{"id":"https://openalex.org/W3157553013","doi":null,"title":"Test-Retest Reliability of Flow Cytometric Quantification of Circulating Endothelial Cells and Endothelial Progenitor Cells in Cardiovascular Diseases","display_name":"Test-Retest Reliability of Flow Cytometric Quantification of Circulating Endothelial Cells and Endothelial Progenitor Cells in Cardiovascular Diseases","publication_year":2021,"publication_date":"2021-04-27","ids":{"openalex":"https://openalex.org/W3157553013","mag":"3157553013"},"language":"en","primary_location":{"id":"mag:3157553013","doi":null,"is_oa":false,"landing_page_url":"https://www.scitechnol.com/peer-review/testretest-reliability-of-flow-cytometric-quantification-of-circulating-endothelial-cells-and-endothelial-progenitor-cells-in-card-5jWz.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764564469","display_name":"International Journal of Cardiovascular Research","issn_l":"2324-8602","issn":["2324-8602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Cardiovascular Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079924425","display_name":"Josephine Buescher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josephine Buescher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042631889","display_name":"Fabian Weisrock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabian Weisrock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075618911","display_name":"Max Fritschka","orcid":"https://orcid.org/0000-0002-4609-3383","observed_orcids":["https://orcid.org/0000-0002-4609-3383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Max Fritschka","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4609-3383","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017858830","display_name":"Sebastian Beckmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebastian Beckmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069025004","display_name":"Simon Litmeier","orcid":"https://orcid.org/0000-0003-3682-133X","observed_orcids":["https://orcid.org/0000-0003-3682-133X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Litmeier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111963214","display_name":"Elvis Tahirovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elvis Tahirovi\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112262437","display_name":"Sara Radenovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Radenovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073076418","display_name":"Andreas Busjahn","orcid":"https://orcid.org/0000-0001-9650-6919","observed_orcids":["https://orcid.org/0000-0001-9650-6919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Busjahn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9650-6919","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103016730","display_name":"Thomas Krahn","orcid":"https://orcid.org/0000-0002-5907-3779","observed_orcids":["https://orcid.org/0000-0002-5907-3779"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Krahn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5907-3779","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086287347","display_name":"Wilfried Dinh","orcid":"https://orcid.org/0000-0001-9929-4253","observed_orcids":["https://orcid.org/0000-0001-9929-4253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilfried Dinh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112634820","display_name":"Hans\u2010Dirk Duengen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans-Dirk D\u00fcengen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2021","issue":"4","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-endothelial-cells","display_name":"circulating endothelial cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/test-retest-reliability","display_name":"test-retest reliability","score":0.9430000185966492},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8809999823570251},{"id":"https://openalex.org/keywords/surrogate-markers","display_name":"surrogate markers","score":0.7950000166893005},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.921999990940094},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intraclass-correlation-coefficient","display_name":"intraclass correlation coefficient","score":0.6850000023841858},{"id":"https://openalex.org/keywords/bland-altman-limits-of-agreement","display_name":"Bland-Altman agreement","score":0.753000020980835},{"id":"https://openalex.org/keywords/whole-blood-analysis","display_name":"whole blood analysis","score":0.4779999852180481},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.4059999883174896},{"id":"https://openalex.org/keywords/cd146","display_name":"CD146","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8893177509307861},{"id":"https://openalex.org/C104709138","wikidata":"https://www.wikidata.org/wiki/Q1671540","display_name":"Intraclass correlation","level":3,"score":0.7252782583236694},{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.7033724188804626},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5930680632591248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.566186249256134},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.546308696269989},{"id":"https://openalex.org/C2779093498","wikidata":"https://www.wikidata.org/wiki/Q14911804","display_name":"CD146","level":4,"score":0.5382803082466125},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5327223539352417},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5004754066467285},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4950546324253082},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.48052796721458435},{"id":"https://openalex.org/C2780152582","wikidata":"https://www.wikidata.org/wiki/Q1340830","display_name":"Endothelial progenitor cell","level":4,"score":0.4571703374385834},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3334816098213196},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.20507192611694336},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.0},{"id":"https://openalex.org/C171606756","wikidata":"https://www.wikidata.org/wiki/Q506132","display_name":"Psychometrics","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3157553013","doi":null,"is_oa":false,"landing_page_url":"https://www.scitechnol.com/peer-review/testretest-reliability-of-flow-cytometric-quantification-of-circulating-endothelial-cells-and-endothelial-progenitor-cells-in-card-5jWz.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764564469","display_name":"International Journal of Cardiovascular Research","issn_l":"2324-8602","issn":["2324-8602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Cardiovascular Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W590111097","https://openalex.org/W1907650756","https://openalex.org/W1970909475","https://openalex.org/W1983541079","https://openalex.org/W1993245079","https://openalex.org/W2002922221","https://openalex.org/W2005156700","https://openalex.org/W2015795623","https://openalex.org/W2021272479","https://openalex.org/W2024081693","https://openalex.org/W2024263079","https://openalex.org/W2025299174","https://openalex.org/W2025806325","https://openalex.org/W2035675650","https://openalex.org/W2067744701","https://openalex.org/W2068994530","https://openalex.org/W2072181292","https://openalex.org/W2085350659","https://openalex.org/W2090131524","https://openalex.org/W2097393771","https://openalex.org/W2109680555","https://openalex.org/W2113617288","https://openalex.org/W2127039247","https://openalex.org/W2127872440","https://openalex.org/W2134388588","https://openalex.org/W2135165880","https://openalex.org/W2141403362","https://openalex.org/W2164177263","https://openalex.org/W2171284332","https://openalex.org/W2327037637","https://openalex.org/W2340327599","https://openalex.org/W2618268791","https://openalex.org/W2644819006","https://openalex.org/W2759026991","https://openalex.org/W2796822136","https://openalex.org/W2898565675","https://openalex.org/W2912349604"],"related_works":["https://openalex.org/W2898565675","https://openalex.org/W6943897806","https://openalex.org/W2025806325","https://openalex.org/W312724539","https://openalex.org/W4205993083","https://openalex.org/W2164177263","https://openalex.org/W1848616724","https://openalex.org/W2085390558","https://openalex.org/W2074626917","https://openalex.org/W2061566600"],"abstract_inverted_index":{"Circulating":[0],"Endothelial":[1,5,17],"Cells":[2,7],"(CECs)":[3],"and":[4,25,41,79,132,163,170,172,179,189,209,216,222,226,244,265,286,307,328,347,367,399],"Progenitor":[6],"(EPCs)":[8],"are":[9],"gaining":[10],"importance":[11],"as":[12,143],"quantifiable":[13],"surrogate":[14],"biomarkers":[15],"of":[16,21,35,51,56,69,73,77,108,161,193,363,365,388,402,421],"Dysfunction":[18],"(ED).":[19],"Lack":[20],"a":[22,27,66,104,144,151,360],"common":[23],"definition":[24],"consequently,":[26],"standardized":[28],"quantification":[29,76,387],"method":[30,43],"has":[31],"limited":[32],"clinical":[33],"applicability":[34],"these":[36,52],"biomarkers.":[37],"A":[38,356],"reliable,":[39],"reproducible,":[40],"practicable":[42],"is":[44,391,415],"required":[45],"to":[46,60,417,428],"achieve":[47],"the":[48,62,194,198,419],"full":[49],"potential":[50],"parameters.":[53],"The":[54],"objective":[55],"this":[57,422],"study":[58,106,149,200],"was":[59,154,236,257,279,300,321,341],"evaluate":[61],"test-retest":[63,407],"reliability":[64,408],"over":[65],"short":[67],"period":[68],"time":[70],"(~7":[71],"days)":[72],"flow":[74,385],"cytometric":[75,386],"CECs":[78,165],"EPCs":[80,173],"in":[81,267,288,309,330,349,393,432],"human":[82],"whole":[83],"blood":[84,152],"from":[85],"patients":[86,91,110,253,275,296,317,394,433],"with":[87,114,122,254,276,297,318,395,434],"cardiovascular":[88],"disease.":[89],"100":[90],"(mean":[92],"age":[93],"65":[94],"years":[95],"\u00b1":[96],"10":[97],"years,":[98],"30":[99],"women)":[100],"were":[101,141,202,211,223,373],"enrolled":[102],"into":[103],"prospective":[105],"consisting":[107],"4":[109],"groups:":[111],"Heart":[112,120],"Failure":[113,121],"reduced":[115],"Ejection":[116,124],"Fraction":[117,125],"(HFrEF;":[118],"n=25),":[119,131],"preserved":[123],"(HFpEF;":[126],"n=26),":[127],"Diabetic":[128],"Nephropathy":[129],"(DN;":[130],"Hypertension":[133],"(HTN;":[134],"n=24).":[135],"In":[136,252,274,295,316,337],"addition,":[137],"11":[138,224],"healthy":[139,338],"volunteers":[140],"included":[142],"control":[145],"group.":[146],"At":[147],"2":[148,199],"visits,":[150],"sample":[153],"drawn,":[155],"which":[156,424],"underwent":[157],"an":[158],"identical":[159],"sequence":[160],"preparation":[162],"analysis.":[164],"(DNA+,":[166],"CD45":[167],"dim,":[168,175],"CD31+,":[169,180],"CD146+)":[171],"(CD45":[174],"CD34":[176],"br,":[177],"CD133+,":[178],"FSC":[181],"short-term":[182],"test":[183],"retest":[184],"reliability,":[185],"correlation":[186,362],"(intraclass":[187],"correlation)":[188],"agreement":[190],"(Bland-Altman":[191],"plot)":[192],"measurements":[195],"obtained":[196],"at":[197,219,229],"visits":[201],"evaluated.":[203],"Across":[204],"all":[205,410],"patients,":[206],"median":[207,369,378],"CECs/ml":[208],"EPCs/ml":[210],"12":[212],"(5th/95th":[213],"percentile:":[214],"6/22)":[215],"679":[217],"(447/1281)":[218],"visit":[220,230],"1":[221],"(6/24)":[225],"736":[227],"(510/1105)":[228],"2,":[231],"respectively;":[232],"Intraclass":[233],"Correlation":[234],"(ICC)":[235],"poor":[237,258,280,301,322,342,406],"for":[238,246,259,269,281,290,302,311,323,332,343,351,377],"CEC":[239,260,282,303,324,344,370,403],"count":[240,248,261,271,283,292,304,313,325,334,345,353],"(0.106;":[241],"ICC-95%":[242],"CI-0.08\u20130.29)":[243],"good":[245,348],"EPC":[247,270,291,312,333,352,379,389],"(0.9;":[249],"0.86\u2013":[250],"0.93).":[251],"HFpEF,":[255,396],"ICC":[256,278,299,320,340],"(0.294;":[262],"95%":[263],"CI-0.08-0.6)":[264],"moderate":[266,329],"strength":[268,289,310,331,350],"(0.694;":[272],"0.43\u20130.85).":[273],"HFrEF,":[277,397],"(0.076;":[284],"-0.32\u20130.45)":[285],"excellent":[287,308],"(0.946;":[293,314],"0.88\u20130.98).":[294,315],"DN,":[298,398],"(-0.031;":[305],"-0.44\u20130.37)":[306],"HTN,":[319],"(0.143;":[326],"-0.27\u20130.51)":[327],"(0.668;":[335],"0.37\u20130.84).":[336],"controls,":[339],"(0.378-0.26\u20130.78)":[346],"(0.846;":[354],"0.59\u20130.96).":[355],"Bland-Altman":[357],"plot":[358],"showed":[359,405],"positive":[361],"variations":[364],"differences":[366],"increasing":[368],"counts;":[371],"there":[372],"no":[374],"distinct":[375],"trends":[376],"counts.":[380],"Our":[381],"analyses":[382],"indicate":[383],"that":[384],"concentrations":[390,404],"reliable":[392],"HTN.":[400],"Quantification":[401],"across":[409],"patient":[411],"groups.":[412],"Further":[413],"research":[414],"necessary":[416],"elucidate":[418],"nature":[420],"finding,":[423],"could":[425],"be":[426],"due":[427],"higher":[429],"biological":[430],"variability":[431],"severe":[435],"ED.":[436],"Clinical":[437],"Trial":[438],"Registration":[439],"Identifier:":[440],"NCT02299960":[441]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-05-10T00:00:00"}
