{"id":"https://openalex.org/W3158041886","doi":"https://doi.org/10.1101/2021.05.03.442455","title":"SARS -CoV-2 T-cell immunity to variants of concern following vaccination","display_name":"SARS -CoV-2 T-cell immunity to variants of concern following vaccination","publication_year":2021,"publication_date":"2021-05-03","ids":{"openalex":"https://openalex.org/W3158041886","doi":"https://doi.org/10.1101/2021.05.03.442455","mag":"3158041886","pmid":"https://pubmed.ncbi.nlm.nih.gov/33972942","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8109204"},"language":"en","primary_location":{"id":"doi:10.1101/2021.05.03.442455","doi":"https://doi.org/10.1101/2021.05.03.442455","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.05.03.442455","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/03/2021.05.03.442455.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/03/2021.05.03.442455.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009794322","display_name":"Kathleen Gallagher","orcid":"https://orcid.org/0009-0004-4818-2082","observed_orcids":["https://orcid.org/0009-0004-4818-2082"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen M.E. Gallagher","raw_affiliation_strings":["Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA","Immune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Immune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012987786","display_name":"Mark B. Leick","orcid":"https://orcid.org/0000-0003-3111-0221","observed_orcids":["https://orcid.org/0000-0003-3111-0221"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark B. Leick","raw_affiliation_strings":["Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062214590","display_name":"Rebecca C. Larson","orcid":"https://orcid.org/0000-0003-0174-061X","observed_orcids":["https://orcid.org/0000-0003-0174-061X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca C. Larson","raw_affiliation_strings":["Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030394595","display_name":"Trisha R. Berger","orcid":"https://orcid.org/0000-0003-3439-3239","observed_orcids":["https://orcid.org/0000-0003-3439-3239"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trisha R. Berger","raw_affiliation_strings":["Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085124532","display_name":"Katelin Katsis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelin Katsis","raw_affiliation_strings":["Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","Immune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Immune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034139871","display_name":"Jennifer Y. Yam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Y. Yam","raw_affiliation_strings":["Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","Immune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Immune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068630923","display_name":"Gabrielle Brini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabrielle Brini","raw_affiliation_strings":["Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","Immune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Immune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033773256","display_name":"Korneel Grauwet","orcid":"https://orcid.org/0009-0003-8077-2763","observed_orcids":["https://orcid.org/0009-0003-8077-2763"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Korneel Grauwet","raw_affiliation_strings":["Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"MGH COVID-19 Collection & Processing Team","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MGH COVID-19 Collection & Processing Team","raw_affiliation_strings":["Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029763484","display_name":"Marcela Valderrama Maus","orcid":"https://orcid.org/0000-0002-7578-0393","observed_orcids":["https://orcid.org/0000-0002-7578-0393"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marcela V. Maus","raw_affiliation_strings":["Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029763484"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/variants-of-concern","display_name":"variants of concern","score":0.7580000162124634},{"id":"https://openalex.org/keywords/mrna-vaccines","display_name":"mRNA vaccines","score":0.7639999985694885},{"id":"https://openalex.org/keywords/spike-protein","display_name":"spike protein","score":0.9380000233650208},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alpha-variant","display_name":"Alpha variant","score":0.949999988079071},{"id":"https://openalex.org/keywords/beta-variant","display_name":"Beta variant","score":1.0},{"id":"https://openalex.org/keywords/vaccine-effectiveness","display_name":"vaccine effectiveness","score":0.5220000147819519},{"id":"https://openalex.org/keywords/convalescent-patients","display_name":"convalescent patients","score":0.7459999918937683},{"id":"https://openalex.org/keywords/antibody-neutralization","display_name":"antibody neutralization","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6683409810066223},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6540059447288513},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6338164806365967},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6138932108879089},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5722949504852295},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5371947884559631},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.48929688334465027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47894102334976196},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.46690255403518677},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.4664470851421356},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46276965737342834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.426002562046051},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.4191737473011017},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.34354496002197266},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09651193022727966},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2021.05.03.442455","doi":"https://doi.org/10.1101/2021.05.03.442455","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.05.03.442455","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/03/2021.05.03.442455.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:33972942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33972942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmh:oai:pubmedcentral.nih.gov:8109204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8109204","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2021.05.03.442455","doi":"https://doi.org/10.1101/2021.05.03.442455","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.05.03.442455","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/03/2021.05.03.442455.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3847398283","display_name":"Training in Transplantation Biology","funder_award_id":"T32AI007529","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6509389587","display_name":"Efficacy and immune effects of anakinra prophylaxis for neurologic toxicity and cytokine release syndrome in patients with lymphoma receiving axicabtagene ciloleucel","funder_award_id":"R01CA252940","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000877653","display_name":"Novel CAR T cell engineering strategies for effective eradication of solid and liquid tumors","funder_award_id":"R01CA238268","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000902506","display_name":"Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells","funder_award_id":"R01CA249062","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308347","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94"},{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320309673","display_name":"Harvard Catalyst","ror":null},{"id":"https://openalex.org/F4320313818","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13"},{"id":"https://openalex.org/F4320319716","display_name":"Massachusetts Consortium on Pathogen Readiness","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3158041886.pdf","grobid_xml":"https://content.openalex.org/works/W3158041886.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1662940398","https://openalex.org/W2135926866","https://openalex.org/W2141787825","https://openalex.org/W2151461700","https://openalex.org/W2292472819","https://openalex.org/W2612594162","https://openalex.org/W2742905047","https://openalex.org/W3004318991","https://openalex.org/W3008394341","https://openalex.org/W3009912996","https://openalex.org/W3029201461","https://openalex.org/W3032255042","https://openalex.org/W3033450058","https://openalex.org/W3036386821","https://openalex.org/W3036931136","https://openalex.org/W3042215122","https://openalex.org/W3043722389","https://openalex.org/W3046309975","https://openalex.org/W3048775784","https://openalex.org/W3080487846","https://openalex.org/W3084879098","https://openalex.org/W3090844627","https://openalex.org/W3092301564","https://openalex.org/W3093231763","https://openalex.org/W3093667122","https://openalex.org/W3094968263","https://openalex.org/W3107586775","https://openalex.org/W3109331896","https://openalex.org/W3111255098","https://openalex.org/W3113734454","https://openalex.org/W3114439193","https://openalex.org/W3119771105","https://openalex.org/W3121008609","https://openalex.org/W3121906900","https://openalex.org/W3126729284","https://openalex.org/W3126950061","https://openalex.org/W3126996424","https://openalex.org/W3128186941","https://openalex.org/W3131995220","https://openalex.org/W3133105869","https://openalex.org/W3133782701","https://openalex.org/W3134208712","https://openalex.org/W3135409471","https://openalex.org/W3137149656","https://openalex.org/W3139451710","https://openalex.org/W3140446408","https://openalex.org/W3141087105","https://openalex.org/W3146894320","https://openalex.org/W3150122045","https://openalex.org/W3153636933","https://openalex.org/W3155262144","https://openalex.org/W3155952134","https://openalex.org/W4205483821"],"related_works":["https://openalex.org/W4311867812","https://openalex.org/W4391396703","https://openalex.org/W4280501043","https://openalex.org/W3200220634","https://openalex.org/W4377091914","https://openalex.org/W3217600504","https://openalex.org/W4210493562","https://openalex.org/W4313407935","https://openalex.org/W4393063116","https://openalex.org/W4207047906"],"abstract_inverted_index":{"SUMMARY":[0],"Recently,":[1],"two":[2,99],"mRNA":[3],"vaccines":[4,40,49],"to":[5,52,71,77,103,107,124,146,178,195,204,209],"severe":[6],"acute":[7],"respiratory":[8],"syndrome":[9],"coronavirus":[10],"2":[11],"(SARS-":[12],"CoV-2)":[13],"have":[14,164],"become":[15],"available,":[16],"but":[17,142,155],"there":[18],"is":[19,36,66,79,87,188],"also":[20,139,165],"an":[21,54,182],"emergence":[22],"of":[23,185,192],"SARS-CoV-2":[24,59,78,108,196],"variants":[25,148,170,180],"with":[26,168],"increased":[27],"transmissibility":[28],"and":[29,97,112,129,151,199],"virulence":[30],"1\u20136":[31],".":[32,75],"A":[33],"major":[34],"concern":[35],"whether":[37],"the":[38,58,90,125,175],"available":[39],"will":[41],"be":[42,201],"equally":[43],"effective":[44],"against":[45,57],"these":[46,179],"variants.":[47,210],"The":[48],"are":[50,197],"designed":[51],"induce":[53],"immune":[55],"response":[56,177,208],"spike":[60,128,147],"protein":[61],"7,":[62],"8":[63],",":[64,172],"which":[65],"required":[67],"for":[68],"viral":[69,186],"entry":[70],"host":[72],"cells":[73],"9":[74],"Immunity":[76],"often":[80],"evaluated":[81],"by":[82],"antibody":[83,162],"production,":[84],"while":[85],"less":[86],"known":[88],"about":[89],"T-cell":[91,105,122,144,176,193],"response.":[92],"Here":[93],"we":[94],"developed,":[95],"characterized,":[96],"implemented":[98],"standardized,":[100],"functional":[101],"assays":[102],"measure":[104],"immunity":[106],"in":[109,161,207],"uninfected,":[110],"convalescent,":[111],"vaccinated":[113,118,154],"individuals.":[114],"We":[115,138],"found":[116,140],"that":[117],"individuals":[119],"had":[120],"robust":[121],"responses":[123,145,194],"wild":[126],"type":[127],"nucleocapsid":[130],"proteins,":[131],"even":[132],"more":[133],"so":[134],"than":[135],"convalescent":[136],"patients.":[137],"detectable":[141],"diminished":[143],"(B.1.1.7,":[149],"B.1.351,":[150],"B.1.1.248)":[152],"among":[153],"otherwise":[156],"healthy":[157],"donors.":[158],"Since":[159],"decreases":[160],"neutralization":[163],"been":[166],"observed":[167],"some":[169],"10\u201312":[171],"investigation":[173],"into":[174],"as":[181],"alternative":[183],"means":[184],"control":[187],"imperative.":[189],"Standardized":[190],"measurements":[191],"feasible":[198],"can":[200],"easily":[202],"adjusted":[203],"determine":[205],"changes":[206]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":20}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-05-10T00:00:00"}
