{"id":"https://openalex.org/W3160486644","doi":"https://doi.org/10.15252/embj.2020107607","title":"Structural basis of TRAPPIII\u2010mediated Rab1 activation","display_name":"Structural basis of TRAPPIII\u2010mediated Rab1 activation","publication_year":2021,"publication_date":"2021-05-21","ids":{"openalex":"https://openalex.org/W3160486644","doi":"https://doi.org/10.15252/embj.2020107607","mag":"3160486644","pmid":"https://pubmed.ncbi.nlm.nih.gov/34018207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8204860"},"language":"en","primary_location":{"id":"doi:10.15252/embj.2020107607","doi":"https://doi.org/10.15252/embj.2020107607","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embj.2020107607","pdf_url":"https://link.springer.com/content/pdf/10.15252/embj.2020107607.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.15252/embj.2020107607.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019235461","display_name":"Aaron M.N. Joiner","orcid":"https://orcid.org/0000-0001-9049-2384","observed_orcids":["https://orcid.org/0000-0001-9049-2384"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron M.N. Joiner","raw_affiliation_strings":["Department of Molecular Biology and Genetics/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-9049-2384","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083203605","display_name":"Ben P. Phillips","orcid":"https://orcid.org/0000-0001-9117-4695","observed_orcids":["https://orcid.org/0000-0001-9117-4695"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ben P. Phillips","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","MRC Laboratory of Molecular Biology Cambridge UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology Cambridge UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088011754","display_name":"Kumar Yugandhar","orcid":"https://orcid.org/0000-0003-1141-4439","observed_orcids":["https://orcid.org/0000-0003-1141-4439"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kumar Yugandhar","raw_affiliation_strings":["Department of Computational Biology/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-1141-4439","affiliations":[{"raw_affiliation_string":"Department of Computational Biology/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087520347","display_name":"Ethan James Sanford","orcid":"https://orcid.org/0000-0003-0722-3058","observed_orcids":["https://orcid.org/0000-0003-0722-3058"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan J. Sanford","raw_affiliation_strings":["Department of Molecular Biology and Genetics/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-0722-3058","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025725461","display_name":"Marcus Bustamante Smolka","orcid":"https://orcid.org/0000-0001-9952-2885","observed_orcids":["https://orcid.org/0000-0001-9952-2885"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus B. Smolka","raw_affiliation_strings":["Department of Molecular Biology and Genetics/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-9952-2885","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067174340","display_name":"Haiyuan Yu","orcid":"https://orcid.org/0000-0001-7597-6049","observed_orcids":["https://orcid.org/0000-0001-7597-6049"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiyuan Yu","raw_affiliation_strings":["Department of Computational Biology/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-7597-6049","affiliations":[{"raw_affiliation_string":"Department of Computational Biology/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050196572","display_name":"Elizabeth A. Miller","orcid":"https://orcid.org/0000-0002-1033-8369","observed_orcids":["https://orcid.org/0000-0002-1033-8369"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Miller","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","MRC Laboratory of Molecular Biology Cambridge UK"],"raw_orcid":"https://orcid.org/0000-0002-1033-8369","affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology Cambridge UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014220267","display_name":"J. Christopher Fromme","orcid":"https://orcid.org/0000-0002-8837-0473","observed_orcids":["https://orcid.org/0000-0002-8837-0473"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Christopher Fromme","raw_affiliation_strings":["Department of Molecular Biology and Genetics/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-8837-0473","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics/Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014220267"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":2.9907,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.92146814,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"40","issue":"12","first_page":"e107607","last_page":"e107607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rab1","display_name":"Rab1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor","display_name":"guanine nucleotide exchange factor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/amphipathic-helix","display_name":"amphipathic helix","score":0.8949999809265137},{"id":"https://openalex.org/keywords/membrane-binding","display_name":"membrane binding","score":0.925000011920929},{"id":"https://openalex.org/keywords/hypervariable-region","display_name":"hypervariable region","score":0.7889999747276306},{"id":"https://openalex.org/keywords/early-secretory-pathway","display_name":"early secretory pathway","score":0.8240000009536743},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9589999914169312},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8859999775886536},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.4650000035762787},{"id":"https://openalex.org/keywords/protein-complex-structure","display_name":"protein complex structure","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.7682636976242065},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.7608261704444885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7391691207885742},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.6792761087417603},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5946420431137085},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5452582836151123},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3945417106151581},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36362239718437195},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.15252/embj.2020107607","doi":"https://doi.org/10.15252/embj.2020107607","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embj.2020107607","pdf_url":"https://link.springer.com/content/pdf/10.15252/embj.2020107607.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"doi:10.1101/2020.10.08.332312","doi":"https://doi.org/10.1101/2020.10.08.332312","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.08.332312","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/08/2020.10.08.332312.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8204860","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8204860","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmid:34018207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34018207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/06e2d4fa-1306-4432-8002-5c0c45dde3d2","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/06e2d4fa-1306-4432-8002-5c0c45dde3d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Joiner, A M N, Phillips, B P, Yugandhar, K, Sanford, E J, Smolka, M B, Yu, H, Miller, E A & Fromme, J C 2021, 'Structural basis of TRAPPIII\u2010mediated Rab1 activation', The EMBO Journal, vol. 40, no. 12, e107607. https://doi.org/10.15252/embj.2020107607","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.15252/embj.2020107607","doi":"https://doi.org/10.15252/embj.2020107607","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embj.2020107607","pdf_url":"https://link.springer.com/content/pdf/10.15252/embj.2020107607.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1205195086","display_name":null,"funder_award_id":"DMR- 1719875","funder_id":"https://openalex.org/F4320333422","funder_display_name":"Materials Research Science and Engineering Center, Harvard University"},{"id":"https://openalex.org/G1321126357","display_name":null,"funder_award_id":"DMR\u20101719875","funder_id":"https://openalex.org/F4320332708","funder_display_name":"Cornell Center for Materials Research"},{"id":"https://openalex.org/G2026150038","display_name":"Quantifying molecular consequences of human missense variants with large-scale interactome perturbation studies","funder_award_id":"R01GM125639","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2072083609","display_name":null,"funder_award_id":"DBI\u20101661380","funder_id":"https://openalex.org/F4320337398","funder_display_name":"Division of Biological Infrastructure"},{"id":"https://openalex.org/G2127518181","display_name":null,"funder_award_id":"MRC_UP_1201/10","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2318728625","display_name":null,"funder_award_id":"DGE 1650441","funder_id":"https://openalex.org/F4320337368","funder_display_name":"Division of Graduate Education"},{"id":"https://openalex.org/G2415270547","display_name":null,"funder_award_id":"DMR-1719875","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G2929996310","display_name":null,"funder_award_id":"DMR-1719875","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3596435321","display_name":"Collaborative Research: ABI Innovation: A Graph Based Approach for the Genome Wide Prediction of Conditionally Essential Genes","funder_award_id":"1661380","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G360725014","display_name":"Regulation of Arf GTPase activation at the Golgi complex","funder_award_id":"R01GM098621","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4019945064","display_name":null,"funder_award_id":"EM17434","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4064232043","display_name":"Cornell Center for Materials Research - MRSEC","funder_award_id":"1719875","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4460773865","display_name":"Regulation of Rab activation at the Golgi complex","funder_award_id":"R01GM116942","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4989108295","display_name":null,"funder_award_id":"DGE-1650441","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5917061246","display_name":null,"funder_award_id":"1719875","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G6142350529","display_name":"Towards a comprehensive multiscale 3D human interactome network","funder_award_id":"R01GM124559","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6223859374","display_name":"Cellular responses to DNA replication stress","funder_award_id":"R01GM097272","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6351810044","display_name":null,"funder_award_id":"1719875","funder_id":"https://openalex.org/F4320333422","funder_display_name":"Materials Research Science and Engineering Center, Harvard University"},{"id":"https://openalex.org/G7031722743","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"1650441","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7767248047","display_name":null,"funder_award_id":"1719875","funder_id":"https://openalex.org/F4320332708","funder_display_name":"Cornell Center for Materials Research"},{"id":"https://openalex.org/G8229174675","display_name":null,"funder_award_id":"DGE-165-0441","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000856448","display_name":"GTPase Regulation of the Golgi Complex","funder_award_id":"R35GM136258","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000860311","display_name":"Signaling Mechanisms in Genome Maintenance","funder_award_id":"R35GM141159","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000884773","display_name":"Coordination of Atr Signaling for Genetic Quality Control, Silencing, and DNA Repair during Meiosis","funder_award_id":"R01HD095296","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320313096","display_name":"Diamond Light Source","ror":"https://ror.org/05etxs293"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332708","display_name":"Cornell Center for Materials Research","ror":null},{"id":"https://openalex.org/F4320333422","display_name":"Materials Research Science and Engineering Center, Harvard University","ror":"https://ror.org/01qa5ep47"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"},{"id":"https://openalex.org/F4320337398","display_name":"Division of Biological Infrastructure","ror":"https://ror.org/04qn9mx93"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3160486644.pdf","grobid_xml":"https://content.openalex.org/works/W3160486644.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W21038192","https://openalex.org/W1575099349","https://openalex.org/W1644001471","https://openalex.org/W1833509159","https://openalex.org/W1948123119","https://openalex.org/W1960037789","https://openalex.org/W1965183541","https://openalex.org/W1966332308","https://openalex.org/W1973035681","https://openalex.org/W1973186763","https://openalex.org/W1973638222","https://openalex.org/W1977811233","https://openalex.org/W1981196662","https://openalex.org/W1993550687","https://openalex.org/W1995235301","https://openalex.org/W1996355353","https://openalex.org/W2005563114","https://openalex.org/W2008388529","https://openalex.org/W2009644279","https://openalex.org/W2010728666","https://openalex.org/W2011793938","https://openalex.org/W2013654291","https://openalex.org/W2020358132","https://openalex.org/W2029582401","https://openalex.org/W2029777285","https://openalex.org/W2045780937","https://openalex.org/W2048041152","https://openalex.org/W2048686416","https://openalex.org/W2052446616","https://openalex.org/W2053353491","https://openalex.org/W2055406931","https://openalex.org/W2056003065","https://openalex.org/W2056735204","https://openalex.org/W2061519290","https://openalex.org/W2069663555","https://openalex.org/W2073144689","https://openalex.org/W2074175128","https://openalex.org/W2075694447","https://openalex.org/W2077178636","https://openalex.org/W2083032550","https://openalex.org/W2096013041","https://openalex.org/W2104152706","https://openalex.org/W2104234755","https://openalex.org/W2106813748","https://openalex.org/W2110905842","https://openalex.org/W2113904137","https://openalex.org/W2119914706","https://openalex.org/W2124026197","https://openalex.org/W2124733101","https://openalex.org/W2126241927","https://openalex.org/W2132099293","https://openalex.org/W2132629607","https://openalex.org/W2137175516","https://openalex.org/W2137516675","https://openalex.org/W2142757818","https://openalex.org/W2145129663","https://openalex.org/W2147539183","https://openalex.org/W2149843002","https://openalex.org/W2159007909","https://openalex.org/W2160213210","https://openalex.org/W2164778558","https://openalex.org/W2165565773","https://openalex.org/W2167279371","https://openalex.org/W2168621448","https://openalex.org/W2169333620","https://openalex.org/W2170678054","https://openalex.org/W2217094724","https://openalex.org/W2376573086","https://openalex.org/W2432427150","https://openalex.org/W2517043764","https://openalex.org/W2554686319","https://openalex.org/W2587625522","https://openalex.org/W2591751109","https://openalex.org/W2593511418","https://openalex.org/W2728385286","https://openalex.org/W2734356283","https://openalex.org/W2752326209","https://openalex.org/W2767606546","https://openalex.org/W2780658608","https://openalex.org/W2791670278","https://openalex.org/W2801376357","https://openalex.org/W2888907793","https://openalex.org/W2899714098","https://openalex.org/W2902400079","https://openalex.org/W2921528384","https://openalex.org/W2938574745","https://openalex.org/W2950967305","https://openalex.org/W2968590403","https://openalex.org/W2973457155","https://openalex.org/W2995405778","https://openalex.org/W2995810360","https://openalex.org/W2997234557","https://openalex.org/W3005655837","https://openalex.org/W3005874143","https://openalex.org/W3017968610","https://openalex.org/W3049001491","https://openalex.org/W4239933263","https://openalex.org/W4297408474"],"related_works":["https://openalex.org/W3092045751","https://openalex.org/W4225414463","https://openalex.org/W2126241927","https://openalex.org/W3163587459","https://openalex.org/W3174260334","https://openalex.org/W4280560458","https://openalex.org/W4365815959","https://openalex.org/W6940381737","https://openalex.org/W2767606546","https://openalex.org/W4311932875"],"abstract_inverted_index":{"The":[0,50],"GTPase":[1],"Rab1":[2,17],"is":[3,13,19,86,99],"a":[4,63,102,120,135],"master":[5],"regulator":[6],"of":[7,39,91,138],"the":[8,27,34,40,53,57,67,73,83,107,115,128],"early":[9],"secretory":[10],"pathway":[11],"and":[12,95,98,143],"critical":[14],"for":[15,56,65,88,127],"autophagy.":[16],"activation":[18,74,90,140],"controlled":[20],"by":[21,82,101],"its":[22,47,124],"guanine":[23],"nucleotide":[24],"exchange":[25],"factor,":[26],"multisubunit":[28],"TRAPPIII":[29,43,84,130],"complex.":[30,131],"Here,":[31],"we":[32],"report":[33],"3.7":[35],"\u00c5":[36],"cryo-EM":[37],"structure":[38,51],"Saccharomyces":[41],"cerevisiae":[42],"complex":[44,68,85],"bound":[45],"to":[46,62],"substrate":[48],"Rab1/Ypt1.":[49],"reveals":[52],"binding":[54,81],"site":[55],"Rab1/Ypt1":[58,92],"hypervariable":[59],"domain,":[60],"leading":[61],"model":[64],"how":[66],"interacts":[69],"with":[70],"membranes":[71],"during":[72],"reaction.":[75],"We":[76],"determined":[77],"that":[78,114],"stable":[79],"membrane":[80,121],"required":[87],"robust":[89],"in":[93,96],"vitro":[94],"vivo,":[97],"mediated":[100],"conserved":[103],"amphipathic":[104,125],"\u03b1-helix":[105],"within":[106],"regulatory":[108],"Trs85":[109,116],"subunit.":[110],"Our":[111],"results":[112],"show":[113],"subunit":[117],"serves":[118],"as":[119],"anchor,":[122],"via":[123],"helix,":[126],"entire":[129],"These":[132],"findings":[133],"provide":[134],"structural":[136],"understanding":[137],"Rab":[139],"on":[141],"organelle":[142],"vesicle":[144],"membranes.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-05-24T00:00:00"}
