{"id":"https://openalex.org/W3154981663","doi":"https://doi.org/10.1038/s41598-021-88025-w","title":"Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects","display_name":"Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects","publication_year":2021,"publication_date":"2021-04-21","ids":{"openalex":"https://openalex.org/W3154981663","doi":"https://doi.org/10.1038/s41598-021-88025-w","mag":"3154981663","pmid":"https://pubmed.ncbi.nlm.nih.gov/33883636"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-88025-w","doi":"https://doi.org/10.1038/s41598-021-88025-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-88025-w","pdf_url":"https://www.nature.com/articles/s41598-021-88025-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-88025-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003421906","display_name":"Satoko Takahashi","orcid":"https://orcid.org/0000-0002-7287-4343","observed_orcids":["https://orcid.org/0000-0002-7287-4343"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoko Takahashi","raw_affiliation_strings":["Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011904381","display_name":"Marenao Tanaka","orcid":"https://orcid.org/0000-0002-6575-9996","observed_orcids":["https://orcid.org/0000-0002-6575-9996"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Marenao Tanaka","raw_affiliation_strings":["Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089380224","display_name":"Masato Furuhashi","orcid":"https://orcid.org/0000-0002-0145-3541","observed_orcids":["https://orcid.org/0000-0002-0145-3541"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masato Furuhashi","raw_affiliation_strings":["Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan. furuhasi@sapmed.ac.jp","Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan. furuhasi@sapmed.ac.jp","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029824713","display_name":"Norihito Moniwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norihito Moniwa","raw_affiliation_strings":["Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034844432","display_name":"Masayuki Koyama","orcid":"https://orcid.org/0000-0002-8165-5855","observed_orcids":["https://orcid.org/0000-0002-8165-5855"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Koyama","raw_affiliation_strings":["Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017459316","display_name":"Yukimura Higashiura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukimura Higashiura","raw_affiliation_strings":["Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081129945","display_name":"Arata Osanami","orcid":"https://orcid.org/0009-0002-9574-0302","observed_orcids":["https://orcid.org/0009-0002-9574-0302"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Arata Osanami","raw_affiliation_strings":["Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081911884","display_name":"Yufu Gocho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yufu Gocho","raw_affiliation_strings":["Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070864329","display_name":"Hirofumi Ohnishi","orcid":"https://orcid.org/0000-0002-5873-6438","observed_orcids":["https://orcid.org/0000-0002-5873-6438"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Ohnishi","raw_affiliation_strings":["Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076182243","display_name":"Keita Numata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keita Numata","raw_affiliation_strings":["Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004099927","display_name":"Takashi Hisasue","orcid":"https://orcid.org/0009-0002-8385-6308","observed_orcids":["https://orcid.org/0009-0002-8385-6308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Hisasue","raw_affiliation_strings":["Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002774870","display_name":"Nagisa Hanawa","orcid":"https://orcid.org/0009-0000-8702-1645","observed_orcids":["https://orcid.org/0009-0000-8702-1645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nagisa Hanawa","raw_affiliation_strings":["Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044149153","display_name":"Tetsuji Miura","orcid":"https://orcid.org/0000-0001-5024-7085","observed_orcids":["https://orcid.org/0000-0001-5024-7085"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuji Miura","raw_affiliation_strings":["Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan","institution_ids":["https://openalex.org/I141882310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089380224"],"corresponding_institution_ids":["https://openalex.org/I141882310"],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":3.9966,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.94859356,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"8606","last_page":"8606"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-liver-index","display_name":"fatty liver index","score":0.9829999804496765},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9779999852180481},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.902999997138977},{"id":"https://openalex.org/keywords/urine-protein","display_name":"urinary protein","score":0.6869999766349792},{"id":"https://openalex.org/keywords/ckd-prediction","display_name":"CKD prediction","score":0.859000027179718},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.597000002861023},{"id":"https://openalex.org/keywords/healthy-adults","display_name":"healthy adults","score":0.5329999923706055},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8133957982063293},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7887909412384033},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7655264139175415},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6802338361740112},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.659044623374939},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6544594168663025},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.6136890649795532},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5443633794784546},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.49135318398475647},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46205583214759827},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.43039023876190186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39360398054122925},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35576876997947693},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35431569814682007},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.307468056678772},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-021-88025-w","doi":"https://doi.org/10.1038/s41598-021-88025-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-88025-w","pdf_url":"https://www.nature.com/articles/s41598-021-88025-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:33883636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33883636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8060251","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8060251","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9857da550b694a85be6ce587cf9f6b9a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9857da550b694a85be6ce587cf9f6b9a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-88025-w","doi":"https://doi.org/10.1038/s41598-021-88025-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-88025-w","pdf_url":"https://www.nature.com/articles/s41598-021-88025-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7200000286102295}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2354203970","display_name":"Elucidation of underlying mechanism of the onset and renal deterioration of kidney disease contributed by lipid chaperones","funder_award_id":"19K08708","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8215159234","display_name":"Elucidation of intracellular actions of fatty acid-binding protein family and application to clinical therapies","funder_award_id":"20K08913","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3154981663.pdf","grobid_xml":"https://content.openalex.org/works/W3154981663.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1570583414","https://openalex.org/W1839386673","https://openalex.org/W1965712234","https://openalex.org/W1967165702","https://openalex.org/W1968955451","https://openalex.org/W1983568514","https://openalex.org/W1986490872","https://openalex.org/W1987504685","https://openalex.org/W1989961712","https://openalex.org/W2045516356","https://openalex.org/W2049517312","https://openalex.org/W2061405430","https://openalex.org/W2065799460","https://openalex.org/W2067485366","https://openalex.org/W2071949222","https://openalex.org/W2075307485","https://openalex.org/W2080760372","https://openalex.org/W2088301140","https://openalex.org/W2096592656","https://openalex.org/W2097270759","https://openalex.org/W2106272645","https://openalex.org/W2106421416","https://openalex.org/W2110267763","https://openalex.org/W2111946630","https://openalex.org/W2121960517","https://openalex.org/W2127612701","https://openalex.org/W2142844314","https://openalex.org/W2152189242","https://openalex.org/W2155384570","https://openalex.org/W2164118055","https://openalex.org/W2168342632","https://openalex.org/W2198999700","https://openalex.org/W2204688218","https://openalex.org/W2322881201","https://openalex.org/W2328176404","https://openalex.org/W2334832052","https://openalex.org/W2393451543","https://openalex.org/W2528273981","https://openalex.org/W2555532689","https://openalex.org/W2593650293","https://openalex.org/W2616283320","https://openalex.org/W2737934310","https://openalex.org/W2767917689","https://openalex.org/W2772777089","https://openalex.org/W2790381739","https://openalex.org/W2797206764","https://openalex.org/W2890757932","https://openalex.org/W2946328047","https://openalex.org/W3015579983","https://openalex.org/W3021955079","https://openalex.org/W3032878975","https://openalex.org/W3041087683","https://openalex.org/W3048946955","https://openalex.org/W3084070158","https://openalex.org/W4212929213","https://openalex.org/W4235374500"],"related_works":["https://openalex.org/W2994176440","https://openalex.org/W2481749367","https://openalex.org/W2510575233","https://openalex.org/W2495367848","https://openalex.org/W830718730","https://openalex.org/W2793477322","https://openalex.org/W4236720793","https://openalex.org/W4320929188","https://openalex.org/W1992882990","https://openalex.org/W1971368128"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"potential":[2],"link":[3],"between":[4,22],"chronic":[5],"kidney":[6],"disease":[7,13],"(CKD)":[8],"and":[9,29,34,91,128],"non-alcoholic":[10],"fatty":[11,23],"liver":[12,24],"(NAFLD)":[14],"has":[15],"been":[16],"suggested.":[17],"We":[18],"investigated":[19],"the":[20,35,85,146,153,173,177,189,203],"relationship":[21],"index":[25],"(FLI),":[26],"a":[27,55,75,106,120,197,211],"noninvasive":[28],"simple":[30],"predictor":[31],"of":[32,37,71,77,98,115,132,138,149,181,200,205],"NAFLD,":[33],"development":[36,117,151,204],"CKD":[38,72,116,150,206],"defined":[39],"as":[40,176],"estimated":[41],"glomerular":[42],"filtration":[43],"rate":[44],"<":[45],"60":[46],"mL/min/1.73":[47],"m2":[48],"or":[49],"positive":[50],"for":[51,192],"urinary":[52],"protein":[53],"during":[54],"10-year":[56,86],"follow-up":[57],"period":[58],"in":[59,125,152,169,172,207,210],"subjects":[60,79],"who":[61],"received":[62],"annual":[63],"health":[64],"examinations":[65],"(n":[66],"=":[67],"28,890).":[68],"After":[69],"exclusion":[70],"at":[73,123,141],"baseline,":[74],"total":[76],"14,163":[78],"(male/female:":[80],"9077/5086)":[81],"were":[82],"recruited.":[83],"During":[84],"period,":[87],"1458":[88],"males":[89,127],"(16.1%)":[90],"737":[92],"females":[93,129],"(14.5%)":[94],"had":[95],"new":[96],"onset":[97],"CKD.":[99,194],"Multivariable":[100],"Cox":[101],"proportional":[102],"hazard":[103,112],"models":[104],"with":[105,119],"restricted":[107],"cubic":[108],"spline":[109],"showed":[110],"that":[111,168],"ratios":[113],"(HRs)":[114],"increased":[118],"higher":[121,166],"FLI":[122,139,182,201],"baseline":[124,142],"both":[126,170,208],"after":[130],"adjustment":[131],"confounders.":[133],"When":[134],"divided":[135],"by":[136],"tertiles":[137],"level":[140,199],"(T1":[143],"~":[144],"T3),":[145],"adjusted":[147],"risk":[148,185],"T3":[154],"group":[155,175],"(HR":[156],"[95%":[157],"confidence":[158],"interval],":[159],"male/female:":[160],"1.33":[161],"[1.16\u20131.54]/1.33":[162],"[1.08\u20131.63])":[163],"was":[164],"significantly":[165,187],"than":[167],"sexes":[171,209],"T1":[174],"reference.":[178],"The":[179],"addition":[180],"into":[183],"traditional":[184],"factors":[186],"improved":[188],"discriminatory":[190],"capability":[191],"predicting":[193],"In":[195],"conclusion,":[196],"high":[198],"predicts":[202],"general":[212],"population.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}