{"id":"https://openalex.org/W3153679970","doi":"https://doi.org/10.1038/s41598-021-86917-5","title":"The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson\u2019s disease","display_name":"The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson\u2019s disease","publication_year":2021,"publication_date":"2021-04-12","ids":{"openalex":"https://openalex.org/W3153679970","doi":"https://doi.org/10.1038/s41598-021-86917-5","mag":"3153679970","pmid":"https://pubmed.ncbi.nlm.nih.gov/33846426","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8041759"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-86917-5","doi":"https://doi.org/10.1038/s41598-021-86917-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-86917-5","pdf_url":"https://www.nature.com/articles/s41598-021-86917-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-86917-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066627243","display_name":"Rachel Mai McQuade","orcid":"https://orcid.org/0000-0002-3510-1288","observed_orcids":["https://orcid.org/0000-0002-3510-1288"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"id":"https://openalex.org/I4210116486","display_name":"Western Health","ror":"https://ror.org/02p4mwa83","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210116486"]},{"id":"https://openalex.org/I71270174","display_name":"Victoria University","ror":"https://ror.org/04j757h98","country_code":"AU","type":"education","lineage":["https://openalex.org/I71270174"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Rachel M. McQuade","raw_affiliation_strings":["College of Health and Biomedicine, Victoria University, Sunshine, VIC, 3021, Australia. rmcquade@unimelb.edu.au","Department of Medicine, Western Health, Melbourne University, Sunshine, VIC, 3021, Australia. rmcquade@unimelb.edu.au","Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia. rmcquade@unimelb.edu.au","Department of Medicine, Western Health, Melbourne University, Sunshine, VIC, 3021, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health and Biomedicine, Victoria University, Sunshine, VIC, 3021, Australia. rmcquade@unimelb.edu.au","institution_ids":["https://openalex.org/I71270174"]},{"raw_affiliation_string":"Department of Medicine, Western Health, Melbourne University, Sunshine, VIC, 3021, Australia. rmcquade@unimelb.edu.au","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210116486"]},{"raw_affiliation_string":"Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia. rmcquade@unimelb.edu.au","institution_ids":["https://openalex.org/I242743682"]},{"raw_affiliation_string":"Department of Medicine, Western Health, Melbourne University, Sunshine, VIC, 3021, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210116486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032557756","display_name":"Lewis M. Singleton","orcid":"https://orcid.org/0000-0002-3317-2701","observed_orcids":["https://orcid.org/0000-0002-3317-2701"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lewis M. Singleton","raw_affiliation_strings":["Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067578524","display_name":"Hongyi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hongyi Wu","raw_affiliation_strings":["Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021179992","display_name":"Sophie Hyesuk Lee","orcid":"https://orcid.org/0000-0002-2049-9756","observed_orcids":["https://orcid.org/0000-0002-2049-9756"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sophie Lee","raw_affiliation_strings":["Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014826585","display_name":"Remy Constable","orcid":"https://orcid.org/0000-0003-1148-9326","observed_orcids":["https://orcid.org/0000-0003-1148-9326"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Remy Constable","raw_affiliation_strings":["Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007932387","display_name":"Madeleine R. Di Natale","orcid":"https://orcid.org/0000-0002-7949-5725","observed_orcids":["https://orcid.org/0000-0002-7949-5725"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Madeleine Di Natale","raw_affiliation_strings":["Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011809566","display_name":"Mitchell Ty Ringuet","orcid":"https://orcid.org/0000-0002-7890-307X","observed_orcids":["https://orcid.org/0000-0002-7890-307X"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mitchell T. Ringuet","raw_affiliation_strings":["Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108082821","display_name":"Joel P. Berger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel P. Berger","raw_affiliation_strings":["JP Berger Consulting, Boston, MA, 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JP Berger Consulting, Boston, MA, 02111, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068932238","display_name":"Jessica A. Kauhausen","orcid":"https://orcid.org/0000-0002-0877-8496","observed_orcids":["https://orcid.org/0000-0002-0877-8496"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jessica Kauhausen","raw_affiliation_strings":["Stem Cells and Neural Development Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cells and Neural Development Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044118193","display_name":"Clare L. Parish","orcid":"https://orcid.org/0000-0001-8212-9884","observed_orcids":["https://orcid.org/0000-0001-8212-9884"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Clare L. Parish","raw_affiliation_strings":["Stem Cells and Neural Development Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cells and Neural Development Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048261317","display_name":"David Isaac Finkelstein","orcid":"https://orcid.org/0000-0002-8167-4917","observed_orcids":["https://orcid.org/0000-0002-8167-4917"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David I. Finkelstein","raw_affiliation_strings":["Parkinson's Disease Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parkinson's Disease Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060226120","display_name":"John B. Furness","orcid":"https://orcid.org/0000-0002-0219-3438","observed_orcids":["https://orcid.org/0000-0002-0219-3438"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John B. Furness","raw_affiliation_strings":["Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC, 3010, Australia","Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032994975","display_name":"Shanti Diwakarla","orcid":"https://orcid.org/0000-0003-2328-3528","observed_orcids":["https://orcid.org/0000-0003-2328-3528"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"id":"https://openalex.org/I4210116486","display_name":"Western Health","ror":"https://ror.org/02p4mwa83","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210116486"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shanti Diwakarla","raw_affiliation_strings":["Department of Medicine, Western Health, Melbourne University, Sunshine, VIC, 3021, Australia","Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Western Health, Melbourne University, Sunshine, VIC, 3021, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210116486"]},{"raw_affiliation_string":"Digestive Physiology and Nutrition Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia","institution_ids":["https://openalex.org/I242743682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066627243"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682","https://openalex.org/I4210116486","https://openalex.org/I71270174"],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":3.319,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.93900606,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"7934","last_page":"7934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/enteric-neuropathy","display_name":"enteric neuropathy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/enteric-nervous-system","display_name":"enteric nervous system","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.7289999723434448},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/rotenone","display_name":"rotenone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/a53t-alpha-synuclein","display_name":"A53T alpha-synuclein","score":0.8650000095367432},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hu-protein","display_name":"HU protein","score":0.5699999928474426},{"id":"https://openalex.org/keywords/neuronal-soma-size","display_name":"neuronal soma size","score":0.6359999775886536},{"id":"https://openalex.org/keywords/gastrointestinal-function","display_name":"gastrointestinal function","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2778389096","wikidata":"https://www.wikidata.org/wiki/Q412388","display_name":"Rotenone","level":3,"score":0.7752131819725037},{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.7610580921173096},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6275516152381897},{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.6194485425949097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.489348828792572},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45267510414123535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39435333013534546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.377664178609848},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.2317599058151245},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19318422675132751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11063972115516663}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005724","descriptor_name":"Ganglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005724","descriptor_name":"Ganglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007418","descriptor_name":"Intestinal Pseudo-Obstruction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012402","descriptor_name":"Rotenone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015632","descriptor_name":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052248","descriptor_name":"Nitric Oxide Synthase Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-021-86917-5","doi":"https://doi.org/10.1038/s41598-021-86917-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-86917-5","pdf_url":"https://www.nature.com/articles/s41598-021-86917-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:33846426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33846426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8041759","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8041759/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/278036","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/278036","pdf_url":"http://hdl.handle.net/11343/278036","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:84b393003cc04c729aedad1290f826e6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/84b393003cc04c729aedad1290f826e6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/27176517","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_association_of_enteric_neuropathy_with_gut_phenotypes_in_acute_and_progressive_models_of_Parkinson_s_disease/27176517","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-86917-5","doi":"https://doi.org/10.1038/s41598-021-86917-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-86917-5","pdf_url":"https://www.nature.com/articles/s41598-021-86917-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1338341643","display_name":null,"funder_award_id":"ID: 4506","funder_id":"https://openalex.org/F4320313734","funder_display_name":"Jack Brockhoff Foundation"},{"id":"https://openalex.org/G3650236882","display_name":"Protecting the Gut: A Novel Therapeutic Avenue for Parkinson\u2019s Disease","funder_award_id":"1183420","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G467983655","display_name":"Unravelling the neuropathological basis of the gastrointestinal manifestations of Parkinson\u2019s Disease","funder_award_id":"1145686","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320313734","display_name":"Jack Brockhoff Foundation","ror":"https://ror.org/02ybsyy31"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3153679970.pdf","grobid_xml":"https://content.openalex.org/works/W3153679970.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W60293109","https://openalex.org/W1232419225","https://openalex.org/W1533496890","https://openalex.org/W1660608324","https://openalex.org/W1709926499","https://openalex.org/W1857585802","https://openalex.org/W1885589840","https://openalex.org/W1978002644","https://openalex.org/W1981005146","https://openalex.org/W1981367331","https://openalex.org/W1988368501","https://openalex.org/W1988527254","https://openalex.org/W1989735540","https://openalex.org/W1999252428","https://openalex.org/W1999385317","https://openalex.org/W2004123088","https://openalex.org/W2011523748","https://openalex.org/W2012286700","https://openalex.org/W2016179616","https://openalex.org/W2016704608","https://openalex.org/W2018603142","https://openalex.org/W2022745281","https://openalex.org/W2029503022","https://openalex.org/W2033185924","https://openalex.org/W2034151625","https://openalex.org/W2044388847","https://openalex.org/W2044580180","https://openalex.org/W2044908785","https://openalex.org/W2046541000","https://openalex.org/W2060112326","https://openalex.org/W2064492560","https://openalex.org/W2073283634","https://openalex.org/W2078250483","https://openalex.org/W2084357246","https://openalex.org/W2085022353","https://openalex.org/W2085850337","https://openalex.org/W2090058235","https://openalex.org/W2093120223","https://openalex.org/W2095649828","https://openalex.org/W2097989918","https://openalex.org/W2104950937","https://openalex.org/W2106022949","https://openalex.org/W2127754136","https://openalex.org/W2140995103","https://openalex.org/W2144941656","https://openalex.org/W2170404941","https://openalex.org/W2230622295","https://openalex.org/W2275269386","https://openalex.org/W2293877091","https://openalex.org/W2503014787","https://openalex.org/W2549296757","https://openalex.org/W2791832333","https://openalex.org/W2806614570","https://openalex.org/W2923824245","https://openalex.org/W2924973872","https://openalex.org/W2940768525","https://openalex.org/W2943359597","https://openalex.org/W2952375798","https://openalex.org/W2987940105","https://openalex.org/W2991891929","https://openalex.org/W3033944848","https://openalex.org/W4211032576"],"related_works":["https://openalex.org/W2036565678","https://openalex.org/W4313199018","https://openalex.org/W1978002644","https://openalex.org/W4408374312","https://openalex.org/W3034483714","https://openalex.org/W7120641894","https://openalex.org/W1660608324","https://openalex.org/W4378648626","https://openalex.org/W4283646577","https://openalex.org/W1981005146"],"abstract_inverted_index":{"Abstract":[0],"Parkinson\u2019s":[1],"disease":[2],"(PD)":[3],"is":[4],"associated":[5,106],"with":[6,65,91,107,159],"neuronal":[7,83],"damage":[8,208],"in":[9,18,43,70,110,135,168,182],"the":[10,19,71,74,99,162,176,203,210,216],"brain":[11],"and":[12,35,57,66,82,88,128,150,174,188,205],"gut.":[13],"This":[14],"work":[15],"compares":[16],"changes":[17],"enteric":[20,201],"nervous":[21],"system":[22],"(ENS)":[23],"of":[24,29,49,53,73,101,132,164,178,200,207],"commonly":[25],"used":[26],"mouse":[27,45],"models":[28,196],"PD":[30,195],"that":[31],"exhibit":[32],"central":[33],"neuropathy":[34,40],"a":[36,129,198],"gut":[37],"phenotype.":[38],"Enteric":[39],"was":[41,105,213],"assessed":[42],"five":[44],"models:":[46],"peripheral":[47],"injection":[48,52],"MPTP;":[50],"intracerebral":[51],"6-OHDA;":[54],"oral":[55],"rotenone;":[56],"mice":[58,119,141,170,190],"transgenic":[59],"for":[60],"A53T":[61,140,189],"variant":[62],"human":[63],"\u03b1-synuclein":[64],"without":[67],"rotenone.":[68],"Changes":[69],"ENS":[72],"colon":[75,136],"were":[76,89],"quantified":[77],"using":[78],"pan-neuronal":[79],"marker,":[80],"Hu,":[81],"nitric":[84],"oxide":[85],"synthase":[86],"(nNOS)":[87],"correlated":[90],"GI":[92],"function.":[93],"MPTP":[94],"had":[95,120,142],"no":[96],"effect":[97],"on":[98,215],"number":[100,163],"Hu+":[102,111,123,145,165,179],"neurons":[103,134],"but":[104],"an":[108],"increase":[109],"nuclear":[112],"translocation":[113],"(P":[114,125,137,147,155,171,185,191],"<":[115,126,138,148,156,172,186,192],"0.04).":[116,193],"6-OHDA":[117],"lesioned":[118],"significantly":[121,143],"fewer":[122,144],"neurons/ganglion":[124],"0.02)":[127,187],"reduced":[130,161],"proportion":[131,177],"nNOS+":[133],"0.001).":[139],"neurons/area":[146],"0.001)":[149],"exhibited":[151,197],"larger":[152],"soma":[153],"size":[154],"0.03).":[157],"Treatment":[158],"rotenone":[160],"cells/mm":[166],"2":[167],"WT":[169,184],"0.006)":[173],"increased":[175],"translocated":[180],"cells":[181],"both":[183],"All":[194],"degree":[199],"neuropathy,":[202],"extent":[204],"type":[206],"to":[209],"ENS,":[211],"however,":[212],"dependent":[214],"model.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-04-26T00:00:00"}
