{"id":"https://openalex.org/W3152671069","doi":"https://doi.org/10.1016/j.jid.2021.02.158","title":"139 Heterochromatin maintenance is crucial for terminal keratinocyte differentiation and inhibition of inflammatory responses in the epidermis","display_name":"139 Heterochromatin maintenance is crucial for terminal keratinocyte differentiation and inhibition of inflammatory responses in the epidermis","publication_year":2021,"publication_date":"2021-04-19","ids":{"openalex":"https://openalex.org/W3152671069","doi":"https://doi.org/10.1016/j.jid.2021.02.158","mag":"3152671069"},"language":"en","primary_location":{"id":"doi:10.1016/j.jid.2021.02.158","doi":"https://doi.org/10.1016/j.jid.2021.02.158","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2021.02.158","pdf_url":"http://www.jidonline.org/article/S0022202X21003833/pdf","source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jidonline.org/article/S0022202X21003833/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072493165","display_name":"Guodong Chen","orcid":"https://orcid.org/0000-0001-9399-9252","observed_orcids":["https://orcid.org/0000-0001-9399-9252"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Chen","raw_affiliation_strings":["Dermatology, Boston University, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Boston University, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026983903","display_name":"Ahmar Aziz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Aziz","raw_affiliation_strings":["Dermatology, Boston University, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Boston University, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023981166","display_name":"Tatyana Y. Sharova","orcid":"https://orcid.org/0000-0003-2123-3906","observed_orcids":["https://orcid.org/0000-0003-2123-3906"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Sharova","raw_affiliation_strings":["Dermatology, Boston University, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Boston University, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012451335","display_name":"Elena Rozhkova","orcid":"https://orcid.org/0000-0002-5793-845X","observed_orcids":["https://orcid.org/0000-0002-5793-845X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Rozhkova","raw_affiliation_strings":["Dermatology, Boston University, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Boston University, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023203483","display_name":"Liu Yang","orcid":"https://orcid.org/0000-0001-5915-1581","observed_orcids":["https://orcid.org/0000-0001-5915-1581"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Yang","raw_affiliation_strings":["University of Washington, Seattle, Washington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, Washington, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049912277","display_name":"Nelson C. Lau","orcid":"https://orcid.org/0000-0001-9907-1404","observed_orcids":["https://orcid.org/0000-0001-9907-1404"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Lau","raw_affiliation_strings":["Biochemistry, Boston University, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry, Boston University, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090650222","display_name":"Vladimir A. Botchkarev","orcid":"https://orcid.org/0000-0002-5212-5353","observed_orcids":["https://orcid.org/0000-0002-5212-5353","https://orcid.org/0000-0002-9119-0895"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V.A. Botchkarev","raw_affiliation_strings":["Dermatology, Boston University, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Boston University, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037783700","display_name":"Kathrin Muegge","orcid":"https://orcid.org/0000-0003-1396-4282","observed_orcids":["https://orcid.org/0000-0003-1396-4282"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Muegge","raw_affiliation_strings":["National Cancer Institute, Bethesda, Maryland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, Maryland, United States","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003961897","display_name":"Andrey A. Sharov","orcid":"https://orcid.org/0000-0002-7240-304X","observed_orcids":["https://orcid.org/0000-0002-7240-304X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Sharov","raw_affiliation_strings":["Dermatology, Boston University, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Boston University, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02773499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"141","issue":"5","first_page":"S25","last_page":"S25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.6039999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.6039999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.26899999380111694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.04989999905228615,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heterochromatin-maintenance","display_name":"heterochromatin maintenance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epidermis","display_name":"epidermis","score":0.875},{"id":"https://openalex.org/keywords/transposable-elements","display_name":"transposable elements","score":0.8029999732971191},{"id":"https://openalex.org/keywords/endogenous-retroviruses","display_name":"endogenous retroviruses","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.7139999866485596},{"id":"https://openalex.org/keywords/h3k9me3","display_name":"H3K9me3","score":0.9430000185966492},{"id":"https://openalex.org/keywords/setdb1","display_name":"SETDB1","score":1.0},{"id":"https://openalex.org/keywords/lsh","display_name":"LSH","score":0.9490000009536743},{"id":"https://openalex.org/keywords/swi-snf-chromatin-remodeling","display_name":"SWI/SNF chromatin remodeling","score":0.9729999899864197},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5199999809265137},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8289883136749268},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.7375849485397339},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5815857648849487},{"id":"https://openalex.org/C7029365","wikidata":"https://www.wikidata.org/wiki/Q413988","display_name":"Retrotransposon","level":5,"score":0.5616097450256348},{"id":"https://openalex.org/C121346293","wikidata":"https://www.wikidata.org/wiki/Q1340715","display_name":"Endogenous retrovirus","level":4,"score":0.5080258846282959},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5038332343101501},{"id":"https://openalex.org/C92149661","wikidata":"https://www.wikidata.org/wiki/Q1616164","display_name":"Heterochromatin protein 1","level":5,"score":0.4829117953777313},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42503973841667175},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.423234760761261},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41296637058258057},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4048006236553192},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.3775068521499634},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.22853830456733704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1929125189781189},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.15603142976760864}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jid.2021.02.158","doi":"https://doi.org/10.1016/j.jid.2021.02.158","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2021.02.158","pdf_url":"http://www.jidonline.org/article/S0022202X21003833/pdf","source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jid.2021.02.158","doi":"https://doi.org/10.1016/j.jid.2021.02.158","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2021.02.158","pdf_url":"http://www.jidonline.org/article/S0022202X21003833/pdf","source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4211168216","https://openalex.org/W2143264878","https://openalex.org/W2955897131","https://openalex.org/W2010126413","https://openalex.org/W2089350008","https://openalex.org/W2137107848","https://openalex.org/W4390458389","https://openalex.org/W2990154534","https://openalex.org/W1581380599","https://openalex.org/W123330465"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}