{"id":"https://openalex.org/W3153082002","doi":"https://doi.org/10.1136/thorax-2020-btsabstracts.205","title":"P60 Evaluation of ventilation parameters on aerosol delivery during mechanical ventilation of COVID-19 patients","display_name":"P60 Evaluation of ventilation parameters on aerosol delivery during mechanical ventilation of COVID-19 patients","publication_year":2021,"publication_date":"2021-01-21","ids":{"openalex":"https://openalex.org/W3153082002","doi":"https://doi.org/10.1136/thorax-2020-btsabstracts.205","mag":"3153082002"},"language":"en","primary_location":{"id":"doi:10.1136/thorax-2020-btsabstracts.205","doi":"https://doi.org/10.1136/thorax-2020-btsabstracts.205","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thorax-2020-btsabstracts.205","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/76/Suppl_1/A120.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ventilatory strategies in COVID-19","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://thorax.bmj.com/content/thoraxjnl/76/Suppl_1/A120.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025197414","display_name":"Elena Fern\u00e1ndez Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-5823-2731","observed_orcids":["https://orcid.org/0000-0002-5823-2731"]},"institutions":[{"id":"https://openalex.org/I4210100542","display_name":"Aerogen (Ireland)","ror":"https://ror.org/019g1wb57","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210100542"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"E Fernandez Fernandez","raw_affiliation_strings":["Aerogen Ltd., Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerogen Ltd., Galway, Ireland","institution_ids":["https://openalex.org/I4210100542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034369133","display_name":"Marc Mac Giolla Eain","orcid":"https://orcid.org/0000-0002-0211-2132","observed_orcids":["https://orcid.org/0000-0002-0211-2132"]},"institutions":[{"id":"https://openalex.org/I4210100542","display_name":"Aerogen (Ireland)","ror":"https://ror.org/019g1wb57","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210100542"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"M Mac Giolla Eain","raw_affiliation_strings":["Aerogen Ltd., Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerogen Ltd., Galway, Ireland","institution_ids":["https://openalex.org/I4210100542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011752665","display_name":"Andrew O\u2019Sullivan","orcid":"https://orcid.org/0000-0002-5434-1260","observed_orcids":["https://orcid.org/0000-0002-5434-1260"]},"institutions":[{"id":"https://openalex.org/I4210100542","display_name":"Aerogen (Ireland)","ror":"https://ror.org/019g1wb57","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210100542"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"A O\u2019Sullivan","raw_affiliation_strings":["Aerogen Ltd., Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerogen Ltd., Galway, Ireland","institution_ids":["https://openalex.org/I4210100542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054898346","display_name":"Ronan J. MacLoughlin","orcid":"https://orcid.org/0000-0002-3164-1607","observed_orcids":["https://orcid.org/0000-0002-3164-1607"]},"institutions":[{"id":"https://openalex.org/I4210100542","display_name":"Aerogen (Ireland)","ror":"https://ror.org/019g1wb57","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210100542"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"R MacLoughlin","raw_affiliation_strings":["Aerogen Ltd., Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerogen Ltd., Galway, Ireland","institution_ids":["https://openalex.org/I4210100542"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210100542"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A120","last_page":"A121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10990","display_name":"Infection Control and Ventilation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/aerosol-drug-delivery","display_name":"aerosol drug delivery","score":0.753000020980835},{"id":"https://openalex.org/keywords/low-tidal-volume-ventilation","display_name":"low tidal volume ventilation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/salbutamol","display_name":"salbutamol","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ventilatory-parameters","display_name":"ventilatory parameters","score":0.5669999718666077},{"id":"https://openalex.org/keywords/inhalation-therapy","display_name":"inhalation therapy","score":0.3930000066757202},{"id":"https://openalex.org/keywords/tidal-volume","display_name":"tidal volume","score":0.6869999766349792},{"id":"https://openalex.org/keywords/respiratory-rate","display_name":"respiratory rate","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ventilator-circuit","display_name":"ventilator circuit","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8550833463668823},{"id":"https://openalex.org/C43396882","wikidata":"https://www.wikidata.org/wiki/Q2197000","display_name":"Exhalation","level":2,"score":0.7043668627738953},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.7032581567764282},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.6710608005523682},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.6299524307250977},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5777003765106201},{"id":"https://openalex.org/C2777394947","wikidata":"https://www.wikidata.org/wiki/Q410358","display_name":"Salbutamol","level":3,"score":0.5431896448135376},{"id":"https://openalex.org/C8213797","wikidata":"https://www.wikidata.org/wiki/Q754250","display_name":"Respiratory rate","level":4,"score":0.4846254289150238},{"id":"https://openalex.org/C79959777","wikidata":"https://www.wikidata.org/wiki/Q754333","display_name":"Respiratory minute volume","level":3,"score":0.45231881737709045},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4260209798812866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19185087084770203},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.10313665866851807},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.09831061959266663},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.07103300094604492},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/thorax-2020-btsabstracts.205","doi":"https://doi.org/10.1136/thorax-2020-btsabstracts.205","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thorax-2020-btsabstracts.205","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/76/Suppl_1/A120.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ventilatory strategies in COVID-19","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/thorax-2020-btsabstracts.205","doi":"https://doi.org/10.1136/thorax-2020-btsabstracts.205","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thorax-2020-btsabstracts.205","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/76/Suppl_1/A120.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ventilatory strategies in COVID-19","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3153082002.pdf","grobid_xml":"https://content.openalex.org/works/W3153082002.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2597070792","https://openalex.org/W3121693121"],"related_works":["https://openalex.org/W3202808629","https://openalex.org/W3009495973","https://openalex.org/W3159925809","https://openalex.org/W7140214251","https://openalex.org/W7163382007","https://openalex.org/W4285812913","https://openalex.org/W4312873910","https://openalex.org/W3138785620","https://openalex.org/W2779777501","https://openalex.org/W2980606232"],"abstract_inverted_index":{"Introduction":[0],"and":[1,149,178,331,348,354],"Objectives":[2],"COVID-19":[3,308],"can":[4],"cause":[5],"serious":[6],"respiratory":[7,334,349],"complications.":[8],"One":[9],"form":[10],"of":[11,53,81,84,105,184,199,218,262,288,340],"treatment":[12],"utilises":[13],"aerosolised":[14,90],"therapeutics":[15],"concurrently":[16],"with":[17,44,68,91,269,285,317,323],"mechanical":[18],"ventilation":[19,27,71,74,256,272,306],"(MV).":[20],"Clinicians":[21],"have":[22],"adopted":[23],"low":[24],"tidal":[25,319,325],"volume":[26],"(LTV)":[28],"strategies":[29,303],"(4\u20136":[30],"mL/kg":[31],"body":[32],"weight)1":[33],"in":[34,42,204,213,222,228,267,276,307],"these":[35],"patients.":[36,309],"Nebuliser":[37],"performance":[38],"is":[39,293],"typically":[40,274],"characterised":[41],"accordance":[43],"international":[45],"ventilatory":[46,241],"standard":[47],"ISO274272":[48],"(ISO":[49],"ventilation).":[50],"The":[51,182,216],"objective":[52],"this":[54,219],"study":[55],"was":[56,89,167,186,211],"to":[57,63,233],"compare":[58],"the":[59,102,106,170,179,197,200,205,226,229,234,238,263,270,289,332],"aerosol":[60,230,264,301],"dose":[61,80,202,231,265,291],"delivered":[62,232,266],"a":[64,92,109,248],"simulated":[65,119,235,249],"adult":[66,125,250],"model":[67],"either":[69],"LTV":[70,255,305],"or":[72],"ISO":[73,131,271],"settings.":[75,242],"Methods":[76],"A":[77,161],"2.5":[78],"ml":[79],"1":[82],"mg/ml":[83],"salbutamol":[85],"(GlaxoSmithKline":[86],"Ltd.,":[87,98],"Ireland)":[88,99,166],"vibrating":[93],"mesh":[94],"nebuliser":[95,278],"(VMN)":[96],"(Aerogen":[97],"positioned":[100],"on":[101],"dry":[103],"side":[104],"humidifier":[107],"within":[108],"dual":[110],"limb":[111],"circuit":[112],"(Fisher":[113],"&":[114],"Paykel,":[115],"New":[116,337],"Zealand)":[117],"during":[118,304],"MV":[120,253],"(Servo-I,":[121],"Maquet,":[122],"Sweden).":[123],"Two":[124],"breath":[126],"patterns":[127],"were":[128],"generated:":[129],"1)":[130],"ventilation,":[132],"Tidal":[133],"Volume":[134],"VT:":[135,152],"500":[136],"mL,":[137,154],"Breathing":[138],"Rate":[139],"BR":[140,155],"=":[141,156],"15":[142],"BPM,":[143,158],"Inhalation":[144],"Exhalation":[145],"ratio":[146],"I:E:":[147,159],"1:1,":[148],"2)":[150],"LTV,":[151],"400":[153],"20":[157],"1:2.":[160],"capture":[162],"filter":[163],"(Respirgard,":[164],"Baxter,":[165],"placed":[168,203],"between":[169],"ETT":[171],"(8.0":[172],"mm,":[173],"Flexicare":[174],"Medical":[175],"Inc.,":[176],"UK)":[177],"test":[180],"lung.":[181],"mass":[183],"drug":[185],"determined":[187],"using":[188],"UV":[189],"spectrophotometry":[190],"(276":[191],"nm).":[192],"Results":[193,215],"are":[194],"expressed":[195],"as":[196,321],"percentage":[198],"nominal":[201],"nebuliser\u2019s":[206],"medication":[207],"cup.":[208],"All":[209],"testing":[210],"performed":[212],"triplicate.":[214],"results":[217,245],"study,":[220],"presented":[221],"figure":[223],"1,":[224],"highlight":[225],"difference":[227],"patient":[236,251],"at":[237],"two":[239],"different":[240],"Conclusions":[243],"Study":[244],"confirm":[246],"that":[247,292],"undergoing":[252],"utilising":[254],"strategy":[257],"would":[258],"receive":[259],"approximately":[260],"half":[261],"comparison":[268],"parameters":[273],"used":[275],"reporting":[277],"performance.":[279],"These":[280],"findings":[281],"should":[282],"provide":[283],"clinicians":[284],"an":[286],"approximation":[287],"administered":[290],"delivered.":[294],"This":[295],"may":[296],"be":[297],"useful":[298],"when":[299],"optimising":[300],"dosing":[302],"References":[310],"Acute":[311],"Respiratory":[312],"Distress":[313],"Syndrome":[314],"Network.":[315],"\u2018Ventilation":[316],"lower":[318],"volumes":[320,326],"compared":[322],"traditional":[324],"for":[327],"acute":[328,333],"lung":[329],"injury":[330],"distress":[335],"syndrome.\u2019":[336],"England":[338],"Journal":[339],"Medicine":[341],"342.18":[342],"(2000):":[343],"1301\u20131308.":[344],"ISO27427:2019":[345],"\u2013":[346,351],"Anaesthetic":[347],"equipment":[350],"Nebulising":[352],"systems":[353],"components.":[355]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2021-04-26T00:00:00"}