{"id":"https://openalex.org/W3152939338","doi":null,"title":"The Regulation of Juvenile Hormone in Dictyoptera: A Functional and Evolutionary Study of USP/RXR and Allatostatin","display_name":"The Regulation of Juvenile Hormone in Dictyoptera: A Functional and Evolutionary Study of USP/RXR and Allatostatin","publication_year":2010,"publication_date":"2010-02-12","ids":{"openalex":"https://openalex.org/W3152939338","mag":"3152939338"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/18762","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/18762","pdf_url":"https://utoronto.scholaris.ca/bitstreams/f011891b-20b8-446f-98df-eff12e1a44fc/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/f011891b-20b8-446f-98df-eff12e1a44fc/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044690381","display_name":"Ekaterina F. Hult","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ekaterina F. Hult","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044690381"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/juvenile-hormone","display_name":"juvenile hormone","score":0.8529999852180481},{"id":"https://openalex.org/keywords/allatostatin","display_name":"allatostatin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neuropeptide-signaling","display_name":"neuropeptide signaling","score":0.7329999804496765},{"id":"https://openalex.org/keywords/insect-endocrinology","display_name":"insect endocrinology","score":0.5950000286102295},{"id":"https://openalex.org/keywords/diploptera-punctata","display_name":"Diploptera punctata","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mecoptera","display_name":"Mecoptera","score":0.8119999766349792},{"id":"https://openalex.org/keywords/receptor-evolution","display_name":"receptor evolution","score":0.621999979019165},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2779204946","wikidata":"https://www.wikidata.org/wiki/Q2087279","display_name":"Dictyoptera","level":3,"score":0.7848464250564575},{"id":"https://openalex.org/C71220013","wikidata":"https://www.wikidata.org/wiki/Q419220","display_name":"Juvenile hormone","level":3,"score":0.6859188079833984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.429377019405365},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3644229769706726},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34536269307136536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3399829864501953},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3227250277996063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.283535897731781},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.15520420670509338},{"id":"https://openalex.org/C2777346155","wikidata":"https://www.wikidata.org/wiki/Q18123008","display_name":"Cockroach","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/18762","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/18762","pdf_url":"https://utoronto.scholaris.ca/bitstreams/f011891b-20b8-446f-98df-eff12e1a44fc/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/18762","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/18762","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3152939338","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/18762/1/Hult_Ekaterina_F_200911_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/18762","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/18762","pdf_url":"https://utoronto.scholaris.ca/bitstreams/f011891b-20b8-446f-98df-eff12e1a44fc/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3152939338.pdf","grobid_xml":"https://content.openalex.org/works/W3152939338.grobid-xml"},"referenced_works_count":299,"referenced_works":["https://openalex.org/W34525891","https://openalex.org/W129841773","https://openalex.org/W217330988","https://openalex.org/W420957490","https://openalex.org/W791550880","https://openalex.org/W1480777853","https://openalex.org/W1481441293","https://openalex.org/W1485004591","https://openalex.org/W1486325159","https://openalex.org/W1497339776","https://openalex.org/W1544451660","https://openalex.org/W1552460409","https://openalex.org/W1555392021","https://openalex.org/W1560325857","https://openalex.org/W1588798914","https://openalex.org/W1589929646","https://openalex.org/W1608900097","https://openalex.org/W1693545577","https://openalex.org/W1920973730","https://openalex.org/W1942904383","https://openalex.org/W1963544126","https://openalex.org/W1963754243","https://openalex.org/W1965283959","https://openalex.org/W1966276708","https://openalex.org/W1966843280","https://openalex.org/W1967261461","https://openalex.org/W1970278987","https://openalex.org/W1970473343","https://openalex.org/W1970524406","https://openalex.org/W1971006425","https://openalex.org/W1972729755","https://openalex.org/W1972923700","https://openalex.org/W1973509623","https://openalex.org/W1978682814","https://openalex.org/W1979215316","https://openalex.org/W1980379735","https://openalex.org/W1981348336","https://openalex.org/W1981939829","https://openalex.org/W1982337117","https://openalex.org/W1982433160","https://openalex.org/W1982607030","https://openalex.org/W1982762925","https://openalex.org/W1983060619","https://openalex.org/W1983781602","https://openalex.org/W1984013464","https://openalex.org/W1984509210","https://openalex.org/W1985266047","https://openalex.org/W1987996415","https://openalex.org/W1989212186","https://openalex.org/W1990723014","https://openalex.org/W1990724825","https://openalex.org/W1992465946","https://openalex.org/W1992853351","https://openalex.org/W1993230431","https://openalex.org/W1995237258","https://openalex.org/W1995728826","https://openalex.org/W1995754186","https://openalex.org/W1996177643","https://openalex.org/W1996291500","https://openalex.org/W1998047403","https://openalex.org/W1998655241","https://openalex.org/W2000097575","https://openalex.org/W2000517171","https://openalex.org/W2000536152","https://openalex.org/W2001842402","https://openalex.org/W2002249019","https://openalex.org/W2002402065","https://openalex.org/W2002811949","https://openalex.org/W2004721388","https://openalex.org/W2005153206","https://openalex.org/W2005736471","https://openalex.org/W2006008686","https://openalex.org/W2006378273","https://openalex.org/W2007421685","https://openalex.org/W2008890305","https://openalex.org/W2009596137","https://openalex.org/W2010780353","https://openalex.org/W2012436588","https://openalex.org/W2012512768","https://openalex.org/W2012561689","https://openalex.org/W2014861681","https://openalex.org/W2015272217","https://openalex.org/W2016133700","https://openalex.org/W2016186775","https://openalex.org/W2016632846","https://openalex.org/W2016842691","https://openalex.org/W2017519756","https://openalex.org/W2017719948","https://openalex.org/W2018406884","https://openalex.org/W2019722237","https://openalex.org/W2020175197","https://openalex.org/W2021452935","https://openalex.org/W2022438793","https://openalex.org/W2023153372","https://openalex.org/W2023931430","https://openalex.org/W2024051621","https://openalex.org/W2024879181","https://openalex.org/W2025238111","https://openalex.org/W2026146775","https://openalex.org/W2027053207","https://openalex.org/W2027170559","https://openalex.org/W2027709057","https://openalex.org/W2028133469","https://openalex.org/W2028481285","https://openalex.org/W2028954201","https://openalex.org/W2029549914","https://openalex.org/W2029775204","https://openalex.org/W2030966943","https://openalex.org/W2034132266","https://openalex.org/W2034689381","https://openalex.org/W2034975889","https://openalex.org/W2036505063","https://openalex.org/W2036962167","https://openalex.org/W2037617836","https://openalex.org/W2037727905","https://openalex.org/W2037959858","https://openalex.org/W2038398738","https://openalex.org/W2038403836","https://openalex.org/W2039781079","https://openalex.org/W2040027190","https://openalex.org/W2040053707","https://openalex.org/W2040168380","https://openalex.org/W2040344455","https://openalex.org/W2040361352","https://openalex.org/W2041270901","https://openalex.org/W2042271211","https://openalex.org/W2042540265","https://openalex.org/W2042583613","https://openalex.org/W2043447223","https://openalex.org/W2044110727","https://openalex.org/W2046461013","https://openalex.org/W2046575349","https://openalex.org/W2046670188","https://openalex.org/W2047243367","https://openalex.org/W2048216262","https://openalex.org/W2048880860","https://openalex.org/W2049828237","https://openalex.org/W2050123774","https://openalex.org/W2050223231","https://openalex.org/W2050839185","https://openalex.org/W2052641263","https://openalex.org/W2052802104","https://openalex.org/W2053868060","https://openalex.org/W2054061557","https://openalex.org/W2055063890","https://openalex.org/W2057394115","https://openalex.org/W2057795636","https://openalex.org/W2058178606","https://openalex.org/W2058759081","https://openalex.org/W2059241870","https://openalex.org/W2059291229","https://openalex.org/W2059559956","https://openalex.org/W2060444798","https://openalex.org/W2060590160","https://openalex.org/W2060747455","https://openalex.org/W2061801471","https://openalex.org/W2062018285","https://openalex.org/W2062738447","https://openalex.org/W2062885108","https://openalex.org/W2064959156","https://openalex.org/W2065327900","https://openalex.org/W2066641152","https://openalex.org/W2067058980","https://openalex.org/W2067244724","https://openalex.org/W2068524611","https://openalex.org/W2068657661","https://openalex.org/W2068747569","https://openalex.org/W2068759489","https://openalex.org/W2069642405","https://openalex.org/W2069949257","https://openalex.org/W2069953832","https://openalex.org/W2070570463","https://openalex.org/W2071056880","https://openalex.org/W2071795676","https://openalex.org/W2071896073","https://openalex.org/W2072135987","https://openalex.org/W2074754684","https://openalex.org/W2075763636","https://openalex.org/W2076320557","https://openalex.org/W2076744485","https://openalex.org/W2077564233","https://openalex.org/W2078119974","https://openalex.org/W2078606549","https://openalex.org/W2079080809","https://openalex.org/W2080046185","https://openalex.org/W2080355074","https://openalex.org/W2080441863","https://openalex.org/W2080810487","https://openalex.org/W2082380119","https://openalex.org/W2083260739","https://openalex.org/W2083436346","https://openalex.org/W2084024307","https://openalex.org/W2084773437","https://openalex.org/W2087633358","https://openalex.org/W2087754320","https://openalex.org/W2088091848","https://openalex.org/W2088769441","https://openalex.org/W2089144152","https://openalex.org/W2089426918","https://openalex.org/W2089994166","https://openalex.org/W2090970892","https://openalex.org/W2091897891","https://openalex.org/W2093246497","https://openalex.org/W2093415279","https://openalex.org/W2094987670","https://openalex.org/W2095115775","https://openalex.org/W2096579700","https://openalex.org/W2096924672","https://openalex.org/W2097382368","https://openalex.org/W2098056422","https://openalex.org/W2099225148","https://openalex.org/W2099383076","https://openalex.org/W2102424972","https://openalex.org/W2102471151","https://openalex.org/W2103273501","https://openalex.org/W2104680567","https://openalex.org/W2105490762","https://openalex.org/W2106814707","https://openalex.org/W2106882534","https://openalex.org/W2108349614","https://openalex.org/W2108885746","https://openalex.org/W2109679303","https://openalex.org/W2109894071","https://openalex.org/W2111762123","https://openalex.org/W2113062644","https://openalex.org/W2113344483","https://openalex.org/W2114828923","https://openalex.org/W2115413512","https://openalex.org/W2115494923","https://openalex.org/W2115897435","https://openalex.org/W2116111392","https://openalex.org/W2116811328","https://openalex.org/W2117590286","https://openalex.org/W2119390497","https://openalex.org/W2119597806","https://openalex.org/W2120972488","https://openalex.org/W2121669373","https://openalex.org/W2122038795","https://openalex.org/W2123673861","https://openalex.org/W2124020075","https://openalex.org/W2124679312","https://openalex.org/W2124790653","https://openalex.org/W2125121305","https://openalex.org/W2127170253","https://openalex.org/W2127426283","https://openalex.org/W2128831868","https://openalex.org/W2129728286","https://openalex.org/W2130283573","https://openalex.org/W2132821014","https://openalex.org/W2132905162","https://openalex.org/W2133348043","https://openalex.org/W2134155314","https://openalex.org/W2135123683","https://openalex.org/W2136702750","https://openalex.org/W2136942954","https://openalex.org/W2138089548","https://openalex.org/W2139008602","https://openalex.org/W2139963479","https://openalex.org/W2140164555","https://openalex.org/W2140534303","https://openalex.org/W2142693509","https://openalex.org/W2143042122","https://openalex.org/W2143481288","https://openalex.org/W2144368480","https://openalex.org/W2145780430","https://openalex.org/W2146373839","https://openalex.org/W2147442859","https://openalex.org/W2147660889","https://openalex.org/W2147685178","https://openalex.org/W2149470117","https://openalex.org/W2149793184","https://openalex.org/W2149970319","https://openalex.org/W2150423374","https://openalex.org/W2151385534","https://openalex.org/W2152040532","https://openalex.org/W2152075687","https://openalex.org/W2156211435","https://openalex.org/W2156511049","https://openalex.org/W2157399606","https://openalex.org/W2157666894","https://openalex.org/W2157699998","https://openalex.org/W2158096004","https://openalex.org/W2158254108","https://openalex.org/W2158512791","https://openalex.org/W2160364329","https://openalex.org/W2161421738","https://openalex.org/W2162227528","https://openalex.org/W2163034231","https://openalex.org/W2164680020","https://openalex.org/W2164850196","https://openalex.org/W2165404480","https://openalex.org/W2165659429","https://openalex.org/W2170565120","https://openalex.org/W2174542542","https://openalex.org/W2182326436","https://openalex.org/W2188574167","https://openalex.org/W2461056654","https://openalex.org/W2978776366","https://openalex.org/W3138770454"],"related_works":["https://openalex.org/W1515579299","https://openalex.org/W2028481285","https://openalex.org/W2612080976","https://openalex.org/W2038398738","https://openalex.org/W2042583613","https://openalex.org/W1988377819","https://openalex.org/W2085663341","https://openalex.org/W2062738447","https://openalex.org/W2116811328","https://openalex.org/W2189584551"],"abstract_inverted_index":{"The":[0],"objective":[1],"of":[2,10,15,28,43,48,76,126],"this":[3,92,95],"study":[4],"was":[5,51],"to":[6,145],"clarify":[7],"the":[8,24,41,45,49,54,80],"regulation":[9],"production":[11,128],"and":[12,26,33],"signal":[13],"transduction":[14],"juvenile":[16],"hormone":[17],"(JH)":[18],"in":[19,79,89,123,129,134,137],"insects":[20],"by":[21],"experimentally":[22],"examining":[23],"function":[25,90],"evolution":[27,108],"a":[29,34],"putative":[30],"receptor":[31,50],"(USP/RXR)":[32],"neuropeptide":[35],"inhibitor":[36],"(FGLamide":[37],"allatostatin).":[38],"To":[39,105],"examine":[40,106],"role":[42],"USP/RXR,":[44],"cDNA":[46],"sequence":[47,74],"obtained":[52],"from":[53],"cockroach":[55,131],"Diploptera":[56],"punctata.":[57],"Transcript":[58],"levels":[59],"during":[60],"developmentally":[61],"critical":[62],"periods":[63],"for":[64,122],"JH":[65,71,127],"sensitivity":[66],"may":[67,97,142],"suggest":[68,86],"USP/RXR":[69],"is":[70],"responsive.":[72],"Comparative":[73],"analysis":[75],"evolutionary":[77],"rates":[78],"Mecopterida":[81],"support":[82],"current":[83],"hypotheses":[84],"which":[85],"some":[87,138],"gain":[88],"along":[91],"lineage,":[93],"although":[94],"acquisition":[96],"have":[98],"occurred":[99],"more":[100],"gradually":[101],"than":[102],"previously":[103],"assumed.":[104],"allatostatin":[107],"within":[109],"insects,":[110],"ancestral":[111,117,139],"peptides":[112,140],"inferred":[113],"using":[114],"maximum":[115],"likelihood":[116],"reconstruction":[118],"methods":[119],"were":[120],"assayed":[121],"vitro":[124],"inhibition":[125],"two":[130],"species.":[132],"Shifts":[133],"peptide":[135,146],"potency":[136],"reconstructed":[141],"be":[143],"related":[144],"copy":[147],"number":[148],"evolution.":[149]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-04-26T00:00:00"}
