{"id":"https://openalex.org/W3159024924","doi":"https://doi.org/10.1201/b15029-14","title":"The 21-Gene Recurrence Score and Benefit of Chemotherapy in Estrogen Receptor-Positive Breast Cancer","display_name":"The 21-Gene Recurrence Score and Benefit of Chemotherapy in Estrogen Receptor-Positive Breast Cancer","publication_year":2013,"publication_date":"2013-06-12","ids":{"openalex":"https://openalex.org/W3159024924","doi":"https://doi.org/10.1201/b15029-14","mag":"3159024924"},"language":"en","primary_location":{"id":"doi:10.1201/b15029-14","doi":"https://doi.org/10.1201/b15029-14","is_oa":false,"landing_page_url":"https://doi.org/10.1201/b15029-14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463722","display_name":"Pan Stanford Publishing eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Therapeutic Biomarkers in Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2489197069","display_name":"Handbook of Therapeutic Biomarkers in Cancer"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084515472","display_name":"Petra Rietschel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Petra Rietschel","raw_affiliation_strings":["Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085875361","display_name":"Joseph A. Sparano","orcid":"https://orcid.org/0000-0002-9031-2010","observed_orcids":["https://orcid.org/0000-0002-9031-2010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Sparano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43485086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"369","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncotype-dx","display_name":"Oncotype DX","score":0.9359999895095825},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.8679999709129333},{"id":"https://openalex.org/keywords/chemotherapy-benefit","display_name":"chemotherapy benefit","score":0.7960000038146973},{"id":"https://openalex.org/keywords/sn-38","display_name":"SN-38","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sn-38-glucuronide","display_name":"SN-38 glucuronide","score":0.8220000267028809},{"id":"https://openalex.org/keywords/ugt1a1","display_name":"UGT1A1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ugt1a9","display_name":"UGT1A9","score":0.8119999766349792},{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.8100000023841858},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.7549999952316284},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.7110000252723694},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4560000002384186},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7839999794960022},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7682440280914307},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6629055738449097},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6175912618637085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6085826754570007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5757918357849121},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.492726594209671},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4694368839263916},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3775707185268402}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1201/b15029-14","doi":"https://doi.org/10.1201/b15029-14","is_oa":false,"landing_page_url":"https://doi.org/10.1201/b15029-14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463722","display_name":"Pan Stanford Publishing eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Therapeutic Biomarkers in Cancer","raw_type":"book-chapter"},{"id":"mag:3159024924","doi":null,"is_oa":false,"landing_page_url":"https://einstein.pure.elsevier.com/en/publications/the-21-gene-recurrence-score-and-benefit-of-chemotherapy-in-estro","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W41523064","https://openalex.org/W1248101097","https://openalex.org/W1575982426","https://openalex.org/W1990364400","https://openalex.org/W1991981766","https://openalex.org/W2002525399","https://openalex.org/W2028236537","https://openalex.org/W2036561111","https://openalex.org/W2043103956","https://openalex.org/W2043235003","https://openalex.org/W2045216597","https://openalex.org/W2051352765","https://openalex.org/W2054942267","https://openalex.org/W2061564540","https://openalex.org/W2084453514","https://openalex.org/W2096910745","https://openalex.org/W2097977223","https://openalex.org/W2097996372","https://openalex.org/W2099832063","https://openalex.org/W2105882193","https://openalex.org/W2106787323","https://openalex.org/W2106811951","https://openalex.org/W2112071941","https://openalex.org/W2112780046","https://openalex.org/W2113769864","https://openalex.org/W2115581335","https://openalex.org/W2117305280","https://openalex.org/W2124640147","https://openalex.org/W2125979795","https://openalex.org/W2128054670","https://openalex.org/W2130639106","https://openalex.org/W2145747877","https://openalex.org/W2151447010","https://openalex.org/W2154582208","https://openalex.org/W2160377567","https://openalex.org/W2163289463","https://openalex.org/W2167730204","https://openalex.org/W2311660836","https://openalex.org/W2590195772"],"related_works":["https://openalex.org/W3029489750","https://openalex.org/W2148623336","https://openalex.org/W2323733603","https://openalex.org/W1981865361","https://openalex.org/W2334813927","https://openalex.org/W2264136803","https://openalex.org/W2182062247","https://openalex.org/W2883536634","https://openalex.org/W2794539234","https://openalex.org/W2417967215","https://openalex.org/W2519727073","https://openalex.org/W2939812112","https://openalex.org/W288898470","https://openalex.org/W334681667","https://openalex.org/W1992814383","https://openalex.org/W2884715656","https://openalex.org/W2527855922","https://openalex.org/W2032234469","https://openalex.org/W1983551749","https://openalex.org/W2056963856"],"abstract_inverted_index":{"Figure":[0],"12.1":[1],"The":[2,31],"conversion":[3,54,99],"of":[4,23,33,66,100,127,130],"the":[5,8,26,36,50,69,98,103,125,131],"irinotecan":[6,101,128],"to":[7,29,35,56,73,80,102],"active":[9],"metabolite,":[10],"7-ethyl-10-hydroxycamptothecin":[11],"(SN-38)":[12],"is":[13,40,47,58,78],"catalyzed":[14,41,59,85],"by":[15,42,60,86],"carboxyesterase":[16],"(CES)":[17],"1":[18],"and":[19,44,89,95,110,121],"2.":[20],"Prolonged":[21],"levels":[22,65],"SN-38":[24,34,67,77],"in":[25,49,68],"plasma":[27],"leads":[28],"neutropenia.":[30],"inactivation":[32],"glucuronide":[37],"form":[38],"(SN-38G)":[39],"UGT1A1":[43],"UGT1A9.":[45,90],"SN-38G":[46,81],"excreted":[48],"bile,":[51],"where":[52],"its":[53],"back":[55],"SN38":[57],"enteric":[61],"bacterial":[62],"\u00df-glucuronidase.":[63],"Increased":[64],"intestine":[70],"can":[71],"lead":[72],"severe":[74],"diarrhea.":[75],"Extrahepatic":[76],"inactivated":[79],"through":[82],"a":[83],"reaction":[84],"UGT1A1,":[87],"UGT1A7,":[88],"Cytochrome":[91],"P-450":[92],"(CYP)":[93],"3A4":[94],"3A5":[96],"catalyze":[97,124],"inactive":[104],"metabolites":[105],"7-ethyl-10-[4-N-(5-aminopentanoic":[106],"acid)-1-piperidino]":[107],"carbonyloxycamptothecin":[108,112],"(APC)":[109],"7-ethyl-10-[4-amino-1-piperidino]":[111],"(NPC).":[113],"Adenosine":[114],"triphosphate-binding":[115],"cassette":[116],"(ABC)":[117],"B1,":[118],"C1,":[119],"C2,":[120],"G2":[122],"function":[123],"transport":[126],"out":[129],"liver.":[132],"Modified":[133],"from":[134],"[2,9].":[135]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2025-10-10T00:00:00"}