{"id":"https://openalex.org/W3160465333","doi":"https://doi.org/10.1371/journal.pone.0250839","title":"Validation of protein arginine methyltransferase 5 (PRMT5) as a candidate therapeutic target in the spontaneous canine model of non-Hodgkin lymphoma","display_name":"Validation of protein arginine methyltransferase 5 (PRMT5) as a candidate therapeutic target in the spontaneous canine model of non-Hodgkin lymphoma","publication_year":2021,"publication_date":"2021-05-14","ids":{"openalex":"https://openalex.org/W3160465333","doi":"https://doi.org/10.1371/journal.pone.0250839","mag":"3160465333","pmid":"https://pubmed.ncbi.nlm.nih.gov/33989303","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8121334"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0250839","doi":"https://doi.org/10.1371/journal.pone.0250839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0250839","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0250839&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0250839&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073002557","display_name":"Shelby L. Sloan","orcid":"https://orcid.org/0000-0001-7366-9184","observed_orcids":["https://orcid.org/0000-0001-7366-9184"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelby L. Sloan","raw_affiliation_strings":["Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America","Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7366-9184","affiliations":[{"raw_affiliation_string":"Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025544597","display_name":"Kyle A. Renaldo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle A. Renaldo","raw_affiliation_strings":["Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037733702","display_name":"Mackenzie Long","orcid":"https://orcid.org/0000-0001-6387-4440","observed_orcids":["https://orcid.org/0000-0001-6387-4440"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mackenzie Long","raw_affiliation_strings":["Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America","Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112682106","display_name":"Ji-Hyun Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji-Hyun Chung","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047182632","display_name":"Lindsay E. Courtney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay E. Courtney","raw_affiliation_strings":["Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051548428","display_name":"Konstantin Shilo","orcid":"https://orcid.org/0000-0002-6702-3130","observed_orcids":["https://orcid.org/0000-0002-6702-3130"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konstantin Shilo","raw_affiliation_strings":["Department of Pathology, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6702-3130","affiliations":[{"raw_affiliation_string":"Department of Pathology, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101974234","display_name":"Youssef Youssef","orcid":"https://orcid.org/0000-0002-0706-3640","observed_orcids":["https://orcid.org/0000-0002-0706-3640"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youssef Youssef","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091900588","display_name":"Sarah Y. Schlotter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Schlotter","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121823975","display_name":"Fiona Brown-Burke","orcid":"https://orcid.org/0000-0001-6692-8678","observed_orcids":["https://orcid.org/0000-0001-6692-8678"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fiona Brown","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032172599","display_name":"Brett G. Klamer","orcid":"https://orcid.org/0000-0002-8334-4831","observed_orcids":["https://orcid.org/0000-0002-8334-4831"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett G. Klamer","raw_affiliation_strings":["Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404558","display_name":"Xiaoli Zhang","orcid":"https://orcid.org/0000-0002-2495-4568","observed_orcids":["https://orcid.org/0000-0002-2495-4568","https://orcid.org/0000-0002-5608-9564"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoli Zhang","raw_affiliation_strings":["Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020710404","display_name":"Ayse Selen Yilmaz","orcid":"https://orcid.org/0000-0002-1584-8800","observed_orcids":["https://orcid.org/0000-0002-1584-8800"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayse S. Yilmaz","raw_affiliation_strings":["Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023990588","display_name":"Hatice G\u00fcl\u00e7in \u00d6zer","orcid":"https://orcid.org/0000-0002-8315-8051","observed_orcids":["https://orcid.org/0000-0002-8315-8051"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hatice G. Ozer","raw_affiliation_strings":["Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108455790","display_name":"Victor E. Valli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor E. Valli","raw_affiliation_strings":["VDx Veterinary Diagnostics, Davis, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VDx Veterinary Diagnostics, Davis, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046355139","display_name":"Kris Vaddi","orcid":"https://orcid.org/0009-0009-8581-6511","observed_orcids":["https://orcid.org/0009-0009-8581-6511"]},"institutions":[{"id":"https://openalex.org/I4405265449","display_name":"Prelude Therapeutics Incorporated (United States)","ror":"https://ror.org/04v7ftc96","country_code":"US","type":"company","lineage":["https://openalex.org/I4405265449"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kris Vaddi","raw_affiliation_strings":["Prelude Therapeutics, Wilmington, Delaware, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prelude Therapeutics, Wilmington, Delaware, United States of America","institution_ids":["https://openalex.org/I4405265449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018193992","display_name":"Peggy Scherle","orcid":"https://orcid.org/0000-0003-0783-6815","observed_orcids":["https://orcid.org/0000-0003-0783-6815"]},"institutions":[{"id":"https://openalex.org/I4405265449","display_name":"Prelude Therapeutics Incorporated (United States)","ror":"https://ror.org/04v7ftc96","country_code":"US","type":"company","lineage":["https://openalex.org/I4405265449"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peggy Scherle","raw_affiliation_strings":["Prelude Therapeutics, Wilmington, Delaware, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prelude Therapeutics, Wilmington, Delaware, United States of America","institution_ids":["https://openalex.org/I4405265449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054730003","display_name":"Lapo Alinari","orcid":"https://orcid.org/0000-0002-8870-4162","observed_orcids":["https://orcid.org/0000-0002-8870-4162"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lapo Alinari","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043559536","display_name":"William C. Kisseberth","orcid":"https://orcid.org/0000-0002-5991-147X","observed_orcids":["https://orcid.org/0000-0002-5991-147X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William C. Kisseberth","raw_affiliation_strings":["Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, United States of America","Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012846289","display_name":"Robert A. Baiocchi","orcid":"https://orcid.org/0000-0002-1619-4853","observed_orcids":["https://orcid.org/0000-0002-1619-4853","https://orcid.org/0000-0002-6518-8169"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert A. Baiocchi","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012846289","https://openalex.org/A5043559536"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":1749,"currency":"USD","value_usd":1749},"apc_paid":{"value":1749,"currency":"USD","value_usd":1749},"fwci":0.4291,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.50817426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"5","first_page":"e0250839","last_page":"e0250839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prmt5","display_name":"PRMT5","score":0.9589999914169312},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/canine-lymphoma","display_name":"canine lymphoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-target-validation","display_name":"drug target validation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/prmt5-inhibitors","display_name":"PRMT5 inhibitors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/symmetric-dimethylarginine","display_name":"symmetric dimethylarginine","score":0.8569999933242798},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6940000057220459},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.6010000109672546},{"id":"https://openalex.org/keywords/preclinical-models","display_name":"preclinical models","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C111819275","wikidata":"https://www.wikidata.org/wiki/Q18035368","display_name":"Protein arginine methyltransferase 5","level":5,"score":0.9964619278907776},{"id":"https://openalex.org/C2908752941","wikidata":"https://www.wikidata.org/wiki/Q1710882","display_name":"Canine Lymphoma","level":3,"score":0.8521411418914795},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.7912909388542175},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6425914764404297},{"id":"https://openalex.org/C107006841","wikidata":"https://www.wikidata.org/wiki/Q18033533","display_name":"BCL10","level":3,"score":0.6058725714683533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.480367511510849},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.355252206325531},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3255576193332672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31459522247314453},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.3059248924255371},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23708948493003845},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1256641447544098},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09156879782676697}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011484","descriptor_name":"Protein-Arginine N-Methyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011484","descriptor_name":"Protein-Arginine N-Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011484","descriptor_name":"Protein-Arginine N-Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0250839","doi":"https://doi.org/10.1371/journal.pone.0250839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0250839","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0250839&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8121334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8121334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:33989303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33989303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d1c4a31ca6364acf832569091ac5b711","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d1c4a31ca6364acf832569091ac5b711","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 16, Iss 5, p e0250839 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0250839","doi":"https://doi.org/10.1371/journal.pone.0250839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0250839","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0250839&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1357606835","display_name":"The OSU Center for Clinical and Translational Science:  Advancing Today's Discoveries to Improve Health","funder_award_id":"UL1TR002733","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1858189645","display_name":null,"funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320309374","funder_display_name":"Ohio State University"},{"id":"https://openalex.org/G216896791","display_name":null,"funder_award_id":"UL1TR002733","funder_id":"https://openalex.org/F4320309374","funder_display_name":"Ohio State University"},{"id":"https://openalex.org/G2184239730","display_name":null,"funder_award_id":"D15CA-026","funder_id":"https://openalex.org/F4320306437","funder_display_name":"Morris Animal Foundation"},{"id":"https://openalex.org/G5429943178","display_name":null,"funder_award_id":"UL1TR002733","funder_id":"https://openalex.org/F4320332726","funder_display_name":"Center for Clinical and Translational Science, Ohio State University"},{"id":"https://openalex.org/G9000887552","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306437","display_name":"Morris Animal Foundation","ror":"https://ror.org/05pg13f04"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320324262","display_name":"Birla Institute of Scientific Research","ror":"https://ror.org/0203yhg37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332726","display_name":"Center for Clinical and Translational Science, Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3160465333.pdf","grobid_xml":"https://content.openalex.org/works/W3160465333.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W108421062","https://openalex.org/W120087923","https://openalex.org/W1510576016","https://openalex.org/W1520966126","https://openalex.org/W1927501023","https://openalex.org/W1964394233","https://openalex.org/W1965311748","https://openalex.org/W1982122127","https://openalex.org/W1982727560","https://openalex.org/W1993023587","https://openalex.org/W2012113208","https://openalex.org/W2016740911","https://openalex.org/W2026964909","https://openalex.org/W2037487541","https://openalex.org/W2042928743","https://openalex.org/W2046273050","https://openalex.org/W2046816028","https://openalex.org/W2054777324","https://openalex.org/W2055773216","https://openalex.org/W2066050590","https://openalex.org/W2068307354","https://openalex.org/W2071576183","https://openalex.org/W2073762029","https://openalex.org/W2087884748","https://openalex.org/W2091471291","https://openalex.org/W2101056961","https://openalex.org/W2102018890","https://openalex.org/W2109483174","https://openalex.org/W2109483913","https://openalex.org/W2109493630","https://openalex.org/W2116941797","https://openalex.org/W2117757143","https://openalex.org/W2120179724","https://openalex.org/W2125323275","https://openalex.org/W2135671816","https://openalex.org/W2137003359","https://openalex.org/W2144582719","https://openalex.org/W2147176162","https://openalex.org/W2156270057","https://openalex.org/W2183418069","https://openalex.org/W2204523824","https://openalex.org/W2401764427","https://openalex.org/W2497974852","https://openalex.org/W2518731208","https://openalex.org/W2608724752","https://openalex.org/W2750416916","https://openalex.org/W2800365069","https://openalex.org/W2800877169","https://openalex.org/W2801096810","https://openalex.org/W2886544137","https://openalex.org/W2888146818","https://openalex.org/W2895452350","https://openalex.org/W2899707256","https://openalex.org/W2902294835","https://openalex.org/W2907539128","https://openalex.org/W2911954550","https://openalex.org/W2912732106","https://openalex.org/W2921189699","https://openalex.org/W2944700391","https://openalex.org/W2945851909","https://openalex.org/W2963711558","https://openalex.org/W2990406257","https://openalex.org/W2995889831","https://openalex.org/W3011808378","https://openalex.org/W3043513814","https://openalex.org/W4247081894","https://openalex.org/W4256513946","https://openalex.org/W6978996086"],"related_works":["https://openalex.org/W2885956727","https://openalex.org/W2915161914","https://openalex.org/W2978895430","https://openalex.org/W4310112181","https://openalex.org/W2561574726","https://openalex.org/W2055773216","https://openalex.org/W2137003359","https://openalex.org/W2127645092","https://openalex.org/W2921189699","https://openalex.org/W2611057136"],"abstract_inverted_index":{"Non-Hodgkin":[0],"lymphoma":[1,70,78,85,104,166,183,194],"(NHL)":[2],"is":[3,36,52],"a":[4,53,80,90,177],"heterogeneous":[5],"group":[6],"of":[7,33,56,66,100,117,125,132,189,200,206],"blood":[8],"cancers":[9],"arising":[10],"in":[11,41,68,94,102,158,164],"lymphoid":[12,108],"tissues":[13],"that":[14,28],"commonly":[15],"effects":[16],"both":[17,42],"humans":[18],"and":[19,39,45,59,64,110,123,136,146,161,184],"dogs.":[20],"Protein":[21],"arginine":[22,34,139],"methyltransferase":[23],"5":[24],"(PRMT5),":[25],"an":[26],"enzyme":[27],"catalyzes":[29],"the":[30,62,186,190,197,204],"symmetric":[31,133,141],"di-methylation":[32],"residues,":[35],"frequently":[37],"overexpressed":[38],"dysregulated":[40],"human":[43,49,84,207],"solid":[44],"hematologic":[46],"malignancies.":[47],"In":[48],"lymphoma,":[50],"PRMT5":[51,67,88,101,118,170,175,201],"known":[54],"driver":[55],"malignant":[57],"transformation":[58],"oncogenesis,":[60],"however,":[61],"expression":[63,98,148],"role":[65],"canine":[69,77,103,111,165,182,193],"has":[71],"not":[72],"been":[73],"explored.":[74],"To":[75],"explore":[76],"as":[79,89,176],"useful":[81],"comparison":[82],"to":[83,120,154],"while":[86,127],"validating":[87],"rational":[91],"therapeutic":[92,179],"target":[93,180],"both,":[95],"we":[96],"characterized":[97],"patterns":[99],"tissue":[105],"microarrays,":[106],"primary":[107],"biopsies,":[109],"lymphoma-derived":[112],"cell":[113],"lines.":[114],"The":[115],"inhibition":[116],"led":[119],"growth":[121],"suppression":[122],"induction":[124],"apoptosis,":[126],"selectively":[128],"decreasing":[129],"global":[130],"marks":[131],"dimethylarginine":[134],"(SDMA)":[135],"histone":[137],"H4":[138],"3":[140],"dimethylation.":[142],"We":[143],"performed":[144],"ATAC-sequencing":[145],"gene":[147],"microarrays":[149],"with":[150],"pathway":[151],"enrichment":[152],"analysis":[153],"characterize":[155],"genome-wide":[156],"changes":[157,163],"chromatin":[159],"accessibility":[160],"whole-transcriptome":[162],"cells":[167],"lines":[168],"upon":[169],"inhibition.":[171],"This":[172],"work":[173],"validates":[174],"promising":[178],"for":[181,196,203],"supports":[185],"continued":[187],"use":[188],"spontaneously":[191],"occurring":[192],"model":[195],"preclinical":[198],"development":[199],"inhibitors":[202],"treatment":[205],"NHL.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-05-24T00:00:00"}