{"id":"https://openalex.org/W3154344530","doi":"https://doi.org/10.3390/cancers13091999","title":"Human Endogenous Retrovirus Reactivation: Implications for Cancer Immunotherapy","display_name":"Human Endogenous Retrovirus Reactivation: Implications for Cancer Immunotherapy","publication_year":2021,"publication_date":"2021-04-21","ids":{"openalex":"https://openalex.org/W3154344530","doi":"https://doi.org/10.3390/cancers13091999","mag":"3154344530","pmid":"https://pubmed.ncbi.nlm.nih.gov/33919186","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8122352"},"language":"en","primary_location":{"id":"doi:10.3390/cancers13091999","doi":"https://doi.org/10.3390/cancers13091999","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13091999","pdf_url":"https://www.mdpi.com/2072-6694/13/9/1999/pdf?version=1619000302","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/13/9/1999/pdf?version=1619000302","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072227057","display_name":"Annacarmen Petrizzo","orcid":"https://orcid.org/0000-0003-3228-6958","observed_orcids":["https://orcid.org/0000-0003-3228-6958"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Annacarmen Petrizzo","raw_affiliation_strings":["Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083575894","display_name":"Concetta Ragone","orcid":"https://orcid.org/0000-0002-9521-6802","observed_orcids":["https://orcid.org/0000-0002-9521-6802"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Concetta Ragone","raw_affiliation_strings":["Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089373718","display_name":"Beatrice Cavalluzzo","orcid":"https://orcid.org/0000-0002-3254-0322","observed_orcids":["https://orcid.org/0000-0002-3254-0322"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Cavalluzzo","raw_affiliation_strings":["Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044359811","display_name":"Angela Mauriello","orcid":"https://orcid.org/0000-0002-0133-7540","observed_orcids":["https://orcid.org/0000-0002-0133-7540"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Mauriello","raw_affiliation_strings":["Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083373234","display_name":"Carmen Manolio","orcid":"https://orcid.org/0000-0001-7579-857X","observed_orcids":["https://orcid.org/0000-0001-7579-857X"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmen Manolio","raw_affiliation_strings":["Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076878292","display_name":"Maria Tagliamonte","orcid":"https://orcid.org/0000-0002-7167-4817","observed_orcids":["https://orcid.org/0000-0002-7167-4817"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Tagliamonte","raw_affiliation_strings":["Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027662125","display_name":"Luigi Buonaguro","orcid":"https://orcid.org/0000-0002-6380-7114","observed_orcids":["https://orcid.org/0000-0002-6380-7114","https://orcid.org/0000-0002-7491-7220"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luigi Buonaguro","raw_affiliation_strings":["Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, \u201cFondazione Pascale\u201d-IRCCS, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027662125","https://openalex.org/A5072227057"],"corresponding_institution_ids":["https://openalex.org/I4210141868"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":0.6202,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.54573171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"13","issue":"9","first_page":"1999","last_page":"1999"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.16859999299049377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-endogenous-retroviruses","display_name":"human endogenous retroviruses","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/viral-mimicry","display_name":"viral mimicry","score":0.7020000219345093},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.8569999933242798},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-specific-antigens","display_name":"tumor-specific antigens","score":0.9769999980926514},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C121346293","wikidata":"https://www.wikidata.org/wiki/Q1340715","display_name":"Endogenous retrovirus","level":4,"score":0.7908350825309753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6770187616348267},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6315390467643738},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5953489542007446},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5699973106384277},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.5251830816268921},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.4772641360759735},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4718259274959564},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45116615295410156},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41766971349716187},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32857847213745117},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2952408492565155},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2919532060623169},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.253182053565979},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24190309643745422}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers13091999","doi":"https://doi.org/10.3390/cancers13091999","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13091999","pdf_url":"https://www.mdpi.com/2072-6694/13/9/1999/pdf?version=1619000302","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8122352","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8122352","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8122352/pdf/cancers-13-01999.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:33919186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33919186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:eb6f330960dc4b4e80f66ae44ae8b063","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/eb6f330960dc4b4e80f66ae44ae8b063","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 13, Iss 1999, p 1999 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers13091999","doi":"https://doi.org/10.3390/cancers13091999","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13091999","pdf_url":"https://www.mdpi.com/2072-6694/13/9/1999/pdf?version=1619000302","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1464101492","display_name":null,"funder_award_id":"FESR 2014-2020","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G1888088267","display_name":null,"funder_award_id":"2014-2020\u2019","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G2095541950","display_name":null,"funder_award_id":"2014/2020","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G4790670037","display_name":null,"funder_award_id":"POR FESR 2014/2020","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G7941423795","display_name":"ERA-NET: Aligning national/regional translational cancer research programmes and activities","funder_award_id":"643638","funder_id":"https://openalex.org/F4320338342","funder_display_name":"H2020 Health"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338342","display_name":"H2020 Health","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3154344530.pdf","grobid_xml":"https://content.openalex.org/works/W3154344530.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W188092122","https://openalex.org/W1509233575","https://openalex.org/W1905278501","https://openalex.org/W1953890763","https://openalex.org/W1969310770","https://openalex.org/W1990278838","https://openalex.org/W2023851657","https://openalex.org/W2028917545","https://openalex.org/W2042957226","https://openalex.org/W2082783780","https://openalex.org/W2087808447","https://openalex.org/W2092243554","https://openalex.org/W2098378506","https://openalex.org/W2108457260","https://openalex.org/W2130641469","https://openalex.org/W2144605452","https://openalex.org/W2162895870","https://openalex.org/W2183798419","https://openalex.org/W2298618221","https://openalex.org/W2342445623","https://openalex.org/W2523397191","https://openalex.org/W2560865719","https://openalex.org/W2562099553","https://openalex.org/W2591046380","https://openalex.org/W2596855995","https://openalex.org/W2620530030","https://openalex.org/W2689610267","https://openalex.org/W2729218605","https://openalex.org/W2766045486","https://openalex.org/W2775351627","https://openalex.org/W2792669235","https://openalex.org/W2793184824","https://openalex.org/W2801545642","https://openalex.org/W2808902544","https://openalex.org/W2810869921","https://openalex.org/W2883220169","https://openalex.org/W2888758049","https://openalex.org/W2889101858","https://openalex.org/W2889530223","https://openalex.org/W2891119826","https://openalex.org/W2891802945","https://openalex.org/W2891846381","https://openalex.org/W2896401613","https://openalex.org/W2901283619","https://openalex.org/W2913744515","https://openalex.org/W2954615294","https://openalex.org/W2998098265","https://openalex.org/W3009255914","https://openalex.org/W3011127849","https://openalex.org/W3015549321","https://openalex.org/W3032059370","https://openalex.org/W3103430703","https://openalex.org/W3103755024","https://openalex.org/W3128646645","https://openalex.org/W3134992827"],"related_works":["https://openalex.org/W2891119826","https://openalex.org/W4391573207","https://openalex.org/W4309990725","https://openalex.org/W3009255914","https://openalex.org/W4401225876","https://openalex.org/W4210712743","https://openalex.org/W2039333400","https://openalex.org/W7154577109","https://openalex.org/W3112397285","https://openalex.org/W3047288045"],"abstract_inverted_index":{"Human":[0],"endogenous":[1],"retroviruses":[2,8],"(HERVs)":[3],"derive":[4],"from":[5,29],"ancestral":[6],"exogenous":[7],"whose":[9],"genetic":[10],"material":[11],"has":[12],"been":[13],"integrated":[14],"in":[15,44,123],"our":[16],"germline":[17],"DNA.":[18],"Several":[19],"lines":[20],"of":[21,95,107],"evidence":[22],"indicate":[23,50],"that":[24,51,63,84,89],"cancer":[25,124,129],"immunotherapy":[26],"may":[27,90],"benefit":[28],"HERV":[30,52,100,121],"reactivation,":[31],"which":[32],"can":[33,55],"be":[34,56],"induced":[35],"either":[36,58],"by":[37,40,70],"drugs":[38],"or":[39,81],"cellular":[41],"changes":[42],"occurring":[43],"tumor":[45],"cells.":[46],"Indeed,":[47],"several":[48],"studies":[49],"proviral":[53],"DNA":[54],"transcribed":[57],"to":[59,76,82,92],"double-stranded":[60],"RNA":[61],"(dsRNA)":[62],"is":[64,85,102],"sensed":[65],"as":[66],"a":[67,77],"\"danger":[68],"signal\"":[69],"pattern":[71],"recognition":[72],"receptors":[73],"(PRRs),":[74],"leading":[75],"viral":[78],"mimicry":[79],"state,":[80],"mRNA":[83],"translated":[86],"into":[87],"proteins":[88],"contribute":[91],"the":[93,105],"landscape":[94],"tumor-specific":[96],"antigens":[97],"(TSAs).":[98],"Alternatively,":[99],"reactivation":[101,122],"associated":[103],"with":[104],"expression":[106],"long":[108],"noncoding":[109],"RNAs":[110],"(lncRNAs).":[111],"In":[112],"this":[113],"review,":[114],"we":[115],"will":[116],"highlight":[117],"recent":[118],"findings":[119],"on":[120],"and":[125],"its":[126],"implications":[127],"for":[128],"immunotherapy.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-04-26T00:00:00"}
