{"id":"https://openalex.org/W3156079136","doi":"https://doi.org/10.1177/19322968211007485","title":"Effect of Hypoglycemia on Heart Rate Variability in People with Type 1 Diabetes and Impaired Awareness of Hypoglycemia","display_name":"Effect of Hypoglycemia on Heart Rate Variability in People with Type 1 Diabetes and Impaired Awareness of Hypoglycemia","publication_year":2021,"publication_date":"2021-04-15","ids":{"openalex":"https://openalex.org/W3156079136","doi":"https://doi.org/10.1177/19322968211007485","mag":"3156079136","pmid":"https://pubmed.ncbi.nlm.nih.gov/33855894","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9445333"},"language":"en","primary_location":{"id":"doi:10.1177/19322968211007485","doi":"https://doi.org/10.1177/19322968211007485","is_oa":true,"landing_page_url":"https://doi.org/10.1177/19322968211007485","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/19322968211007485","source":{"id":"https://openalex.org/S2754852731","display_name":"Journal of Diabetes Science and Technology","issn_l":"1932-2968","issn":["1932-2968","1932-3107"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/19322968211007485","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056460748","display_name":"Mats Koeneman","orcid":"https://orcid.org/0000-0001-7336-7135","observed_orcids":["https://orcid.org/0000-0001-7336-7135"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Mats Koeneman","raw_affiliation_strings":["Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","REshape Innovation Center, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-7336-7135","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"REshape Innovation Center, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085886030","display_name":"Marleen Olde Bekkink","orcid":"https://orcid.org/0000-0002-2619-3897","observed_orcids":["https://orcid.org/0000-0002-2619-3897"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marleen Olde Bekkink","raw_affiliation_strings":["Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022606553","display_name":"Lian A. van Meijel","orcid":"https://orcid.org/0000-0001-6579-8488","observed_orcids":["https://orcid.org/0000-0001-6579-8488"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lian van Meijel","raw_affiliation_strings":["Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080539094","display_name":"Sebastian J.H. Bredie","orcid":"https://orcid.org/0000-0002-6973-7540","observed_orcids":["https://orcid.org/0000-0002-6973-7540"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sebastian Bredie","raw_affiliation_strings":["Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","REshape Innovation Center, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"REshape Innovation Center, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065175958","display_name":"Bastiaan E. de Galan","orcid":"https://orcid.org/0000-0002-1255-7741","observed_orcids":["https://orcid.org/0000-0002-1255-7741"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bastiaan de Galan","raw_affiliation_strings":["CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands","Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands","Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056460748"],"corresponding_institution_ids":["https://openalex.org/I2802934949"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.2017,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76967573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"5","first_page":"1144","last_page":"1149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/impaired-awareness-of-hypoglycemia","display_name":"impaired awareness of hypoglycemia","score":0.9490000009536743},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":1.0},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.6480000019073486},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.8939999938011169},{"id":"https://openalex.org/keywords/wearable-devices","display_name":"wearable devices","score":0.5289999842643738},{"id":"https://openalex.org/keywords/hypoglycemia-detection","display_name":"hypoglycemia detection","score":0.8029999732971191},{"id":"https://openalex.org/keywords/lf-hf-ratio","display_name":"LF/HF ratio","score":0.7789999842643738},{"id":"https://openalex.org/keywords/rmssd","display_name":"RMSSD","score":0.8379999995231628},{"id":"https://openalex.org/keywords/autonomic-function","display_name":"autonomic function","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.9314429759979248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7932669520378113},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.6990654468536377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6354135274887085},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.47301533818244934},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45156338810920715},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.44187408685684204},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4363492429256439},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2798542380332947},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1177/19322968211007485","doi":"https://doi.org/10.1177/19322968211007485","is_oa":true,"landing_page_url":"https://doi.org/10.1177/19322968211007485","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/19322968211007485","source":{"id":"https://openalex.org/S2754852731","display_name":"Journal of Diabetes Science and Technology","issn_l":"1932-2968","issn":["1932-2968","1932-3107"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Science and Technology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9445333","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9445333","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Diabetes Sci Technol","raw_type":"Text"},{"id":"pmid:33855894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33855894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of diabetes science and technology","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/159635f6-9ac5-4da3-8ca0-ace1658a085c","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/159635f6-9ac5-4da3-8ca0-ace1658a085c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Koeneman, M, Olde Bekkink, M, Meijel, L V, Bredie, S & de Galan, B 2022, 'Effect of Hypoglycemia on Heart Rate Variability in People with Type 1 Diabetes and Impaired Awareness of Hypoglycemia', DST Journal of Diabetes Science and Technology, vol. 16, no. 5, pp. 1144-1149. https://doi.org/10.1177/19322968211007485","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/282322","doi":null,"is_oa":false,"landing_page_url":"https://repository.ubn.ru.nl/handle/2066/282322","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/282322","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/282322","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Diabetes Science and Technology, 16, 1144 - 1149","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/159635f6-9ac5-4da3-8ca0-ace1658a085c","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/159635f6-9ac5-4da3-8ca0-ace1658a085c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DST Journal of Diabetes Science and Technology, 16(5), 1144 - 1149. Diabetes Technology Society","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1177/19322968211007485","doi":"https://doi.org/10.1177/19322968211007485","is_oa":true,"landing_page_url":"https://doi.org/10.1177/19322968211007485","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/19322968211007485","source":{"id":"https://openalex.org/S2754852731","display_name":"Journal of Diabetes Science and Technology","issn_l":"1932-2968","issn":["1932-2968","1932-3107"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Science and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1702853972","display_name":null,"funder_award_id":"2016.30.004","funder_id":"https://openalex.org/F4320321708","funder_display_name":"Diabetes Fonds"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320321708","display_name":"Diabetes Fonds","ror":"https://ror.org/04ch2g225"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3156079136.pdf","grobid_xml":"https://content.openalex.org/works/W3156079136.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1842840699","https://openalex.org/W1976645118","https://openalex.org/W1992483091","https://openalex.org/W1999804954","https://openalex.org/W2006165608","https://openalex.org/W2011565562","https://openalex.org/W2023826463","https://openalex.org/W2024177262","https://openalex.org/W2026699230","https://openalex.org/W2031264880","https://openalex.org/W2041853828","https://openalex.org/W2049312388","https://openalex.org/W2072645032","https://openalex.org/W2085631712","https://openalex.org/W2100314278","https://openalex.org/W2144991899","https://openalex.org/W2148513135","https://openalex.org/W2167321173","https://openalex.org/W2264072095","https://openalex.org/W2285072859","https://openalex.org/W2299876101","https://openalex.org/W2410998497","https://openalex.org/W2412743669","https://openalex.org/W2463825848","https://openalex.org/W2581630660","https://openalex.org/W2808729425","https://openalex.org/W2922249064","https://openalex.org/W2940421610","https://openalex.org/W3006776390","https://openalex.org/W4298441315"],"related_works":["https://openalex.org/W2922249064","https://openalex.org/W2946222082","https://openalex.org/W2809398210","https://openalex.org/W3030778936","https://openalex.org/W3022137985","https://openalex.org/W2795833283","https://openalex.org/W1967055473","https://openalex.org/W4408070034","https://openalex.org/W2412743669","https://openalex.org/W4313443573"],"abstract_inverted_index":{"Background:":[0],"People":[1],"with":[2,31,41,57,230,255],"impaired":[3],"awareness":[4],"of":[5,12,86,92,228,251],"hypoglycemia":[6,16,32,48,147,252],"(IAH)":[7],"are":[8,223],"at":[9,141],"elevated":[10],"risk":[11],"severe,":[13],"potentially":[14],"hazardous,":[15],"and":[17,59,97,159,181,194,232,234],"would":[18],"benefit":[19],"from":[20,138],"a":[21,50,65,82,242],"device":[22],"alerting":[23],"to":[24,34,99,143,154,212],"hypoglycemia.":[25,213],"Heart":[26],"rate":[27],"variability":[28],"(HRV)":[29],"changes":[30,220,237],"due":[33],"sympathetic":[35,43],"activity.":[36],"Since":[37],"IAH":[38],"is":[39],"associated":[40],"suppressed":[42],"activity,":[44],"we":[45],"investigated":[46],"whether":[47],"elicits":[49],"measurable":[51],"change":[52,204],"in":[53,55,177,183,191,196,205,210,221,225,253],"HRV":[54,78,87,112,206,222,246],"patients":[56,254],"T1D":[58,231],"IAH.":[60,256],"Method:":[61],"Eligible":[62],"participants":[63,118,179],"underwent":[64],"modified":[66],"hyperinsulinemic":[67],"euglycemic":[68],"hypoglycemic":[69],"clamp":[70],"(glucose":[71],"nadir,":[72],"43.1":[73],"\u00b1":[74,124,130,134],"0.90":[75],"mg/dl),":[76],"while":[77],"was":[79,107],"measured":[80],"by":[81,241],"VitalConnect":[83],"HealthPatch.":[84],"Measurements":[85],"included":[88,116],"Root":[89],"Mean":[90],"Square":[91],"the":[93,156,226],"Successive":[94],"Differences":[95],"(RMSSD)":[96],"low":[98],"high":[100],"frequency":[101],"(LF:HF)":[102],"ratio.":[103],"Wilcoxon":[104],"rank-sum":[105],"test":[106],"used":[108],"for":[109,164,249],"testing":[110],"within-subject":[111],"changes.":[113],"Results:":[114],"We":[115],"12":[117,125],"(8":[119],"female,":[120],"mean":[121,127],"age":[122],"57":[123,129],"years,":[126],"HbA1c":[128],"5":[131],"mmol/mol":[132],"(7.4":[133],"0.4%)).":[135],"Symptoms":[136],"increased":[137,161,176,195],"4.0":[139],"(1.5-7.0)":[140],"euglycemia":[142,168],"7.5":[144],"(5.0-11.0)":[145],"during":[146,167],"(":[148],"P":[149,170],"=":[150],".003).":[151],"In":[152,200],"response":[153,211],"hypoglycemia,":[155],"LF:HF":[157,174],"ratio":[158,175],"RMSSD":[160,189],"when":[162],"normalized":[163],"data":[165],"obtained":[166],"(both":[169],"<":[171],".01).":[172],"The":[173,188],"6":[178],"(50%)":[180],"declined":[182],"one":[184],"other":[185],"participant":[186],"(8%).":[187],"decreased":[190],"3":[192],"(25%)":[193],"4":[197],"(33%)":[198],"participants.":[199],"2":[201],"patients,":[202],"no":[203],"could":[207],"be":[208,239],"detected":[209,240],"Conclusions:":[214],"This":[215],"study":[216],"reveals":[217],"that":[218,235],"hypoglycemia-induced":[219],"retained":[224],"majority":[227],"people":[229],"IAH,":[233],"these":[236],"can":[238],"wearable":[243],"device.":[244],"Real-time":[245],"seems":[247],"usable":[248],"detection":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-04-26T00:00:00"}