{"id":"https://openalex.org/W3157770596","doi":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4285","title":"Targeting Chymotrypsin-Like Elastase 1 with Anti-CELA1 KF4 Antibody to Prevent Emphysema Progression in COPD","display_name":"Targeting Chymotrypsin-Like Elastase 1 with Anti-CELA1 KF4 Antibody to Prevent Emphysema Progression in COPD","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3157770596","doi":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4285","mag":"3157770596"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4285","doi":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4285","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4285","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TP109. TP109 COPD AND E-CIGARETTES: PRE-CLINICAL MODELS AND MECHANISMS","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047338456","display_name":"Brian  Michael Varisco","orcid":"https://orcid.org/0000-0003-0180-2577","observed_orcids":["https://orcid.org/0000-0003-0180-2577"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.M. Varisco","raw_affiliation_strings":["Critical Care Medicine, Cincinnati Childrens Med Ctr, Cincinnati, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine, Cincinnati Childrens Med Ctr, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Q. Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Q. Fan","raw_affiliation_strings":["Critical Care Medicine, Cincinnati Childrens Med Ctr, Cincinnati, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine, Cincinnati Childrens Med Ctr, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016215153","display_name":"E. Goodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Goodman","raw_affiliation_strings":["Critical Care Medicine, Cincinnati Childrens Med Ctr, Cincinnati, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine, Cincinnati Childrens Med Ctr, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030918014","display_name":"Mohit Ojha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281027232","display_name":"Lincoln Medical Center","ror":"https://ror.org/035a72598","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281027232","https://openalex.org/I1283621791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Ojha","raw_affiliation_strings":["Pediatrics, Lincoln Medical and Mental Health Center, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Lincoln Medical and Mental Health Center, New York, NY, United States","institution_ids":["https://openalex.org/I1281027232"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Schuman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Schuman","raw_affiliation_strings":["Antibody Immunoassay Consultants, Rockville, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antibody Immunoassay Consultants, Rockville, MD, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"R. Joshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Joshi","raw_affiliation_strings":["Critical Care Medicine, Cincinnati Childrens Med Ctr, Cincinnati, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine, Cincinnati Childrens Med Ctr, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A4285","last_page":"A4285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emphysema-progression","display_name":"emphysema progression","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.949999988079071},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.6600000262260437},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7137666344642639},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.6541565656661987},{"id":"https://openalex.org/C2778401398","wikidata":"https://www.wikidata.org/wiki/Q383836","display_name":"Chymotrypsin","level":4,"score":0.5689302086830139},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5637408494949341},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4835343360900879},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27802854776382446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2760062515735626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2498699128627777},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2002960443496704},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.16005578637123108},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12352877855300903}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4285","doi":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4285","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4285","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TP109. TP109 COPD AND E-CIGARETTES: PRE-CLINICAL MODELS AND MECHANISMS","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390659765","https://openalex.org/W4225302811","https://openalex.org/W3021271123","https://openalex.org/W4367600153","https://openalex.org/W4385447984","https://openalex.org/W4396827712","https://openalex.org/W3041254001","https://openalex.org/W4404748984","https://openalex.org/W2438947159","https://openalex.org/W4321605829"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2021-05-10T00:00:00"}
