{"id":"https://openalex.org/W315586249","doi":null,"title":"[Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs].","display_name":"[Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs].","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W315586249","mag":"315586249","pmid":"https://pubmed.ncbi.nlm.nih.gov/16320678"},"language":"ru","primary_location":{"id":"pmid:16320678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16320678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004375160","display_name":"Vadim Borisovich Bregovskiy","orcid":"https://orcid.org/0000-0002-5285-8303","observed_orcids":["https://orcid.org/0000-0002-5285-8303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V B Bregovski\u012d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044365859","display_name":"O. V. Posokhina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O V Posokhina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027989120","display_name":"I A Karpova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I A Karpova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1237,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.34076275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"77","issue":"10","first_page":"15","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.45969998836517334,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.45969998836517334,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.38350000977516174,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":1.0},{"id":"https://openalex.org/keywords/diabetic-polyneuropathy","display_name":"diabetic polyneuropathy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lower-limb","display_name":"lower extremity","score":0.6909999847412109},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/predictors-of-treatment-efficacy","display_name":"predictors of treatment efficacy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/neuropathy-severity","display_name":"neuropathy severity","score":0.6600000262260437},{"id":"https://openalex.org/keywords/vibration-threshold","display_name":"vibration threshold","score":0.7450000047683716},{"id":"https://openalex.org/keywords/electroneurography","display_name":"electroneurography","score":0.6439999938011169},{"id":"https://openalex.org/keywords/diabetes-duration","display_name":"diabetes duration","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9318519234657288},{"id":"https://openalex.org/C2775892965","wikidata":"https://www.wikidata.org/wiki/Q1502312","display_name":"Polyneuropathy","level":2,"score":0.6904033422470093},{"id":"https://openalex.org/C80782408","wikidata":"https://www.wikidata.org/wiki/Q5358206","display_name":"Electroneuronography","level":3,"score":0.6064397096633911},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5783213973045349},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5594828128814697},{"id":"https://openalex.org/C110235638","wikidata":"https://www.wikidata.org/wiki/Q17119820","display_name":"Sensory threshold","level":2,"score":0.5230385065078735},{"id":"https://openalex.org/C2779178840","wikidata":"https://www.wikidata.org/wiki/Q2046550","display_name":"Diabetic neuropathy","level":3,"score":0.4897887706756592},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48069435358047485},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.46675729751586914},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2540004849433899},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C523008124","wikidata":"https://www.wikidata.org/wiki/Q5357996","display_name":"Electrodiagnosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008063","descriptor_name":"Thioctic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008063","descriptor_name":"Thioctic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012684","descriptor_name":"Sensory Thresholds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014732","descriptor_name":"Vibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035002","descriptor_name":"Lower Extremity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16320678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16320678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"Comparative Study"},{"id":"mag:315586249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16320678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2037682503","https://openalex.org/W2417220152","https://openalex.org/W1618234909","https://openalex.org/W2325268563","https://openalex.org/W2026875986","https://openalex.org/W1867011124","https://openalex.org/W4385977857","https://openalex.org/W1970945844","https://openalex.org/W2135500154","https://openalex.org/W1564843335"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"study":[2],"efficacy":[3],"of":[4,27,82,103,119,137,144,151,161,169,181,198],"sensory":[5,83,104,115,170],"deficiency":[6,84,105,116,171],"treatment":[7,33,107,168],"with":[8,18,177],"alpha-lipoic":[9],"acid":[10],"(ALA).":[11],"MATERIAL":[12],"AND":[13],"METHODS:":[14],"Twenty":[15],"seven":[16],"patients":[17,176],"diabetes":[19],"mellitus":[20],"(DM)":[21],"type":[22],"1":[23],"and":[24,98,106,113,183],"diabetic":[25],"polyneuropathy":[26,145],"the":[28,120,138],"lower":[29],"limbs":[30],"received":[31],"ALA":[32,167],"(600":[34],"mg,":[35,44],"i.v.,":[36],"drip,":[37],"for":[38,47,133],"15":[39],"days":[40],"followed":[41],"by":[42,87,190],"600":[43],"per":[45],"os,":[46],"2":[48],"months).":[49],"Mean":[50],"age":[51],"40.9":[52],"+/-":[53,59,63],"6.9":[54],"years,":[55,61],"DM":[56,111,182],"history":[57,180],"17.6":[58],"5.1":[60],"HbA1c--9.44":[62],"1.94%":[64],"(standard":[65],"4.0-6.2%).":[66],"Tactile,":[67],"vibration,":[68],"pain":[69],"sensitivity":[70,153,200],"was":[71,78,85,123,131,146,172],"assessed,":[72],"electroneurography":[73],"(n.":[74],"suralis,":[75],"n.":[76],"tibialis)":[77],"made.":[79],"The":[80,101,140],"severity":[81,102,130,163,189],"determined":[86],"10-score":[88],"Young":[89,192],"scale.":[90],"RESULTS:":[91],"There":[92],"were":[93],"positive":[94,142],"changes":[95],"in":[96,148,158,175],"objective":[97],"electrophysiological":[99],"parameters.":[100],"effect":[108],"depend":[109],"on":[110],"duration":[112],"initial":[114,128,149,185],"(predictory":[117],"value":[118],"regression":[121],"model":[122],"92%,":[124],"p":[125],"=":[126],"0.001),":[127],"neuropathy":[129,162],"responsible":[132],"up":[134],"to":[135],"66%":[136],"effect.":[139],"highest":[141],"response":[143],"achieved":[147],"threshold":[150,197],"vibration":[152,199],"under":[154,164,194,201],"16":[155,202],"V":[156],"or":[157],"total":[159],"score":[160],"6.":[165],"CONCLUSION:":[166],"most":[173],"effective":[174],"a":[178],"short":[179],"mild":[184],"neurological":[186],"disorders":[187],"(neuropathy":[188],"M.":[191],"scale":[193],"6":[195],"scores,":[196],"V).":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}