{"id":"https://openalex.org/W3158009838","doi":"https://doi.org/10.1007/s11418-021-01518-w","title":"Brazilian propolis (AF-08) inhibits collagen-induced platelet aggregation without affecting blood coagulation","display_name":"Brazilian propolis (AF-08) inhibits collagen-induced platelet aggregation without affecting blood coagulation","publication_year":2021,"publication_date":"2021-05-04","ids":{"openalex":"https://openalex.org/W3158009838","doi":"https://doi.org/10.1007/s11418-021-01518-w","mag":"3158009838","pmid":"https://pubmed.ncbi.nlm.nih.gov/33945121"},"language":"en","primary_location":{"id":"doi:10.1007/s11418-021-01518-w","doi":"https://doi.org/10.1007/s11418-021-01518-w","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11418-021-01518-w","pdf_url":null,"source":{"id":"https://openalex.org/S165299079","display_name":"Journal of Natural Medicines","issn_l":"1340-3443","issn":["1340-3443","1861-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Medicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077363907","display_name":"Chihiro Sugita","orcid":"https://orcid.org/0009-0003-4069-7009","observed_orcids":["https://orcid.org/0009-0003-4069-7009","https://orcid.org/0000-0001-9514-6798"]},"institutions":[{"id":"https://openalex.org/I11023767","display_name":"Kyushu University of Medical Science","ror":"https://ror.org/01banz567","country_code":"JP","type":"education","lineage":["https://openalex.org/I11023767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chihiro Sugita","raw_affiliation_strings":["Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan","institution_ids":["https://openalex.org/I11023767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072777516","display_name":"Atsushi Yamashita","orcid":"https://orcid.org/0000-0001-5487-7594","observed_orcids":["https://orcid.org/0000-0001-5487-7594"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Yamashita","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110758390","display_name":"Shigetoshi Tsutsumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigetoshi Tsutsumi","raw_affiliation_strings":["Amazonfood Co., Ltd, 3-1-8 Misaki-cho, Chiyoda, Tokyo, 101-0061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amazonfood Co., Ltd, 3-1-8 Misaki-cho, Chiyoda, Tokyo, 101-0061, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066180560","display_name":"Hisahiro Kai","orcid":"https://orcid.org/0000-0003-3483-7231","observed_orcids":["https://orcid.org/0000-0003-3483-7231"]},"institutions":[{"id":"https://openalex.org/I11023767","display_name":"Kyushu University of Medical Science","ror":"https://ror.org/01banz567","country_code":"JP","type":"education","lineage":["https://openalex.org/I11023767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisahiro Kai","raw_affiliation_strings":["Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan","institution_ids":["https://openalex.org/I11023767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111879882","display_name":"Tohru Sonoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11023767","display_name":"Kyushu University of Medical Science","ror":"https://ror.org/01banz567","country_code":"JP","type":"education","lineage":["https://openalex.org/I11023767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Sonoda","raw_affiliation_strings":["Department of Occupational Therapy, School of Health and Science, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational Therapy, School of Health and Science, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan","institution_ids":["https://openalex.org/I11023767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025682247","display_name":"Hiroki Yoshida","orcid":"https://orcid.org/0000-0002-6903-2401","observed_orcids":["https://orcid.org/0000-0002-6903-2401"]},"institutions":[{"id":"https://openalex.org/I11023767","display_name":"Kyushu University of Medical Science","ror":"https://ror.org/01banz567","country_code":"JP","type":"education","lineage":["https://openalex.org/I11023767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Yoshida","raw_affiliation_strings":["Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan","institution_ids":["https://openalex.org/I11023767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100669485","display_name":"Ryuichi Yamamoto","orcid":"https://orcid.org/0000-0003-0299-5470","observed_orcids":["https://orcid.org/0000-0003-0299-5470"]},"institutions":[{"id":"https://openalex.org/I11023767","display_name":"Kyushu University of Medical Science","ror":"https://ror.org/01banz567","country_code":"JP","type":"education","lineage":["https://openalex.org/I11023767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuichi Yamamoto","raw_affiliation_strings":["Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan","institution_ids":["https://openalex.org/I11023767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051382077","display_name":"Yujiro Asada","orcid":"https://orcid.org/0000-0001-5105-2159","observed_orcids":["https://orcid.org/0000-0001-5105-2159"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yujiro Asada","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101985321","display_name":"Masahiko Kurokawa","orcid":"https://orcid.org/0000-0002-8701-9454","observed_orcids":["https://orcid.org/0000-0002-8701-9454"]},"institutions":[{"id":"https://openalex.org/I11023767","display_name":"Kyushu University of Medical Science","ror":"https://ror.org/01banz567","country_code":"JP","type":"education","lineage":["https://openalex.org/I11023767"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masahiko Kurokawa","raw_affiliation_strings":["Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan. b2mk@phoenix.ac.jp","Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan. b2mk@phoenix.ac.jp","institution_ids":["https://openalex.org/I11023767"]},{"raw_affiliation_string":"Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan","institution_ids":["https://openalex.org/I11023767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101985321"],"corresponding_institution_ids":["https://openalex.org/I11023767"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":0.6635,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61488812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"75","issue":"4","first_page":"975","last_page":"984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.07649999856948853,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brazilian-propolis","display_name":"Brazilian propolis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8730000257492065},{"id":"https://openalex.org/keywords/apigenin","display_name":"apigenin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chrysin","display_name":"chrysin","score":1.0},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":1.0},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/collagen-induced-platelet-aggregation","display_name":"collagen-induced aggregation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/prothrombin-time","display_name":"prothrombin time","score":0.8270000219345093},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":1.0},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.6959999799728394},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.7088642716407776},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.693202018737793},{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.6881440877914429},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6117460131645203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5854567289352417},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.5189437866210938},{"id":"https://openalex.org/C2778609962","wikidata":"https://www.wikidata.org/wiki/Q424567","display_name":"Apigenin","level":4,"score":0.4721650779247284},{"id":"https://openalex.org/C2780009322","wikidata":"https://www.wikidata.org/wiki/Q7202246","display_name":"Platelet adhesiveness","level":4,"score":0.4700815975666046},{"id":"https://openalex.org/C2780434524","wikidata":"https://www.wikidata.org/wiki/Q1144385","display_name":"Prothrombin time","level":2,"score":0.43333712220191956},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.41872942447662354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36382168531417847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34104758501052856},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.335387647151947},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22558048367500305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22449946403503418},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.18610462546348572},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011429","descriptor_name":"Propolis","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11418-021-01518-w","doi":"https://doi.org/10.1007/s11418-021-01518-w","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11418-021-01518-w","pdf_url":null,"source":{"id":"https://openalex.org/S165299079","display_name":"Journal of Natural Medicines","issn_l":"1340-3443","issn":["1340-3443","1861-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Medicines","raw_type":"journal-article"},{"id":"pmid:33945121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33945121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural medicines","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2290801477","display_name":"Effect of insulin on platelet aggregation in coronary artery bypass grafting","funder_award_id":"17K10771","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W167482731","https://openalex.org/W295511661","https://openalex.org/W590922583","https://openalex.org/W1614233229","https://openalex.org/W1963618232","https://openalex.org/W1972431032","https://openalex.org/W1975014548","https://openalex.org/W1981184057","https://openalex.org/W1983261646","https://openalex.org/W1988852401","https://openalex.org/W1995637970","https://openalex.org/W2003431957","https://openalex.org/W2008771544","https://openalex.org/W2018777979","https://openalex.org/W2022443471","https://openalex.org/W2025166282","https://openalex.org/W2040270316","https://openalex.org/W2050180685","https://openalex.org/W2050314749","https://openalex.org/W2063495439","https://openalex.org/W2067813060","https://openalex.org/W2068468428","https://openalex.org/W2086559976","https://openalex.org/W2091052964","https://openalex.org/W2091401363","https://openalex.org/W2097210000","https://openalex.org/W2101149356","https://openalex.org/W2105214139","https://openalex.org/W2118447955","https://openalex.org/W2136057525","https://openalex.org/W2137137814","https://openalex.org/W2138712613","https://openalex.org/W2151938814","https://openalex.org/W2168719124","https://openalex.org/W2170055916","https://openalex.org/W2171365098","https://openalex.org/W2396194974","https://openalex.org/W2527071281","https://openalex.org/W2562296007","https://openalex.org/W2761257924","https://openalex.org/W2763549184","https://openalex.org/W2805683386","https://openalex.org/W2979590428","https://openalex.org/W4245219249"],"related_works":["https://openalex.org/W4390654329","https://openalex.org/W3203113796","https://openalex.org/W2761257924","https://openalex.org/W4415388720","https://openalex.org/W2805683386","https://openalex.org/W1998029089","https://openalex.org/W2528741198","https://openalex.org/W2315724314","https://openalex.org/W2030428802","https://openalex.org/W6947893557"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-05-10T00:00:00"}
