{"id":"https://openalex.org/W3157380871","doi":null,"title":"CAN017, a novel anti-HER3 antibody, exerted great potency in mouse avatars of esophageal squamous cell carcinoma with NRG1 as a biomarker.","display_name":"CAN017, a novel anti-HER3 antibody, exerted great potency in mouse avatars of esophageal squamous cell carcinoma with NRG1 as a biomarker.","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3157380871","mag":"3157380871","pmid":"https://pubmed.ncbi.nlm.nih.gov/33948383","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8085865"},"language":"en","primary_location":{"id":"pmid:33948383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33948383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8085865/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Haiyan Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyan Liao","raw_affiliation_strings":["National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen 518116, China","National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen 518116, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439606","display_name":"Cheng Zhang","orcid":"https://orcid.org/0000-0001-8932-0585","observed_orcids":["https://orcid.org/0000-0001-8932-0585"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Zhang","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute Beijing 100142, China","Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute Beijing 100142, China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061570382","display_name":"Zuhua Chen","orcid":"https://orcid.org/0009-0003-0819-7418","observed_orcids":["https://orcid.org/0009-0003-0819-7418","https://orcid.org/0000-0002-3162-089X"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zuhua Chen","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute Beijing 100142, China","Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute Beijing 100142, China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003473894","display_name":"Ya Gao","orcid":"https://orcid.org/0000-0002-4391-430X","observed_orcids":["https://orcid.org/0000-0002-4391-430X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya Gao","raw_affiliation_strings":["CANbridge Life Sciences Ltd. Beijing 100012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CANbridge Life Sciences Ltd. Beijing 100012, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100771219","display_name":"Zhongwu Li","orcid":"https://orcid.org/0000-0003-3440-9077","observed_orcids":["https://orcid.org/0000-0003-3440-9077"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongwu Li","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital and Institute Beijing 100142, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital and Institute Beijing 100142, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lingyu Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingyu Wang","raw_affiliation_strings":["SIP (Suzhou Industrial Park) LifeLink Oncology Research Institute Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIP (Suzhou Industrial Park) LifeLink Oncology Research Institute Suzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324150","display_name":"Yanyan Li","orcid":"https://orcid.org/0009-0005-7231-9293","observed_orcids":["https://orcid.org/0009-0005-7231-9293"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyan Li","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute Beijing 100142, China","Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute Beijing 100142, China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100720707","display_name":"Lin Shen","orcid":"https://orcid.org/0000-0003-1134-2922","observed_orcids":["https://orcid.org/0000-0003-1134-2922"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Shen","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute Beijing 100142, China","SIP (Suzhou Industrial Park) LifeLink Oncology Research Institute Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute Beijing 100142, China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"SIP (Suzhou Industrial Park) LifeLink Oncology Research Institute Suzhou, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100672091","display_name":"Jing Gao","orcid":"https://orcid.org/0000-0002-3613-9413","observed_orcids":["https://orcid.org/0000-0002-3613-9413"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Gao","raw_affiliation_strings":["National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen 518116, China","National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen 518116, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4992,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61989957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"4","first_page":"1697","last_page":"1708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-her3-antibody","display_name":"anti-HER3 antibody","score":0.9810000061988831},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/neuregulin-1","display_name":"neuregulin-1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8700000047683716},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8859999775886536},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7458297610282898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7340983152389526},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6807903051376343},{"id":"https://openalex.org/C2994415158","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal squamous cell carcinoma","level":3,"score":0.6137776970863342},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5784079432487488},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5692244172096252},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5331636667251587},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5139686465263367},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.5057120323181152},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4860685169696808},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4850549101829529},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2268517017364502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14369750022888184},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10676798224449158},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:33948383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33948383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8085865","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8085865/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8085865","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8085865/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1544959878","https://openalex.org/W1838614196","https://openalex.org/W1963662298","https://openalex.org/W1965864591","https://openalex.org/W1980980623","https://openalex.org/W2033488181","https://openalex.org/W2046740077","https://openalex.org/W2049309222","https://openalex.org/W2049610624","https://openalex.org/W2050461681","https://openalex.org/W2051867845","https://openalex.org/W2054041826","https://openalex.org/W2069526613","https://openalex.org/W2075657881","https://openalex.org/W2103576580","https://openalex.org/W2120213327","https://openalex.org/W2122352172","https://openalex.org/W2125065379","https://openalex.org/W2152163220","https://openalex.org/W2155104309","https://openalex.org/W2164986334","https://openalex.org/W2165411051","https://openalex.org/W2169961966","https://openalex.org/W2287555689","https://openalex.org/W2439644539","https://openalex.org/W2569188130","https://openalex.org/W2603997054","https://openalex.org/W2620739590","https://openalex.org/W2724177236","https://openalex.org/W2789245685","https://openalex.org/W2792526713","https://openalex.org/W2809321578","https://openalex.org/W2889391845","https://openalex.org/W2999385732"],"related_works":["https://openalex.org/W7148887597","https://openalex.org/W7162669209","https://openalex.org/W1665134662","https://openalex.org/W2499099171","https://openalex.org/W2565763757","https://openalex.org/W2805645085","https://openalex.org/W4379984928","https://openalex.org/W4226072756","https://openalex.org/W2096869304","https://openalex.org/W2605777005"],"abstract_inverted_index":{"CAN017":[0,32,109,120,134,180],"(AV-203),":[1],"a":[2,208],"novel":[3],"anti-HER3":[4],"antibody,":[5],"exerts":[6],"very":[7],"promising":[8],"anti-tumor":[9,177],"activities":[10],"in":[11,33,145,154,167,181,199,214],"several":[12],"human":[13],"tumor":[14,122,202],"models.":[15],"The":[16],"aim":[17],"of":[18,31,45,84,91,97,113,133,170,179],"this":[19],"study":[20,79],"was":[21,135,193],"to":[22,78,94,108,119,128,196,211],"further":[23],"investigated":[24],"the":[25,80,89,95,131,142,175],"efficacy":[26,81,132],"and":[27,62,82,110,141,157,204],"possible":[28],"responsive":[29],"biomarkers":[30],"esophageal":[34],"squamous":[35],"cell":[36],"carcinoma":[37],"(ESCC)":[38],"with":[39,121,138,184],"Chinese":[40],"characteristics.":[41],"Two":[42],"separate":[43],"cohorts":[44],"ESCC":[46,201],"patient-derived":[47],"xenograft":[48],"(PDX)":[49],"models":[50,104,117,169,183],"including":[51],"24":[52,114],"(cohort":[53,64],"1":[54,147],"as":[55,66,86,88,174,207],"training":[56],"models,":[57,68,74,160],"from":[58,69],"Crown":[59],"Bioscience":[60],"Inc.)":[61],"22":[63],"2":[65,172],"validating":[67],"Peking":[70],"University":[71],"Cancer":[72],"Hospital)":[73],"respectively,":[75],"were":[76,148,164],"used":[77],"safety":[83],"CAN017,":[85],"well":[87],"correlation":[90],"NRG1":[92,139,155,185,205],"expression":[93,140,159],"response":[96,143],"CAN017.":[98],"In":[99,188],"cohort":[100,146,171],"1,":[101],"all":[102],"PDX":[103,116,168,182],"showed":[105],"good":[106],"tolerance":[107],"8":[111],"out":[112],"(33.3%)":[115],"responded":[118],"growth":[123],"inhibition":[124],"(TGI)":[125],"\u226570%":[126],"compared":[127],"controls.":[129],"Furthermore,":[130],"positively":[136],"correlated":[137],"rates":[144],"73%":[149],"(8/11)":[150],"versus":[151],"0%":[152],"(0/13)":[153],"high":[156,186],"low":[158],"respectively.":[161],"These":[162],"results":[163],"also":[165],"validated":[166],"indicated":[173],"powerful":[176],"activity":[178],"expression.":[187],"our":[189],"study,":[190],"HER3-targeting":[191],"therapy":[192],"first":[194],"demonstrated":[195],"have":[197],"potency":[198],"inhibiting":[200],"growth,":[203],"served":[206],"predictive":[209],"biomarker":[210],"screen":[212],"patients":[213],"future":[215],"clinical":[216],"trials.":[217]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-05-10T00:00:00"}