{"id":"https://openalex.org/W3159532101","doi":"https://doi.org/10.1210/jendso/bvab048.1644","title":"Estrogen Receptor Alpha Is Required to Protect Daily Metabolic Rhythms From Disruption by High-Fat Feeding in Female Mice","display_name":"Estrogen Receptor Alpha Is Required to Protect Daily Metabolic Rhythms From Disruption by High-Fat Feeding in Female Mice","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3159532101","doi":"https://doi.org/10.1210/jendso/bvab048.1644","mag":"3159532101"},"language":"en","primary_location":{"id":"doi:10.1210/jendso/bvab048.1644","doi":"https://doi.org/10.1210/jendso/bvab048.1644","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvab048.1644","pdf_url":null,"source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1210/jendso/bvab048.1644","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068379670","display_name":"Oluwabukola B. Omotola","orcid":"https://orcid.org/0000-0001-8899-756X","observed_orcids":["https://orcid.org/0000-0001-8899-756X"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oluwabukola B Omotola","raw_affiliation_strings":["UNIVERSITY OF KENTUCKY, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF KENTUCKY, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082649459","display_name":"Julie S. Pendergast","orcid":"https://orcid.org/0000-0001-7299-6589","observed_orcids":["https://orcid.org/0000-0001-7299-6589"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie S Pendergast","raw_affiliation_strings":["UNIVERSITY OF KENTUCKY, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF KENTUCKY, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":2625,"currency":"USD","value_usd":2625},"apc_paid":{"value":2625,"currency":"USD","value_usd":2625},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"Supplement_1","first_page":"A808","last_page":"A808"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.597000002861023},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.8809999823570251},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8180000185966492},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/feeding-behavior","display_name":"feeding behavior","score":0.3540000021457672},{"id":"https://openalex.org/keywords/locomotor-activity-rhythm","display_name":"locomotor activity rhythm","score":0.9269999861717224},{"id":"https://openalex.org/keywords/liver-clock","display_name":"liver clock","score":0.6179999709129333},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/metabolic-rhythms","display_name":"metabolic rhythms","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8341885805130005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8234997987747192},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7268644571304321},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6586229205131531},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6522167325019836},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.6300071477890015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6081464290618896},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5712733268737793},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.503048837184906},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4173269271850586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23150122165679932},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1210/jendso/bvab048.1644","doi":"https://doi.org/10.1210/jendso/bvab048.1644","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvab048.1644","pdf_url":null,"source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8089639","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8089639","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocr Soc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1210/jendso/bvab048.1644","doi":"https://doi.org/10.1210/jendso/bvab048.1644","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvab048.1644","pdf_url":null,"source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3175686190","https://openalex.org/W7138407631","https://openalex.org/W2601179638","https://openalex.org/W6903771758","https://openalex.org/W7162081911","https://openalex.org/W1992794338","https://openalex.org/W2558169831","https://openalex.org/W6960038492","https://openalex.org/W7160732771","https://openalex.org/W3176621167"],"abstract_inverted_index":{"Abstract":[0],"The":[1,176],"circadian":[2,94,183],"system":[3],"is":[4,18,44],"a":[5],"critical":[6],"regulator":[7],"of":[8,132,136,152,168,198],"obesity":[9],"in":[10,16,32,61,74,85,139,172,191,210,238],"male":[11],"mice,":[12],"but":[13,41,142],"its":[14],"role":[15],"females":[17,75,118,194],"poorly":[19],"understood.":[20],"In":[21,147,161],"our":[22],"previous":[23],"studies":[24],"we":[25,64,81],"found":[26],"that":[27,68,223],"estrogen":[28,51,69,224],"regulates":[29,70],"daily":[30,71,83,134,230],"rhythms":[31,73,84,232],"female":[33,86,106,145,239],"mice":[34,97,107,213],"to":[35,38,55,121,215,228],"confer":[36],"resistance":[37],"diet-induced":[39,122],"obesity,":[40],"the":[42,49,66,93,130,133,150,153,166,169,196,199],"mechanism":[43],"unknown.":[45],"Estrogen":[46],"signals":[47,225],"via":[48,76,226],"classical":[50],"receptor":[52],"alpha":[53],"(ER\u03b1)":[54],"regulate":[56],"metabolism":[57],"and":[58,110,181],"obesity.":[59,123],"Therefore,":[60],"this":[62],"study":[63],"tested":[65],"hypothesis":[67],"metabolic":[72,231],"ER\u03b1.":[77],"To":[78],"do":[79],"so,":[80],"studied":[82],"global":[87],"ER\u03b1":[88,104,140,173,192,211,227],"knockout":[89],"(ER\u03b1":[90],"KO)":[91],"with":[92],"reporter,":[95],"PERIOD2::LUCIFERASE,":[96],"fed":[98,113],"high-fat":[99,114,125,159,163,189,208,236],"diet":[100,126],"for":[101],"6":[102],"weeks.":[103],"KO":[105,174,193,212],"became":[108],"obese":[109],"hyperglycemic":[111],"when":[112],"diet,":[115],"while":[116],"wild-type":[117,148,216],"were":[119],"resistant":[120],"Chronic":[124],"feeding":[127,164,190,209,237],"also":[128],"reduced":[129],"amplitude":[131,151,167],"rhythm":[135,156,171,202],"eating":[137],"behavior":[138],"KO,":[141],"not":[143],"wild-type,":[144],"mice.":[146,240],"females,":[149],"locomotor":[154],"activity":[155,170],"increased":[157],"during":[158],"feeding.":[160],"contrast,":[162],"decreased":[165],"females.":[175,217],"temporal":[177],"relationship":[178],"between":[179],"central":[180],"peripheral":[182],"tissue":[184],"clocks":[185],"was":[186,203],"disrupted":[187],"by":[188,207,235],"since":[195],"phase":[197],"liver":[200],"PERIOD2::LUCIFERASE":[201],"advanced":[204],"4":[205],"hours":[206],"compared":[214],"Taken":[218],"together":[219],"these":[220],"results":[221],"show":[222],"protect":[229],"from":[233],"disruption":[234]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-05-10T00:00:00"}