{"id":"https://openalex.org/W3158043263","doi":"https://doi.org/10.1016/j.phymed.2021.153589","title":"Anti-inflammatory and tight junction protective activity of the herbal preparation STW 5-II on mouse intestinal organoids","display_name":"Anti-inflammatory and tight junction protective activity of the herbal preparation STW 5-II on mouse intestinal organoids","publication_year":2021,"publication_date":"2021-05-06","ids":{"openalex":"https://openalex.org/W3158043263","doi":"https://doi.org/10.1016/j.phymed.2021.153589","mag":"3158043263","pmid":"https://pubmed.ncbi.nlm.nih.gov/34111617"},"language":"en","primary_location":{"id":"doi:10.1016/j.phymed.2021.153589","doi":"https://doi.org/10.1016/j.phymed.2021.153589","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2021.153589","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.phymed.2021.153589","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112695181","display_name":"Mohamed Elbadawi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mohamed Elbadawi","raw_affiliation_strings":["Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074542878","display_name":"Ramy M. Ammar","orcid":"https://orcid.org/0000-0002-5183-2232","observed_orcids":["https://orcid.org/0000-0002-5183-2232"]},"institutions":[{"id":"https://openalex.org/I4405269851","display_name":"Bayer Consumer Health (Germany)","ror":"https://ror.org/05dz2s881","country_code":"DE","type":"company","lineage":["https://openalex.org/I4405269851"]},{"id":"https://openalex.org/I4405270706","display_name":"Steigerwald Arzneimittelwerk (Germany)","ror":"https://ror.org/016tgjt09","country_code":"DE","type":"company","lineage":["https://openalex.org/I4405270706"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ramy M. Ammar","raw_affiliation_strings":["Bayer Consumer Health, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Consumer Health, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany","institution_ids":["https://openalex.org/I4405269851","https://openalex.org/I4405270706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071514675","display_name":"Heba Aziz-Kalbhenn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269851","display_name":"Bayer Consumer Health (Germany)","ror":"https://ror.org/05dz2s881","country_code":"DE","type":"company","lineage":["https://openalex.org/I4405269851"]},{"id":"https://openalex.org/I4405270706","display_name":"Steigerwald Arzneimittelwerk (Germany)","ror":"https://ror.org/016tgjt09","country_code":"DE","type":"company","lineage":["https://openalex.org/I4405270706"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heba Aziz-Kalbhenn","raw_affiliation_strings":["Bayer Consumer Health, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Consumer Health, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany","institution_ids":["https://openalex.org/I4405269851","https://openalex.org/I4405270706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073352777","display_name":"Sabine Rabini","orcid":"https://orcid.org/0000-0002-2619-3491","observed_orcids":["https://orcid.org/0000-0002-2619-3491"]},"institutions":[{"id":"https://openalex.org/I4405269851","display_name":"Bayer Consumer Health (Germany)","ror":"https://ror.org/05dz2s881","country_code":"DE","type":"company","lineage":["https://openalex.org/I4405269851"]},{"id":"https://openalex.org/I4405270706","display_name":"Steigerwald Arzneimittelwerk (Germany)","ror":"https://ror.org/016tgjt09","country_code":"DE","type":"company","lineage":["https://openalex.org/I4405270706"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Rabini","raw_affiliation_strings":["Bayer Consumer Health, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2619-3491","affiliations":[{"raw_affiliation_string":"Bayer Consumer Health, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany","institution_ids":["https://openalex.org/I4405269851","https://openalex.org/I4405270706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081738047","display_name":"Sabine M. Klauck","orcid":"https://orcid.org/0000-0001-7293-9920","observed_orcids":["https://orcid.org/0000-0001-7293-9920"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine M. Klauck","raw_affiliation_strings":["Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210111460","https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mona Dawood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I224517680","display_name":"Al-Neelain University","ror":"https://ror.org/05dvsnx49","country_code":"SD","type":"education","lineage":["https://openalex.org/I224517680"]}],"countries":["DE","SD"],"is_corresponding":false,"raw_author_name":"Mona Dawood","raw_affiliation_strings":["Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany; Department of Molecular Biology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan","Department of Molecular Biology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan","Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany; Department of Molecular Biology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I224517680"]},{"raw_affiliation_string":"Department of Molecular Biology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan","institution_ids":["https://openalex.org/I224517680"]},{"raw_affiliation_string":"Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101422891","display_name":"Mohamed E.M. Saeed","orcid":"https://orcid.org/0000-0003-1944-8043","observed_orcids":["https://orcid.org/0000-0003-1944-8043"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mohamed E M Saeed","raw_affiliation_strings":["Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088849372","display_name":"Christopher Johannes Kampf","orcid":"https://orcid.org/0000-0002-8751-5140","observed_orcids":["https://orcid.org/0000-0002-8751-5140"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christopher J. Kampf","raw_affiliation_strings":["Department of Chemistry, Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033575797","display_name":"Thomas Efferth","orcid":"https://orcid.org/0000-0002-2637-1681","observed_orcids":["https://orcid.org/0000-0002-2637-1681"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Efferth","raw_affiliation_strings":["Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany. Electronic address: efferth@uni-mainz.de","Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2637-1681","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany. Electronic address: efferth@uni-mainz.de","institution_ids":["https://openalex.org/I197323543"]},{"raw_affiliation_string":"Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5033575797"],"corresponding_institution_ids":["https://openalex.org/I197323543"],"apc_list":{"value":2930,"currency":"USD","value_usd":2930},"apc_paid":{"value":2930,"currency":"USD","value_usd":2930},"fwci":4.0629,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.94605499,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"88","issue":null,"first_page":"153589","last_page":"153589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.8629999756813049},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/intestinal-organoids","display_name":"intestinal organoids","score":0.9629999995231628},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8330000042915344},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8629999756813049},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cytokine-mediated-inflammation","display_name":"cytokine-induced inflammation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.7022373676300049},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.5754815340042114},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5208066701889038},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.4469256103038788},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43027547001838684},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42429038882255554},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36526960134506226},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.355538010597229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3509521484375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32579952478408813},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.324259877204895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3032316565513611},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1603744924068451},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15513145923614502},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08560004830360413},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062826","descriptor_name":"Zonula Occludens-1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phymed.2021.153589","doi":"https://doi.org/10.1016/j.phymed.2021.153589","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2021.153589","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},{"id":"pmid:34111617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34111617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine : international journal of phytotherapy and phytopharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.phymed.2021.153589","doi":"https://doi.org/10.1016/j.phymed.2021.153589","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2021.153589","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307771","display_name":"Bayer","ror":"https://ror.org/04hmn8g73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1934044244","https://openalex.org/W1966590215","https://openalex.org/W1968011717","https://openalex.org/W1978022020","https://openalex.org/W1980572807","https://openalex.org/W1981849746","https://openalex.org/W2000271138","https://openalex.org/W2012154760","https://openalex.org/W2020098107","https://openalex.org/W2024021877","https://openalex.org/W2040223383","https://openalex.org/W2048544637","https://openalex.org/W2061253126","https://openalex.org/W2107277218","https://openalex.org/W2111819970","https://openalex.org/W2117794452","https://openalex.org/W2134174082","https://openalex.org/W2155337537","https://openalex.org/W2163551971","https://openalex.org/W2272258630","https://openalex.org/W2292057783","https://openalex.org/W2292223354","https://openalex.org/W2322610535","https://openalex.org/W2323444465","https://openalex.org/W2324060319","https://openalex.org/W2518290289","https://openalex.org/W2533205357","https://openalex.org/W2594724854","https://openalex.org/W2596770143","https://openalex.org/W2610876315","https://openalex.org/W2613796312","https://openalex.org/W2772558633","https://openalex.org/W2773564046","https://openalex.org/W2781779907","https://openalex.org/W2791939105","https://openalex.org/W2799510895","https://openalex.org/W2802224054","https://openalex.org/W2806920198","https://openalex.org/W2891770021","https://openalex.org/W2892512578","https://openalex.org/W2897483789","https://openalex.org/W2898436077","https://openalex.org/W2899927373","https://openalex.org/W2900734207","https://openalex.org/W2912496831","https://openalex.org/W2913164636","https://openalex.org/W2947506452","https://openalex.org/W3003965112","https://openalex.org/W3084166496","https://openalex.org/W3088420899","https://openalex.org/W3135713284","https://openalex.org/W4211073917","https://openalex.org/W6754796236","https://openalex.org/W6783629258"],"related_works":["https://openalex.org/W3088157307","https://openalex.org/W2471817208","https://openalex.org/W2533205357","https://openalex.org/W3215868628","https://openalex.org/W6926472544","https://openalex.org/W1975383741","https://openalex.org/W2766178989","https://openalex.org/W1985977592","https://openalex.org/W2075295270","https://openalex.org/W2313946459"],"abstract_inverted_index":{"BACKGROUND:":[0],"Irritable":[1],"bowel":[2,8,23],"syndrome":[3],"(IBS)":[4],"is":[5,15,27],"a":[6,20,28,35,92,129,211,219],"functional":[7],"disorder,":[9],"in":[10,22,39,49,78,161,255],"which":[11],"recurrent":[12],"abdominal":[13],"pain":[14],"associated":[16],"with":[17,34,108],"defecation":[18],"or":[19],"change":[21],"habits.":[24],"STW":[25,71,112,168,179,195,228,236],"5-II":[26,180,196,229,237],"combination":[29],"of":[30,67,94,111,139,167,186,200,223],"six":[31],"medicinal":[32],"herbs":[33],"clinically":[36,252],"proven":[37,253],"efficacy":[38,254],"managing":[40,256],"IBS.":[41],"AIM:":[42],"This":[43,206],"study":[44],"aims":[45],"to":[46,58,150],"establish":[47],"an":[48],"vitro":[50],"IBS":[51,174,257],"model":[52,175],"using":[53,120],"mouse":[54],"intestinal":[55],"organoids":[56,75],"and":[57,62,81,85,100,114,128,143,152,192,233],"explore":[59],"the":[60,68,137,154,163,183,187,201],"anti-inflammatory":[61,165,240],"tight":[63,86,202,244],"junction":[64,87,203,245],"protective":[65,246],"activities":[66,247],"multi-herbal":[69],"preparation":[70],"5-II.":[72,169],"METHODS:":[73],"Intestinal":[74],"were":[76,89,106,148],"cultured":[77],"1:1":[79],"Matrigel\u2122":[80],"medium":[82],"domes.":[83],"Inflammation":[84],"disruption":[88],"induced":[90],"by":[91,210],"cocktail":[93],"cytokines":[95],"(TNF\u03b1,":[96],"IFN\u03b3,":[97],"IL-1\u03b2,":[98],"IL-6)":[99],"bacterial":[101],"proteins":[102],"(LPS,":[103],"flagellin).":[104],"Organoids":[105],"treated":[107],"different":[109],"concentrations":[110],"5-II,":[113],"its":[115,251],"multi-target":[116,164],"activity":[117,166,222],"was":[118,176,208],"assessed":[119],"microarray":[121],"analyses,":[122],"RT-qPCR,":[123],"immunofluorescence,":[124],"western":[125],"blot,":[126],"immunohistochemistry,":[127],"FITC":[130,212],"permeability":[131,213],"assay.":[132,214],"In":[133,145,215],"addition,":[134],"we":[135],"analyzed":[136],"expression":[138],"pNF-\u03baB,":[140,190],"pSTAT1,":[141],"iNOS":[142],"ZO-1.":[144,205],"silico":[146,216],"analyses":[147,217],"conducted":[149],"predict":[151],"identify":[153],"active":[155],"components":[156],"that":[157,248],"may":[158],"be":[159],"responsible":[160],"mediating":[162],"RESULTS:":[170],"An":[171],"organoid":[172],"based":[173],"successfully":[177],"established.":[178],"effectively":[181],"reduced":[182],"cytokines-induced":[184],"overexpression":[185],"pro-inflammatory":[188],"mediators":[189],"pSTAT1":[191],"iNOS.":[193,234],"Moreover,":[194],"attenuated":[197],"cytokine-mediated":[198],"downregulation":[199],"protein,":[204],"finding":[207],"confirmed":[209],"revealed":[218],"promising":[220],"inhibitory":[221],"some":[224],"isolated":[225],"compounds":[226],"from":[227],"against":[230],"NF-\u03baB,":[231],"STAT1":[232],"CONCLUSION:":[235],"possesses":[238],"multiple":[239],"as":[241,243],"well":[242],"could":[249],"explain":[250],"symptoms.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-05-10T00:00:00"}