{"id":"https://openalex.org/W3159828296","doi":"https://doi.org/10.1210/jendso/bvab048.1577","title":"MicroRNA-21 Modulates White Adipose Tissue Browning and Altered Thermogenesis in a Mouse Model of Polycystic Ovary Syndrome","display_name":"MicroRNA-21 Modulates White Adipose Tissue Browning and Altered Thermogenesis in a Mouse Model of Polycystic Ovary Syndrome","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3159828296","doi":"https://doi.org/10.1210/jendso/bvab048.1577","mag":"3159828296"},"language":"en","primary_location":{"id":"doi:10.1210/jendso/bvab048.1577","doi":"https://doi.org/10.1210/jendso/bvab048.1577","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvab048.1577","pdf_url":"https://academic.oup.com/jes/article-pdf/5/Supplement_1/A775/37205546/bvab048.1577.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/jes/article-pdf/5/Supplement_1/A775/37205546/bvab048.1577.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077581148","display_name":"Samar Rezq","orcid":"https://orcid.org/0000-0003-4421-0686","observed_orcids":["https://orcid.org/0000-0003-4421-0686"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samar Rezq","raw_affiliation_strings":["UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011991388","display_name":"Alexandra M Huffman","orcid":"https://orcid.org/0000-0003-1223-1888","observed_orcids":["https://orcid.org/0000-0003-1223-1888"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra M Huffman","raw_affiliation_strings":["UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002898172","display_name":"Maryam Syed","orcid":"https://orcid.org/0000-0002-4920-7577","observed_orcids":["https://orcid.org/0000-0002-4920-7577"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Syed","raw_affiliation_strings":["UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059942058","display_name":"Jelina Basnet","orcid":"https://orcid.org/0000-0001-5282-3859","observed_orcids":["https://orcid.org/0000-0001-5282-3859"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jelina Basnet","raw_affiliation_strings":["UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033683577","display_name":"Jussara Marcia do Carmo","orcid":"https://orcid.org/0000-0003-0471-0512","observed_orcids":["https://orcid.org/0000-0003-0471-0512"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jussara M do Carmo","raw_affiliation_strings":["UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011992841","display_name":"Sydney P. Moak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sydney P Moak","raw_affiliation_strings":["UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001142311","display_name":"Licy L. Yanes Cardozo","orcid":"https://orcid.org/0000-0002-7295-1871","observed_orcids":["https://orcid.org/0000-0002-7295-1871"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Licy L Yanes Cardozo","raw_affiliation_strings":["UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082512025","display_name":"Dami\u00e1n G. Romero","orcid":"https://orcid.org/0000-0002-7268-9690","observed_orcids":["https://orcid.org/0000-0002-7268-9690"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Damian G Romero","raw_affiliation_strings":["UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MS, USA","institution_ids":["https://openalex.org/I29606459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I29606459"],"apc_list":{"value":2625,"currency":"USD","value_usd":2625},"apc_paid":{"value":2625,"currency":"USD","value_usd":2625},"fwci":0.1529,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.43293297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"5","issue":"Supplement_1","first_page":"A775","last_page":"A776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.968999981880188},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9049999713897705},{"id":"https://openalex.org/keywords/white-adipose-tissue-browning","display_name":"white adipose tissue browning","score":0.9649999737739563},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.8140000104904175},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.8460000157356262},{"id":"https://openalex.org/keywords/androgen-exposure","display_name":"androgen exposure","score":0.6389999985694885},{"id":"https://openalex.org/keywords/beige-adipose-tissue","display_name":"beige adipose tissue","score":0.6269999742507935},{"id":"https://openalex.org/keywords/ucp1","display_name":"UCP1","score":0.7020000219345093},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5899999737739563},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.746999979019165},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.6460000276565552},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8879945278167725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8799055814743042},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.7694226503372192},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.7535465359687805},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.743843674659729},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.6798590421676636},{"id":"https://openalex.org/C143128242","wikidata":"https://www.wikidata.org/wiki/Q18045527","display_name":"PRDM16","level":4,"score":0.5439993143081665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5057861804962158},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4560759365558624},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.4553965628147125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3219324052333832},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.20961645245552063},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.19859015941619873},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16747647523880005}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1210/jendso/bvab048.1577","doi":"https://doi.org/10.1210/jendso/bvab048.1577","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvab048.1577","pdf_url":"https://academic.oup.com/jes/article-pdf/5/Supplement_1/A775/37205546/bvab048.1577.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8090175","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8090175","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocr Soc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1210/jendso/bvab048.1577","doi":"https://doi.org/10.1210/jendso/bvab048.1577","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvab048.1577","pdf_url":"https://academic.oup.com/jes/article-pdf/5/Supplement_1/A775/37205546/bvab048.1577.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3159828296.pdf","grobid_xml":"https://content.openalex.org/works/W3159828296.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400486927","https://openalex.org/W3016929965","https://openalex.org/W4308138368","https://openalex.org/W4319238214","https://openalex.org/W3118197256","https://openalex.org/W4225393621","https://openalex.org/W4401276890","https://openalex.org/W4416439336","https://openalex.org/W2905585023","https://openalex.org/W7154610457"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,12,17,30,63,77,83,123,151,162,164,167,176,192,215,248,252,267,329,365,381,416,424],"Aim:":[3],"Polycystic":[4],"ovary":[5],"syndrome":[6],"(PCOS)":[7],"is":[8],"associated":[9],"with":[10,99,256,293,333],"obesity,":[11],"white":[13],"adipose":[14,19,47,371],"tissue":[15,20,48,372],"(WAT)":[16],"brown":[18,60],"(BAT)":[21],"dysregulation.":[22],"However,":[23],"the":[24,69,257,315,350,353,356,383,402],"molecular":[25],"mechanisms":[26],"that":[27,370],"mediate":[28],"WAT":[29,40],"BAT":[31,249],"derangements":[32,79],"in":[33,59,74,80,174,224,234,245,265,271,280,303,342,345,349,355,362,379,386],"PCOS":[34,380],"are":[35],"poorly":[36],"understood.":[37],"Subcutaneous":[38],"(SC)":[39],"(SC-WAT)":[41],"can":[42],"transition":[43],"to":[44,67,325,414,420],"a":[45,323,376,397],"beige/brite":[46],"phenotype":[49],"(browning)":[50],"under":[51],"altered":[52],"thermogenic":[53],"conditions.":[54],"MicroRNAs":[55],"play":[56],"critical":[57],"functions":[58],"adipocyte":[61],"differentiation":[62],"maintenance.":[64],"We":[65],"aim":[66],"study":[68],"role":[70,378],"of":[71,392,404],"microRNA-21":[72],"(miR-21)":[73],"androgen-mediated":[75],"browning":[76,157,228,346],"beiging":[78,165,358],"both":[81,246],"SC-WAT":[82,175,247,266],"BAT.":[84,177,272],"Methods:":[85],"Three":[86],"week-old":[87],"miR-21":[88,373,393],"knockout":[89],"(miR21KO)":[90],"or":[91,105,222,306],"wild":[92],"type":[93],"(WT)":[94],"female":[95],"mice":[96,275,321],"were":[97,128,230,262],"treated":[98],"dihydrotestosterone":[100],"(DHT,":[101],"8":[102],"mg/silastic":[103],"tube)":[104],"vehicle":[106],"for":[107,156,401],"90":[108],"days":[109],"(n=12/grp).":[110],"Body":[111],"composition":[112],"was":[113,135,145,170,360],"measured":[114,129,136],"by":[115,130,137,172,232,314,409],"EchoMRI.":[116],"Energy":[117],"expenditure":[118],"(EE),":[119],"oxygen":[120],"consumption":[121],"(VO2),":[122],"carbon":[124],"dioxide":[125],"production":[126],"(VCO2)":[127],"indirect":[131],"calorimetry.":[132],"Glucose":[133],"homeostasis":[134],"oral":[138],"glucose":[139,150],"tolerance":[140],"test":[141],"(OGTT).":[142],"HOMA-IR":[143,316],"index":[144],"calculated":[146,313],"from":[147],"fasting":[148],"serum":[149],"insulin":[152,310],"levels.":[153],"Gene":[154,336],"expression":[155,337,348],"(UCP1,":[158],"Cox7a1,":[159],"Elov3,":[160],"Dio2":[161],"Cidea)":[163],"(Hspb7":[166],"Txb1)":[168],"markers":[169,229,261,347],"quantified":[171],"RT-qPCR":[173],"Results:":[178],"DHT":[179,233],"increased":[180],"body":[181,281],"weight":[182,282],"(25.07":[183],"\u00b1":[184,188,196,200,207,211,284,288],"0.52":[185,289],"vs":[186,198,209,286],"21.79":[187],"0.47":[189],"g,":[190,202,290],"p<0.05)":[191,291],"fat":[193,304],"mass":[194,305],"(4.60":[195],"0.46":[197],"1.98":[199],"0.12":[201],"p<0.05),":[203,214],"impaired":[204],"OGTT":[205,307],"(186.10":[206],"5.99":[208],"250.70":[210],"14.76":[212],"mg.min/dL,":[213],"did":[216,268,298],"not":[217,269,299],"significantly":[218,263],"change":[219,270],"EE,":[220,327],"VO2":[221,328],"VCO2":[223,330],"WT":[225,294],"mice.":[226,259,295],"All":[227],"downregulated":[231],"SC-WAT;":[235],"however,":[236],"only":[237],"iodothyronine":[238],"deiodinase":[239],"2":[240],"(Dio2)":[241],"downregulation":[242],"reached":[243],"significance":[244],"(by":[250],"53":[251],"40%,":[253],"respectively)":[254],"compared":[255,292,332],"vehicle-treated":[258],"Beiging":[260],"upregulated":[264],"DHT-treated":[273,319,334],"miR21KO":[274,320],"showed":[276,322,339],"attenuated":[277],"DHT-mediated":[278,301,343,384],"increase":[279,302],"(23.84":[283],"0.99":[285],"25.07":[287],"MiR-21":[296],"ablation":[297],"modify":[300],"but":[308],"worsened":[309],"resistance":[311],"as":[312],"index.":[317],"Additionally,":[318,352],"trend":[324],"reduced":[326],"values":[331],"WT.":[335],"analysis":[338],"an":[340],"exacerbation":[341],"reduction":[344],"SC-WAT.":[351,363],"induction":[354],"adaptive":[357],"response":[359],"abolished":[361],"Conclusion":[364],"Significance:":[366],"These":[367],"findings":[368],"suggest":[369],"may":[374],"have":[375],"protective":[377],"ameliorate":[382],"decrease":[385],"energy":[387],"expenditure.":[388],"Adipose":[389],"tissue-specific":[390],"modulation":[391],"levels":[394],"could":[395],"be":[396],"novel":[398],"therapeutic":[399],"approach":[400],"treatment":[403],"PCOS-associated":[405],"metabolic":[406],"derangements.":[407],"(Supported":[408],"NIH":[410],"grants":[411],"NIGMS":[412,422],"P20GM121334":[413],"LLYC":[415],"DGR,":[417,421],"NIDDK":[418],"R21DK113500":[419],"P20GM104357":[423],"NHLBI":[425],"P01HL51971).":[426]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-05-10T00:00:00"}