{"id":"https://openalex.org/W3154202971","doi":null,"title":"Mechanismen idiosynkratischer Lebertoxizit\u00e4t - Einfluss von Arzneistoff-unabh\u00e4ngigen Stressfaktoren auf die Bildung reaktiver Metaboliten und zellul\u00e4ren Stress","display_name":"Mechanismen idiosynkratischer Lebertoxizit\u00e4t - Einfluss von Arzneistoff-unabh\u00e4ngigen Stressfaktoren auf die Bildung reaktiver Metaboliten und zellul\u00e4ren Stress","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W3154202971","mag":"3154202971"},"language":"de","primary_location":{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:6323","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-74342","pdf_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-74342","source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-74342","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042674529","display_name":"Susanne Ramm","orcid":"https://orcid.org/0000-0003-1108-5620","observed_orcids":["https://orcid.org/0000-0003-1108-5620"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Susanne Ramm","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1108-5620","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042674529"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiosyncratic-drug-induced-liver-injury","display_name":"idiosyncratic drug-induced liver injury","score":0.8980000019073486},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.9390000104904175},{"id":"https://openalex.org/keywords/reactive-metabolites","display_name":"reactive metabolites","score":0.7279999852180481},{"id":"https://openalex.org/keywords/cellular-stress","display_name":"cellular stress","score":0.7149999737739563},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9279999732971191},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.9179999828338623},{"id":"https://openalex.org/keywords/buthionine-sulfoximine","display_name":"buthionine sulfoximine","score":0.9319999814033508},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6299999952316284},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.47200000286102295},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4090000092983246},{"id":"https://openalex.org/keywords/concomitant-medications","display_name":"concomitant medications","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6015346050262451},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4930257499217987},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34362494945526123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19017070531845093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:6323","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-74342","pdf_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-74342","source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralthesis"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-025498470","doi":null,"is_oa":false,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-74342","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},{"id":"mag:3154202971","doi":null,"is_oa":false,"landing_page_url":"https://opus.bibliothek.uni-wuerzburg.de/files/6323/Dissertation_SusanneRamm.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:6323","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-74342","pdf_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-74342","source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralthesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3154202971.pdf","grobid_xml":"https://content.openalex.org/works/W3154202971.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7112177716","https://openalex.org/W2049151398","https://openalex.org/W4245762615","https://openalex.org/W2913087796","https://openalex.org/W2003181581","https://openalex.org/W7148343273","https://openalex.org/W7097470970","https://openalex.org/W2600952483","https://openalex.org/W2148727766","https://openalex.org/W2036523827"],"abstract_inverted_index":{"Idiosynkratische":[0],"Lebersch\u00e4digung":[1,423],"durch":[2,43,133,192,279,345],"Arzneimittel":[3],"(z.B.":[4,154,269,332,379],"Diclofenac)":[5],"stellt":[6],"trotz":[7],"ihres":[8],"seltenen":[9],"Auftretens":[10],"eine":[11,59,65,132,174,322,370,409,415],"erhebliche":[12],"Komplikation":[13],"in":[14,75,84,141,145,171,198,284,341,395,435],"der":[15,85,88,137,146,181,277,342,420],"Arzneimittelentwicklung":[16],"und":[17,27,69,109,272,304,326,337,364,399],"-therapie":[18],"dar.":[19],"Die":[20,159],"zu":[21,81,215,264,430,446,452],"idiosynkratischen":[22],"Reaktionen":[23],"f\u00fchrenden,":[24],"komplexen":[25],"chemischen":[26],"biologischen":[28],"Abl\u00e4ufe":[29],"sind":[30,268],"noch":[31],"weitgehend":[32],"unklar.":[33],"Inzwischen":[34],"wird":[35],"jedoch":[36,190,235,367],"vermutet,":[37],"dass":[38,210,237,308,321,408],"die":[39,76,94,177,208,211,221,238,258,260,275,280,306,360,393,440,458],"Toxizit\u00e4t":[40,95,138],"eines":[41],"Arzneimittels":[42],"Arzneistoff-unabh\u00e4ngige":[44,309],"Risikofaktoren,":[45],"wie":[46,392],"Krankheiten,":[47],"Entz\u00fcndungsreaktionen,":[48],"Co-Medikation":[49],"oder":[50,156,194,202,217,249,296,432],"Alkohol,":[51],"erh\u00f6ht":[52],"werden":[53],"kann.":[54],"M\u00f6gliche":[55],"Mechanismen":[56],"k\u00f6nnten":[57],"hierbei":[58],"vermehrte":[60],"Bildung":[61,223,246,313],"reaktiver":[62,247,417],"Metaboliten":[63,248,266],"bzw.":[64,117,148,197,414],"ver\u00e4nderte":[66],"zellul\u00e4re":[67],"Stress-":[68],"Immunantwort":[70],"sein.":[71],"Um":[72],"tiefere":[73],"Einblicke":[74],"Bedeutung":[77],"m\u00f6glicher":[78],"Arzneistoff-unabh\u00e4ngiger":[79],"Risikofaktoren":[80],"erhalten,":[82],"wurde":[83,129],"vorliegenden":[86],"Arbeit":[87],"Einfluss":[89],"drei":[90],"verschiedener":[91],"Stressfaktoren":[92,102,134],"auf":[93],"von":[96,139,213,228,240,262,362,412,442,461],"Diclofenac":[97,214,365],"(Dcl)":[98],"untersucht.":[99],"Bei":[100],"diesen":[101],"handelte":[103],"es":[104],"sich":[105],"um":[106,121],"Lipopolysaccharid":[107],"(LPS)":[108],"Poly":[110],"I:C":[111],"(PIC)":[112],"zur":[113,124,226],"Simulation":[114],"einer":[115,150,161,167,447,453],"bakteriellen":[116],"viralen":[118],"Entz\u00fcndung":[119],"sowie":[120,220,274,376,451],"Buthionin-Sulfoximin":[122],"(BSO)":[123],"Depletion":[125],"zellul\u00e4ren":[126],"Glutathions.":[127],"Zus\u00e4tzlich":[128,387],"getestet,":[130],"ob":[131],"ausgel\u00f6ste":[135],"Erh\u00f6hung":[136],"Dcl":[140,195,243,263,350,356,400,413,462],"Ratten":[142],"mit":[143,149,166,178,200,282,328,347,353,397],"Ver\u00e4nderungen":[144],"Biotransformation":[147],"Hochregulation":[151,301,329],"co-stimulatorischer":[152,324,330,449],"Faktoren":[153,303,331],"Zytokine":[155],"Alarmsignale)":[157],"einhergeht.":[158],"Kombination":[160,199,361],"einw\u00f6chigen":[162],"therapeutisch":[163],"dosierten":[164],"Dcl-Behandlung":[165],"einmaligen":[168],"LPS-Dosis":[169],"erzeugte":[170],"den":[172,396,436],"Tieren":[173,402],"ausgepr\u00e4gte":[175],"Hepatotoxizit\u00e4t,":[176],"erh\u00f6hten":[179],"Aktivit\u00e4ten":[180],"Aminotransferasen":[182],"im":[183],"Serum":[184],"einherging.":[185],"Diese":[186],"adversen":[187],"Effekte":[188],"konnten":[189,233],"nicht":[191,424],"LPS":[193,241,283,348,363,398,443],"alleine,":[196],"PIC":[201,354,431],"BSO":[203,433],"erzeugt":[204],"werden.":[205],"Es":[206],"besteht":[207],"Annahme,":[209],"Bioaktivierung":[212],"5-OH-Dcl":[216],"Dcl-Acylglucuronid":[218],"(AG)":[219],"folgende":[222],"kovalenter":[224],"Proteinaddukte":[225,251],"Entwicklung":[227,421],"Lebertoxizit\u00e4t":[229],"beitr\u00e4gt.":[230],"Mittels":[231],"LC-MS/MS-Messungen":[232],"wir":[234],"nachweisen,":[236],"Gabe":[239,441],"+":[242,349,355],"keine":[244,300,311],"erh\u00f6hte":[245,312],"Dcl-AG-abh\u00e4ngiger":[250],"ausl\u00f6st.":[252],"Im":[253,428],"Einklang":[254],"damit":[255],"wurden":[256],"Enzyme,":[257],"f\u00fcr":[259,294],"Bio-aktivierung":[261],"reaktiven":[265],"verantwortlich":[267],"Cyp2C11,":[270],"Cyp2C7":[271],"UGT2B1),":[273],"MRP-Effluxtransporter":[276],"Leber":[278,343],"Co-Behandlung":[281],"ihrer":[285],"Genexpression":[286],"gehemmt.":[287,403],"Zus\u00e4tzliche":[288],"qRT-PCR-Analysen":[289],"Nrf2-abh\u00e4ngiger":[290],"Gene,":[291],"als":[292,351,444],"Sensor":[293],"elektrophilen":[295],"oxidativen":[297],"Stress,":[298],"zeigten":[299],"zytoprotektiver":[302],"unterst\u00fctzen":[305],"Schlussfolgerung,":[307],"Stress-faktoren":[310],"toxischer":[314],"Dcl-Metaboliten":[315,418],"ausl\u00f6sen.":[316],"Schlie\u00dflich":[317],"ergaben":[318],"unsere":[319,406],"Analysen,":[320],"Aktivierung":[323,411,448],"NF\u03baB-":[325],"MAPK-Signalwege":[327],"IL-1\u03b2,":[333,380],"TNF-\u03b1,":[334,381],"CINC-1,":[335,382],"iNOS)":[336],"Akkumulation":[338,416],"neutrophiler":[339],"Granulozyten":[340],"sowohl":[344],"Behandlung":[346],"auch":[352],"induziert":[357],"wurde.":[358,464],"Nur":[359],"bewirkte":[366],"dar\u00fcber":[368],"hinaus":[369],"massive":[371],"Freisetzung":[372],"pro-inflammatorischer":[373],"Zytokine,":[374],"Chemokine":[375],"toxizit\u00e4tsf\u00f6rdernder":[377],"Alarmsignale":[378],"HMGB1,":[383],"LTB4)":[384],"ins":[385],"Plasma.":[386],"waren":[388],"sch\u00fctzende":[389],"negative":[390],"Feed-back-Mechanismen,":[391],"Hitzeschockreaktion,":[394],"behandelten":[401],"Zusammenfassend":[404],"zeigen":[405],"Ergebnisse,":[407],"metabolische":[410],"an":[419],"idiosynkratischer":[422],"ausschlaggebend":[425],"beteiligt":[426],"ist.":[427],"Gegensatz":[429],"f\u00fchrte":[434],"verabreichten":[437],"Dosen":[438],"nur":[439],"Stressfaktor":[445],"Signalwege":[450],"Hemmung":[454],"protektiver":[455],"Systeme,":[456],"wodurch":[457],"lebersch\u00e4digende":[459],"Wirkung":[460],"potenziert":[463]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-04-26T00:00:00"}
