{"id":"https://openalex.org/W3157534412","doi":"https://doi.org/10.5603/fm.a2021.0047","title":"The influence of functional pinealectomy and exogenous melatonin application on healing of a burr hole in adult rat calvaria: a histological and immunohistochemical study","display_name":"The influence of functional pinealectomy and exogenous melatonin application on healing of a burr hole in adult rat calvaria: a histological and immunohistochemical study","publication_year":2021,"publication_date":"2021-05-17","ids":{"openalex":"https://openalex.org/W3157534412","doi":"https://doi.org/10.5603/fm.a2021.0047","mag":"3157534412","pmid":"https://pubmed.ncbi.nlm.nih.gov/33997947"},"language":"en","primary_location":{"id":"doi:10.5603/fm.a2021.0047","doi":"https://doi.org/10.5603/fm.a2021.0047","is_oa":true,"landing_page_url":"https://doi.org/10.5603/fm.a2021.0047","pdf_url":"https://journals.viamedica.pl/folia_morphologica/article/download/FM.a2021.0047/62203","source":{"id":"https://openalex.org/S187689108","display_name":"Folia Morphologica","issn_l":"0015-5659","issn":["0015-5659","1644-3284"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320293","host_organization_name":"Via Medica","host_organization_lineage":["https://openalex.org/P4310320293"],"host_organization_lineage_names":["Via Medica"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Morphologica","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3157534412"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.viamedica.pl/folia_morphologica/article/download/FM.a2021.0047/62203","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101869250","display_name":"Hatice K\u00fcbra Ba\u015falo\u011flu","orcid":"https://orcid.org/0000-0002-1470-2842","observed_orcids":["https://orcid.org/0000-0002-1470-2842","https://orcid.org/0000-0002-0594-6773"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H. K. Basaloglu","raw_affiliation_strings":["Department of Histology and Embryology, Adnan Menderes University, Faculty of Medicine, Ayd\u0131n, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Adnan Menderes University, Faculty of Medicine, Ayd\u0131n, Turkey","institution_ids":["https://openalex.org/I76806599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061838658","display_name":"Mehmet Turgut","orcid":"https://orcid.org/0000-0001-7130-2530","observed_orcids":["https://orcid.org/0000-0001-7130-2530"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M. Turgut","raw_affiliation_strings":["Department of Histology and Embryology, Adnan Menderes University, Health Sciences Institute, Ayd\u0131n, Turkey","Department of Neurosurgery, Adnan Menderes University, Faculty of Medicine, Ayd\u0131n, Turkey","Department of Neurosurgery, Ayd\u0131n Adnan Menderes University Faculty of Medicine, 09010 Ayd\u0131n,, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Adnan Menderes University, Health Sciences Institute, Ayd\u0131n, Turkey","institution_ids":["https://openalex.org/I76806599"]},{"raw_affiliation_string":"Department of Neurosurgery, Adnan Menderes University, Faculty of Medicine, Ayd\u0131n, Turkey","institution_ids":["https://openalex.org/I76806599"]},{"raw_affiliation_string":"Department of Neurosurgery, Ayd\u0131n Adnan Menderes University Faculty of Medicine, 09010 Ayd\u0131n,, Turkey","institution_ids":["https://openalex.org/I76806599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018137378","display_name":"Cans\u0131n \u015eirin","orcid":"https://orcid.org/0000-0002-4530-701X","observed_orcids":["https://orcid.org/0000-0002-4530-701X"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"C. \u015eirin","raw_affiliation_strings":["Department of Histology and Embryology, Ege University, Faculty of Medicine, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Ege University, Faculty of Medicine, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025737700","display_name":"Yi\u011fit Uyan\u0131kgil","orcid":"https://orcid.org/0000-0002-4016-0522","observed_orcids":["https://orcid.org/0000-0002-4016-0522"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Y. Uyanikgil","raw_affiliation_strings":["Cord Blood, Cell and Tissue Research and Application Centre, Ege University, Izmir, Turkey","Department of Histology and Embryology, Ege University, Faculty of Medicine, Izmir, Turkey","Department of Stem Cell, Ege University, Health Science Institute, Izmir, Turkey","Department of Stem Cell, Ege University, Health Science Institue, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cord Blood, Cell and Tissue Research and Application Centre, Ege University, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Histology and Embryology, Ege University, Faculty of Medicine, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Stem Cell, Ege University, Health Science Institute, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Stem Cell, Ege University, Health Science Institue, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012491433","display_name":"Buket Demirci","orcid":"https://orcid.org/0000-0002-3442-5061","observed_orcids":["https://orcid.org/0000-0002-3442-5061"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"B. Demirci","raw_affiliation_strings":["Department of Pharmacology, Adnan Menderes University, Faculty of Medicine, Ayd\u0131n, Turkey","Department of Pharmacology, Ayd\u0131n Adnan Menderes University Faculty of Medicine, Ayd\u0131n, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Adnan Menderes University, Faculty of Medicine, Ayd\u0131n, Turkey","institution_ids":["https://openalex.org/I76806599"]},{"raw_affiliation_string":"Department of Pharmacology, Ayd\u0131n Adnan Menderes University Faculty of Medicine, Ayd\u0131n, Turkey","institution_ids":["https://openalex.org/I76806599"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012999137","display_name":"Emel \u00d6yk\u00fc \u00c7etin","orcid":"https://orcid.org/0000-0001-8822-9130","observed_orcids":["https://orcid.org/0000-0001-8822-9130"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"E. O. Cetin","raw_affiliation_strings":["Department of Pharmaceutical Technology, Department of Biopharmaceutics and Pharmacokinetics, Ege University Faculty of Pharmacy, Izmir, Turkey. emel.oyku.cetin@ege.edu.tr","Department of Pharmaceutical Technology, Department of Biopharmaceutics and Pharmacokinetics, EgeUniversity Faculty of Pharmacy, 35100 \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Department of Biopharmaceutics and Pharmacokinetics, Ege University Faculty of Pharmacy, Izmir, Turkey. emel.oyku.cetin@ege.edu.tr","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Pharmaceutical Technology, Department of Biopharmaceutics and Pharmacokinetics, EgeUniversity Faculty of Pharmacy, 35100 \u0130zmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2725,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.39799689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"81","issue":"2","first_page":"271","last_page":"279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.15649999678134918,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/calvarial-defect","display_name":"calvarial defect","score":0.6489999890327454},{"id":"https://openalex.org/keywords/burr-hole","display_name":"burr hole","score":0.7910000085830688},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.7919999957084656},{"id":"https://openalex.org/keywords/critical-sized-bone-defects","display_name":"critical-size bone defect","score":0.6539999842643738},{"id":"https://openalex.org/keywords/bone-sialoprotein","display_name":"bone sialoprotein","score":0.7630000114440918},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.5199999809265137},{"id":"https://openalex.org/keywords/vascularization","display_name":"vascularization","score":0.593999981880188},{"id":"https://openalex.org/keywords/connective-tissue","display_name":"connective tissue","score":0.6150000095367432},{"id":"https://openalex.org/keywords/cranial-defect-reconstruction","display_name":"cranial defect repair","score":0.6570000052452087},{"id":"https://openalex.org/keywords/histomorphometry","display_name":"histomorphometry","score":0.7929999828338623},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6629999876022339},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7450000047683716},{"id":"https://openalex.org/keywords/ossification","display_name":"ossification","score":0.3930000066757202},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.5320000052452087},{"id":"https://openalex.org/keywords/neurosurgery","display_name":"neurosurgery","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2776201020","wikidata":"https://www.wikidata.org/wiki/Q7195422","display_name":"Pinealectomy","level":4,"score":0.8127387762069702},{"id":"https://openalex.org/C2779918246","wikidata":"https://www.wikidata.org/wiki/Q613203","display_name":"Calvaria","level":3,"score":0.8021582365036011},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.6864784359931946},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.6062706112861633},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.4873424470424652},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4800349473953247},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.46690139174461365},{"id":"https://openalex.org/C2776919888","wikidata":"https://www.wikidata.org/wiki/Q1146112","display_name":"Haematoxylin","level":3,"score":0.4402180314064026},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.37038105726242065},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36981701850891113},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3346661329269409},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29365503787994385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25261878967285156},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.12293711304664612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076822","descriptor_name":"Pinealectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002921","descriptor_name":"Cicatrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.5603/fm.a2021.0047","doi":"https://doi.org/10.5603/fm.a2021.0047","is_oa":true,"landing_page_url":"https://doi.org/10.5603/fm.a2021.0047","pdf_url":"https://journals.viamedica.pl/folia_morphologica/article/download/FM.a2021.0047/62203","source":{"id":"https://openalex.org/S187689108","display_name":"Folia Morphologica","issn_l":"0015-5659","issn":["0015-5659","1644-3284"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320293","host_organization_name":"Via Medica","host_organization_lineage":["https://openalex.org/P4310320293"],"host_organization_lineage_names":["Via Medica"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Morphologica","raw_type":"journal-article"},{"id":"pmid:33997947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33997947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia morphologica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:400b18ba075a47d9bfef69af1e152a6c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/400b18ba075a47d9bfef69af1e152a6c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Folia Morphologica, Vol 81, Iss 2 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.5603/fm.a2021.0047","doi":"https://doi.org/10.5603/fm.a2021.0047","is_oa":true,"landing_page_url":"https://doi.org/10.5603/fm.a2021.0047","pdf_url":"https://journals.viamedica.pl/folia_morphologica/article/download/FM.a2021.0047/62203","source":{"id":"https://openalex.org/S187689108","display_name":"Folia Morphologica","issn_l":"0015-5659","issn":["0015-5659","1644-3284"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320293","host_organization_name":"Via Medica","host_organization_lineage":["https://openalex.org/P4310320293"],"host_organization_lineage_names":["Via Medica"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Morphologica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321404","display_name":"Adnan Menderes \u00dcniversitesi","ror":"https://ror.org/03n7yzv56"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3157534412.pdf","grobid_xml":"https://content.openalex.org/works/W3157534412.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1542961428","https://openalex.org/W1608747354","https://openalex.org/W1962185126","https://openalex.org/W1966028716","https://openalex.org/W1971528961","https://openalex.org/W1973935082","https://openalex.org/W1995819685","https://openalex.org/W2003510900","https://openalex.org/W2004607162","https://openalex.org/W2029600778","https://openalex.org/W2030066465","https://openalex.org/W2041287210","https://openalex.org/W2051185914","https://openalex.org/W2065901631","https://openalex.org/W2067049827","https://openalex.org/W2075058479","https://openalex.org/W2089976663","https://openalex.org/W2093501456","https://openalex.org/W2097662042","https://openalex.org/W2108507651","https://openalex.org/W2119494005","https://openalex.org/W2125907262","https://openalex.org/W2137380130","https://openalex.org/W2141560931","https://openalex.org/W2169789838","https://openalex.org/W2172818901","https://openalex.org/W2184812605","https://openalex.org/W2209997302","https://openalex.org/W2255170193","https://openalex.org/W2295204083","https://openalex.org/W2332583451","https://openalex.org/W2335489080","https://openalex.org/W2342347913","https://openalex.org/W2390944247","https://openalex.org/W2572559357","https://openalex.org/W2588534180","https://openalex.org/W2614587782","https://openalex.org/W2752123155","https://openalex.org/W2945792041","https://openalex.org/W2952782502","https://openalex.org/W2959268580","https://openalex.org/W2973920508","https://openalex.org/W3092846787","https://openalex.org/W6632882072"],"related_works":["https://openalex.org/W2884698494","https://openalex.org/W2902000312","https://openalex.org/W2001010930","https://openalex.org/W2342347913","https://openalex.org/W1508575006","https://openalex.org/W2460623183","https://openalex.org/W2124020987","https://openalex.org/W2087959716","https://openalex.org/W2937999298","https://openalex.org/W2042513850"],"abstract_inverted_index":{"BACKGROUND:":[0],"Even":[1],"today,":[2],"repair":[3,69,265,366,396],"of":[4,35,38,50,58,86,148,169,208,210,275,324,390],"the":[5,33,56,67,146,167,170,183,254,263,268,276,280,292,296,301,314,330,337,341,348,351,354,394],"cranial":[6],"defects":[7,134],"still":[8],"represents":[9],"a":[10,77,142,238,285],"significant":[11],"challenge":[12],"in":[13,76,145,156,182,188,195,267,336,353,370,397],"neurosurgery":[14],"and":[15,62,71,120,174,190,213,229,300,316,344],"various":[16],"options":[17],"have":[18],"been":[19],"used":[20,204,236],"for":[21,129,163,205],"their":[22],"reconstruction":[23],"to":[24,54,273,380],"date.":[25],"However,":[26],"there":[27,243],"are":[28],"very":[29],"few":[30],"studies":[31],"investigating":[32],"effects":[34,57],"exogenous":[36,63,375],"administration":[37,65],"melatonin":[39],"(MEL)":[40],"as":[41,237],"an":[42,152],"agent":[43],"that":[44,262,274,291,329,364,388],"promotes":[45],"bone":[46,68,172,212,264,365,395],"regeneration.":[47],"The":[48,84],"goal":[49],"this":[51,382],"study":[52],"was":[53,92,203,218,235,244,271,289,311,327,334,350,368,378],"investigate":[55],"functional":[59,110,118,281,371],"pinealectomy":[60],"(Px)":[61],"MEL":[64,160,376,391],"on":[66],"properties":[70],"surrounding":[72,178],"connective":[73,175],"tissue":[74,176,343],"alterations":[75,177],"rat":[78,184],"calvaria":[79,185],"model.":[80],"MATERIALS":[81],"AND":[82],"METHODS:":[83],"total":[85],"30":[87],"adult":[88],"female":[89],"Wistar-Albino":[90],"rats":[91],"randomly":[93],"divided":[94],"into":[95],"three":[96],"groups":[97,318],"(n":[98],"=":[99,320],"10):":[100],"control":[101,217],"group":[102,112,122,158,270,283,294,339,356],"(CO;":[103],"12":[104,130,164],"h":[105,107,114],"light/12":[106],"dark":[108],"exposure),":[109],"Px":[111,124,282,293,355,372],"(24":[113],"light":[115],"exposure,":[116],"light-induced":[117],"Px),":[119],"Px+MEL":[121,157,269,317,338],"(light-induced":[123],"+":[125],"MEL,":[126],"20":[127,161],"mg/kg/day":[128,162],"weeks).":[131],"Critical-sized":[132],"burr-hole":[133],"(diameter:":[135],"3.0":[136],"mm)":[137],"were":[138,186,225,251],"surgically":[139],"created":[140],"by":[141,220,227],"single":[143],"operator":[144],"calvarium":[147],"all":[149],"rats,":[150],"using":[151],"electric":[153],"drill.":[154],"Animals":[155],"received":[159],"weeks.":[165],"At":[166],"end":[168],"study,":[171],"healing":[173],"drilled":[179],"defect":[180],"area":[181],"determined":[187],"haematoxylin-eosin-stained":[189],"Mallory":[191],"Azan":[192],"slices":[193],"applied":[194],"anti-bone":[196],"sialoprotein.":[197],"Image":[198],"Pro":[199],"Express":[200],"4.5":[201],"programme":[202],"histomorphometric":[206],"calculation":[207],"areas":[209],"new":[211],"fibrotic":[214,303],"tissue.":[215],"Normality":[216],"performed":[219,252],"Shapiro-Wilk":[221,228],"test.":[222],"Variance":[223],"homogeneities":[224],"examined":[226],"Levene":[230],"tests;":[231],"Tukey":[232],"HSD":[233],"test":[234],"post":[239],"hoc":[240],"method":[241],"since":[242],"no":[245,307],"homogeneity":[246],"problem.":[247],"All":[248],"hypothesis":[249],"tests":[250],"at":[253],"0.05":[255],"significance":[256,310],"level.":[257],"RESULTS:":[258],"Histological":[259],"analysis":[260],"showed":[261,284],"process":[266,367],"similar":[272],"CO":[277,315],"group,":[278,373],"whereas":[279],"delay.":[286],"Histomorphometrically,":[287],"it":[288,326,385],"found":[290,312,335],"had":[295],"largest":[297],"hole":[298],"diameter":[299],"most":[302,331],"scar":[304,342],"area,":[305],"although":[306],"binary":[308],"statistical":[309],"between":[313],"(p":[319,357],"0.910).":[321],"In":[322],"terms":[323],"vascularisation,":[325],"observed":[328],"vascular":[332],"structure":[333],"among":[340],"ossification":[345],"areas,":[346],"while":[347],"vascularisation":[349],"least":[352],"<":[358],"0.001).":[359],"CONCLUSIONS:":[360],"Our":[361],"findings":[362],"revealed":[363],"impaired":[369],"but":[374],"replacement":[377],"able":[379],"restore":[381],"response.":[383],"Thus,":[384],"is":[386],"concluded":[387],"utilisation":[389],"may":[392],"improve":[393],"calvarial":[398],"defects.":[399]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-05-10T00:00:00"}
