{"id":"https://openalex.org/W3152932450","doi":"https://doi.org/10.1007/s12035-021-02467-x","title":"Maternal Ethanol Exposure Acutely Elevates Src Family Kinase Activity in the Fetal Cortex","display_name":"Maternal Ethanol Exposure Acutely Elevates Src Family Kinase Activity in the Fetal Cortex","publication_year":2021,"publication_date":"2021-07-16","ids":{"openalex":"https://openalex.org/W3152932450","doi":"https://doi.org/10.1007/s12035-021-02467-x","mag":"3152932450","pmid":"https://pubmed.ncbi.nlm.nih.gov/34272687","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8497457"},"language":"en","primary_location":{"id":"doi:10.1007/s12035-021-02467-x","doi":"https://doi.org/10.1007/s12035-021-02467-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12035-021-02467-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12035-021-02467-x.pdf","source":{"id":"https://openalex.org/S194681035","display_name":"Molecular Neurobiology","issn_l":"0893-7648","issn":["0893-7648","1559-1182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12035-021-02467-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100462165","display_name":"Dandan Wang","orcid":"https://orcid.org/0000-0002-5626-8968","observed_orcids":["https://orcid.org/0000-0002-5626-8968","https://orcid.org/0000-0003-3493-1615"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dandan Wang","raw_affiliation_strings":["Department of Neuroscience and Physiology, SUNY Upstate Medical University, 505 Irving Ave, Syracuse, NY, 13210, USA","Developmental Exposure to Alcohol Research Center (DEARC), Binghamton University, Binghamton, NY, 13902, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Physiology, SUNY Upstate Medical University, 505 Irving Ave, Syracuse, NY, 13210, USA","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"Developmental Exposure to Alcohol Research Center (DEARC), Binghamton University, Binghamton, NY, 13902, USA","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033347099","display_name":"Brian W. Howell","orcid":"https://orcid.org/0000-0002-0204-0773","observed_orcids":["https://orcid.org/0000-0002-0204-0773"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian W. Howell","raw_affiliation_strings":["Department of Neuroscience and Physiology, SUNY Upstate Medical University, 505 Irving Ave, Syracuse, NY, 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Physiology, SUNY Upstate Medical University, 505 Irving Ave, Syracuse, NY, 13210, USA","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079239156","display_name":"Eric C. Olson","orcid":"https://orcid.org/0000-0002-1545-6532","observed_orcids":["https://orcid.org/0000-0002-1545-6532","https://orcid.org/0000-0002-3642-8020"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric C. Olson","raw_affiliation_strings":["Department of Neuroscience and Physiology, SUNY Upstate Medical University, 505 Irving Ave, Syracuse, NY, 13210, USA. olsone@upstate.edu","Developmental Exposure to Alcohol Research Center (DEARC), Binghamton University, Binghamton, NY, 13902, USA. olsone@upstate.edu","Developmental Exposure to Alcohol Research Center (DEARC), Binghamton University, Binghamton, NY, 13902, USA"],"raw_orcid":"https://orcid.org/0000-0002-1545-6532","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Physiology, SUNY Upstate Medical University, 505 Irving Ave, Syracuse, NY, 13210, USA. olsone@upstate.edu","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"Developmental Exposure to Alcohol Research Center (DEARC), Binghamton University, Binghamton, NY, 13902, USA. olsone@upstate.edu","institution_ids":["https://openalex.org/I123946342"]},{"raw_affiliation_string":"Developmental Exposure to Alcohol Research Center (DEARC), Binghamton University, Binghamton, NY, 13902, USA","institution_ids":["https://openalex.org/I123946342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079239156"],"corresponding_institution_ids":["https://openalex.org/I123946342","https://openalex.org/I20388574"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":0.678,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64874854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"58","issue":"10","first_page":"5210","last_page":"5223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-alcohol-syndrome","display_name":"fetal alcohol syndrome","score":0.8600000143051147},{"id":"https://openalex.org/keywords/maternal-ethanol-exposure","display_name":"maternal ethanol exposure","score":0.9829999804496765},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.968999981880188},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/fetal-cerebral-cortex","display_name":"fetal cerebral cortex","score":0.8579999804496765},{"id":"https://openalex.org/keywords/reelin-signaling","display_name":"Reelin signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/dab1","display_name":"Dab1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9129999876022339},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cortical-neuron-migration","display_name":"cortical neuron migration","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.8009359836578369},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.763029158115387},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5945013761520386},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5765782594680786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5552899241447449},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.46196219325065613},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.45362818241119385},{"id":"https://openalex.org/C188209991","wikidata":"https://www.wikidata.org/wiki/Q14916487","display_name":"DAB1","level":4,"score":0.42767447233200073},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42506396770477295},{"id":"https://openalex.org/C37686147","wikidata":"https://www.wikidata.org/wiki/Q423628","display_name":"FYN","level":4,"score":0.4131830036640167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34402668476104736},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3325565457344055},{"id":"https://openalex.org/C2778063154","wikidata":"https://www.wikidata.org/wiki/Q13561329","display_name":"Reelin","level":3,"score":0.3049432635307312},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18301555514335632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15651199221611023},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s12035-021-02467-x","doi":"https://doi.org/10.1007/s12035-021-02467-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12035-021-02467-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12035-021-02467-x.pdf","source":{"id":"https://openalex.org/S194681035","display_name":"Molecular Neurobiology","issn_l":"0893-7648","issn":["0893-7648","1559-1182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurobiology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-409416/v1","doi":"https://doi.org/10.21203/rs.3.rs-409416/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-409416/v1","pdf_url":"https://www.researchsquare.com/article/rs-409416/v1.pdf?c=1631895390000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:34272687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34272687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular neurobiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8497457","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8497457/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Neurobiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s12035-021-02467-x","doi":"https://doi.org/10.1007/s12035-021-02467-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12035-021-02467-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12035-021-02467-x.pdf","source":{"id":"https://openalex.org/S194681035","display_name":"Molecular Neurobiology","issn_l":"0893-7648","issn":["0893-7648","1559-1182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurobiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000913995","display_name":"Developmental Exposure Alcohol Research Center","funder_award_id":"P50AA017823","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320309644","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08"},{"id":"https://openalex.org/F4320310407","display_name":"Beckman Research Institute, City of Hope","ror":"https://ror.org/00w6g5w60"},{"id":"https://openalex.org/F4320332681","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77"},{"id":"https://openalex.org/F4320333038","display_name":"State University of New York Upstate Medical University","ror":"https://ror.org/040kfrw16"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3152932450.pdf","grobid_xml":"https://content.openalex.org/works/W3152932450.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W1484094963","https://openalex.org/W1497439949","https://openalex.org/W1624427347","https://openalex.org/W1631910077","https://openalex.org/W1667992367","https://openalex.org/W1817249348","https://openalex.org/W1830240816","https://openalex.org/W1966161684","https://openalex.org/W1969412061","https://openalex.org/W1973063454","https://openalex.org/W1973376874","https://openalex.org/W1976119455","https://openalex.org/W1978013837","https://openalex.org/W1979890518","https://openalex.org/W1980436204","https://openalex.org/W1986367012","https://openalex.org/W1990915902","https://openalex.org/W1990935914","https://openalex.org/W1993570554","https://openalex.org/W1994406909","https://openalex.org/W1996642171","https://openalex.org/W1997278612","https://openalex.org/W2000170431","https://openalex.org/W2000590675","https://openalex.org/W2000663949","https://openalex.org/W2003191511","https://openalex.org/W2003973314","https://openalex.org/W2005826876","https://openalex.org/W2008441088","https://openalex.org/W2013940103","https://openalex.org/W2022888964","https://openalex.org/W2023441280","https://openalex.org/W2025579230","https://openalex.org/W2029863283","https://openalex.org/W2031525292","https://openalex.org/W2033339393","https://openalex.org/W2039005185","https://openalex.org/W2040407429","https://openalex.org/W2044304997","https://openalex.org/W2045419701","https://openalex.org/W2050599523","https://openalex.org/W2050748045","https://openalex.org/W2052453869","https://openalex.org/W2057685032","https://openalex.org/W2058510290","https://openalex.org/W2063236277","https://openalex.org/W2063511140","https://openalex.org/W2065244129","https://openalex.org/W2065323140","https://openalex.org/W2067172671","https://openalex.org/W2077247278","https://openalex.org/W2079396188","https://openalex.org/W2090867494","https://openalex.org/W2092606584","https://openalex.org/W2099263400","https://openalex.org/W2108867585","https://openalex.org/W2108986540","https://openalex.org/W2112125323","https://openalex.org/W2115136264","https://openalex.org/W2117220243","https://openalex.org/W2117547988","https://openalex.org/W2127822723","https://openalex.org/W2134021871","https://openalex.org/W2142219689","https://openalex.org/W2154343843","https://openalex.org/W2156126807","https://openalex.org/W2156289507","https://openalex.org/W2158694460","https://openalex.org/W2162321314","https://openalex.org/W2162720854","https://openalex.org/W2339632831","https://openalex.org/W2395307675","https://openalex.org/W2409097008","https://openalex.org/W2414979813","https://openalex.org/W2743782034","https://openalex.org/W2754719948","https://openalex.org/W2763742869","https://openalex.org/W2792288381","https://openalex.org/W2912765031","https://openalex.org/W3015031339","https://openalex.org/W4230842046","https://openalex.org/W4253570880"],"related_works":["https://openalex.org/W2912765031","https://openalex.org/W2030340360","https://openalex.org/W2102779795","https://openalex.org/W4242840686","https://openalex.org/W2136790318","https://openalex.org/W1994673776","https://openalex.org/W7097660436","https://openalex.org/W7099913201","https://openalex.org/W2888073233","https://openalex.org/W1498787004"],"abstract_inverted_index":{"Fetal":[0],"alcohol":[1,18],"syndrome":[2],"(FAS)":[3],"is":[4,23,199,225],"characterized":[5],"by":[6,201,254],"disrupted":[7,234],"fetal":[8,72,93],"brain":[9,73],"development":[10],"and":[11,21,82,96,102,122,146,160,165,180,214,233],"postnatal":[12],"cognitive":[13],"impairment.":[14],"The":[15,151,242],"targets":[16,177],"of":[17,50,87,100,119,162,207,219,230,252],"are":[19,28],"diverse,":[20],"it":[22],"not":[24],"clear":[25],"whether":[26],"there":[27],"common":[29],"underlying":[30],"molecular":[31],"mechanisms":[32],"producing":[33],"these":[34],"disruptions.":[35],"Prior":[36],"work":[37],"established":[38],"that":[39,63,98],"acute":[40],"ethanol":[41,113,255],"exposure":[42],"causes":[43],"a":[44,64,188,209,245],"transient":[45,68,173],"increase":[46,145],"in":[47,53,70,91,156,185,204,238,247],"tyrosine":[48,66,89,107,148],"phosphorylation":[49,67,90,108,129,149,152,197,206],"multiple":[51,261],"proteins":[52],"cultured":[54],"embryonic":[55],"cortical":[56,193,240],"cells.":[57],"In":[58],"this":[59],"study,":[60],"we":[61,84],"show":[62],"similar":[65],"occurs":[69],"the":[71,92,136,143,147,157,170,249,257],"after":[74,111,269],"maternal":[75,112,133,270],"dosing":[76],"with":[77,135,227],"ethanol.":[78],"Using":[79],"phospho-specific":[80],"antibodies":[81],"immunohistochemistry,":[83],"mapped":[85],"regions":[86],"highest":[88],"cerebral":[94],"cortex":[95],"found":[97],"areas":[99,118],"dendritic":[101],"axonal":[103],"growth":[104],"showed":[105],"elevated":[106],"10":[109],"min":[110],"exposure.":[114,271],"These":[115],"were":[116],"also":[117],"Src":[120,123,179],"expression":[121],"family":[124],"kinase":[125],"(SFK)":[126],"activation":[127,251],"loop":[128],"(pY416)":[130],"expression.":[131],"Importantly,":[132,169],"pretreatment":[134],"SFK":[137],"inhibitor":[138],"dasatinib":[139],"completely":[140],"prevents":[141],"both":[142,178],"pY416":[144],"response.":[150],"response":[153,198],"was":[154],"observed":[155],"perisomatic":[158],"region":[159],"neurites":[161],"immature":[163],"migrating":[164],"differentiating":[166],"primary":[167],"neurons.":[168,241],"initial":[171,196,250],"phosphotyrosine":[172],"(~":[174],"30":[175],"min)":[176],"Dab1,":[181],"two":[182],"critical":[183,210],"elements":[184],"Reelin":[186,220],"signaling,":[187],"pathway":[189],"required":[190],"for":[191,266],"normal":[192],"development.":[194],"This":[195,222],"followed":[200],"sustained":[202,228],"reduction":[203,229],"Ser3":[205],"n-cofilin,":[208],"actin":[211],"severing":[212],"protein":[213],"an":[215],"identified":[216],"downstream":[217],"effector":[218],"signaling.":[221],"biochemical":[223],"disruption":[224],"associated":[226],"F-actin":[231],"content":[232],"Golgi":[235],"apparatus":[236],"morphology":[237],"developing":[239],"finding":[243],"outlines":[244],"model":[246],"which":[248],"SFKs":[253],"has":[256],"potential":[258],"to":[259],"disrupt":[260],"developmentally":[262],"important":[263],"signaling":[264],"systems":[265],"several":[267],"hours":[268]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-04-26T00:00:00"}