{"id":"https://openalex.org/W3158986010","doi":"https://doi.org/10.1210/jendso/bvab048.1906","title":"Hashimoto\u2019s Thyroiditis Presenting With Hoffman\u2019s Syndrome in a Patient With the Coronavirus Disease 2019 (COVID 19): Hormone Replacement in the Time of the Pandemic","display_name":"Hashimoto\u2019s Thyroiditis Presenting With Hoffman\u2019s Syndrome in a Patient With the Coronavirus Disease 2019 (COVID 19): Hormone Replacement in the Time of the Pandemic","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3158986010","doi":"https://doi.org/10.1210/jendso/bvab048.1906","mag":"3158986010","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8089815"},"language":"en","primary_location":{"id":"doi:10.1210/jendso/bvab048.1906","doi":"https://doi.org/10.1210/jendso/bvab048.1906","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvab048.1906","pdf_url":"https://academic.oup.com/jes/article-pdf/5/Supplement_1/A932/37203713/bvab048.1906.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/jes/article-pdf/5/Supplement_1/A932/37203713/bvab048.1906.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031731784","display_name":"Ramon B. Larrazabal","orcid":"https://orcid.org/0000-0003-1135-6400","observed_orcids":["https://orcid.org/0000-0003-1135-6400"]},"institutions":[{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Ramon Bagaporo Larrazabal","raw_affiliation_strings":["University of the Philippines Manila, Metro Manila, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the Philippines Manila, Metro Manila, Philippines","institution_ids":["https://openalex.org/I5791819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007085030","display_name":"Harold Henrison C. Chiu","orcid":"https://orcid.org/0000-0002-2021-7843","observed_orcids":["https://orcid.org/0000-0002-2021-7843"]},"institutions":[{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Harold Henrison Chang Chiu","raw_affiliation_strings":["University of the Philippines Manila, Metro Manila, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the Philippines Manila, Metro Manila, Philippines","institution_ids":["https://openalex.org/I5791819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009501202","display_name":"Franz Michael Magnaye","orcid":"https://orcid.org/0000-0003-3320-6155","observed_orcids":["https://orcid.org/0000-0003-3320-6155"]},"institutions":[{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Franz Michael Millar Magnaye","raw_affiliation_strings":["UNIVERSITY OF THE PHILIPPINES MANILA, Sto. Tomas, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF THE PHILIPPINES MANILA, Sto. Tomas, Philippines","institution_ids":["https://openalex.org/I5791819"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058827397","display_name":"Laura Trajano Acampado","orcid":"https://orcid.org/0000-0002-0891-5999","observed_orcids":["https://orcid.org/0000-0002-0891-5999"]},"institutions":[{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Laura T Acampado","raw_affiliation_strings":["University of the Philippines Manila, Metro Manila, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the Philippines Manila, Metro Manila, Philippines","institution_ids":["https://openalex.org/I5791819"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5791819"],"apc_list":{"value":2625,"currency":"USD","value_usd":2625},"apc_paid":{"value":2625,"currency":"USD","value_usd":2625},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"Supplement_1","first_page":"A932","last_page":"A933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hashimoto-s-thyroiditis","display_name":"Hashimoto's thyroiditis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.8510000109672546},{"id":"https://openalex.org/keywords/primary-hypothyroidism","display_name":"primary hypothyroidism","score":0.8009999990463257},{"id":"https://openalex.org/keywords/thyroid-hormone-replacement-therapy","display_name":"thyroid hormone replacement","score":0.628000020980835},{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.7480000257492065},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7400000095367432},{"id":"https://openalex.org/keywords/anti-thyroid-peroxidase-antibodies","display_name":"thyroid peroxidase antibodies","score":0.7300000190734863},{"id":"https://openalex.org/keywords/muscle-weakness","display_name":"muscle weakness","score":0.5059999823570251},{"id":"https://openalex.org/keywords/pseudohypertrophy","display_name":"pseudohypertrophy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/acute-respiratory-failure","display_name":"acute respiratory failure","score":0.621999979019165},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.5149999856948853},{"id":"https://openalex.org/keywords/hemoperfusion","display_name":"hemoperfusion","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.726771891117096},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5033676028251648},{"id":"https://openalex.org/C2776418732","wikidata":"https://www.wikidata.org/wiki/Q270421","display_name":"Muscle weakness","level":2,"score":0.49764111638069153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49325793981552124},{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.48852217197418213},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.48370033502578735},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3810497522354126},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.2958392798900604}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1210/jendso/bvab048.1906","doi":"https://doi.org/10.1210/jendso/bvab048.1906","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvab048.1906","pdf_url":"https://academic.oup.com/jes/article-pdf/5/Supplement_1/A932/37203713/bvab048.1906.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8089815","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8089815/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocr Soc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1210/jendso/bvab048.1906","doi":"https://doi.org/10.1210/jendso/bvab048.1906","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvab048.1906","pdf_url":"https://academic.oup.com/jes/article-pdf/5/Supplement_1/A932/37203713/bvab048.1906.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3158986010.pdf","grobid_xml":"https://content.openalex.org/works/W3158986010.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3043082091","https://openalex.org/W4293206595","https://openalex.org/W4387798018","https://openalex.org/W4402903807","https://openalex.org/W4200406013","https://openalex.org/W4410263002","https://openalex.org/W3196851470","https://openalex.org/W4308133039","https://openalex.org/W4403149270","https://openalex.org/W4288049305"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Hoffmann\u2019s":[2],"syndrome":[3],"is":[4,246,360,372],"a":[5,78,84,219,374,389],"very":[6],"rare":[7],"and":[8,23,44,58,62,94,117,151,165,209,238,266,308,329,370],"reversible":[9],"manifestation":[10],"of":[11,17,83,98,221,272,301,344,364,394],"hypothyroidism":[12,18,180],"presenting":[13],"as":[14,282,348],"classic":[15],"features":[16],"with":[19,140,178,248,355],"muscle":[20,113,224],"stiffness,":[21],"weakness,":[22],"pseudohypertrophy.":[24],"Clinical":[25],"Case:":[26],"A":[27],"62-year-old":[28],"man":[29],"was":[30,53,59,126,159,171,218,252,280],"admitted":[31,128],"to":[32,36,64,228,254,264,316,318,342,376],"our":[33],"institution":[34],"due":[35],"dyspnea.":[37],"He":[38,89,158,251],"also":[39],"had":[40,90,108],"progressive":[41],"muscular":[42],"weakness":[43,114],"recurrent":[45],"cramps":[46],"four":[47],"months":[48],"prior.":[49],"On":[50,104],"admission,":[51],"he":[52,107,260,323],"seen":[54],"in":[55],"respiratory":[56,69],"distress":[57],"eventually":[60],"intubated":[61],"hooked":[63],"mechanical":[65],"ventilation":[66],"for":[67],"acute":[68],"failure":[70],"brought":[71],"about":[72],"by":[73,77],"COVID-19":[74,141],"pneumonia":[75],"(confirmed":[76],"reverse":[79],"transcriptase-polymerase":[80],"chain":[81],"reaction":[82],"nasopharyngeal":[85],"swab":[86],"on":[87],"admission).":[88],"an":[91,283],"unremarkable":[92],"head":[93],"neck":[95],"examination;":[96],"both":[97],"his":[99,304],"calf":[100],"muscles":[101],"were":[102,121,142,176,226,314],"hypertrophied.":[103],"neurological":[105],"examination,":[106],"mild":[109],"proximal":[110],"lower":[111],"limb":[112],"(power":[115],"4/5)":[116],"deep":[118],"tendon":[119],"reflexes":[120],"sluggish":[122],"(+1).":[123],"The":[124],"patient":[125],"subsequently":[127],"into":[129,325],"the":[130,270,286,296,332,362],"intensive":[131],"care":[132],"unit.":[133],"Laboratory":[134],"data":[135],"showed":[136],"inflammatory":[137],"markers":[138],"associated":[139],"elevated:":[143],"Lactate":[144],"Dehydrogenase":[145],"(857":[146],"u/L;":[147],"NV:":[148,155,187,193,199,206,214,235,242],"120-246":[149],"u/L)":[150],"Interleukin-6":[152],"(137":[153],"pg/mL;":[154],"0-50":[156],"pg/mL).":[157],"given":[160,281],"tocilizumab,":[161],"convalescent":[162],"plasma":[163],"therapy,":[164],"underwent":[166],"hemoperfusion.":[167],"His":[168],"serum":[169],"chemistry":[170],"unremarkable.":[172],"Thyroid":[173],"function":[174],"tests":[175],"consistent":[177,247],"primary":[179],"from":[181],"Hashimoto\u2019s":[182,349],"thyroiditis:":[183],"TSH":[184],"(22.6712":[185],"UIU/mL;":[186],"0.35-4.94":[188],"UIU/mL),":[189],"fT3":[190],"(<2.30":[191],"PMOL/L;":[192,198],"2.89-4.88":[194],"PMOL/L),":[195,201],"fT4":[196],"(<5.15":[197],"9.01-19.05":[200],"anti-Tg":[202],"Ab":[203,211],"(1810.3":[204],"IU/mL;":[205,213],"<50":[207],"IU/mL)":[208],"Anti-TPO":[210],"(2610.4":[212],"<100":[215],"IU/mL).":[216],"There":[217],"consideration":[220],"Hoffman\u2019s":[222,249,356],"syndrome;":[223],"enzymes":[225],"noted":[227],"be":[229],"elevated":[230],"also:":[231],"CK-Total":[232],"(2589":[233],"U/L;":[234,241],"55-170":[236],"U/L)":[237],"CK-MB":[239],"(85.7":[240],"0-16":[243],"U/L).":[244],"This":[245],"syndrome.":[250],"supposed":[253],"start":[255],"hormone":[256,302,378],"replacement":[257,359],"therapy.":[258],"However,":[259],"developed":[261],"ileus":[262],"(attributed":[263],"sepsis":[265],"hypothyroidism)":[267],"which":[268],"precluded":[269],"use":[271],"oral":[273,297,319],"levothyroxine.":[274],"To":[275],"circumvent":[276],"this":[277,352],"roadblock,":[278],"levothyroxine":[279,320],"enema":[284],"via":[285],"rectal":[287],"route":[288],"at":[289],"300":[290],"mcg":[291],"once":[292],"daily":[293],"(approximately":[294],"twice":[295],"dose).":[298],"Upon":[299],"initiation":[300],"replacement,":[303],"sensorium,":[305],"hemodynamic":[306],"parameters,":[307],"bowel":[309],"movement":[310],"improved.":[311],"Thus,":[312],"we":[313],"able":[315],"shift":[317],"eventually.":[321],"Unfortunately,":[322],"went":[324],"sudden":[326],"cardiac":[327],"arrest":[328],"expired":[330],"after":[331],"11th":[333],"hospital":[334],"day.":[335],"Conclusion:":[336],"COVID":[337,367],"19":[338,368],"infection":[339,369],"could":[340],"lead":[341],"exacerbations":[343],"pre-existing":[345],"conditions":[346],"such":[347],"Thyroiditis":[350],"(in":[351],"case,":[353],"manifesting":[354],"syndrome).":[357],"Hormone":[358],"still":[361],"treatment":[363,371],"choice.":[365],"Concomitant":[366],"not":[373],"contraindication":[375],"delay":[377],"replacement.":[379],"Reference:":[380],"(1)":[381],"Senanayake,":[382],"Hemal":[383],"Ms":[384],"et":[385],"al.":[386],"\u201cHoffmann":[387],"syndrome:":[388],"case":[390],"report.\u201d":[391],"International":[392],"archives":[393],"medicine":[395],"vol.":[396],"7,1":[397],"2.":[398],"6":[399],"Jan.":[400],"2014,":[401],"doi:10.1186/1755-7682-7-2.":[402]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-05-10T00:00:00"}