000-0002-6034-5364","observed_orcids":["https://orcid.org/0000-0002-6034-5364"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Noortje A. M. Smits","raw_affiliation_strings":["Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001377048","display_name":"Sandra Imholz","orcid":"https://orcid.org/0000-0003-2486-2847","observed_orcids":["https://orcid.org/0000-0003-2486-2847"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sandra Imholz","raw_affiliation_strings":["Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083959953","display_name":"Bhawani Nagarajah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bhawani Nagarajah","raw_affiliation_strings":["Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011000328","display_name":"Conny T. van Oostrom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Conny T. van Oostrom","raw_affiliation_strings":["Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004870117","display_name":"Renata M. C. Brandt","orcid":"https://orcid.org/0000-0003-0514-5623","observed_orcids":["https://orcid.org/0000-0003-0514-5623"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Renata M. C. Brandt","raw_affiliation_strings":["Department of Molecular Genetics, Erasmus MC, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Erasmus MC, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047763604","display_name":"Wilbert P. Vermeij","orcid":"https://orcid.org/0000-0002-9690-1385","observed_orcids":["https://orcid.org/0000-0002-9690-1385"]},"institutions":[{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210127118","display_name":"Princess M\u00e1xima Center","ror":"https://ror.org/02aj7yc53","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127118"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wilbert P. Vermeij","raw_affiliation_strings":["Oncode Institute, Utrecht, Netherlands","Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncode Institute, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210111138"]},{"raw_affiliation_string":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210127118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035765579","display_name":"Martijn E.T. Doll\u00e9","orcid":"https://orcid.org/0000-0001-6137-6544","observed_orcids":["https://orcid.org/0000-0001-6137-6544"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martijn E. T. Doll\u00e9","raw_affiliation_strings":["Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021613232","display_name":"Teun Guichelaar","orcid":"https://orcid.org/0000-0002-5112-8923","observed_orcids":["https://orcid.org/0000-0002-5112-8923"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Teun Guichelaar","raw_affiliation_strings":["Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021613232"],"corresponding_institution_ids":["https://openalex.org/I4210104433"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.4456,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.53025175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ercc1","display_name":"ERCC1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dna-excision-repair","display_name":"excision repair","score":0.8410000205039978},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.8510000109672546},{"id":"https://openalex.org/keywords/t-cell-senescence","display_name":"T cell senescence","score":0.7039999961853027},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.9959999918937683},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.7609999775886536},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nuclear-dna-damage","display_name":"nuclear DNA damage","score":0.7770000100135803},{"id":"https://openalex.org/keywords/accelerated-aging","display_name":"accelerated aging","score":0.6019999980926514},{"id":"https://openalex.org/keywords/t-cell-responsiveness","display_name":"T cell responsiveness","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6002609133720398},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5930876135826111},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5851583480834961},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5627766251564026},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.5590493083000183},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5158966779708862},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5026471614837646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4256078004837036},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.41747045516967773},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40745842456817627},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4016273021697998},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37475383281707764},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23343542218208313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14442825317382812},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13193035125732422},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11506876349449158},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11455044150352478}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fragi.2021.667193","doi":"https://doi.org/10.3389/fragi.2021.667193","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2021.667193","pdf_url":"https://www.frontiersin.org/articles/10.3389/fragi.2021.667193/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},{"id":"pmid:35474946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35474946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in aging","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9037984","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9037984","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Aging","raw_type":"Text"},{"id":"pmh:oai:rivm.openrepository.com:10029/653112","doi":null,"is_oa":false,"landing_page_url":"https://rivm.openrepository.com/handle/10029/653112","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.3389/fragi.2021.667193","doi":"https://doi.org/10.3389/fragi.2021.667193","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2021.667193","pdf_url":"https://www.frontiersin.org/articles/10.3389/fragi.2021.667193/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5099999904632568}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1242343652","display_name":null,"funder_award_id":"P01- AG017242","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1545034917","display_name":null,"funder_award_id":"AG017242","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4452823214","display_name":null,"funder_award_id":"S/112006","funder_id":"https://openalex.org/F4320321645","funder_display_name":"Ministerie van Volksgezondheid, Welzijn en Sport"},{"id":"https://openalex.org/G5669151532","display_name":null,"funder_award_id":"733050810","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G7300687447","display_name":null,"funder_award_id":"S/112006","funder_id":"https://openalex.org/F4320335216","funder_display_name":"Rijksinstituut voor Volksgezondheid en Milieu"},{"id":"https://openalex.org/G8093415072","display_name":"DNA Repair, Mutations and Cellular Aging","funder_award_id":"5p01ag017242-28","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000093672","display_name":null,"funder_award_id":"AG017242","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320321645","display_name":"Ministerie van Volksgezondheid, Welzijn en Sport","ror":"https://ror.org/041evnj42"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335216","display_name":"Rijksinstituut voor Volksgezondheid en Milieu","ror":"https://ror.org/01cesdt21"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3160806387.pdf","grobid_xml":"https://content.openalex.org/works/W3160806387.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W47217405","https://openalex.org/W1510545292","https://openalex.org/W1560562878","https://openalex.org/W1843328901","https://openalex.org/W1890771959","https://openalex.org/W1903749320","https://openalex.org/W1943933230","https://openalex.org/W1978161786","https://openalex.org/W1978410307","https://openalex.org/W1981148605","https://openalex.org/W1982602899","https://openalex.org/W1982729887","https://openalex.org/W1992431343","https://openalex.org/W1993026821","https://openalex.org/W2002726823","https://openalex.org/W2009124426","https://openalex.org/W2009644403","https://openalex.org/W2010583480","https://openalex.org/W2025133084","https://openalex.org/W2033505817","https://openalex.org/W2033748513","https://openalex.org/W2037150299","https://openalex.org/W2042000503","https://openalex.org/W2044346962","https://openalex.org/W2048376025","https://openalex.org/W2051122503","https://openalex.org/W2052845629","https://openalex.org/W2063814906","https://openalex.org/W2064876347","https://openalex.org/W2068367301","https://openalex.org/W2078519775","https://openalex.org/W2084369408","https://openalex.org/W2097142668","https://openalex.org/W2112018589","https://openalex.org/W2116054786","https://openalex.org/W2117636996","https://openalex.org/W2126525177","https://openalex.org/W2128084403","https://openalex.org/W2155447972","https://openalex.org/W2164224099","https://openalex.org/W2169519600","https://openalex.org/W2511049107","https://openalex.org/W2516117533","https://openalex.org/W2529494470","https://openalex.org/W2737785069","https://openalex.org/W2790327509","https://openalex.org/W2797023968","https://openalex.org/W2902725541","https://openalex.org/W2934371654","https://openalex.org/W2948309692","https://openalex.org/W2948314199","https://openalex.org/W2966678440","https://openalex.org/W2969244270","https://openalex.org/W2984736033","https://openalex.org/W3122418361"],"related_works":["https://openalex.org/W2760815521","https://openalex.org/W2747101336","https://openalex.org/W1991644354","https://openalex.org/W2033918102","https://openalex.org/W1972094156","https://openalex.org/W2055890925","https://openalex.org/W2004480716","https://openalex.org/W3125757075","https://openalex.org/W2108718931","https://openalex.org/W2107516157"],"abstract_inverted_index":{"Decline":[0],"of":[1,14,38,60,91,124,153,190,205,222,237],"immune":[2],"function":[3],"during":[4],"aging":[5,40],"has":[6],"in":[7,78,96,138,167],"part":[8],"been":[9],"ascribed":[10],"to":[11,28,56,100,133,140,162],"the":[12,36,58,122,150,168,203,220],"accumulation":[13,90,221],"regulatory":[15],"T":[16,29,48,71,118,127,131],"cells":[17,30,49,72,132],"(Tregs)":[18],"and":[19,67,111,129,135,143,207,228],"decreased":[20],"T-cell":[21,65,141,169,231],"responses":[22],"with":[23,75,108,184,193,224],"age.":[24],"Aside":[25],"from":[26,73],"changes":[27,165],"that":[31,149,164,215],"occur":[32],"over":[33],"a":[34,76],"lifetime,":[35],"impact":[37,59],"intracellular":[39],"processes":[41],"such":[42],"as":[43],"compromised":[44,61,172,216],"DNA":[45,62,80,93,158,173,217],"repair":[46,63,159,174,218],"on":[47,64],"remains":[50],"incompletely":[51],"defined.":[52],"Here":[53],"we":[54],"aimed":[55],"define":[57],"phenotype":[66,227],"responsiveness":[68],"by":[69,171,181],"studying":[70],"mice":[74,88,105,192],"deficiency":[77],"their":[79,116],"excision-repair":[81],"gene":[82],"Ercc1.":[83],"These":[84],"Ercc1":[85],"mutant":[86],"(Ercc1\u2212/\u03947)":[87],"show":[89],"nuclear":[92],"damage":[94],"resulting":[95],"accelerated":[97],"aging.":[98],"Similarly":[99],"wild-type":[101],"aged":[102],"mice,":[103],"Ercc1\u2212/\u03947":[104,191],"accumulated":[106],"Tregs":[107,210,223],"reduced":[109,230],"CD25":[110,137],"increased":[112,202],"PD-1":[113],"expression":[114],"among":[115],"naive":[117],"cells.":[119],"Ercc1-deficiency":[120],"limited":[121],"capacity":[123],"Tregs,":[125],"helper":[126],"cells,":[128],"cytotoxic":[130],"proliferate":[134],"upregulate":[136],"response":[139],"receptor-":[142],"IL-2-mediated":[144],"stimulation.":[145],"The":[146],"recent":[147],"demonstration":[148],"mammalian":[151],"target":[152],"rapamycin":[154,194],"(mTOR)":[155],"may":[156,175,234],"impair":[157],"lead":[160],"us":[161],"hypothesize":[163],"induced":[166],"population":[170],"be":[176,235],"slowed":[177],"down":[178],"or":[179],"reversed":[180],"blocking":[182],"mTOR":[183,238],"rapamycin.":[185],"In":[186],"vivo":[187],"dietary":[188],"treatment":[189],"did":[195],"not":[196],"reduce":[197],"Treg":[198],"levels,":[199],"but":[200],"highly":[201],"proportion":[204],"CD25+":[206],"PD-1+":[208],"memory":[209],"instead.":[211],"Our":[212],"study":[213],"elucidates":[214],"promotes":[219],"an":[225],"aging-related":[226],"causes":[229],"responsiveness,":[232],"which":[233],"independent":[236],"activation.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
