{"id":"https://openalex.org/W3157448655","doi":"https://doi.org/10.1080/10406638.2021.1916543","title":"Reactions and Antibacterial Activity of 6-Bromo-3-(2-Bromoacetyl)-2H-Chromen-2-One","display_name":"Reactions and Antibacterial Activity of 6-Bromo-3-(2-Bromoacetyl)-2H-Chromen-2-One","publication_year":2021,"publication_date":"2021-04-30","ids":{"openalex":"https://openalex.org/W3157448655","doi":"https://doi.org/10.1080/10406638.2021.1916543","mag":"3157448655"},"language":"en","primary_location":{"id":"doi:10.1080/10406638.2021.1916543","doi":"https://doi.org/10.1080/10406638.2021.1916543","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10406638.2021.1916543","pdf_url":null,"source":{"id":"https://openalex.org/S178924077","display_name":"Polycyclic aromatic compounds","issn_l":"1026-7743","issn":["1026-7743","1040-6638","1563-5333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polycyclic Aromatic Compounds","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3157448655"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004450291","display_name":"Anhar Abdel\u2010Aziem","orcid":"https://orcid.org/0000-0002-3871-3183","observed_orcids":["https://orcid.org/0000-0002-3871-3183"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Anhar Abdel-Aziem","raw_affiliation_strings":["Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-3871-3183","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001593302","display_name":"Basma Saad Baaiu","orcid":"https://orcid.org/0000-0002-1675-4670","observed_orcids":["https://orcid.org/0000-0002-1675-4670"]},"institutions":[{"id":"https://openalex.org/I31439502","display_name":"University of Benghazi","ror":"https://ror.org/03fh7t044","country_code":"LY","type":"education","lineage":["https://openalex.org/I31439502"]}],"countries":["LY"],"is_corresponding":false,"raw_author_name":"Basma Saad Baaiu","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Benghazi University, Benghazi, Libya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Benghazi University, Benghazi, Libya","institution_ids":["https://openalex.org/I31439502"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036355787","display_name":"Eslam Reda El-Sawy","orcid":"https://orcid.org/0000-0002-7505-3356","observed_orcids":["https://orcid.org/0000-0002-7505-3356"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Eslam R. El-Sawy","raw_affiliation_strings":["Chemistry of Natural Compounds Department, National Research Centre, Dokki, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry of Natural Compounds Department, National Research Centre, Dokki, Giza, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004450291"],"corresponding_institution_ids":["https://openalex.org/I184834183"],"apc_list":null,"apc_paid":null,"fwci":0.8622,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.6307091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"42","issue":"7","first_page":"4809","last_page":"4818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.050700001418590546,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coumarins","display_name":"coumarins","score":0.9020000100135803},{"id":"https://openalex.org/keywords/1-3-4-thiadiazines","display_name":"1,3,4-thiadiazines","score":0.9290000200271606},{"id":"https://openalex.org/keywords/benzofurans","display_name":"benzofurans","score":0.9620000123977661},{"id":"https://openalex.org/keywords/naphthofurans","display_name":"naphthofurans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thiazole-derivatives","display_name":"thiazole derivatives","score":0.7229999899864197},{"id":"https://openalex.org/keywords/phthalic-anhydride-derivatives","display_name":"phthalic anhydride derivatives","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pyrazolones","display_name":"pyrazolone derivatives","score":0.8100000023841858},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9800000190734863},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9449743032455444},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.7396597266197205},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.6880295276641846},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6695905923843384},{"id":"https://openalex.org/C2778226065","wikidata":"https://www.wikidata.org/wiki/Q410882","display_name":"Phthalic anhydride","level":3,"score":0.6693618297576904},{"id":"https://openalex.org/C2781338262","wikidata":"https://www.wikidata.org/wiki/Q111812","display_name":"Coumarin","level":2,"score":0.595893144607544},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.5485556125640869},{"id":"https://openalex.org/C2776589655","wikidata":"https://www.wikidata.org/wiki/Q410089","display_name":"Benzofuran","level":2,"score":0.5469943284988403},{"id":"https://openalex.org/C161369605","wikidata":"https://www.wikidata.org/wiki/Q41803","display_name":"Gram","level":3,"score":0.5434556007385254},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5004940032958984},{"id":"https://openalex.org/C2776051709","wikidata":"https://www.wikidata.org/wiki/Q632006","display_name":"Gram-negative bacteria","level":4,"score":0.48952755331993103},{"id":"https://openalex.org/C2779518903","wikidata":"https://www.wikidata.org/wiki/Q857288","display_name":"Gram-positive bacteria","level":3,"score":0.46905139088630676},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.4629420042037964},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3324854373931885},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3106412887573242},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.254386305809021},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.22095531225204468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13166719675064087},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07473152875900269},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/10406638.2021.1916543","doi":"https://doi.org/10.1080/10406638.2021.1916543","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10406638.2021.1916543","pdf_url":null,"source":{"id":"https://openalex.org/S178924077","display_name":"Polycyclic aromatic compounds","issn_l":"1026-7743","issn":["1026-7743","1040-6638","1563-5333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polycyclic Aromatic Compounds","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W48771090","https://openalex.org/W63468034","https://openalex.org/W147149661","https://openalex.org/W594050491","https://openalex.org/W993054348","https://openalex.org/W1519731306","https://openalex.org/W1804954287","https://openalex.org/W1965230091","https://openalex.org/W1998354077","https://openalex.org/W2042843520","https://openalex.org/W2048171879","https://openalex.org/W2050687710","https://openalex.org/W2054741197","https://openalex.org/W2054846909","https://openalex.org/W2081478070","https://openalex.org/W2114524747","https://openalex.org/W2136931384","https://openalex.org/W2160663143","https://openalex.org/W2256576087","https://openalex.org/W2300293459","https://openalex.org/W2512628626","https://openalex.org/W2520519379","https://openalex.org/W2536020486","https://openalex.org/W2587397432","https://openalex.org/W2611800005","https://openalex.org/W2614825124","https://openalex.org/W2759448669","https://openalex.org/W2770277203","https://openalex.org/W2787550429","https://openalex.org/W2797161582","https://openalex.org/W2811066730","https://openalex.org/W2871057886","https://openalex.org/W2895645940","https://openalex.org/W2912394321","https://openalex.org/W2914679775","https://openalex.org/W2917852830","https://openalex.org/W2935145114","https://openalex.org/W2938983253","https://openalex.org/W2953219852","https://openalex.org/W2972968641","https://openalex.org/W2974363744","https://openalex.org/W2990592629","https://openalex.org/W2996165122","https://openalex.org/W2997313217","https://openalex.org/W3009229119","https://openalex.org/W3009542477","https://openalex.org/W3013811742","https://openalex.org/W3037966692","https://openalex.org/W3043487380","https://openalex.org/W3081242030","https://openalex.org/W3207977280","https://openalex.org/W4289866386","https://openalex.org/W4294235357"],"related_works":["https://openalex.org/W3037966692","https://openalex.org/W2992079883","https://openalex.org/W1683215142","https://openalex.org/W2742766349","https://openalex.org/W2952261586","https://openalex.org/W2109508190","https://openalex.org/W2027491573","https://openalex.org/W1981788169","https://openalex.org/W4385491279","https://openalex.org/W2101475291"],"abstract_inverted_index":{"In":[0],"this":[1],"investigation,":[2],"we":[3],"continued":[4],"to":[5,18,38,50],"study":[6],"the":[7,32,63],"reaction":[8],"of":[9,62],"6-bromo-3-(2-bromoacetyl)-2H-chromen-2-one":[10],"(2)":[11],"with":[12,28,40],"different":[13,52],"active":[14],"compounds":[15,66,84],"in":[16],"order":[17],"synthesize":[19],"1,3,4-thiadiazine":[20],"4,":[21],"benzofuran":[22],"6,":[23],"and":[24,58,77,86],"naphthofuran":[25],"8":[26],"associated":[27],"coumarin":[29],"moiety.":[30],"On":[31],"other":[33],"side,":[34],"6-bromo-3-(2-hydrazinylthiazol-4-yl)-2H-chromen-2-one":[35],"(9)":[36],"allowed":[37],"condense":[39],"6-bromo-3-acetylcoumarin":[41],"(1),":[42],"phthalic":[43],"anhydride":[44],"derivatives":[45],"11a,b,":[46],"or":[47],"4-(4-substituted-benzylidene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one":[48],"14a,b":[49],"afford":[51],"(2H-chromen-3-yl)thiazol-2-derivatives":[53],"10,":[54],"12a,":[55],"12b,":[56],"15a,":[57],"15b,":[59],"respectively.":[60],"Six":[61],"newly":[64],"synthesized":[65],"were":[67],"screened":[68],"for":[69],"their":[70],"in-vitro":[71],"antibacterial":[72],"activity":[73,91,101],"against":[74],"Gram-positive":[75],"bacteria,":[76],"Gram-negative":[78],"bacteria.":[79],"The":[80],"results":[81],"indicated":[82],"that,":[83],"4":[85],"10":[87],"showed":[88],"strong":[89,100],"inhibition":[90],"toward":[92,102],"Enterococcus":[93],"faecalis":[94],"(Gram-positive":[95],"bacteria),":[96],"while":[97],"12a":[98],"revealed":[99],"Pseudomonas":[103],"aeruginosa":[104],"(Gram-negative":[105],"bacteria).":[106]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-05-10T00:00:00"}