{"id":"https://openalex.org/W3157771663","doi":"https://doi.org/10.21203/rs.3.rs-96041/v1","title":"Adamantinoma-like Ewing Sarcoma in a Metatarsal Bone After Chemotherapy Treated with an Osteocutaneous Fibular Transfer: A Case Report.","display_name":"Adamantinoma-like Ewing Sarcoma in a Metatarsal Bone After Chemotherapy Treated with an Osteocutaneous Fibular Transfer: A Case Report.","publication_year":2020,"publication_date":"2020-10-26","ids":{"openalex":"https://openalex.org/W3157771663","doi":"https://doi.org/10.21203/rs.3.rs-96041/v1","mag":"3157771663"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-96041/v1","doi":"https://doi.org/10.21203/rs.3.rs-96041/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-96041/v1","pdf_url":"https://www.researchsquare.com/article/rs-96041/v1.pdf?c=1631873119000","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-96041/v1.pdf?c=1631873119000","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007209130","display_name":"Yolandi Anne Marais","orcid":"https://orcid.org/0000-0003-1170-6378","observed_orcids":["https://orcid.org/0000-0003-1170-6378"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Yolandi Anne Marais","raw_affiliation_strings":["Stellenbosch University"],"raw_orcid":"https://orcid.org/0000-0003-1170-6378","affiliations":[{"raw_affiliation_string":"Stellenbosch University","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069496787","display_name":"Aaron Kumar Saini","orcid":"https://orcid.org/0000-0002-2661-8445","observed_orcids":["https://orcid.org/0000-0002-2661-8445"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Aaron Saini","raw_affiliation_strings":["Stellenbosch University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017630249","display_name":"Nando Ferreira","orcid":"https://orcid.org/0000-0002-0567-3373","observed_orcids":["https://orcid.org/0000-0002-0567-3373"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Nando Ferreira","raw_affiliation_strings":["Stellenbosch University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062357512","display_name":"Kershinee Reddy","orcid":"https://orcid.org/0000-0003-1511-1478","observed_orcids":["https://orcid.org/0000-0003-1511-1478"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Kershinee Reddy","raw_affiliation_strings":["Stellenbosch University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080775452","display_name":"Alexander Z\u00fchlke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Alexander Z\u00fchlke","raw_affiliation_strings":["Stellenbosch University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011381953","display_name":"Nelmarie Rossouw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Nelmarie Rossouw","raw_affiliation_strings":["Stellenbosch University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113943053","display_name":"Stefan Dan Zaharie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Stefan Dan Zaharie","raw_affiliation_strings":["Stellenbosch University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001155140","display_name":"Pawel Tomasz Schubert","orcid":"https://orcid.org/0000-0003-4422-7349","observed_orcids":["https://orcid.org/0000-0003-4422-7349"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Pawel Tomasz Schubert","raw_affiliation_strings":["Stellenbosch University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University","institution_ids":["https://openalex.org/I26092322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007209130"],"corresponding_institution_ids":["https://openalex.org/I26092322"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/pediatric-bone-tumors","display_name":"pediatric bone tumors","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cytokeratin-expression","display_name":"cytokeratin expression","score":0.6259999871253967},{"id":"https://openalex.org/keywords/rhabdoid-morphology","display_name":"rhabdoid morphology","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2780443816","wikidata":"https://www.wikidata.org/wiki/Q2521747","display_name":"Adamantinoma","level":4,"score":0.9001531600952148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7258061766624451},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6576260328292847},{"id":"https://openalex.org/C2777434363","wikidata":"https://www.wikidata.org/wiki/Q320524","display_name":"Metatarsal bones","level":2,"score":0.6462640166282654},{"id":"https://openalex.org/C2910547128","wikidata":"https://www.wikidata.org/wiki/Q5454211","display_name":"First metatarsal","level":3,"score":0.5253745317459106},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5007345676422119},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33562982082366943},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.1623452603816986},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1567395031452179},{"id":"https://openalex.org/C122246415","wikidata":"https://www.wikidata.org/wiki/Q350956","display_name":"Maxilla","level":2,"score":0.08160260319709778},{"id":"https://openalex.org/C2775876115","wikidata":"https://www.wikidata.org/wiki/Q461857","display_name":"Ameloblastoma","level":3,"score":0.057641953229904175},{"id":"https://openalex.org/C2776389721","wikidata":"https://www.wikidata.org/wiki/Q2167748","display_name":"Osteotomy","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-96041/v1","doi":"https://doi.org/10.21203/rs.3.rs-96041/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-96041/v1","pdf_url":"https://www.researchsquare.com/article/rs-96041/v1.pdf?c=1631873119000","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-96041/v1","doi":"https://doi.org/10.21203/rs.3.rs-96041/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-96041/v1","pdf_url":"https://www.researchsquare.com/article/rs-96041/v1.pdf?c=1631873119000","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322663","display_name":"Universiteit Stellenbosch","ror":"https://ror.org/05bk57929"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3157771663.pdf","grobid_xml":"https://content.openalex.org/works/W3157771663.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W580831080","https://openalex.org/W1993672184","https://openalex.org/W1993962872","https://openalex.org/W1995410500","https://openalex.org/W2008697610","https://openalex.org/W2013029471","https://openalex.org/W2022672136","https://openalex.org/W2033443224","https://openalex.org/W2039094494","https://openalex.org/W2047219974","https://openalex.org/W2058781784","https://openalex.org/W2061233213","https://openalex.org/W2065289547","https://openalex.org/W2069208590","https://openalex.org/W2077708245","https://openalex.org/W2089480450","https://openalex.org/W2117562826","https://openalex.org/W2165492048","https://openalex.org/W2259633388","https://openalex.org/W2497935672","https://openalex.org/W2558954199","https://openalex.org/W2807813230","https://openalex.org/W2912576631","https://openalex.org/W2999863489","https://openalex.org/W3010942798","https://openalex.org/W3015526419","https://openalex.org/W3018136871","https://openalex.org/W4232313822","https://openalex.org/W6776732140"],"related_works":["https://openalex.org/W4210295630","https://openalex.org/W4251660442","https://openalex.org/W3127594950","https://openalex.org/W4405652297","https://openalex.org/W2069208590","https://openalex.org/W2330348207","https://openalex.org/W3171475921","https://openalex.org/W4224821734","https://openalex.org/W2497935672","https://openalex.org/W2061745878"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Adamantinoma-like":[2,66,191,197],"Ewing":[3,10,55,62,85,128,192,198],"sarcoma":[4,11,63,129,199],"is":[5,49,188],"a":[6,32,59,111,148,229,242,255],"rare":[7],"variant":[8,227,238],"of":[9,39,54,61,84,90,115],"known":[12],"to":[13,75,101,220,234],"have":[14,98],"cytokeratin":[15],"expression":[16,97,178,202],"and":[17,27,79,134,147,176,187,239],"squamous":[18,93,165],"differentiation.":[19],"It":[20,42,216],"occurs":[21,248],"more":[22,236],"commonly":[23],"in":[24,36,82,167,183,249],"the":[25,40,52,121,168,184,213,221,235],"head":[26],"neck":[28],"region":[29],"with":[30,95,110,130,153,172,190,200],"only":[31,68],"few":[33],"cases":[34,83],"reported":[35,74],"long":[37],"bones":[38],"limbs.":[41],"also":[43],"harbours":[44],"EWSR1-FLI1":[45],"gene":[46],"fusion":[47],"which":[48,179],"required":[50],"for":[51,223],"diagnosis":[53],"sarcoma.":[56],"We":[57],"present":[58],"case":[60,195],"that":[64],"manifested":[65],"morphology":[67,81],"post":[69],"chemotherapy.":[70],"Chemotherapy":[71],"has":[72],"been":[73,99],"induce":[76],"neuronal":[77],"maturation":[78],"rhabdoid":[80],"sarcoma,":[86],"but":[87],"no":[88],"reports":[89],"treatment":[91],"induced":[92],"differentiation":[94,166],"P40/P63":[96,177,201],"demonstrated":[100],"date.Case":[102],"presentation:":[103],"An":[104],"11":[105],"year":[106,113],"old":[107],"boy":[108],"presented":[109],"one":[112],"history":[114],"an":[116,154,250],"enlarging":[117],"painless":[118],"mass":[119],"over":[120],"left":[122],"first":[123],"metatarsal.":[124],"Initial":[125],"biopsy":[126,186],"showed":[127,163],"typical":[131],"morphological":[132],"features":[133],"EWSR1":[135],"rearrangement":[136],"confirmed":[137],"on":[138,212],"fluorescent":[139],"in-situ":[140],"hybridization.":[141],"The":[142],"patient":[143,252],"underwent":[144],"neo-adjuvant":[145,204],"chemotherapy":[146,205],"subsequent":[149],"wide":[150],"local":[151],"excision":[152],"ipsilateral":[155],"pedicled":[156],"osteocutaneous":[157],"fibula":[158],"transfer.":[159],"Subsequent":[160],"histological":[161],"examination":[162],"frank":[164],"soft":[169],"tissue":[170],"component":[171],"keratin":[173],"pearl":[174],"formation":[175],"was":[180,209],"not":[181,210],"observed":[182],"initial":[185,214],"compatible":[189],"sarcoma.Conclusion:":[193],"This":[194,207,226],"describes":[196],"after":[203],"treatment.":[206],"immunophenotype":[208],"apparent":[211],"biopsy.":[215],"remains":[217],"uncertain":[218],"as":[219,254],"reason":[222],"this":[224],"change.":[225],"carries":[228],"poorer":[230],"clinical":[231],"outcome":[232],"compared":[233],"conventional":[237],"could":[240],"pose":[241],"diagnostic":[243],"challenge(s)":[244],"particularly":[245],"if":[246],"it":[247],"older":[251],"or":[253],"metastatic":[256],"lesion.":[257]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-05-10T00:00:00"}
