{"id":"https://openalex.org/W3157634603","doi":"https://doi.org/10.1101/2021.05.04.442539","title":"TISON: a next-generation multi-scale modeling theatre for in silico systems oncology","display_name":"TISON: a next-generation multi-scale modeling theatre for in silico systems oncology","publication_year":2021,"publication_date":"2021-05-05","ids":{"openalex":"https://openalex.org/W3157634603","doi":"https://doi.org/10.1101/2021.05.04.442539","mag":"3157634603"},"language":"en","primary_location":{"id":"doi:10.1101/2021.05.04.442539","doi":"https://doi.org/10.1101/2021.05.04.442539","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.05.04.442539","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/05/2021.05.04.442539.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/05/2021.05.04.442539.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051444369","display_name":"Mahnoor Naseer Gondal","orcid":"https://orcid.org/0000-0002-9419-6758","observed_orcids":["https://orcid.org/0000-0002-9419-6758"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mahnoor N Gondal","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002804434","display_name":"Muhammad Umer Sultan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad U Sultan","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110763204","display_name":"Ammar Arif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ammar Arif","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074551463","display_name":"Abdul Rehman Basharat","orcid":"https://orcid.org/0000-0002-4675-5375","observed_orcids":["https://orcid.org/0000-0002-4675-5375"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Abdul Rehman","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111221921","display_name":"Hira A. Awan","orcid":"https://orcid.org/0000-0003-2422-2639","observed_orcids":["https://orcid.org/0000-0003-2422-2639"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK","US"],"is_corresponding":false,"raw_author_name":"Hira A Awan","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Department of Biostatistics and Bioinformatics, School of Medicine, Duke University","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","Department of Biostatistics and Bioinformatics, School of Medicine, Duke University, Durham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, School of Medicine, Duke University","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, School of Medicine, Duke University, Durham, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075950392","display_name":"Zainab Arshad","orcid":"https://orcid.org/0009-0003-5928-6955","observed_orcids":["https://orcid.org/0009-0003-5928-6955"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zainab Arshad","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Waleed Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Waleed Ahmed","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112634914","display_name":"Muhammad FA Chaudhary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK","US"],"is_corresponding":false,"raw_author_name":"Muhammad FA Chaudhary","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","The Roy J. Carver Department of Biomedical Engineering, The University of Iowa","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","The Roy J. Carver Department of Biomedical Engineering, The University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"The Roy J. Carver Department of Biomedical Engineering, The University of Iowa","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"The Roy J. Carver Department of Biomedical Engineering, The University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101061604","display_name":"Salaar Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Salaar Khan","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033889342","display_name":"Zain Bin Tanveer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zain B Tanveer","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047498461","display_name":"Rida Nasir Butt","orcid":"https://orcid.org/0000-0001-6388-6230","observed_orcids":["https://orcid.org/0000-0001-6388-6230"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Rida Nasir Butt","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014399618","display_name":"Risham Hussain","orcid":"https://orcid.org/0000-0002-3966-9241","observed_orcids":["https://orcid.org/0000-0002-3966-9241"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Risham Hussain","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041046089","display_name":"Huma Khawar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Huma Khawar","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101777776","display_name":"Amina Bibi","orcid":"https://orcid.org/0000-0002-3509-1788","observed_orcids":["https://orcid.org/0000-0002-3509-1788"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Bibi Amina","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113942992","display_name":"Rida Akbar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Rida Akbar","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fatima Abbas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Fatima Abbas","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096936848","display_name":"Misha N Jami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Misha N Jami","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108915731","display_name":"Zainab Nasir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zainab Nasir","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088020914","display_name":"Osama Shiraz Shah","orcid":"https://orcid.org/0000-0003-4756-4535","observed_orcids":["https://orcid.org/0000-0003-4756-4535"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Osama S Shah","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038021624","display_name":"Hadia Hameed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Hadia Hameed","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103968880","display_name":"Muhammad FA Butt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad FA Butt","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ghulam Mustafa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ghulam Mustafa","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102712205","display_name":"Muhammad Ahmad","orcid":"https://orcid.org/0009-0000-8383-2643","observed_orcids":["https://orcid.org/0009-0000-8383-2643"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad M Ahmad","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101059271","display_name":"Sameer Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sameer Ahmed","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070641714","display_name":"Romena Qazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128772","display_name":"Shaukat Khanum Memorial Cancer Hospital and Research Center","ror":"https://ror.org/03btpnr35","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210128772"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Romena Qazi","raw_affiliation_strings":["Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre","Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre","institution_ids":["https://openalex.org/I4210128772"]},{"raw_affiliation_string":"Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan","institution_ids":["https://openalex.org/I4210128772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108194846","display_name":"Fayyaz Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99165933","display_name":"University of Gujrat","ror":"https://ror.org/01xe5fb92","country_code":"PK","type":"education","lineage":["https://openalex.org/I99165933"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Fayyaz Ahmed","raw_affiliation_strings":["Department of Statistics, University of Gujrat","Department of Statistics, University of Gujrat, Gujrat, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Gujrat","institution_ids":["https://openalex.org/I99165933"]},{"raw_affiliation_string":"Department of Statistics, University of Gujrat, Gujrat, Pakistan","institution_ids":["https://openalex.org/I99165933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022915799","display_name":"Omer Ishaq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201384688","display_name":"National University of Computer and Emerging Sciences","ror":"https://ror.org/003eyb898","country_code":"PK","type":"education","lineage":["https://openalex.org/I201384688"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Omer Ishaq","raw_affiliation_strings":["Department of Computer Science, National University of Computer and Emerging Sciences","Department of Computer Science, National University of Computer and Emerging Sciences, Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, National University of Computer and Emerging Sciences","institution_ids":["https://openalex.org/I201384688"]},{"raw_affiliation_string":"Department of Computer Science, National University of Computer and Emerging Sciences, Islamabad, Pakistan","institution_ids":["https://openalex.org/I201384688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075369228","display_name":"Syed Waqar Nabi","orcid":"https://orcid.org/0000-0003-3835-4851","observed_orcids":["https://orcid.org/0000-0003-3835-4851"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Syed W Nabi","raw_affiliation_strings":["School of Computing Science, University of Glasgow","School of Computing Science, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing Science, University of Glasgow","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"School of Computing Science, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047735250","display_name":"Wim A. Vanderbauwhede","orcid":"https://orcid.org/0000-0001-6768-0037","observed_orcids":["https://orcid.org/0000-0001-6768-0037"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wim Vanderbauwhede","raw_affiliation_strings":["School of Computing Science, University of Glasgow","School of Computing Science, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing Science, University of Glasgow","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"School of Computing Science, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051600305","display_name":"Bilal Wajid","orcid":"https://orcid.org/0000-0003-0220-7788","observed_orcids":["https://orcid.org/0000-0003-0220-7788"]},"institutions":[{"id":"https://openalex.org/I87482320","display_name":"University of Management and Technology","ror":"https://ror.org/0095xcq10","country_code":"PK","type":"education","lineage":["https://openalex.org/I87482320"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Bilal Wajid","raw_affiliation_strings":["Sabz Qalam","University of Management and Technology","Sabz Qalam, Lahore, Pakistan","University of Management and Technology, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sabz Qalam","institution_ids":[]},{"raw_affiliation_string":"University of Management and Technology","institution_ids":["https://openalex.org/I87482320"]},{"raw_affiliation_string":"Sabz Qalam, Lahore, Pakistan","institution_ids":[]},{"raw_affiliation_string":"University of Management and Technology, Lahore, Pakistan","institution_ids":["https://openalex.org/I87482320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004190668","display_name":"Huma Shehwana","orcid":"https://orcid.org/0000-0002-3665-8846","observed_orcids":["https://orcid.org/0000-0002-3665-8846"]},"institutions":[{"id":"https://openalex.org/I4210155929","display_name":"National University of Medical Sciences","ror":"https://ror.org/04tj88f69","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210155929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Huma Shehwana","raw_affiliation_strings":["National University of Medical Sciences","National University of Medical Sciences, Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Medical Sciences","institution_ids":["https://openalex.org/I4210155929"]},{"raw_affiliation_string":"National University of Medical Sciences, Islamabad, Pakistan","institution_ids":["https://openalex.org/I4210155929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028986327","display_name":"Emad Uddin","orcid":"https://orcid.org/0000-0002-5177-4554","observed_orcids":["https://orcid.org/0000-0002-5177-4554"]},"institutions":[{"id":"https://openalex.org/I12003341","display_name":"National University of Science and Technology","ror":"https://ror.org/019vsm959","country_code":"RU","type":"education","lineage":["https://openalex.org/I12003341"]},{"id":"https://openalex.org/I312958679","display_name":"National University of Science and Technology","ror":"https://ror.org/02kesvt12","country_code":"ZW","type":"education","lineage":["https://openalex.org/I312958679"]},{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK","RU","ZW"],"is_corresponding":false,"raw_author_name":"Emad Uddin","raw_affiliation_strings":["National University of Science and Technology","National University of Science and Technology, Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Science and Technology","institution_ids":["https://openalex.org/I12003341","https://openalex.org/I312958679"]},{"raw_affiliation_string":"National University of Science and Technology, Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Muhammad Safdar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12003341","display_name":"National University of Science and Technology","ror":"https://ror.org/019vsm959","country_code":"RU","type":"education","lineage":["https://openalex.org/I12003341"]},{"id":"https://openalex.org/I312958679","display_name":"National University of Science and Technology","ror":"https://ror.org/02kesvt12","country_code":"ZW","type":"education","lineage":["https://openalex.org/I312958679"]},{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK","RU","ZW"],"is_corresponding":false,"raw_author_name":"Muhammad Safdar","raw_affiliation_strings":["National University of Science and Technology","National University of Science and Technology, Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Science and Technology","institution_ids":["https://openalex.org/I12003341","https://openalex.org/I312958679"]},{"raw_affiliation_string":"National University of Science and Technology, Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044048047","display_name":"Irfan Javed","orcid":"https://orcid.org/0000-0002-0268-9767","observed_orcids":["https://orcid.org/0000-0002-0268-9767"]},"institutions":[{"id":"https://openalex.org/I134276161","display_name":"Pakistan Institute of Engineering and Applied Sciences","ror":"https://ror.org/04d4mbk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I134276161"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Irfan Javed","raw_affiliation_strings":["Pakistan Institute of Engineering and Applied Sciences","Pakistan Institute of Engineering and Applied Sciences, Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pakistan Institute of Engineering and Applied Sciences","institution_ids":["https://openalex.org/I134276161"]},{"raw_affiliation_string":"Pakistan Institute of Engineering and Applied Sciences, Islamabad, Pakistan","institution_ids":["https://openalex.org/I134276161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022063454","display_name":"Muhammad Tariq","orcid":"https://orcid.org/0000-0002-0666-1075","observed_orcids":["https://orcid.org/0000-0002-0666-1075"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Tariq","raw_affiliation_strings":["Department of Biology, Lahore University of Management Sciences","Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087031667","display_name":"Amir Faisal","orcid":"https://orcid.org/0000-0002-7376-8286","observed_orcids":["https://orcid.org/0000-0002-7376-8286"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Amir Faisal","raw_affiliation_strings":["Department of Biology, Lahore University of Management Sciences","Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043191237","display_name":"Safee Ullah Chaudhary","orcid":"https://orcid.org/0000-0002-3758-6581","observed_orcids":["https://orcid.org/0000-0002-3758-6581"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Safee U Chaudhary","raw_affiliation_strings":["Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences","institution_ids":["https://openalex.org/I207789805"]},{"raw_affiliation_string":"Biomedical Informatics Research Laboratory, Department of Biology, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5043191237"],"corresponding_institution_ids":["https://openalex.org/I207789805"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.23430000245571136,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiscale-modeling","display_name":"multiscale modeling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/web-based-simulation-platform","display_name":"web-based simulation platform","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8100000023841858},{"id":"https://openalex.org/keywords/biomolecular-networks","display_name":"biomolecular networks","score":0.7910000085830688},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.7379999756813049},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.9810000061988831},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.9700000286102295},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6777142286300659},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6043902635574341},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5505927205085754},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5470550656318665},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5061714053153992},{"id":"https://openalex.org/C162215914","wikidata":"https://www.wikidata.org/wiki/Q93241","display_name":"Hypertext","level":2,"score":0.4759678244590759},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.4251599907875061},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2052585482597351},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1801961064338684},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.16322454810142517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10651451349258423},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.08623307943344116},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2021.05.04.442539","doi":"https://doi.org/10.1101/2021.05.04.442539","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.05.04.442539","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/05/2021.05.04.442539.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2021.05.04.442539","doi":"https://doi.org/10.1101/2021.05.04.442539","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.05.04.442539","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/05/2021.05.04.442539.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4099999964237213}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3456672709","display_name":null,"funder_award_id":"RF-NCBC-015","funder_id":"https://openalex.org/F4320308571","funder_display_name":"North Carolina Biotechnology Center"},{"id":"https://openalex.org/G7748824640","display_name":null,"funder_award_id":"20-3629/NRPU/R","funder_id":"https://openalex.org/F4320308571","funder_display_name":"North Carolina Biotechnology Center"}],"funders":[{"id":"https://openalex.org/F4320308571","display_name":"North Carolina Biotechnology Center","ror":"https://ror.org/03hj4jr80"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3157634603.pdf","grobid_xml":"https://content.openalex.org/works/W3157634603.grobid-xml"},"referenced_works_count":102,"referenced_works":["https://openalex.org/W99337718","https://openalex.org/W1511154369","https://openalex.org/W1571953570","https://openalex.org/W1576195516","https://openalex.org/W1585895556","https://openalex.org/W1604620983","https://openalex.org/W1629431972","https://openalex.org/W1753841117","https://openalex.org/W1908148254","https://openalex.org/W1966107523","https://openalex.org/W1979159204","https://openalex.org/W1979302584","https://openalex.org/W1980531127","https://openalex.org/W1986885614","https://openalex.org/W1998418598","https://openalex.org/W2005282179","https://openalex.org/W2007624857","https://openalex.org/W2009913017","https://openalex.org/W2011762419","https://openalex.org/W2012034410","https://openalex.org/W2018440302","https://openalex.org/W2018838463","https://openalex.org/W2019237060","https://openalex.org/W2027083184","https://openalex.org/W2027266940","https://openalex.org/W2031369606","https://openalex.org/W2035824523","https://openalex.org/W2040554855","https://openalex.org/W2042835353","https://openalex.org/W2044013267","https://openalex.org/W2050342291","https://openalex.org/W2051588629","https://openalex.org/W2062835218","https://openalex.org/W2072891907","https://openalex.org/W2082340690","https://openalex.org/W2093647165","https://openalex.org/W2094048860","https://openalex.org/W2096024592","https://openalex.org/W2097319997","https://openalex.org/W2097832852","https://openalex.org/W2099020540","https://openalex.org/W2101405933","https://openalex.org/W2102040917","https://openalex.org/W2102653059","https://openalex.org/W2105135903","https://openalex.org/W2113354827","https://openalex.org/W2115901680","https://openalex.org/W2120989152","https://openalex.org/W2122949547","https://openalex.org/W2124436671","https://openalex.org/W2125077627","https://openalex.org/W2126882378","https://openalex.org/W2131295012","https://openalex.org/W2132848998","https://openalex.org/W2133647014","https://openalex.org/W2137297899","https://openalex.org/W2138929167","https://openalex.org/W2149873003","https://openalex.org/W2154304171","https://openalex.org/W2158508062","https://openalex.org/W2160533336","https://openalex.org/W2167031279","https://openalex.org/W2168921892","https://openalex.org/W2169990865","https://openalex.org/W2172109211","https://openalex.org/W2173363282","https://openalex.org/W2195194805","https://openalex.org/W2237379835","https://openalex.org/W2248907500","https://openalex.org/W2272546316","https://openalex.org/W2296679604","https://openalex.org/W2336617253","https://openalex.org/W2359027293","https://openalex.org/W2413899142","https://openalex.org/W2499561107","https://openalex.org/W2535389011","https://openalex.org/W2550535012","https://openalex.org/W2550946621","https://openalex.org/W2554058313","https://openalex.org/W2567777922","https://openalex.org/W2568859793","https://openalex.org/W2577025303","https://openalex.org/W2598152211","https://openalex.org/W2604791900","https://openalex.org/W2611370172","https://openalex.org/W2615688110","https://openalex.org/W2677527222","https://openalex.org/W2757254843","https://openalex.org/W2765974598","https://openalex.org/W2767683865","https://openalex.org/W2801859531","https://openalex.org/W2801898580","https://openalex.org/W2807099646","https://openalex.org/W2807695862","https://openalex.org/W2911948847","https://openalex.org/W2946917009","https://openalex.org/W2950753203","https://openalex.org/W2950985821","https://openalex.org/W2979769490","https://openalex.org/W2980357235","https://openalex.org/W3088907504","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W1536970214","https://openalex.org/W1565135491","https://openalex.org/W2985427592","https://openalex.org/W1815780662","https://openalex.org/W2101501829","https://openalex.org/W2897383060","https://openalex.org/W2400569965","https://openalex.org/W3126015170"],"abstract_inverted_index":{"Abstract":[0],"Multi-scale":[1],"models":[2,121],"integrating":[3],"biomolecular":[4,80],"data":[5,105,117],"from":[6,79],"genetic,":[7],"transcriptional,":[8],"and":[9,34,57,90,104,134,138,164],"translational":[10],"levels,":[11],"coupled":[12],"with":[13],"extracellular":[14],"microenvironments":[15],"can":[16,157],"assist":[17,158],"in":[18,45,61,86,159],"decoding":[19],"the":[20,31,95],"complex":[21],"mechanisms":[22],"underlying":[23],"system-level":[24],"diseases":[25],"such":[26,38],"as":[27,150,152],"cancer.":[28],"To":[29,93],"investigate":[30],"emergent":[32],"properties":[33],"clinical":[35],"translation":[36],"of":[37,98,166],"cancer":[39],"models,":[40,100],"we":[41],"present":[42],"Theatre":[43],"for":[44,60,70,148],"silico":[46,62,87],"Systems":[47],"Oncology":[48],"(TISON,":[49],"https://tison.lums.edu.pk":[50],"),":[51],"a":[52,67,101,143],"next-generation":[53],"web-based":[54],"multi-scale":[55,71,99,145],"modeling":[56,137,146],"simulation":[58,102],"platform":[59],"systems":[63,154],"oncology.":[64],"TISON":[65,112,141],"provides":[66,142],"\u201czero-code\u201d":[68],"environment":[69],"model":[72],"development":[73,165],"by":[74],"seamlessly":[75],"coupling":[76],"scale-specific":[77,149],"information":[78],"networks,":[81],"microenvironments,":[82],"cell":[83,88],"decision":[84],"circuits,":[85],"lines,":[89],"organoid":[91],"geometries.":[92],"compute":[94],"temporal":[96],"evolution":[97],"engine":[103],"analysis":[106,139],"features":[107],"are":[108],"also":[109],"provided.":[110],"Furthermore,":[111],"integrates":[113],"patient-specific":[114],"gene":[115],"expression":[116],"to":[118,132],"evaluate":[119],"patient-centric":[120],"towards":[122],"personalized":[123,167],"therapeutics.":[124,168],"Several":[125],"literature-based":[126],"case":[127],"studies":[128],"have":[129],"been":[130],"developed":[131],"exemplify":[133],"validate":[135],"TISON\u2019s":[136],"capabilities.":[140],"cutting-edge":[144],"pipeline":[147],"well":[151],"integrative":[153],"oncology":[155],"that":[156],"drug":[160],"target":[161],"discovery,":[162],"repositioning,":[163]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
