{"id":"https://openalex.org/W3160597412","doi":"https://doi.org/10.1093/jas/skab096.048","title":"Genomic Effects of Arginine on Cell Behavior of Conceptus Trophectoderm in Ungulates","display_name":"Genomic Effects of Arginine on Cell Behavior of Conceptus Trophectoderm in Ungulates","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3160597412","doi":"https://doi.org/10.1093/jas/skab096.048","mag":"3160597412"},"language":"en","primary_location":{"id":"doi:10.1093/jas/skab096.048","doi":"https://doi.org/10.1093/jas/skab096.048","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jas/skab096.048","pdf_url":null,"source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8104857","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042285458","display_name":"Sudikshya Paudel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudikshya Paudel","raw_affiliation_strings":["Department of Animal Science, North Carolina State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, North Carolina State University","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013989253","display_name":"Hongyao Yu","orcid":"https://orcid.org/0000-0003-3752-8442","observed_orcids":["https://orcid.org/0000-0003-3752-8442"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyao Yu","raw_affiliation_strings":["Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101518385","display_name":"Tianyuan Wang","orcid":"https://orcid.org/0000-0002-3970-0771","observed_orcids":["https://orcid.org/0000-0002-3970-0771"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianyuan Wang","raw_affiliation_strings":["Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021286537","display_name":"Fuller W. Bazer","orcid":"https://orcid.org/0000-0002-5823-5086","observed_orcids":["https://orcid.org/0000-0002-5823-5086"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fuller W Bazer","raw_affiliation_strings":["Department of Animal Science, Texas A&M University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, Texas A&M University","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044475205","display_name":"Guoyao Wu","orcid":"https://orcid.org/0000-0001-8058-6969","observed_orcids":["https://orcid.org/0000-0001-8058-6969"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoyao Wu","raw_affiliation_strings":["Department of Animal Science, Texas A&M University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, Texas A&M University","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064099505","display_name":"Robert C. Burghardt","orcid":"https://orcid.org/0000-0003-1021-8444","observed_orcids":["https://orcid.org/0000-0003-1021-8444"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Burghardt","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, Texas A&M University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061137912","display_name":"Guang Hu","orcid":"https://orcid.org/0000-0003-0437-4723","observed_orcids":["https://orcid.org/0000-0003-0437-4723"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guang Hu","raw_affiliation_strings":["Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032665881","display_name":"Xiaoqiu Wang","orcid":"https://orcid.org/0000-0001-9660-528X","observed_orcids":["https://orcid.org/0000-0001-9660-528X"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoqiu Wang","raw_affiliation_strings":["Department of Animal Science, North Carolina State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, North Carolina State University","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"99","issue":"Supplement_2","first_page":"27","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.12449999898672104,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.03539999946951866,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.7850000262260437},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.7720000147819519},{"id":"https://openalex.org/keywords/actin-cytoskeleton-signaling","display_name":"actin cytoskeleton signaling","score":0.8730000257492065},{"id":"https://openalex.org/keywords/igf-1-signaling","display_name":"IGF-1 signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.7540000081062317},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.7440000176429749},{"id":"https://openalex.org/keywords/implantation","display_name":"implantation","score":0.3569999933242798},{"id":"https://openalex.org/keywords/ungulates","display_name":"ungulates","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C32253518","wikidata":"https://www.wikidata.org/wiki/Q5158447","display_name":"Conceptus","level":4,"score":0.9214529991149902},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7797116041183472},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.6758446097373962},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5863116383552551},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.565324068069458},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.451200395822525},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.417820006608963},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.413104385137558},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36477887630462646},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.343746542930603},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.2932708263397217},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.2597750127315521},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.233175128698349},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22235828638076782},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20741719007492065},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1528272032737732},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.08292028307914734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/jas/skab096.048","doi":"https://doi.org/10.1093/jas/skab096.048","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jas/skab096.048","pdf_url":null,"source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8104857","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8104857","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anim Sci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8104857","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8104857","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anim Sci","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414894618","https://openalex.org/W2595880960","https://openalex.org/W2134322174","https://openalex.org/W2122061266","https://openalex.org/W2595480760","https://openalex.org/W2156485556","https://openalex.org/W4396531742","https://openalex.org/W2046250834","https://openalex.org/W7100836639","https://openalex.org/W2132578671"],"abstract_inverted_index":{"Abstract":[0],"Hatched":[1],"ungulate":[2],"(e.g.,":[3],"pigs,":[4],"sheep":[5],"and":[6,24,55,81,156,175,187,196,210,221,224,232,244,261,284,287],"other":[7],"ruminants)":[8],"blastocysts":[9],"undergo":[10],"dramatic":[11],"morphological":[12],"transitions":[13],"from":[14,106,121,272],"spherical":[15],"to":[16,18,21,42,49,85,127,130,163,237],"tubular":[17],"filamentous":[19],"forms":[20],"conceptuses":[22,124,286],"(embryo/fetus":[23],"associated":[25,240],"extraembryonic":[26],"membranes)":[27],"before":[28],"implantation.":[29],"L-Arginine":[30],"(Arg),":[31],"a":[32,75,140,146,168],"conditionally":[33],"essential":[34],"amino":[35],"acid,":[36],"is":[37,69],"required":[38],"for":[39,74,280],"this":[40,273],"process":[41],"activate":[43],"the":[44,61,133,184,203,252,268,289],"mTOR":[45],"cell":[46,103,118,227],"signaling":[47,263],"pathway":[48,200],"induce":[50],"proliferation":[51],"of":[52,64,79,89,93,136,148,170,215,226,277,282,292],"both":[53,208],"porcine":[54,80,100,108,285],"ovine":[56,82,115,123,283],"conceptus":[57],"trophectoderm":[58,67,83,96,101,116],"cells.":[59,97,270],"However,":[60],"genomic":[62],"effects":[63,88],"arginine":[65],"on":[66,91],"cells":[68,84],"unknown.":[70],"RNA-seq":[71],"was":[72],"used":[73,126],"comparative":[76],"transcriptome":[77],"analysis":[78],"further":[86],"understand":[87],"Arg":[90,131],"regulation":[92],"metabolism":[94],"in":[95,139,161,207,251,267],"An":[98],"established":[99,114],"(pTr)":[102],"line":[104,119],"isolated":[105,120],"D12":[107],"conceptuses,":[109],"as":[110,112],"well":[111],"an":[113],"(oTr)":[117],"D15":[122],"were":[125,159,178,248,264],"determine":[128],"response":[129,162,236],"at":[132],"physiological":[134],"concentration":[135],"0.2":[137],"mM":[138],"48-h":[141],"culture.":[142],"In":[143,165,235],"pTr":[144,186,209,253],"cells,":[145,167,212],"total":[147,169],"2,723":[149],"differentially":[150],"expressed":[151],"genes":[152],"(DEG;":[153],"1,482":[154],"up":[155,174,195],"1,241":[157],"down)":[158,177],"identified":[160,202],"Arg.":[164],"oTr":[166,188,211,269],"5,369":[171],"DEG":[172,193],"(2,819":[173],"2,550":[176],"detected.":[179],"Comparison":[180],"analyses":[181,201],"showed":[182],"that":[183],"Arg-treated":[185],"transcriptomes":[189],"share":[190],"873":[191],"common":[192],"(273":[194],"342":[197],"down).":[198],"Canonical":[199],"top":[204],"enriched":[205],"pathways":[206,239],"including":[213],"activation":[214],"actin":[216],"cytoskeleton":[217],"signaling,":[218,220,257,260],"adrenomedullin":[219],"IGF-1":[222],"signaling;":[223],"inhibition":[225],"cycle":[228],"G2/M":[229],"checkpoint":[230],"regulation,":[231],"p53":[233],"signaling.":[234],"Arg,":[238],"with":[241],"cholesterol":[242],"biosynthesis,":[243],"estrogen-mediated":[245],"S-phase":[246],"entry":[247],"exclusively":[249],"activated":[250,266],"cells;":[254],"whereas":[255],"interferon":[256],"ephrin":[258],"receptor":[259],"integrin":[262],"specifically":[265],"Results":[271],"study":[274],"advance":[275],"understanding":[276],"mechanisms":[278],"responsible":[279],"elongation":[281],"enable":[288],"rational":[290],"design":[291],"future":[293],"experiments.":[294]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-05-24T00:00:00"}
