{"id":"https://openalex.org/W3155802007","doi":"https://doi.org/10.3389/fped.2021.660627","title":"Case Report: The Use of Intravenous SMOFlipid Infusion to Treat Severe Asparaginase-Induced Hypertriglyceridemia in Two Pediatric Acute Lymphoblastic Leukemia Patients","display_name":"Case Report: The Use of Intravenous SMOFlipid Infusion to Treat Severe Asparaginase-Induced Hypertriglyceridemia in Two Pediatric Acute Lymphoblastic Leukemia Patients","publication_year":2021,"publication_date":"2021-04-22","ids":{"openalex":"https://openalex.org/W3155802007","doi":"https://doi.org/10.3389/fped.2021.660627","mag":"3155802007","pmid":"https://pubmed.ncbi.nlm.nih.gov/33968859","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8100240"},"language":"en","primary_location":{"id":"doi:10.3389/fped.2021.660627","doi":"https://doi.org/10.3389/fped.2021.660627","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2021.660627","pdf_url":"https://www.frontiersin.org/articles/10.3389/fped.2021.660627/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fped.2021.660627/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079190813","display_name":"Sie Chong Doris Lau","orcid":"https://orcid.org/0000-0002-4925-0495","observed_orcids":["https://orcid.org/0000-0002-4925-0495"]},"institutions":[{"id":"https://openalex.org/I2801594805","display_name":"University Kebangsaan Malaysia Medical Centre","ror":"https://ror.org/01590nj79","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I2801594805"]},{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Sie Chong Doris Lau","raw_affiliation_strings":["Pediatric Hematology and Oncology Unit, Department of Pediatrics, UKM Medical Centre, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Hematology and Oncology Unit, Department of Pediatrics, UKM Medical Centre, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I2801594805","https://openalex.org/I885383172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110919785","display_name":"C\u2010Khai Loh","orcid":"https://orcid.org/0000-0002-9797-2089","observed_orcids":["https://orcid.org/0000-0002-9797-2089"]},"institutions":[{"id":"https://openalex.org/I2801594805","display_name":"University Kebangsaan Malaysia Medical Centre","ror":"https://ror.org/01590nj79","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I2801594805"]},{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"C-Khai Loh","raw_affiliation_strings":["Pediatric Hematology and Oncology Unit, Department of Pediatrics, UKM Medical Centre, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Hematology and Oncology Unit, Department of Pediatrics, UKM Medical Centre, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I2801594805","https://openalex.org/I885383172"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031665016","display_name":"Hamidah Alias","orcid":"https://orcid.org/0000-0003-3952-5368","observed_orcids":["https://orcid.org/0000-0003-3952-5368"]},"institutions":[{"id":"https://openalex.org/I2801594805","display_name":"University Kebangsaan Malaysia Medical Centre","ror":"https://ror.org/01590nj79","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I2801594805"]},{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Hamidah Alias","raw_affiliation_strings":["Pediatric Hematology and Oncology Unit, Department of Pediatrics, UKM Medical Centre, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Hematology and Oncology Unit, Department of Pediatrics, UKM Medical Centre, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I2801594805","https://openalex.org/I885383172"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031665016"],"corresponding_institution_ids":["https://openalex.org/I2801594805","https://openalex.org/I885383172"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.4857,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.61781421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"9","issue":null,"first_page":"660627","last_page":"660627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12426","display_name":"Lymphatic Disorders and Treatments","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smoflipid","display_name":"SMOFlipid","score":0.9610000252723694},{"id":"https://openalex.org/keywords/intravenous-lipid-emulsion","display_name":"intravenous lipid emulsion","score":0.5910000205039978},{"id":"https://openalex.org/keywords/childhood-acute-lymphoblastic-leukemia","display_name":"childhood acute lymphoblastic leukemia","score":0.9279999732971191},{"id":"https://openalex.org/keywords/high-risk-all","display_name":"high-risk ALL","score":0.6399999856948853},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.47699999809265137},{"id":"https://openalex.org/keywords/lipid-monitoring","display_name":"lipid monitoring","score":0.6129999756813049},{"id":"https://openalex.org/keywords/hyperviscosity-syndrome","display_name":"hyperviscosity syndrome","score":0.8320000171661377},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/asparaginase-toxicity","display_name":"asparaginase toxicity","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9282892942428589},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.8922224044799805},{"id":"https://openalex.org/C2776907643","wikidata":"https://www.wikidata.org/wiki/Q1641166","display_name":"Hyperviscosity syndrome","level":3,"score":0.6791982054710388},{"id":"https://openalex.org/C2778904437","wikidata":"https://www.wikidata.org/wiki/Q105296036","display_name":"Asparaginase","level":4,"score":0.6553263068199158},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.638444185256958},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.582819402217865},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5138235688209534},{"id":"https://openalex.org/C2908622408","wikidata":"https://www.wikidata.org/wiki/Q1641166","display_name":"Hyperviscosity","level":3,"score":0.48767125606536865},{"id":"https://openalex.org/C2910129229","wikidata":"https://www.wikidata.org/wiki/Q56014077","display_name":"Hypofibrinogenemia","level":3,"score":0.4822031259536743},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.47808384895324707},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.46376606822013855},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.39644166827201843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31894612312316895},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.27280694246292114},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11321234703063965},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.0},{"id":"https://openalex.org/C2994203641","wikidata":"https://www.wikidata.org/wiki/Q5712543","display_name":"Blood viscosity","level":2,"score":0.0},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.0},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fped.2021.660627","doi":"https://doi.org/10.3389/fped.2021.660627","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2021.660627","pdf_url":"https://www.frontiersin.org/articles/10.3389/fped.2021.660627/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8100240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8100240","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pediatr","raw_type":"Text"},{"id":"pmid:33968859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33968859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pediatrics","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:beaddf7ababb4a04b7a7eab63c8c75fa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/beaddf7ababb4a04b7a7eab63c8c75fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pediatrics, Vol 9 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fped.2021.660627","doi":"https://doi.org/10.3389/fped.2021.660627","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2021.660627","pdf_url":"https://www.frontiersin.org/articles/10.3389/fped.2021.660627/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3155802007.pdf","grobid_xml":"https://content.openalex.org/works/W3155802007.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W29032839","https://openalex.org/W1939338713","https://openalex.org/W1975128607","https://openalex.org/W1994793513","https://openalex.org/W1998826672","https://openalex.org/W1999935075","https://openalex.org/W2055089766","https://openalex.org/W2057774108","https://openalex.org/W2077501432","https://openalex.org/W2085001946","https://openalex.org/W2088359261","https://openalex.org/W2092916784","https://openalex.org/W2103963325","https://openalex.org/W2104514985","https://openalex.org/W2124651354","https://openalex.org/W2151848739","https://openalex.org/W2156840245","https://openalex.org/W2332785980","https://openalex.org/W2471256249","https://openalex.org/W2789330083","https://openalex.org/W2981463210"],"related_works":["https://openalex.org/W4411628844","https://openalex.org/W1975128607","https://openalex.org/W2088660840","https://openalex.org/W2057774108","https://openalex.org/W3130302673","https://openalex.org/W1968061537","https://openalex.org/W3021107920","https://openalex.org/W2971536791","https://openalex.org/W1923292257","https://openalex.org/W326984338"],"abstract_inverted_index":{"Asparaginase-induced":[0],"hypertriglyceridemia":[1,54],"can":[2],"have":[3],"a":[4,34,67],"spectrum":[5],"of":[6,49,63],"clinical":[7],"presentations,":[8],"from":[9],"being":[10],"asymptomatic":[11],"to":[12,45],"having":[13],"life-threatening":[14],"thrombosis":[15],"or":[16],"hyperviscosity":[17],"syndrome.":[18],"At":[19],"present,":[20],"there":[21],"is":[22],"no":[23],"recommendation":[24],"on":[25,37,52],"routine":[26],"lipid":[27],"monitoring":[28],"during":[29],"asparaginase-containing":[30],"treatment":[31,68],"phase,":[32],"nor":[33],"standardized":[35],"guideline":[36],"its":[38],"management.":[39],"Two":[40],"cases":[41],"are":[42],"presented":[43],"here":[44],"illustrate":[46],"the":[47,61],"effects":[48],"concurrent":[50],"infection":[51],"asparaginase-induced":[53],"in":[55,70],"patients":[56],"with":[57],"high-risk":[58],"ALL":[59],"and":[60],"use":[62],"SMOFlipid":[64],"infusion":[65],"as":[66],"option":[69],"an":[71],"acute":[72],"situation.":[73]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-04-26T00:00:00"}
